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The map label for this gene is fsr [H]

Identifier: 170025389

GI number: 170025389

Start: 3467287

End: 3467745

Strand: Direct

Name: fsr [H]

Synonym: YPK_3172

Alternate gene names: 170025389

Gene position: 3467287-3467745 (Clockwise)

Preceding gene: 170025388

Following gene: 170025390

Centisome position: 73.94

GC content: 48.37

Gene sequence:

>459_bases
ATGACCGATCGTTCTGATACCGGATGTCAGCAGCCCGTTAATGTTTCAGTCAAACGTACATCTTTCTCTATTTTGGGTGC
TATCAGCGTATCTCACCTACTCAACGATATGATCCAGTCGCTGATCCTGGCGATTTATCCTTTATTACAAGCTGAGTTCT
CATTGAGTTTTGCTCAAATAGGATTGATCACGCTAACTTACCAATTGACGGCTTCGTTACTACAACCGCTGATTGGCTTA
TATACGGATAAACACCCCCAGCCATACTCATTACCCATCGGTATGGGGTTCACGCTGTCTGGCATATTACTGCTGGCAGT
AGCCACAACCTTCCCGGTGGTATTATTAGCGGCAGCATTGGTCGGTACTGGCTCTTCTGTATTCCACCCAGAATCATCAC
GAGTCGCCCGTATGGCATCCGGTGGGCGCCATGGTTGTGCCCAGAAAACCCCCAGCTAG

Upstream 100 bases:

>100_bases
ATCAAATCGTTCATATGTAGTAAAAATCATACAATATGCCTAGTATGTATTCATTATCAAAATAGCATTAACATTCAAAA
TTATTAGGTGAATACTCACT

Downstream 100 bases:

>100_bases
GCTGGGGGTTCAGTAAAGCTTTCAGCTTTGGGTCAGTTATAAAAACCCCTTTTGATTTGTTAAAACAGTTTGCGGTCTGG
CAACTGCAAATGTTCAACAA

Product: putative membrane efflux protein

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MTDRSDTGCQQPVNVSVKRTSFSILGAISVSHLLNDMIQSLILAIYPLLQAEFSLSFAQIGLITLTYQLTASLLQPLIGL
YTDKHPQPYSLPIGMGFTLSGILLLAVATTFPVVLLAAALVGTGSSVFHPESSRVARMASGGRHGCAQKTPS

Sequences:

>Translated_152_residues
MTDRSDTGCQQPVNVSVKRTSFSILGAISVSHLLNDMIQSLILAIYPLLQAEFSLSFAQIGLITLTYQLTASLLQPLIGL
YTDKHPQPYSLPIGMGFTLSGILLLAVATTFPVVLLAAALVGTGSSVFHPESSRVARMASGGRHGCAQKTPS
>Mature_151_residues
TDRSDTGCQQPVNVSVKRTSFSILGAISVSHLLNDMIQSLILAIYPLLQAEFSLSFAQIGLITLTYQLTASLLQPLIGLY
TDKHPQPYSLPIGMGFTLSGILLLAVATTFPVVLLAAALVGTGSSVFHPESSRVARMASGGRHGCAQKTPS

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=130, Percent_Identity=80.7692307692308, Blast_Score=213, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 16088; Mature: 15957

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRSDTGCQQPVNVSVKRTSFSILGAISVSHLLNDMIQSLILAIYPLLQAEFSLSFAQI
CCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLITLTYQLTASLLQPLIGLYTDKHPQPYSLPIGMGFTLSGILLLAVATTFPVVLLAAAL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VGTGSSVFHPESSRVARMASGGRHGCAQKTPS
HCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TDRSDTGCQQPVNVSVKRTSFSILGAISVSHLLNDMIQSLILAIYPLLQAEFSLSFAQI
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLITLTYQLTASLLQPLIGLYTDKHPQPYSLPIGMGFTLSGILLLAVATTFPVVLLAAAL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VGTGSSVFHPESSRVARMASGGRHGCAQKTPS
HCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]