The gene/protein map for NC_012032 is currently unavailable.
Definition Yersinia pseudotuberculosis YPIII chromosome, complete genome.
Accession NC_010465
Length 4,689,441

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The map label for this gene is serS

Identifier: 170024906

GI number: 170024906

Start: 2956443

End: 2957735

Strand: Reverse

Name: serS

Synonym: YPK_2681

Alternate gene names: 170024906

Gene position: 2957735-2956443 (Counterclockwise)

Preceding gene: 170024908

Following gene: 170024905

Centisome position: 63.07

GC content: 49.11

Gene sequence:

>1293_bases
ATGCTCGATCCCAATATGCTGCGCAATGAGCTAGACGCAGTCGCCGAAAAACTGGCTCGCAGAGGTTTTAAACTTGATGT
TGAGGTGTTGCGCCAACAAGAAGAGCGCCGCAAAGTTTTACAGGTTGAAACAGAAAGTCTGCAGGCAGAACGTAACTCCC
GATCGAAACAGATCGGTGCAGCAAAGGCGCGTGGCGAAGATATCGAACCATTACGTCTGGAAGTGAATGCTCTGGGTGAA
AAACTGGATGCCGCTAAAGCTGAGTTGGATAAGTTACAAAACGAAATCCGCGATTTAGCGCTGTCTATCCCTAATCTGCC
AGATGATTCAGTACCGGTAGGTAAAAACGAGAATGACAATATTGAAGTCAGTCGGTGGGGCGAGCCTCGCAAATATGACT
TCGACGTAAAAGATCATGTTTCTCTGGGCGAAATGGCCGGTGGCCTTGATTTTGCTGCCGCTGTGAAACTGACCGGCGCA
CGCTTTGTGGTGATGAAAGGGCAAATTGCCCGTATGCACCGTGCTCTGTCTCAGTTCATGTTAGACCTGCACACCGAGAA
ACACGGTTATCTGGAAGCTTACGTCCCTTATCTGGTTAATCATGCCACCTTGTACGGTACGGGTCAGTTACCCAAGTTTG
GTGAAGATCTATTCCATACTAAACCGTTGGCAGAAGAATCAGATAACAGTAACTATGCTTTGATTCCTACTGCTGAAGTT
CCGCTGACCAACTTGGTGCGCGATGAAATTTTGGAAGAGGATTCTCTGCCATTGAAGTTGACCGCCCATACACCATGCTT
CCGTTCTGAAGCAGGTTCCTATGGCCGTGATACCCGTGGTTTGATCCGGATGCATCAATTCGACAAAGTTGAAATGGTGC
AGATCACTCGTCCGGAAGATTCTATGGCCGCGCTGGAAGAGTTGACAGGGCACGCCGAGAAAGTTCTGCAATTACTGGAG
TTGCCATACCGCAAGGTATTGCTGTGTACGGGTGATATGGGCTTTGGCTCCAGCAAAACTTACGATCTGGAAGTATGGTT
GCCAGCACAGGACACTTACCGCGAAATATCCTCATGTTCTAACATGTGGGATTTCCAGGCGCGCCGTATGCAGGCCCGTT
ATCGCAACAAGACCGACAGAAAGACGCGTTTAGTGCACACGCTGAACGGCTCTGGTTTGGCGGTTGGGCGTACCTTGGTA
GCGGTGTTGGAAAACTATCAACAGGCAGATGGTCGTATCCAGGTCCCTGACGTATTACGTCCATATATGGGTGGCTTGGA
ATATATTGGTTAA

Upstream 100 bases:

>100_bases
AGCCTACGAAGGCCAAGTGATTCGAGTGAGCTGGGGCTGCTAATACCGCAGTAACGTCAAGTCAAAAGGGTATATCCATA
ACTACAAGCACAGGACTAGC

Downstream 100 bases:

>100_bases
TTGGTTAATTGGTTAATTGGTTAATTGCCGCGTCTGTTATCTGCTATTTCGAAAGCGTCTACGGGCGCTTTTCTTTTTTT
GTGTATCCCCCTCACTGCCA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MLDPNMLRNELDAVAEKLARRGFKLDVEVLRQQEERRKVLQVETESLQAERNSRSKQIGAAKARGEDIEPLRLEVNALGE
KLDAAKAELDKLQNEIRDLALSIPNLPDDSVPVGKNENDNIEVSRWGEPRKYDFDVKDHVSLGEMAGGLDFAAAVKLTGA
RFVVMKGQIARMHRALSQFMLDLHTEKHGYLEAYVPYLVNHATLYGTGQLPKFGEDLFHTKPLAEESDNSNYALIPTAEV
PLTNLVRDEILEEDSLPLKLTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQITRPEDSMAALEELTGHAEKVLQLLE
LPYRKVLLCTGDMGFGSSKTYDLEVWLPAQDTYREISSCSNMWDFQARRMQARYRNKTDRKTRLVHTLNGSGLAVGRTLV
AVLENYQQADGRIQVPDVLRPYMGGLEYIG

Sequences:

