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The map label for this gene is acrR [H]

Identifier: 170025423

GI number: 170025423

Start: 3506594

End: 3507250

Strand: Reverse

Name: acrR [H]

Synonym: YPK_3206

Alternate gene names: 170025423

Gene position: 3507250-3506594 (Counterclockwise)

Preceding gene: 170025433

Following gene: 170025422

Centisome position: 74.79

GC content: 43.23

Gene sequence:

>657_bases
ATGGCACGAAAAACCAAACAGAAAGCCGAAGAGACCCGGCAACAAATTCTAGATGCCGCAGTGCGGGAGTTTTCTGCGCA
TGGCGTTTCCAGGACTTCTCTTACCGATATTGCTATCGCTGCGGGTGTAACCCGAGGCGCTATTTACTGGCACTTCAAGA
ATAAGGTAGACCTATTTAACGAAGTTTGGGAGCTATCCGAGTCTAAAATTGATCAGCTCGAGATAGAGTATCAGGCAAAA
TATCCTGATAATCCACTACGTATCCTCCGCGAACTCCTAATCTATATTTTGGTTTCTACTCGTGAGGACCGCCGACGTCG
TGCACTGATGGAAATTGTTTTCCATAAATGTGAATTCGTCGGTGAAATGACCTCCGTTCATGACGCACGTAAAGTCCTTG
ATTTAGCTAGCTATGAGCGAATTGAGTCGGTTTTACAAGGTTGCATCGATGCTAATCAATTACCGGTCAATCTCAATACT
CATCGTGCGGCAATTATTATGAGAGCCTATATTACAGGTTTGATGGAGAATTGGCTTTTTATGCCAGAAAGCTTTGATAT
AAAACAAGAGGCACCTGTATTAATTGATGCCTATCTGGAGATGCTAGGCCAGAGTTTTTCATTACGAAACGAGATGAATA
GCAGAGTATCGGATTAA

Upstream 100 bases:

>100_bases
ACAAGCTTTAAAACCCATTGCTGCGTAAATGATATGTGCGTGCTATGGTACATACATTCGTGAATGTATGTAAATCTCAC
CCCCCCGAAAAAACAACGCT

Downstream 100 bases:

>100_bases
CTGGAGGTTTATATGCATTCGCTGGTCATTATTGCTAATGGTGCCGCTTATGGCCATGAGTCATTATTTAATGCCTTACG
CCTATCGATTGCGTTGAAAG

Product: DNA-binding transcriptional repressor AcrR

Products: NA

Alternate protein names: Potential acrAB operon repressor [H]

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MARKTKQKAEETRQQILDAAVREFSAHGVSRTSLTDIAIAAGVTRGAIYWHFKNKVDLFNEVWELSESKIDQLEIEYQAK
YPDNPLRILRELLIYILVSTREDRRRRALMEIVFHKCEFVGEMTSVHDARKVLDLASYERIESVLQGCIDANQLPVNLNT
HRAAIIMRAYITGLMENWLFMPESFDIKQEAPVLIDAYLEMLGQSFSLRNEMNSRVSD

Sequences:

>Translated_218_residues
MARKTKQKAEETRQQILDAAVREFSAHGVSRTSLTDIAIAAGVTRGAIYWHFKNKVDLFNEVWELSESKIDQLEIEYQAK
YPDNPLRILRELLIYILVSTREDRRRRALMEIVFHKCEFVGEMTSVHDARKVLDLASYERIESVLQGCIDANQLPVNLNT
HRAAIIMRAYITGLMENWLFMPESFDIKQEAPVLIDAYLEMLGQSFSLRNEMNSRVSD
>Mature_217_residues
ARKTKQKAEETRQQILDAAVREFSAHGVSRTSLTDIAIAAGVTRGAIYWHFKNKVDLFNEVWELSESKIDQLEIEYQAKY
PDNPLRILRELLIYILVSTREDRRRRALMEIVFHKCEFVGEMTSVHDARKVLDLASYERIESVLQGCIDANQLPVNLNTH
RAAIIMRAYITGLMENWLFMPESFDIKQEAPVLIDAYLEMLGQSFSLRNEMNSRVSD

Specific function: Potential regulator protein for the acrAB genes [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=210, Percent_Identity=64.2857142857143, Blast_Score=278, Evalue=2e-76,
Organism=Escherichia coli, GI1789664, Length=202, Percent_Identity=38.6138613861386, Blast_Score=149, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 25240; Mature: 25109

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKTKQKAEETRQQILDAAVREFSAHGVSRTSLTDIAIAAGVTRGAIYWHFKNKVDLFN
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHCEEEEEECCHHHHHH
EVWELSESKIDQLEIEYQAKYPDNPLRILRELLIYILVSTREDRRRRALMEIVFHKCEFV
HHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
GEMTSVHDARKVLDLASYERIESVLQGCIDANQLPVNLNTHRAAIIMRAYITGLMENWLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
MPESFDIKQEAPVLIDAYLEMLGQSFSLRNEMNSRVSD
CCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
ARKTKQKAEETRQQILDAAVREFSAHGVSRTSLTDIAIAAGVTRGAIYWHFKNKVDLFN
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHCEEEEEECCHHHHHH
EVWELSESKIDQLEIEYQAKYPDNPLRILRELLIYILVSTREDRRRRALMEIVFHKCEFV
HHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
GEMTSVHDARKVLDLASYERIESVLQGCIDANQLPVNLNTHRAAIIMRAYITGLMENWLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
MPESFDIKQEAPVLIDAYLEMLGQSFSLRNEMNSRVSD
CCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]