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The map label for this gene is mtr [H]

Identifier: 170025001

GI number: 170025001

Start: 3063260

End: 3064504

Strand: Direct

Name: mtr [H]

Synonym: YPK_2776

Alternate gene names: 170025001

Gene position: 3063260-3064504 (Clockwise)

Preceding gene: 170024999

Following gene: 170025002

Centisome position: 65.32

GC content: 51.49

Gene sequence:

>1245_bases
ATGTCGATGGCCTTATCCCAACCGTTGTCACGGCCTTCCGTTTTGGGTGGCGCGATGATTGTCGCAGGTACCGCAGTGGG
TGCGGGCATGTTCTCAATCCCAATCGTGACAGCCGGGGTATGGTTCAGCGGCTCAGTGGTGCTGCTGATCTACACCTGGG
CATGTATGTTAGTGTCCGGGCTGATGATTCTGGAAGCTAACCTGAACTACCCAAGTGGCGCCAGTTTCCACACCATGGTG
CAAGACCTGCTAGGCAAGGTGTGGAGCTCAATTAACGGGCTGTCCATTACCTTTGTGCTCTACATTCTGACCTACGCCTA
TATCTCCGCCGGTGGTTCGATCATCGCCCATACGCTGCAAAACGTAGCCGGAATTGGCCAGACCAGCGCAGGCTTTATCT
TTGCACTTTTGGTGGCCTTTATCGTGTGGTTATCCACCCGAGCAGTGGATCGCCTCAGTACAATATTAATCGGCGGCATG
GTTATCACATTTGTCATGTCTGTCGGTGATATGTTCAGCCATGTAGAAAGTGCGGTGTTGTTTAATCAGACAGACAGTAA
TGCCCACTATCTGCCCTATGCACTGGCGGCATTGCCTTATTTGCTGACCTCTTTTGGCTACCACGGCAATGTGCCGGGCC
TGGTGAAGTACTACAACAAAGACAGCAAAGCCGTTGTGCGCAGCCTGCTGTACGGAACATTGATTGCCTTGGTGATTTAT
CTCCTTTGGCAGTATGCCATTCAGGGCAATATCGCCCGGGATGCTTTCAAACAGGTTATTGCCGATGGCGGTAATATCGG
CAATCTATTGCAACAAATGGACACCGTTTCTGCCAGTAAAGCCACCAGCCAGCTACTCAATGCCTTCTCTTATATGGCAC
TGGCCAGTTCGTTCCTTGGCGTGTCGCTCGGGTTGTTTGATTATATTTCTGATTTATTTGACTTTACCGATGACCGCAGC
GGGCGAACTAAATCAGCATTAATGACCTTTGTCCCTCCGACTCTCGGTGCCCTGCTGTTCCCGGATGGCTTCTTATATGC
CATTGGCTTTGCGGGGTTAGCCGCCACCATTTGGGCGGTTATTGTGCCCGCATTAATGGCGCGAGCCAGCCGTAAACGCT
TCCCACAAGCCCGTTACCGTGCTCCCGGAGGCCGTTTTATGATTGGTTTTATTATCCTGTTTGGCCTGGTCAATGCGGTA
GCCCATATTTCAGCCTTGTTCGGCCTATTGCCGGTTTATCAATAG

Upstream 100 bases:

>100_bases
ATTTGGTTACTCTCATTGACTATAACGATTCTCACTTAATATAACGACTCTCACTTAATATAAAGAAGTTACCCGCAGCC
GGGTATCTCAGGAGCAATAG

Downstream 100 bases:

>100_bases
TGCAGAATTTATTACACCTTTTCGCGCTATCTGCTTGCCTGAATCTCACGGCGCGAGTAACTTGTCGCAACTTATCTTTA
ATCCCGATTGGCAGGTTATT

Product: aromatic amino acid transporter

Products: Indole [Cytoplasm]; L-tryptophan [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Tryptophan permease [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSMALSQPLSRPSVLGGAMIVAGTAVGAGMFSIPIVTAGVWFSGSVVLLIYTWACMLVSGLMILEANLNYPSGASFHTMV
QDLLGKVWSSINGLSITFVLYILTYAYISAGGSIIAHTLQNVAGIGQTSAGFIFALLVAFIVWLSTRAVDRLSTILIGGM
VITFVMSVGDMFSHVESAVLFNQTDSNAHYLPYALAALPYLLTSFGYHGNVPGLVKYYNKDSKAVVRSLLYGTLIALVIY
LLWQYAIQGNIARDAFKQVIADGGNIGNLLQQMDTVSASKATSQLLNAFSYMALASSFLGVSLGLFDYISDLFDFTDDRS
GRTKSALMTFVPPTLGALLFPDGFLYAIGFAGLAATIWAVIVPALMARASRKRFPQARYRAPGGRFMIGFIILFGLVNAV
AHISALFGLLPVYQ

