Click here to switch to the map view.

The map label for this gene is aroA [H]

Identifier: 170024895

GI number: 170024895

Start: 2939353

End: 2940639

Strand: Reverse

Name: aroA [H]

Synonym: YPK_2670

Alternate gene names: 170024895

Gene position: 2940639-2939353 (Counterclockwise)

Preceding gene: 170024896

Following gene: 170024894

Centisome position: 62.71

GC content: 51.59

Gene sequence:

>1287_bases
ATGCTGGAATCCCTGACCTTACAACCCATTGCCCTGGTTAATGGCACCGTTAATTTACCTGGTTCGAAGAGTGTCTCTAA
CCGCGCACTGCTTCTGGCCGCGTTGGCCGAAGGGACCACTCAGTTGAATAACGTGTTAGACAGCGATGACATCCGCCACA
TGCTCAATGCATTACAGGCATTAGGGGTGAACTTCCGCCTTTCTGCTGATCGCACATGCTGTGAGGTTGATGGTCTGGGG
GGGAAATTAGTGGCTGAACAGCCATTGTCGCTTTTCTTGGGCAATGCCGGCACCGCCATGCGTCCTTTGGCCGCGGTGTT
ATGTTTGGGTAATAGCGATATCGTACTGACGGGTGAGCCTCGGATGAAGGAGCGGCCAATTGGCCATTTGGTGGATGCGC
TACGTCAGGGCGGTGCACAGATCGATTATCTGGAACAAGAAAATTACCCGCCATTACGTTTACGTGGTGGTTTCCGAGGG
GGGGAGTTAACTGTTGATGGGCGTGTCTCTAGCCAGTTCCTGACTGCTTTATTGATGACCGCCCCGCTGGCGGAGCAAGA
TACGACTATTCGGATTATGGGTGATCTGGTTTCCAAACCTTATATCGATATTACTCTGCACTTGATGAAAGCATTTGGTA
TTGACGTGGGGCATGAGAACTACCAAATTTTCCACATCAAAGGGGGCCAGACCTACCGCTCACCAGGGACTTATTTGGTT
GAGGGCGATGCCTCGTCGGCTTCCTACTTCTTAGCGGCTGCGGCTATTAAGGGGGGAACAGTGCGTGTCACTGGTATTGG
CAAGAAAAGTGTACAGGGCGACACTAAATTTGCCGATGTGTTGGAAAAAATGGGCGCGAAAGTGACGTGGGGGGATGATT
ATATCGAGTGCAGTCGTGGTGAATTACAGGGCATTGACATGGATATGAACCACATTCCTGATGCTGCAATGACCATTGCG
ACTACGGCATTATTTGCCACGGGCCCAACGACGATCCGCAATATCTACAACTGGCGGGTAAAAGAAACTGACCGGCTGAC
GGCGATGGCAACCGAGTTGAGAAAAGTAGGTGCTGAAGTGGAAGAGGGGGAAGATTACATCCGCGTGGTTCCACCCGTGC
AGCTAACTGCTGCAGATATTGGTACCTACGATGACCACCGTATGGCGATGTGTTTCTCGCTGGTCGCGTTATCAGACACC
CCCGTGACGATCCTTGACCCGAAATGTACCGCAAAAACCTTCCCTGATTATTTTGAACAGTTTGCGCGTCTGAGCCAACT
GGCCTGA

Upstream 100 bases:

>100_bases
GCGTTAACTCGTAATAATTCGTAATAACACGTTAATTTGTAATAACAGCTTCGTTTTGTTCGAGGCTGTTGCCTATACAA
GACTGGAGAATGTTTTTCCC

Downstream 100 bases:

>100_bases
TAGCACCTGAATTGAATGGGTTCTATCACACTAAAACGGGCGCGAATCAAGCGCCTATTTCTATAGGATATCTCTCTTCA
TTGTTCATTTTTTTTATAAA

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MLESLTLQPIALVNGTVNLPGSKSVSNRALLLAALAEGTTQLNNVLDSDDIRHMLNALQALGVNFRLSADRTCCEVDGLG
GKLVAEQPLSLFLGNAGTAMRPLAAVLCLGNSDIVLTGEPRMKERPIGHLVDALRQGGAQIDYLEQENYPPLRLRGGFRG
GELTVDGRVSSQFLTALLMTAPLAEQDTTIRIMGDLVSKPYIDITLHLMKAFGIDVGHENYQIFHIKGGQTYRSPGTYLV
EGDASSASYFLAAAAIKGGTVRVTGIGKKSVQGDTKFADVLEKMGAKVTWGDDYIECSRGELQGIDMDMNHIPDAAMTIA
TTALFATGPTTIRNIYNWRVKETDRLTAMATELRKVGAEVEEGEDYIRVVPPVQLTAADIGTYDDHRMAMCFSLVALSDT
PVTILDPKCTAKTFPDYFEQFARLSQLA

Sequences:

>Translated_428_residues
MLESLTLQPIALVNGTVNLPGSKSVSNRALLLAALAEGTTQLNNVLDSDDIRHMLNALQALGVNFRLSADRTCCEVDGLG
GKLVAEQPLSLFLGNAGTAMRPLAAVLCLGNSDIVLTGEPRMKERPIGHLVDALRQGGAQIDYLEQENYPPLRLRGGFRG
GELTVDGRVSSQFLTALLMTAPLAEQDTTIRIMGDLVSKPYIDITLHLMKAFGIDVGHENYQIFHIKGGQTYRSPGTYLV
EGDASSASYFLAAAAIKGGTVRVTGIGKKSVQGDTKFADVLEKMGAKVTWGDDYIECSRGELQGIDMDMNHIPDAAMTIA
TTALFATGPTTIRNIYNWRVKETDRLTAMATELRKVGAEVEEGEDYIRVVPPVQLTAADIGTYDDHRMAMCFSLVALSDT
PVTILDPKCTAKTFPDYFEQFARLSQLA
>Mature_428_residues
MLESLTLQPIALVNGTVNLPGSKSVSNRALLLAALAEGTTQLNNVLDSDDIRHMLNALQALGVNFRLSADRTCCEVDGLG
GKLVAEQPLSLFLGNAGTAMRPLAAVLCLGNSDIVLTGEPRMKERPIGHLVDALRQGGAQIDYLEQENYPPLRLRGGFRG
GELTVDGRVSSQFLTALLMTAPLAEQDTTIRIMGDLVSKPYIDITLHLMKAFGIDVGHENYQIFHIKGGQTYRSPGTYLV
EGDASSASYFLAAAAIKGGTVRVTGIGKKSVQGDTKFADVLEKMGAKVTWGDDYIECSRGELQGIDMDMNHIPDAAMTIA
TTALFATGPTTIRNIYNWRVKETDRLTAMATELRKVGAEVEEGEDYIRVVPPVQLTAADIGTYDDHRMAMCFSLVALSDT
PVTILDPKCTAKTFPDYFEQFARLSQLA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1787137, Length=427, Percent_Identity=80.327868852459, Blast_Score=696, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320332, Length=444, Percent_Identity=40.7657657657658, Blast_Score=271, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792 [H]

Pfam domain/function: PF00275 EPSP_synthase [H]

EC number: =2.5.1.19 [H]

Molecular weight: Translated: 46321; Mature: 46321

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00104 EPSP_SYNTHASE_1 ; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLESLTLQPIALVNGTVNLPGSKSVSNRALLLAALAEGTTQLNNVLDSDDIRHMLNALQA
CCCCCCCCEEEEECCEEECCCCCCCCCCEEEEEHHHHCHHHHHHHCCCHHHHHHHHHHHH
LGVNFRLSADRTCCEVDGLGGKLVAEQPLSLFLGNAGTAMRPLAAVLCLGNSDIVLTGEP
HCCCEEEECCCCEEEECCCCCEEECCCCCEEEECCCCCHHHHHHHEEEECCCCEEEECCC
RMKERPIGHLVDALRQGGAQIDYLEQENYPPLRLRGGFRGGELTVDGRVSSQFLTALLMT
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCEEEECCCHHHHHHHHHHHH
APLAEQDTTIRIMGDLVSKPYIDITLHLMKAFGIDVGHENYQIFHIKGGQTYRSPGTYLV
CCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCEECCCCCEEE
EGDASSASYFLAAAAIKGGTVRVTGIGKKSVQGDTKFADVLEKMGAKVTWGDDYIECSRG
ECCCCCCCEEEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHCCEEEECCCCEECCCC
ELQGIDMDMNHIPDAAMTIATTALFATGPTTIRNIYNWRVKETDRLTAMATELRKVGAEV
CCCCCCCCHHHCCCHHHHHHHHHHHCCCCHHHHHHHCCEECCCHHHHHHHHHHHHHCCCC
EEGEDYIRVVPPVQLTAADIGTYDDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQ
CCCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHH
FARLSQLA
HHHHHHCC
>Mature Secondary Structure
MLESLTLQPIALVNGTVNLPGSKSVSNRALLLAALAEGTTQLNNVLDSDDIRHMLNALQA
CCCCCCCCEEEEECCEEECCCCCCCCCCEEEEEHHHHCHHHHHHHCCCHHHHHHHHHHHH
LGVNFRLSADRTCCEVDGLGGKLVAEQPLSLFLGNAGTAMRPLAAVLCLGNSDIVLTGEP
HCCCEEEECCCCEEEECCCCCEEECCCCCEEEECCCCCHHHHHHHEEEECCCCEEEECCC
RMKERPIGHLVDALRQGGAQIDYLEQENYPPLRLRGGFRGGELTVDGRVSSQFLTALLMT
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCEEEECCCHHHHHHHHHHHH
APLAEQDTTIRIMGDLVSKPYIDITLHLMKAFGIDVGHENYQIFHIKGGQTYRSPGTYLV
CCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCEECCCCCEEE
EGDASSASYFLAAAAIKGGTVRVTGIGKKSVQGDTKFADVLEKMGAKVTWGDDYIECSRG
ECCCCCCCEEEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHCCEEEECCCCEECCCC
ELQGIDMDMNHIPDAAMTIATTALFATGPTTIRNIYNWRVKETDRLTAMATELRKVGAEV
CCCCCCCCHHHCCCHHHHHHHHHHHCCCCHHHHHHHCCEECCCHHHHHHHHHHHHHCCCC
EEGEDYIRVVPPVQLTAADIGTYDDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQ
CCCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHH
FARLSQLA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2691337 [H]