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The map label for this gene is nagC [H]

Identifier: 170025221

GI number: 170025221

Start: 3298372

End: 3299598

Strand: Direct

Name: nagC [H]

Synonym: YPK_2999

Alternate gene names: 170025221

Gene position: 3298372-3299598 (Clockwise)

Preceding gene: 170025220

Following gene: 170025222

Centisome position: 70.34

GC content: 50.04

Gene sequence:

>1227_bases
ATGAGCACCGGCGGACAAGCACAAATTGGTAACGTGGATCTGGTAAAACAACTCAATGGAGCCGTGGTTTATCGGCTAAT
TGATCAGCAAGGCCCGATTTCTCGCATACAGATTGCCGATCTCAGCCAGCTAGCCCCCGCCAGTGTCACCAAAATCACCC
GGCAATTGTTGGAGCGCGGGCTGATCAAAGAGGTCGATCAGCAAGCCTCCACCGGGGGGCGTCGCGCTATCTCTATCGTG
ACGGAAAACCGCCAATTCCATACCGTTGCAGTCCGTTTAGGTCGTAATGATGCCACGATCACCCTCTTTGATATGAGCGG
TAAATCGCTGGGTGAAGAGCACTATGCCCTGCCAGAACGAACACAAGAAACGCTGGAACACGCCTTATTTAATATCATCA
GTCAGTTTATTGACGCCTATCAGCGTAAATTACGTGAACTGATTGCCATCGCGGTTATCCTGCCTGGGCTGGTTGAGCAA
AGCAAAGGTATCGTGCGCTATATGCCGCATATCAGTGTCAGTAACTGGCCGTTAGTCGATAATCTACAAGCGCGCTTTAA
CGTCACCAGTTTTGTGGGTCACGATATCCGCAGCCTGGCACTGGCCGAGCAGTATTTTGGTGCAACCCGTGACTGTGAAG
ACTCCATTTTGGTTCGTCTACATCGAGGCACGGGTGCCGGTATTATCGTTAACAGCCAAATATTTTTAGGCAGCAACGGC
AACGTTGGCGAGATAGGCCATATTCAGATTGATCCATTGGGTGATCGCTGCTATTGCGGTAACTTTGGTTGTCTGGAAAC
CGTGGCATCCAACGCCGCGATTGAAAACCGCGTCAAGCACCTTCTCACCCAGGGTTATCCAAGTAAGCTGTCTCTTGATG
ACTGCCATATTGGTGCTATCTGTAAGGCCGCAAACCGCGGTGACTTGCTGGCCTGCGAAGTGATTGAACATGTTGGTCGC
TACTTGGGGAAAGCCATTGCTATCACCATAAACTTATTCAACCCACAAAAAGTGGTGATTGCCGGTGAAATTATTGAAGC
CGAGAAAATCCTACTACCCGCCATTCAGGGTTGCATTAATACGCAAGTTTTGAAAAACTTCCGCCAAAACCTGCCGATAG
TGACATCACAACTTAACCACCAGTCGGCTATCGGCGCTTTCGCACTGGCTAAGCGCGCTATGCTCAATGGTGTCTTGCTG
CAACGTTTGCTAGAAACTCACCCGTAG

Upstream 100 bases:

>100_bases
GGCAAAGTTGCCAACCTGACTGCCTTTACCCGCGATTATAAAATCACTAAAACCATCGTTAATGGCAACGAGGTTTTATC
ATAAGCGAGTAACTTTATTG

Downstream 100 bases:

>100_bases
GTTGAAAGAAACTGTCATGGCCACAGCCATGTTATAGTGACCTATTGCCGCGCTAAATGAGTAATATAAACAATGACAAT
CAAAAGCGTTATTTGCGATA

Product: ROK family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MSTGGQAQIGNVDLVKQLNGAVVYRLIDQQGPISRIQIADLSQLAPASVTKITRQLLERGLIKEVDQQASTGGRRAISIV
TENRQFHTVAVRLGRNDATITLFDMSGKSLGEEHYALPERTQETLEHALFNIISQFIDAYQRKLRELIAIAVILPGLVEQ
SKGIVRYMPHISVSNWPLVDNLQARFNVTSFVGHDIRSLALAEQYFGATRDCEDSILVRLHRGTGAGIIVNSQIFLGSNG
NVGEIGHIQIDPLGDRCYCGNFGCLETVASNAAIENRVKHLLTQGYPSKLSLDDCHIGAICKAANRGDLLACEVIEHVGR
YLGKAIAITINLFNPQKVVIAGEIIEAEKILLPAIQGCINTQVLKNFRQNLPIVTSQLNHQSAIGAFALAKRAMLNGVLL
QRLLETHP

Sequences:

>Translated_408_residues
MSTGGQAQIGNVDLVKQLNGAVVYRLIDQQGPISRIQIADLSQLAPASVTKITRQLLERGLIKEVDQQASTGGRRAISIV
TENRQFHTVAVRLGRNDATITLFDMSGKSLGEEHYALPERTQETLEHALFNIISQFIDAYQRKLRELIAIAVILPGLVEQ
SKGIVRYMPHISVSNWPLVDNLQARFNVTSFVGHDIRSLALAEQYFGATRDCEDSILVRLHRGTGAGIIVNSQIFLGSNG
NVGEIGHIQIDPLGDRCYCGNFGCLETVASNAAIENRVKHLLTQGYPSKLSLDDCHIGAICKAANRGDLLACEVIEHVGR
YLGKAIAITINLFNPQKVVIAGEIIEAEKILLPAIQGCINTQVLKNFRQNLPIVTSQLNHQSAIGAFALAKRAMLNGVLL
QRLLETHP
>Mature_407_residues
STGGQAQIGNVDLVKQLNGAVVYRLIDQQGPISRIQIADLSQLAPASVTKITRQLLERGLIKEVDQQASTGGRRAISIVT
ENRQFHTVAVRLGRNDATITLFDMSGKSLGEEHYALPERTQETLEHALFNIISQFIDAYQRKLRELIAIAVILPGLVEQS
KGIVRYMPHISVSNWPLVDNLQARFNVTSFVGHDIRSLALAEQYFGATRDCEDSILVRLHRGTGAGIIVNSQIFLGSNGN
VGEIGHIQIDPLGDRCYCGNFGCLETVASNAAIENRVKHLLTQGYPSKLSLDDCHIGAICKAANRGDLLACEVIEHVGRY
LGKAIAITINLFNPQKVVIAGEIIEAEKILLPAIQGCINTQVLKNFRQNLPIVTSQLNHQSAIGAFALAKRAMLNGVLLQ
RLLETHP

Specific function: Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566315, Length=302, Percent_Identity=23.841059602649, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI298566325, Length=302, Percent_Identity=23.841059602649, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI4885285, Length=302, Percent_Identity=23.841059602649, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI190014632, Length=302, Percent_Identity=23.841059602649, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1786891, Length=405, Percent_Identity=77.5308641975309, Blast_Score=653, Evalue=0.0,
Organism=Escherichia coli, GI1787878, Length=400, Percent_Identity=40, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI87082127, Length=333, Percent_Identity=22.2222222222222, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790522, Length=296, Percent_Identity=25, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081733, Length=272, Percent_Identity=22.7941176470588, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI87082230, Length=267, Percent_Identity=26.2172284644195, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000835
- InterPro:   IPR000600
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01047 MarR; PF00480 ROK [H]

EC number: NA

Molecular weight: Translated: 44615; Mature: 44484

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTGGQAQIGNVDLVKQLNGAVVYRLIDQQGPISRIQIADLSQLAPASVTKITRQLLERG
CCCCCCCCCCCHHHHHHCCCEEEEEEECCCCCCCEEEECCHHHCCCHHHHHHHHHHHHHH
LIKEVDQQASTGGRRAISIVTENRQFHTVAVRLGRNDATITLFDMSGKSLGEEHYALPER
HHHHHHHHHCCCCCEEEEEEECCCEEEEEEEEECCCCCEEEEEECCCCCCCCHHCCCCHH
TQETLEHALFNIISQFIDAYQRKLRELIAIAVILPGLVEQSKGIVRYMPHISVSNWPLVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCC
NLQARFNVTSFVGHDIRSLALAEQYFGATRDCEDSILVRLHRGTGAGIIVNSQIFLGSNG
CCHHHEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEEEEECCCC
NVGEIGHIQIDPLGDRCYCGNFGCLETVASNAAIENRVKHLLTQGYPSKLSLDDCHIGAI
CCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
CKAANRGDLLACEVIEHVGRYLGKAIAITINLFNPQKVVIAGEIIEAEKILLPAIQGCIN
HHCCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHH
TQVLKNFRQNLPIVTSQLNHQSAIGAFALAKRAMLNGVLLQRLLETHP
HHHHHHHHHCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STGGQAQIGNVDLVKQLNGAVVYRLIDQQGPISRIQIADLSQLAPASVTKITRQLLERG
CCCCCCCCCCHHHHHHCCCEEEEEEECCCCCCCEEEECCHHHCCCHHHHHHHHHHHHHH
LIKEVDQQASTGGRRAISIVTENRQFHTVAVRLGRNDATITLFDMSGKSLGEEHYALPER
HHHHHHHHHCCCCCEEEEEEECCCEEEEEEEEECCCCCEEEEEECCCCCCCCHHCCCCHH
TQETLEHALFNIISQFIDAYQRKLRELIAIAVILPGLVEQSKGIVRYMPHISVSNWPLVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCC
NLQARFNVTSFVGHDIRSLALAEQYFGATRDCEDSILVRLHRGTGAGIIVNSQIFLGSNG
CCHHHEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEEEEECCCC
NVGEIGHIQIDPLGDRCYCGNFGCLETVASNAAIENRVKHLLTQGYPSKLSLDDCHIGAI
CCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
CKAANRGDLLACEVIEHVGRYLGKAIAITINLFNPQKVVIAGEIIEAEKILLPAIQGCIN
HHCCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHH
TQVLKNFRQNLPIVTSQLNHQSAIGAFALAKRAMLNGVLLQRLLETHP
HHHHHHHHHCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]