Sequences:

>Translated_414_residues
MSMALSQPLSRPSVLGGAMIVAGTAVGAGMFSIPIVTAGVWFSGSVVLLIYTWACMLVSGLMILEANLNYPSGASFHTMV
QDLLGKVWSSINGLSITFVLYILTYAYISAGGSIIAHTLQNVAGIGQTSAGFIFALLVAFIVWLSTRAVDRLSTILIGGM
VITFVMSVGDMFSHVESAVLFNQTDSNAHYLPYALAALPYLLTSFGYHGNVPGLVKYYNKDSKAVVRSLLYGTLIALVIY
LLWQYAIQGNIARDAFKQVIADGGNIGNLLQQMDTVSASKATSQLLNAFSYMALASSFLGVSLGLFDYISDLFDFTDDRS
GRTKSALMTFVPPTLGALLFPDGFLYAIGFAGLAATIWAVIVPALMARASRKRFPQARYRAPGGRFMIGFIILFGLVNAV
AHISALFGLLPVYQ
>Mature_413_residues
SMALSQPLSRPSVLGGAMIVAGTAVGAGMFSIPIVTAGVWFSGSVVLLIYTWACMLVSGLMILEANLNYPSGASFHTMVQ
DLLGKVWSSINGLSITFVLYILTYAYISAGGSIIAHTLQNVAGIGQTSAGFIFALLVAFIVWLSTRAVDRLSTILIGGMV
ITFVMSVGDMFSHVESAVLFNQTDSNAHYLPYALAALPYLLTSFGYHGNVPGLVKYYNKDSKAVVRSLLYGTLIALVIYL
LWQYAIQGNIARDAFKQVIADGGNIGNLLQQMDTVSASKATSQLLNAFSYMALASSFLGVSLGLFDYISDLFDFTDDRSG
RTKSALMTFVPPTLGALLFPDGFLYAIGFAGLAATIWAVIVPALMARASRKRFPQARYRAPGGRFMIGFIILFGLVNAVA
HISALFGLLPVYQ

Specific function: Involved in transporting tryptophan across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789552, Length=411, Percent_Identity=57.9075425790754, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI1790145, Length=412, Percent_Identity=43.9320388349515, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI1788218, Length=403, Percent_Identity=34.9875930521092, Blast_Score=235, Evalue=4e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 44362; Mature: 44230

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SMALSQPLSRPSVLGGAMIVAGTAVGAGMFSIPIVTAGVWFSGSVVLLIYTWACMLVSG
CCCCCCCCCCCHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LMILEANLNYPSGASFHTMVQDLLGKVWSSINGLSITFVLYILTYAYISAGGSIIAHTLQ
HHHEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
NVAGIGQTSAGFIFALLVAFIVWLSTRAVDRLSTILIGGMVITFVMSVGDMFSHVESAVL
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNQTDSNAHYLPYALAALPYLLTSFGYHGNVPGLVKYYNKDSKAVVRSLLYGTLIALVIY
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LLWQYAIQGNIARDAFKQVIADGGNIGNLLQQMDTVSASKATSQLLNAFSYMALASSFLG
HHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSLGLFDYISDLFDFTDDRSGRTKSALMTFVPPTLGALLFPDGFLYAIGFAGLAATIWAV
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
IVPALMARASRKRFPQARYRAPGGRFMIGFIILFGLVNAVAHISALFGLLPVYQ
HHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Indole [Periplasm]; L-tryptophan [Periplasm]; Proton [Periplasm] [C]

Specific reaction: Proton [Periplasm] + indole [Periplasm] = Proton [Cytoplasm] + indole [Cytoplasm] L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]