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The map label for this gene is yeiQ [H]

Identifier: 170025004

GI number: 170025004

Start: 3067079

End: 3068551

Strand: Direct

Name: yeiQ [H]

Synonym: YPK_2779

Alternate gene names: 170025004

Gene position: 3067079-3068551 (Clockwise)

Preceding gene: 170025002

Following gene: 170025007

Centisome position: 65.4

GC content: 51.46

Gene sequence:

>1473_bases
ATGAACACCATTGCCAACAGCGCCCTTCCCTCAACCGTACAGCAACCCAATTATGATCGGGCGGCGCTGAGAAGCCGTAT
TGTTCACATTGGATTTGGTGCTTTTCATCGAGCCCACCAGGCACTGCTCACTGACCGGGTATTAAATACGCAAGGCGGTG
ATTGGGGTATTTGCGAAGTCAGCCTCTTTGGTGCTGATACGCTGATTCAAGAGTTACGTAAACAGGACCACCTCTTTTCC
GTCTTGGAAAAAGGGGCGCAGGGTAATCAGGCGATTGTGGTCGGTTCAGTGTGTGAATCCGTACATGCTCGTTTAGACGG
CATCATGCAAGTATTGGCGAAATTGGTCGAGCCACAAGTGGCCATCGTCTCTCTGACCATCACCGAGAAAGGGTATTGCA
TCGAGCCGGGCACCGGCCAATTGGATCTGCAGAACGAGTTTATTCGTGCCGATCTGGCCGTCCCTAATGCACCGACATCA
GCACCTGGGGTGTTGGTGGAAGCACTCCGCTTGCGCCGTTTACGTGGATTGCCTCCCTTTACCGTCCTTTCTTGCGATAA
CATCCCGGAAAACGGTGATGTGGTAAGAAACGCGGTACTCGGTCTGGCCACGGTCCGTGATCCAGCGCTGGCTAATTGGA
TTCAGCAACATGTCACTTTCCCGAACACCATGGTTGACCGCATCGTTCCCGCAGCGACAGCGGAAACGTTACAGGAAATC
GCCGATACCCTTGGGGTCGCAGACTCTTGTGGGATCGCCTGCGAACCCTTTATTCAGTGGGTCGTCGAAGACAAATTTGT
TGCAGGCCGTCCAGATTGGCAAGTGGCGGGCGTACAGTTGGTTGATGATGTCTTGCCGTTTGAAGAAATGAAGCTACGTA
TGCTGAACGGGAGCCATTCGTATCTCTCTTATTTAGGCTATCTGGCCGGTTATCAACATATTAATGATTGTATGGCTGAC
GAGAATTATCGCCTAACGGCTCGTCGCTTAATGATGAATGAGCAAGCGCCCACTTTACGTGTCACCGGTATTGATCTGAA
TGCTTATGCTGATCAGTTGATTGAGCGTTACTGTAACCCCGCGCTCAAACACCGCACCTGGCAAATTGCCATGGATGGGA
GCCAGAAATTACCACAACGGATGTTGGATTCCGTCCGCTGGCATTTAAAACAGGGTAATGCGTATCCTTGTCTGGCTTTA
GGCATTGCAGGTTGGATGCGCTATGTAGGGGGCATCGATGATAACGGCCAGGTTATTGATATCCGTGATCCGATGGTGGA
TAGCTTTAAACAATGCGTTGCGGCCAGCGAAGATGGGGCAGCTCGGGTACAAAGTTTGCTGACACTGAAAGCACTGTTTG
GTGAAACGCTGCCACAACAGCCAACATTTGTGCAGGCAGTGACCGAGGCTTATCTCAGCTTGCAACAATTTGGCGCGAAA
GAGACAGTACGCCGCTTAGCCGAACAGGCTTAA

Upstream 100 bases:

>100_bases
AGCCACACAAAACTGGTCTAACAACTTTTCTATTTGCCACCTTTTATGTTAATCCCCATCAGTCCCCGTACTGTCAGGGG
GAATAATTCTGGAGCCACCT

Downstream 100 bases:

>100_bases
GACACACGACGATGAGCTGAATCAAGGCTATTCAGCTCATCGGTATTGTTGGCGTTTAGTTCTGTTGATATTAGTTCTGT
TGACGTTAGTACTCTTGGTG

Product: mannitol dehydrogenase domain-containing protein

Products: D-fructuronate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MNTIANSALPSTVQQPNYDRAALRSRIVHIGFGAFHRAHQALLTDRVLNTQGGDWGICEVSLFGADTLIQELRKQDHLFS
VLEKGAQGNQAIVVGSVCESVHARLDGIMQVLAKLVEPQVAIVSLTITEKGYCIEPGTGQLDLQNEFIRADLAVPNAPTS
APGVLVEALRLRRLRGLPPFTVLSCDNIPENGDVVRNAVLGLATVRDPALANWIQQHVTFPNTMVDRIVPAATAETLQEI
ADTLGVADSCGIACEPFIQWVVEDKFVAGRPDWQVAGVQLVDDVLPFEEMKLRMLNGSHSYLSYLGYLAGYQHINDCMAD
ENYRLTARRLMMNEQAPTLRVTGIDLNAYADQLIERYCNPALKHRTWQIAMDGSQKLPQRMLDSVRWHLKQGNAYPCLAL
GIAGWMRYVGGIDDNGQVIDIRDPMVDSFKQCVAASEDGAARVQSLLTLKALFGETLPQQPTFVQAVTEAYLSLQQFGAK
ETVRRLAEQA

Sequences:

>Translated_490_residues
MNTIANSALPSTVQQPNYDRAALRSRIVHIGFGAFHRAHQALLTDRVLNTQGGDWGICEVSLFGADTLIQELRKQDHLFS
VLEKGAQGNQAIVVGSVCESVHARLDGIMQVLAKLVEPQVAIVSLTITEKGYCIEPGTGQLDLQNEFIRADLAVPNAPTS
APGVLVEALRLRRLRGLPPFTVLSCDNIPENGDVVRNAVLGLATVRDPALANWIQQHVTFPNTMVDRIVPAATAETLQEI
ADTLGVADSCGIACEPFIQWVVEDKFVAGRPDWQVAGVQLVDDVLPFEEMKLRMLNGSHSYLSYLGYLAGYQHINDCMAD
ENYRLTARRLMMNEQAPTLRVTGIDLNAYADQLIERYCNPALKHRTWQIAMDGSQKLPQRMLDSVRWHLKQGNAYPCLAL
GIAGWMRYVGGIDDNGQVIDIRDPMVDSFKQCVAASEDGAARVQSLLTLKALFGETLPQQPTFVQAVTEAYLSLQQFGAK
ETVRRLAEQA
>Mature_490_residues
MNTIANSALPSTVQQPNYDRAALRSRIVHIGFGAFHRAHQALLTDRVLNTQGGDWGICEVSLFGADTLIQELRKQDHLFS
VLEKGAQGNQAIVVGSVCESVHARLDGIMQVLAKLVEPQVAIVSLTITEKGYCIEPGTGQLDLQNEFIRADLAVPNAPTS
APGVLVEALRLRRLRGLPPFTVLSCDNIPENGDVVRNAVLGLATVRDPALANWIQQHVTFPNTMVDRIVPAATAETLQEI
ADTLGVADSCGIACEPFIQWVVEDKFVAGRPDWQVAGVQLVDDVLPFEEMKLRMLNGSHSYLSYLGYLAGYQHINDCMAD
ENYRLTARRLMMNEQAPTLRVTGIDLNAYADQLIERYCNPALKHRTWQIAMDGSQKLPQRMLDSVRWHLKQGNAYPCLAL
GIAGWMRYVGGIDDNGQVIDIRDPMVDSFKQCVAASEDGAARVQSLLTLKALFGETLPQQPTFVQAVTEAYLSLQQFGAK
ETVRRLAEQA

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788497, Length=483, Percent_Identity=64.1821946169772, Blast_Score=662, Evalue=0.0,
Organism=Escherichia coli, GI1787823, Length=484, Percent_Identity=57.6446280991736, Blast_Score=581, Evalue=1e-167,
Organism=Escherichia coli, GI1790779, Length=489, Percent_Identity=58.8957055214724, Blast_Score=572, Evalue=1e-164,
Organism=Escherichia coli, GI48994885, Length=497, Percent_Identity=24.5472837022133, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790028, Length=254, Percent_Identity=27.1653543307087, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324401, Length=494, Percent_Identity=38.663967611336, Blast_Score=362, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6320765, Length=494, Percent_Identity=38.663967611336, Blast_Score=362, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: 1.1.1.57

Molecular weight: Translated: 53959; Mature: 53959

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTIANSALPSTVQQPNYDRAALRSRIVHIGFGAFHRAHQALLTDRVLNTQGGDWGICEV
CCCCCCCCCCCHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
SLFGADTLIQELRKQDHLFSVLEKGAQGNQAIVVGSVCESVHARLDGIMQVLAKLVEPQV
EECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCE
AIVSLTITEKGYCIEPGTGQLDLQNEFIRADLAVPNAPTSAPGVLVEALRLRRLRGLPPF
EEEEEEEECCCEEECCCCCCEECCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCE
TVLSCDNIPENGDVVRNAVLGLATVRDPALANWIQQHVTFPNTMVDRIVPAATAETLQEI
EEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHH
ADTLGVADSCGIACEPFIQWVVEDKFVAGRPDWQVAGVQLVDDVLPFEEMKLRMLNGSHS
HHHHCCCCCCCCCHHHHHHHHHHCCEECCCCCCEEHHHHHHHHHCCHHHHHHHHHCCCHH
YLSYLGYLAGYQHINDCMADENYRLTARRLMMNEQAPTLRVTGIDLNAYADQLIERYCNP
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCH
ALKHRTWQIAMDGSQKLPQRMLDSVRWHLKQGNAYPCLALGIAGWMRYVGGIDDNGQVID
HHHCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEE
IRDPMVDSFKQCVAASEDGAARVQSLLTLKALFGETLPQQPTFVQAVTEAYLSLQQFGAK
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHH
ETVRRLAEQA
HHHHHHHHCC
>Mature Secondary Structure
MNTIANSALPSTVQQPNYDRAALRSRIVHIGFGAFHRAHQALLTDRVLNTQGGDWGICEV
CCCCCCCCCCCHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
SLFGADTLIQELRKQDHLFSVLEKGAQGNQAIVVGSVCESVHARLDGIMQVLAKLVEPQV
EECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCE
AIVSLTITEKGYCIEPGTGQLDLQNEFIRADLAVPNAPTSAPGVLVEALRLRRLRGLPPF
EEEEEEEECCCEEECCCCCCEECCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCE
TVLSCDNIPENGDVVRNAVLGLATVRDPALANWIQQHVTFPNTMVDRIVPAATAETLQEI
EEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHH
ADTLGVADSCGIACEPFIQWVVEDKFVAGRPDWQVAGVQLVDDVLPFEEMKLRMLNGSHS
HHHHCCCCCCCCCHHHHHHHHHHCCEECCCCCCEEHHHHHHHHHCCHHHHHHHHHCCCHH
YLSYLGYLAGYQHINDCMADENYRLTARRLMMNEQAPTLRVTGIDLNAYADQLIERYCNP
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCH
ALKHRTWQIAMDGSQKLPQRMLDSVRWHLKQGNAYPCLALGIAGWMRYVGGIDDNGQVID
HHHCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEE
IRDPMVDSFKQCVAASEDGAARVQSLLTLKALFGETLPQQPTFVQAVTEAYLSLQQFGAK
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHH
ETVRRLAEQA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-mannonate; NAD+

Specific reaction: D-mannonate + NAD+ = D-fructuronate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]