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The map label for this gene is lnt

Identifier: 170025230

GI number: 170025230

Start: 3309648

End: 3311195

Strand: Direct

Name: lnt

Synonym: YPK_3009

Alternate gene names: 170025230

Gene position: 3309648-3311195 (Clockwise)

Preceding gene: 170025229

Following gene: 170025231

Centisome position: 70.58

GC content: 51.1

Gene sequence:

>1548_bases
ATGTCTATTGCTCTATTCCTCCAACGCCAGTGGGTTCGCGCCCTACTGGCGCTATTTTTTGGTGCCTGTGGCACGCTTGC
TTACTCGCCGTTTGATCATTGGCCTGCCGCCATTGTTTCACTATTCGGTTTGCTCAGTCTGACGTTGAACCGCACCACCA
AACAAGCCACCTTCATTGGTTTTTGTTGGGGGATGGGGCTATTTGGCAGTGGCATCAACTGGGTGTATGTCAGCATCTCC
GAATTTGGGGGTATGCCAACGGCAATCAATATCGTCCTCGTCATCTTGCTAGCAGCATATTTATCACTCTACACCATGCT
ATTCGCCGGTTTATTAGCCCGCCTGTGCCCTAAGGCTACCTGGTGGCGGCTCGCGATTGCGGCCCCGGTACTCTGGCAAT
TAACTGAATTCCTACGTGGCTGGGTATTAACGGGTTTCCCGTGGTTACAATTCGGCTACAGCCAAATTAACGGCCCTCTG
CGAGGGATAGCTCCCCTCCTCGGTGTTGATGGCATCACATTTATCTTGATGGCTATCAGTGGCTTGCTGGTCTACGCCTG
CTATCAACGTCGTATTGTCGCAGCAATTATCGCGCTGGCCTTACTGCTGCTGCCCTGGCCACTGCGCCAAATACAGTGGT
TCACACCAGAGCCTGAAAGAGCAGTCAATATCGCCATGGTACAAGGCAATATTGCTCAGTCAATGAAGTGGGATCCCAAA
GCCCTGATCACCACATTGCAAATTTATCTTGATGAAACCCGGCCATTTATGGGCAAAGCCCCCATTATTATCTGGCCAGA
ATCAGCTATTCCCGATATTGAAACCGATCAGAACACCTTCCTGACAATGATAGATGGCCTGATGCGGGCAAATCATAGCA
GCCTGATCACCGGCATTGTAGATGCCAAGCGGCAACCCGAGGGGCAAGGGTATCAATTCTTTAACAGCATCATTGTGTTA
GGCGATAAAGATACCTATCAATACCCGACCCGCAACCGTTATAGCAAACATCACTTGGTGCCCTTCGGTGAGTACGTACC
GCTCGAGTCCCTACTGCGCCCGCTGGCTCCGTTATTTAATTTACCCATGTCTTCATTTAACCGGGGTGATTATGTTCAAC
CCCCACTCACTATCGCTGGATTTAACCTCACGGCGGCTATTTGTTATGAAATCGTCTTGGGCCAGCAAGTACGGGATAAC
TTCCGCCCTGAAACAGATTTTCTACTGACTATCTCCAATGATGCCTGGTTTGGTCACTCCATTGGGCCGTGGCAACATTT
CCAAATGGCACGTATGCGCGCACTGGAGCTGGGCCGCCCGCTACTGCGCAGCACCAATAATGGCATTACTGCCGCTATTG
GCCCAAGTGGTGAAATTCTGGCGCAGATCCCACAGTTCACTCAACAGGTTTTAGAGGTCAAGGTCACCCCAACCACCGGT
ATCACGCCATATGCCCGTTTTGGCTCATGGCCAATGTGGATTATTACTCTGGTTTTGGGCGCCTTTACCCTGTACTGCGC
AATCCGGGGGCGCTCTGATAAGCACTAA

Upstream 100 bases:

>100_bases
TTATTTAAAGTTGCCATGGCAGATAGTCGACGTATCATTCAGGTTCATGTAAAAATCCCGGATGATGCTCCGCAACCTAA
ACTGGAAGAATAAATTCTTG

Downstream 100 bases:

>100_bases
TTTATGATCAGTACTAATTGATGATAAGCCTTGGTCAACTTGCCATAAACATTGGCTAACCTGTTATAAAAACGGGCTAA
TTTGCTATAAGCATCGATAG

Product: apolipoprotein N-acyltransferase

Products: NA

Alternate protein names: ALP N-acyltransferase

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MSIALFLQRQWVRALLALFFGACGTLAYSPFDHWPAAIVSLFGLLSLTLNRTTKQATFIGFCWGMGLFGSGINWVYVSIS
EFGGMPTAINIVLVILLAAYLSLYTMLFAGLLARLCPKATWWRLAIAAPVLWQLTEFLRGWVLTGFPWLQFGYSQINGPL
RGIAPLLGVDGITFILMAISGLLVYACYQRRIVAAIIALALLLLPWPLRQIQWFTPEPERAVNIAMVQGNIAQSMKWDPK
ALITTLQIYLDETRPFMGKAPIIIWPESAIPDIETDQNTFLTMIDGLMRANHSSLITGIVDAKRQPEGQGYQFFNSIIVL
GDKDTYQYPTRNRYSKHHLVPFGEYVPLESLLRPLAPLFNLPMSSFNRGDYVQPPLTIAGFNLTAAICYEIVLGQQVRDN
FRPETDFLLTISNDAWFGHSIGPWQHFQMARMRALELGRPLLRSTNNGITAAIGPSGEILAQIPQFTQQVLEVKVTPTTG
ITPYARFGSWPMWIITLVLGAFTLYCAIRGRSDKH

Sequences:

>Translated_515_residues
MSIALFLQRQWVRALLALFFGACGTLAYSPFDHWPAAIVSLFGLLSLTLNRTTKQATFIGFCWGMGLFGSGINWVYVSIS
EFGGMPTAINIVLVILLAAYLSLYTMLFAGLLARLCPKATWWRLAIAAPVLWQLTEFLRGWVLTGFPWLQFGYSQINGPL
RGIAPLLGVDGITFILMAISGLLVYACYQRRIVAAIIALALLLLPWPLRQIQWFTPEPERAVNIAMVQGNIAQSMKWDPK
ALITTLQIYLDETRPFMGKAPIIIWPESAIPDIETDQNTFLTMIDGLMRANHSSLITGIVDAKRQPEGQGYQFFNSIIVL
GDKDTYQYPTRNRYSKHHLVPFGEYVPLESLLRPLAPLFNLPMSSFNRGDYVQPPLTIAGFNLTAAICYEIVLGQQVRDN
FRPETDFLLTISNDAWFGHSIGPWQHFQMARMRALELGRPLLRSTNNGITAAIGPSGEILAQIPQFTQQVLEVKVTPTTG
ITPYARFGSWPMWIITLVLGAFTLYCAIRGRSDKH
>Mature_514_residues
SIALFLQRQWVRALLALFFGACGTLAYSPFDHWPAAIVSLFGLLSLTLNRTTKQATFIGFCWGMGLFGSGINWVYVSISE
FGGMPTAINIVLVILLAAYLSLYTMLFAGLLARLCPKATWWRLAIAAPVLWQLTEFLRGWVLTGFPWLQFGYSQINGPLR
GIAPLLGVDGITFILMAISGLLVYACYQRRIVAAIIALALLLLPWPLRQIQWFTPEPERAVNIAMVQGNIAQSMKWDPKA
LITTLQIYLDETRPFMGKAPIIIWPESAIPDIETDQNTFLTMIDGLMRANHSSLITGIVDAKRQPEGQGYQFFNSIIVLG
DKDTYQYPTRNRYSKHHLVPFGEYVPLESLLRPLAPLFNLPMSSFNRGDYVQPPLTIAGFNLTAAICYEIVLGQQVRDNF
RPETDFLLTISNDAWFGHSIGPWQHFQMARMRALELGRPLLRSTNNGITAAIGPSGEILAQIPQFTQQVLEVKVTPTTGI
TPYARFGSWPMWIITLVLGAFTLYCAIRGRSDKH

Specific function: Transfers the fatty acyl group on membrane lipoproteins

COG id: COG0815

COG function: function code M; Apolipoprotein N-acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 CN hydrolase domain

Homologues:

Organism=Escherichia coli, GI1786878, Length=511, Percent_Identity=65.1663405088063, Blast_Score=700, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LNT_YERPE (Q8D124)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AD0319
- RefSeq:   NP_668516.1
- RefSeq:   NP_992466.1
- RefSeq:   YP_002347572.1
- ProteinModelPortal:   Q8D124
- GeneID:   1146137
- GeneID:   1175445
- GeneID:   2766677
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO2616
- KEGG:   ypk:y1190
- KEGG:   ypm:YP_1097
- HOGENOM:   HBG616234
- OMA:   FESYFPE
- ProtClustDB:   PRK00302
- BioCyc:   YPES187410:Y1190-MONOMER
- BioCyc:   YPES214092:YPO2616-MONOMER
- HAMAP:   MF_01148
- InterPro:   IPR004563
- InterPro:   IPR003010
- Gene3D:   G3DSA:3.60.110.10
- TIGRFAMs:   TIGR00546

Pfam domain/function: PF00795 CN_hydrolase; SSF56317 Ntlse/CNhydtse

EC number: 2.3.1.- [C]

Molecular weight: Translated: 57672; Mature: 57541

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS50263 CN_HYDROLASE

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x18decc70)-; HASH(0x14e3bfa4)-; HASH(0x196b6f54)-; HASH(0x19aa4ee8)-; HASH(0x19244264)-; HASH(0x192134cc)-; HASH(0x405b2bd8)-; HASH(0x19c2f3ac)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIALFLQRQWVRALLALFFGACGTLAYSPFDHWPAAIVSLFGLLSLTLNRTTKQATFIG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
FCWGMGLFGSGINWVYVSISEFGGMPTAINIVLVILLAAYLSLYTMLFAGLLARLCPKAT
HHHHHHHHCCCCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
WWRLAIAAPVLWQLTEFLRGWVLTGFPWLQFGYSQINGPLRGIAPLLGVDGITFILMAIS
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHH
GLLVYACYQRRIVAAIIALALLLLPWPLRQIQWFTPEPERAVNIAMVQGNIAQSMKWDPK
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCEECCCCCCCEEEEEEEECCHHHHCCCCHH
ALITTLQIYLDETRPFMGKAPIIIWPESAIPDIETDQNTFLTMIDGLMRANHSSLITGIV
HHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
DAKRQPEGQGYQFFNSIIVLGDKDTYQYPTRNRYSKHHLVPFGEYVPLESLLRPLAPLFN
HHCCCCCCCCCEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LPMSSFNRGDYVQPPLTIAGFNLTAAICYEIVLGQQVRDNFRPETDFLLTISNDAWFGHS
CCHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCC
IGPWQHFQMARMRALELGRPLLRSTNNGITAAIGPSGEILAQIPQFTQQVLEVKVTPTTG
CCCHHHHHHHHHHHHHHCCHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHEEEECCCCC
ITPYARFGSWPMWIITLVLGAFTLYCAIRGRSDKH
CCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure 
SIALFLQRQWVRALLALFFGACGTLAYSPFDHWPAAIVSLFGLLSLTLNRTTKQATFIG
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
FCWGMGLFGSGINWVYVSISEFGGMPTAINIVLVILLAAYLSLYTMLFAGLLARLCPKAT
HHHHHHHHCCCCCEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
WWRLAIAAPVLWQLTEFLRGWVLTGFPWLQFGYSQINGPLRGIAPLLGVDGITFILMAIS
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHH
GLLVYACYQRRIVAAIIALALLLLPWPLRQIQWFTPEPERAVNIAMVQGNIAQSMKWDPK
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCEECCCCCCCEEEEEEEECCHHHHCCCCHH
ALITTLQIYLDETRPFMGKAPIIIWPESAIPDIETDQNTFLTMIDGLMRANHSSLITGIV
HHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
DAKRQPEGQGYQFFNSIIVLGDKDTYQYPTRNRYSKHHLVPFGEYVPLESLLRPLAPLFN
HHCCCCCCCCCEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LPMSSFNRGDYVQPPLTIAGFNLTAAICYEIVLGQQVRDNFRPETDFLLTISNDAWFGHS
CCHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCC
IGPWQHFQMARMRALELGRPLLRSTNNGITAAIGPSGEILAQIPQFTQQVLEVKVTPTTG
CCCHHHHHHHHHHHHHHCCHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHEEEECCCCC
ITPYARFGSWPMWIITLVLGAFTLYCAIRGRSDKH
CCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430