>Translated_430_residues
MLDPNMLRNELDAVAEKLARRGFKLDVEVLRQQEERRKVLQVETESLQAERNSRSKQIGAAKARGEDIEPLRLEVNALGE
KLDAAKAELDKLQNEIRDLALSIPNLPDDSVPVGKNENDNIEVSRWGEPRKYDFDVKDHVSLGEMAGGLDFAAAVKLTGA
RFVVMKGQIARMHRALSQFMLDLHTEKHGYLEAYVPYLVNHATLYGTGQLPKFGEDLFHTKPLAEESDNSNYALIPTAEV
PLTNLVRDEILEEDSLPLKLTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQITRPEDSMAALEELTGHAEKVLQLLE
LPYRKVLLCTGDMGFGSSKTYDLEVWLPAQDTYREISSCSNMWDFQARRMQARYRNKTDRKTRLVHTLNGSGLAVGRTLV
AVLENYQQADGRIQVPDVLRPYMGGLEYIG
>Mature_430_residues
MLDPNMLRNELDAVAEKLARRGFKLDVEVLRQQEERRKVLQVETESLQAERNSRSKQIGAAKARGEDIEPLRLEVNALGE
KLDAAKAELDKLQNEIRDLALSIPNLPDDSVPVGKNENDNIEVSRWGEPRKYDFDVKDHVSLGEMAGGLDFAAAVKLTGA
RFVVMKGQIARMHRALSQFMLDLHTEKHGYLEAYVPYLVNHATLYGTGQLPKFGEDLFHTKPLAEESDNSNYALIPTAEV
PLTNLVRDEILEEDSLPLKLTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQITRPEDSMAALEELTGHAEKVLQLLE
LPYRKVLLCTGDMGFGSSKTYDLEVWLPAQDTYREISSCSNMWDFQARRMQARYRNKTDRKTRLVHTLNGSGLAVGRTLV
AVLENYQQADGRIQVPDVLRPYMGGLEYIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=375, Percent_Identity=35.7333333333333, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI225579074, Length=421, Percent_Identity=27.5534441805226, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI8923421, Length=353, Percent_Identity=28.8951841359773, Blast_Score=152, Evalue=6e-37,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=84.8837209302326, Blast_Score=769, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539260, Length=334, Percent_Identity=33.8323353293413, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17542084, Length=334, Percent_Identity=30.5389221556886, Blast_Score=150, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6321799, Length=388, Percent_Identity=31.9587628865979, Blast_Score=199, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6320226, Length=408, Percent_Identity=32.3529411764706, Blast_Score=193, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24581334, Length=372, Percent_Identity=34.6774193548387, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI17737985, Length=365, Percent_Identity=31.7808219178082, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_YERP3 (A7FJY0)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001401558.1
- ProteinModelPortal:   A7FJY0
- SMR:   A7FJY0
- STRING:   A7FJY0
- GeneID:   5385816
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_2593
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   ENGYTEV
- ProtClustDB:   PRK05431
- BioCyc:   YPSE349747:YPSIP31758_2593-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48570; Mature: 48570

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 291-291 BINDING 391-391

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MLDPNMLRNELDAVAEKLARRGFKLDVEVLRQQEERRKVLQVETESLQAERNSRSKQIGA
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AKARGEDIEPLRLEVNALGEKLDAAKAELDKLQNEIRDLALSIPNLPDDSVPVGKNENDN
HHCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
IEVSRWGEPRKYDFDVKDHVSLGEMAGGLDFAAAVKLTGARFVVMKGQIARMHRALSQFM
EEEEECCCCCCCCCCHHHCCCHHHHCCCCCHHHHEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTEKHGYLEAYVPYLVNHATLYGTGQLPKFGEDLFHTKPLAEESDNSNYALIPTAEV
HHHHCCCCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCC
PLTNLVRDEILEEDSLPLKLTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQITRPED
CHHHHHHHHHHCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHCCCEEEEEEECCCH
SMAALEELTGHAEKVLQLLELPYRKVLLCTGDMGFGSSKTYDLEVWLPAQDTYREISSCS
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHHHH
NMWDFQARRMQARYRNKTDRKTRLVHTLNGSGLAVGRTLVAVLENYQQADGRIQVPDVLR
HHHHHHHHHHHHHHCCCCCHHHHEEEEECCCCHHHHHHHHHHHHHHHHCCCEEECHHHHH
PYMGGLEYIG
HHHCCCCCCC
>Mature Secondary Structure
MLDPNMLRNELDAVAEKLARRGFKLDVEVLRQQEERRKVLQVETESLQAERNSRSKQIGA
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AKARGEDIEPLRLEVNALGEKLDAAKAELDKLQNEIRDLALSIPNLPDDSVPVGKNENDN
HHCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
IEVSRWGEPRKYDFDVKDHVSLGEMAGGLDFAAAVKLTGARFVVMKGQIARMHRALSQFM
EEEEECCCCCCCCCCHHHCCCHHHHCCCCCHHHHEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTEKHGYLEAYVPYLVNHATLYGTGQLPKFGEDLFHTKPLAEESDNSNYALIPTAEV
HHHHCCCCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCC
PLTNLVRDEILEEDSLPLKLTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQITRPED
CHHHHHHHHHHCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHCCCEEEEEEECCCH
SMAALEELTGHAEKVLQLLELPYRKVLLCTGDMGFGSSKTYDLEVWLPAQDTYREISSCS
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHHHH
NMWDFQARRMQARYRNKTDRKTRLVHTLNGSGLAVGRTLVAVLENYQQADGRIQVPDVLR
HHHHHHHHHHHHHHCCCCCHHHHEEEEECCCCHHHHHHHHHHHHHHHHCCCEEECHHHHH
PYMGGLEYIG
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA