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The map label for this gene is pyrD [H]

Identifier: 170024869

GI number: 170024869

Start: 2902742

End: 2903752

Strand: Reverse

Name: pyrD [H]

Synonym: YPK_2644

Alternate gene names: 170024869

Gene position: 2903752-2902742 (Counterclockwise)

Preceding gene: 170024870

Following gene: 170024868

Centisome position: 61.92

GC content: 43.32

Gene sequence:

>1011_bases
ATGTATTATCCACTTGTCAGAAAAGCACTATTTCAGCTTGATCCAGAACGTGCCCATGAATTGACTTTTCGTCAGTTAAA
GCGTGTTAGCGGCACACCTTTGGAATTTTTGGTACGCCAGTCGGTACCCACCAAACCGGTCAGTTGTATGGGCCTGTCTT
TTAAAAATCCAGTAGGTTTGGCTGCGGGCCTGGATAAAGACGGTGAGTGTATTGATGCCTTGGGCGCCATGGGCTTTGGT
TTCATTGAAGTGGGCACTGTGACACCACGGCCTCAGGTGGGGAATGATAAGCCGAGATTATTCAGGATCGTCGAAGCTGA
AGGTTTGATCAACCGCATGGGGTTTAATAATCATGGGGTCGACAACCTTATTGAAAATGTTAAAAAATCCCATTTTGGCG
GTATATTGGGCATTAATATCGGCAAGAATAAAGATACGCCAGTCGAACAAGGTAAAGAAGATTACCTGATTTGCATGGAT
AAAATTTATCCTTATGCTGGATATATTGCGATTAATATTTCCTCACCTAATACACCGGGGTTACGATCCTTACAGTACGG
TGAAGCATTAGATGATTTATTAGCTGCAATTAAAGATAAACAAACTGAGCTACATCAACGCCATCATAAGTATGTTCCCG
TAGCGGTGAAGATCGCGCCGGATCTTACTGAAGAGGAATTGATCCAAATAGCAGATAGCTTGGTCCGCCATAATATTGAT
GGCGTTATTGCTACTAATACGACTTTAGATCGTTCTCTGATTCAGGGATTAAATTATTGCGAGCAAGCCGGTGGATTAAG
TGGCCGCCCATTACAATTACGCAGTACTGAGGTTATTCATCGTTTATCACAAGAGCTAAAAGGGCGCCTGCCTATTATCG
GTGTTGGTGGTATTGATTCCGTTACTGCAGCACGGGAAAAGATGGCGGCTGGTGCTTCATTGATTCAAATCTATTCCGGA
TTTATCTTCCGTGGGCCGGGTTTGATTAAGAATATCGTCACTCATATCTAA

Upstream 100 bases:

>100_bases
GCTAGCGGGATTAGACAACAGTGCTGATAACGTTAACTGGCTACAGCACGACAGAATTAGTGCTTGCTAACCGCTTGTCA
CTGATCGCTCAGGAGATCAC

Downstream 100 bases:

>100_bases
TTATTTATCTTCATTACCTGCTGGGGGTTTATTTCTGCCCCCGGCTAGTCTATATTTTACTCCGGTAGATTGAATATTCA
GCAAAATGCTTAAAAATGCT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MYYPLVRKALFQLDPERAHELTFRQLKRVSGTPLEFLVRQSVPTKPVSCMGLSFKNPVGLAAGLDKDGECIDALGAMGFG
FIEVGTVTPRPQVGNDKPRLFRIVEAEGLINRMGFNNHGVDNLIENVKKSHFGGILGINIGKNKDTPVEQGKEDYLICMD
KIYPYAGYIAINISSPNTPGLRSLQYGEALDDLLAAIKDKQTELHQRHHKYVPVAVKIAPDLTEEELIQIADSLVRHNID
GVIATNTTLDRSLIQGLNYCEQAGGLSGRPLQLRSTEVIHRLSQELKGRLPIIGVGGIDSVTAAREKMAAGASLIQIYSG
FIFRGPGLIKNIVTHI

Sequences:

>Translated_336_residues
MYYPLVRKALFQLDPERAHELTFRQLKRVSGTPLEFLVRQSVPTKPVSCMGLSFKNPVGLAAGLDKDGECIDALGAMGFG
FIEVGTVTPRPQVGNDKPRLFRIVEAEGLINRMGFNNHGVDNLIENVKKSHFGGILGINIGKNKDTPVEQGKEDYLICMD
KIYPYAGYIAINISSPNTPGLRSLQYGEALDDLLAAIKDKQTELHQRHHKYVPVAVKIAPDLTEEELIQIADSLVRHNID
GVIATNTTLDRSLIQGLNYCEQAGGLSGRPLQLRSTEVIHRLSQELKGRLPIIGVGGIDSVTAAREKMAAGASLIQIYSG
FIFRGPGLIKNIVTHI
>Mature_336_residues
MYYPLVRKALFQLDPERAHELTFRQLKRVSGTPLEFLVRQSVPTKPVSCMGLSFKNPVGLAAGLDKDGECIDALGAMGFG
FIEVGTVTPRPQVGNDKPRLFRIVEAEGLINRMGFNNHGVDNLIENVKKSHFGGILGINIGKNKDTPVEQGKEDYLICMD
KIYPYAGYIAINISSPNTPGLRSLQYGEALDDLLAAIKDKQTELHQRHHKYVPVAVKIAPDLTEEELIQIADSLVRHNID
GVIATNTTLDRSLIQGLNYCEQAGGLSGRPLQLRSTEVIHRLSQELKGRLPIIGVGGIDSVTAAREKMAAGASLIQIYSG
FIFRGPGLIKNIVTHI

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=333, Percent_Identity=44.1441441441441, Blast_Score=238, Evalue=6e-63,
Organism=Escherichia coli, GI1787177, Length=336, Percent_Identity=83.6309523809524, Blast_Score=594, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI17509475, Length=304, Percent_Identity=44.078947368421, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI281361352, Length=340, Percent_Identity=40.2941176470588, Blast_Score=245, Evalue=4e-65,
Organism=Drosophila melanogaster, GI17137316, Length=340, Percent_Identity=40.2941176470588, Blast_Score=245, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36832; Mature: 36832

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYYPLVRKALFQLDPERAHELTFRQLKRVSGTPLEFLVRQSVPTKPVSCMGLSFKNPVGL
CCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCEECCCCCCCCCE
AAGLDKDGECIDALGAMGFGFIEVGTVTPRPQVGNDKPRLFRIVEAEGLINRMGFNNHGV
ECCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCCCCH
DNLIENVKKSHFGGILGINIGKNKDTPVEQGKEDYLICMDKIYPYAGYIAINISSPNTPG
HHHHHHHHHHHCCCEEEEECCCCCCCCHHCCCCCEEEEHHHCCCCCCEEEEEECCCCCCC
LRSLQYGEALDDLLAAIKDKQTELHQRHHKYVPVAVKIAPDLTEEELIQIADSLVRHNID
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
GVIATNTTLDRSLIQGLNYCEQAGGLSGRPLQLRSTEVIHRLSQELKGRLPIIGVGGIDS
CEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCEEEECCCCH
VTAAREKMAAGASLIQIYSGFIFRGPGLIKNIVTHI
HHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHCC
>Mature Secondary Structure
MYYPLVRKALFQLDPERAHELTFRQLKRVSGTPLEFLVRQSVPTKPVSCMGLSFKNPVGL
CCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCEECCCCCCCCCE
AAGLDKDGECIDALGAMGFGFIEVGTVTPRPQVGNDKPRLFRIVEAEGLINRMGFNNHGV
ECCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCCCCH
DNLIENVKKSHFGGILGINIGKNKDTPVEQGKEDYLICMDKIYPYAGYIAINISSPNTPG
HHHHHHHHHHHCCCEEEEECCCCCCCCHHCCCCCEEEEHHHCCCCCCEEEEEECCCCCCC
LRSLQYGEALDDLLAAIKDKQTELHQRHHKYVPVAVKIAPDLTEEELIQIADSLVRHNID
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
GVIATNTTLDRSLIQGLNYCEQAGGLSGRPLQLRSTEVIHRLSQELKGRLPIIGVGGIDS
CEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCEEEECCCCH
VTAAREKMAAGASLIQIYSGFIFRGPGLIKNIVTHI
HHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA