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The map label for this gene is apt

Identifier: 170025416

GI number: 170025416

Start: 3500002

End: 3500565

Strand: Reverse

Name: apt

Synonym: YPK_3199

Alternate gene names: 170025416

Gene position: 3500565-3500002 (Counterclockwise)

Preceding gene: 170025417

Following gene: 170025415

Centisome position: 74.65

GC content: 48.76

Gene sequence:

>564_bases
ATGACCGCTTCTGCATCTAAGACAGCACAACAGCTTAAATATATAAAAGACAGTATCAAAACTATCCCCGATTATCCAAA
AGCGGGAATATTGTTCCGTGATGTGACCAGCTTGCTGGAGAATCCAAAGGCCTATTCCGCCAGCATCGAACTGCTGTCTG
AACACTATAGTGAGTCCGGTGTGACAAAAGTCGTGGGTACTGAAGCTCGCGGTTTTTTGTTTGGTGCCCCGGTGGCACTG
GCGCTGGGGGTAGGTTTTGTTCCGGTGCGTAAACCGGGAAAATTGCCACGTGAAACGATCAGTGAAAGCTATGAATTAGA
ATACGGCACTGACACATTAGAGATCCATACGGATAGCATCCAACCGGGTGATAAAGTCTTGGTTGTTGATGATCTATTGG
CGACTGGCGGCACCATTGAAGCCACGGTTAAGCTTATTCGCCGCTTGGGGGGGGAAGTGGTTCACGCGGCATTTATTATT
AATTTACCTGAACTGGGGGGCGAGGCTCGCCTGACTCAGCAAGGGATTCATTGCTACAGCCTCGTTTCTTTCGACGGTCA
TTGA

Upstream 100 bases:

>100_bases
TTATCGAAACTTTTCGGTGGCCTATGTCACTCAGATAACGCTATTTTCGCATTATCTGGCCGCGCTTTAGTATGTCCAGC
AGTTTTATCAGGCACAAATT

Downstream 100 bases:

>100_bases
TTGCATTGAAAACAACAGCCTCGCTATCTATATAGAATCAGTCCAATAGCGGGGCTGTTGAGTCCATAATTCCGATCACC
CAGCCTCATCTTCTGGCCTG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MTASASKTAQQLKYIKDSIKTIPDYPKAGILFRDVTSLLENPKAYSASIELLSEHYSESGVTKVVGTEARGFLFGAPVAL
ALGVGFVPVRKPGKLPRETISESYELEYGTDTLEIHTDSIQPGDKVLVVDDLLATGGTIEATVKLIRRLGGEVVHAAFII
NLPELGGEARLTQQGIHCYSLVSFDGH

Sequences:

>Translated_187_residues
MTASASKTAQQLKYIKDSIKTIPDYPKAGILFRDVTSLLENPKAYSASIELLSEHYSESGVTKVVGTEARGFLFGAPVAL
ALGVGFVPVRKPGKLPRETISESYELEYGTDTLEIHTDSIQPGDKVLVVDDLLATGGTIEATVKLIRRLGGEVVHAAFII
NLPELGGEARLTQQGIHCYSLVSFDGH
>Mature_186_residues
TASASKTAQQLKYIKDSIKTIPDYPKAGILFRDVTSLLENPKAYSASIELLSEHYSESGVTKVVGTEARGFLFGAPVALA
LGVGFVPVRKPGKLPRETISESYELEYGTDTLEIHTDSIQPGDKVLVVDDLLATGGTIEATVKLIRRLGGEVVHAAFIIN
LPELGGEARLTQQGIHCYSLVSFDGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=178, Percent_Identity=39.8876404494382, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI71773201, Length=129, Percent_Identity=44.1860465116279, Blast_Score=121, Evalue=3e-28,
Organism=Escherichia coli, GI1786675, Length=182, Percent_Identity=80.2197802197802, Blast_Score=295, Evalue=9e-82,
Organism=Caenorhabditis elegans, GI17509087, Length=173, Percent_Identity=43.9306358381503, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6323619, Length=173, Percent_Identity=41.0404624277457, Blast_Score=125, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6320649, Length=164, Percent_Identity=37.1951219512195, Blast_Score=96, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17136334, Length=186, Percent_Identity=43.5483870967742, Blast_Score=144, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_YERP3 (A7FL92)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001402020.1
- ProteinModelPortal:   A7FL92
- SMR:   A7FL92
- STRING:   A7FL92
- GeneID:   5388154
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_3060
- NMPDR:   fig|349747.3.peg.3647
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   YPSE349747:YPSIP31758_3060-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 20115; Mature: 19984

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASASKTAQQLKYIKDSIKTIPDYPKAGILFRDVTSLLENPKAYSASIELLSEHYSESG
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
VTKVVGTEARGFLFGAPVALALGVGFVPVRKPGKLPRETISESYELEYGTDTLEIHTDSI
CEEEECCCCCCEEEHHHHHHHHCCCCEECCCCCCCCHHHHCCCEEEEECCCEEEEEECCC
QPGDKVLVVDDLLATGGTIEATVKLIRRLGGEVVHAAFIINLPELGGEARLTQQGIHCYS
CCCCEEEEEEHHHHCCCHHHHHHHHHHHHCHHHEEHHHEEECCCCCCCCHHHHCCCEEEE
LVSFDGH
EEEECCC
>Mature Secondary Structure 
TASASKTAQQLKYIKDSIKTIPDYPKAGILFRDVTSLLENPKAYSASIELLSEHYSESG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
VTKVVGTEARGFLFGAPVALALGVGFVPVRKPGKLPRETISESYELEYGTDTLEIHTDSI
CEEEECCCCCCEEEHHHHHHHHCCCCEECCCCCCCCHHHHCCCEEEEECCCEEEEEECCC
QPGDKVLVVDDLLATGGTIEATVKLIRRLGGEVVHAAFIINLPELGGEARLTQQGIHCYS
CCCCEEEEEEHHHHCCCHHHHHHHHHHHHCHHHEEHHHEEECCCCCCCCHHHHCCCEEEE
LVSFDGH
EEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA