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The map label for this gene is moeA [H]

Identifier: 170024803

GI number: 170024803

Start: 2832506

End: 2833780

Strand: Direct

Name: moeA [H]

Synonym: YPK_2578

Alternate gene names: 170024803

Gene position: 2832506-2833780 (Clockwise)

Preceding gene: 170024802

Following gene: 170024804

Centisome position: 60.4

GC content: 49.96

Gene sequence:

>1275_bases
ATGGATCACTGTAATACCTCGGATTTACTCTCTCTGGAACAAGCACTGACCAAAATGCTATCACAGGCCACACCATTGCC
AGCAACAGAGGTCATCCCATTGTCTGAGGCTGCGGGCCGCATCACCGCCAGCGCCATTACTTCACCTATTGCTGTCCCAC
CTTTCGCCAACTCAGCGATGGACGGCTATGCGGTACGTTGGCATGAATTGAGCGACGAGATACCCTTACCCGTCGCAGGG
GTAGCGTTTGCAGGTGCGCCGTTTAAAGATGTGTGGCCGGAAAAGACCTGCATTCGCATTATGACAGGTGCACCACTCCC
CAAGGGTGCAGATACCGTTGTCATGCAAGAGCACGCTGTCGTGAGTGAACAAGGTGTCATATTCAATAGTAACATTCGAA
TCGGGCAAAACATTCGGCTGGCGGGTGAAGATATCCAGCAAGGGGCGGCAGTTTTTCCGGCTGGCGTTAAATTAGGTGCA
GCACAGCTACCGCTATTAGCCTCGTTAGGTATTACTGAAATCGCGGTTTATCGTGCATTAAAAGTGGCTATTTTCTCAAC
CGGTGATGAATTACAGCCTATCGGACAGCCCTTAGCTGAAGGACAGATTTACGATACTAACCGCTTTGCCGTCAGGCTAA
TGTTGCAGCAATTGGGGTGTCAAATCATCGATCTTGGTGTTATCCGTGACGATCAACATGCACTACGTGCAGCATTTCAG
CAGGCGGATACTGCAGCAGACTTGGTCATCAGCAGTGGGGGCGTTTCAGTTGGTGAAGCCGATTATACCAAACAGATACT
GGACGAACTCGGGGATATTGGTTTTTGGAAATTAGCCATAAAGCCCGGTAAACCTTTTGCTTTTGGTAAACTTAGCAATG
CCTGGTTCTGCGGTTTGCCAGGGAATCCTGTCTCTGCGGCCCTAACATTCTATCAACTGGTACAACCGCTGTTGGCAAAG
CTGTCCGGGCATACAGAATGGCATCCACCACTGCGATTAAAAGCCAAAGCGACAACACCACTGAAAAAAACACCAGGCCG
CTTGGACTTTCAACGTGGGATTTTTTCCAGCAATGCGGACGGTCAGTTAGAGGTTCGCACGACTGGCCACCAAGGCTCCC
ACATTTTCAGTTCATTCAGTCAAGGCAACTGTTTTATCGTGCTTGAACGGGAGCGCGGTTCGGTAGCCGTGGGGGAATCC
GTAGAAATAGAGTTGTTTAATGAATTGTTAGGAGGTAATCGACCGTTTGCCATTCATCACCCTGTCGGAGGTTGA

Upstream 100 bases:

>100_bases
CCTCAGGCAATCTCTGCCATAATGGCCTTCTTATTTTAATTGATAGCTCTGCCCCGTGACTCTCCTTTAACCGCGGCGCA
CCCAGACCTCGGAGTTCAGC

Downstream 100 bases:

>100_bases
TATGTTGCCGGAACTTTCAGATGTTGAGGCCCTGCGCTATAACCGGCAAATCACATTACGCGGTTTTGATTTTGACGGCC
AAGAGAAACTGAAAGCGGCC

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MDHCNTSDLLSLEQALTKMLSQATPLPATEVIPLSEAAGRITASAITSPIAVPPFANSAMDGYAVRWHELSDEIPLPVAG
VAFAGAPFKDVWPEKTCIRIMTGAPLPKGADTVVMQEHAVVSEQGVIFNSNIRIGQNIRLAGEDIQQGAAVFPAGVKLGA
AQLPLLASLGITEIAVYRALKVAIFSTGDELQPIGQPLAEGQIYDTNRFAVRLMLQQLGCQIIDLGVIRDDQHALRAAFQ
QADTAADLVISSGGVSVGEADYTKQILDELGDIGFWKLAIKPGKPFAFGKLSNAWFCGLPGNPVSAALTFYQLVQPLLAK
LSGHTEWHPPLRLKAKATTPLKKTPGRLDFQRGIFSSNADGQLEVRTTGHQGSHIFSSFSQGNCFIVLERERGSVAVGES
VEIELFNELLGGNRPFAIHHPVGG

Sequences:

>Translated_424_residues
MDHCNTSDLLSLEQALTKMLSQATPLPATEVIPLSEAAGRITASAITSPIAVPPFANSAMDGYAVRWHELSDEIPLPVAG
VAFAGAPFKDVWPEKTCIRIMTGAPLPKGADTVVMQEHAVVSEQGVIFNSNIRIGQNIRLAGEDIQQGAAVFPAGVKLGA
AQLPLLASLGITEIAVYRALKVAIFSTGDELQPIGQPLAEGQIYDTNRFAVRLMLQQLGCQIIDLGVIRDDQHALRAAFQ
QADTAADLVISSGGVSVGEADYTKQILDELGDIGFWKLAIKPGKPFAFGKLSNAWFCGLPGNPVSAALTFYQLVQPLLAK
LSGHTEWHPPLRLKAKATTPLKKTPGRLDFQRGIFSSNADGQLEVRTTGHQGSHIFSSFSQGNCFIVLERERGSVAVGES
VEIELFNELLGGNRPFAIHHPVGG
>Mature_424_residues
MDHCNTSDLLSLEQALTKMLSQATPLPATEVIPLSEAAGRITASAITSPIAVPPFANSAMDGYAVRWHELSDEIPLPVAG
VAFAGAPFKDVWPEKTCIRIMTGAPLPKGADTVVMQEHAVVSEQGVIFNSNIRIGQNIRLAGEDIQQGAAVFPAGVKLGA
AQLPLLASLGITEIAVYRALKVAIFSTGDELQPIGQPLAEGQIYDTNRFAVRLMLQQLGCQIIDLGVIRDDQHALRAAFQ
QADTAADLVISSGGVSVGEADYTKQILDELGDIGFWKLAIKPGKPFAFGKLSNAWFCGLPGNPVSAALTFYQLVQPLLAK
LSGHTEWHPPLRLKAKATTPLKKTPGRLDFQRGIFSSNADGQLEVRTTGHQGSHIFSSFSQGNCFIVLERERGSVAVGES
VEIELFNELLGGNRPFAIHHPVGG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=397, Percent_Identity=34.7607052896725, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI10880983, Length=397, Percent_Identity=34.7607052896725, Blast_Score=188, Evalue=8e-48,
Organism=Escherichia coli, GI1787049, Length=407, Percent_Identity=67.5675675675676, Blast_Score=549, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI25147659, Length=356, Percent_Identity=30.6179775280899, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17562606, Length=318, Percent_Identity=25.4716981132075, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136978, Length=377, Percent_Identity=29.7082228116711, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24638841, Length=377, Percent_Identity=29.7082228116711, Blast_Score=132, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45300; Mature: 45300

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHCNTSDLLSLEQALTKMLSQATPLPATEVIPLSEAAGRITASAITSPIAVPPFANSAM
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHCCCEEHHHHCCCCCCCCCCCCCC
DGYAVRWHELSDEIPLPVAGVAFAGAPFKDVWPEKTCIRIMTGAPLPKGADTVVMQEHAV
CCCEEEEEECCCCCCCCCCCCEECCCCHHHCCCCCCEEEEEECCCCCCCCCEEEEEHHHE
VSEQGVIFNSNIRIGQNIRLAGEDIQQGAAVFPAGVKLGAAQLPLLASLGITEIAVYRAL
ECCCCEEEECCEEECCEEEECCHHHHCCCEECCCCCCCCCHHCCHHHHCCHHHHHHHHHH
KVAIFSTGDELQPIGQPLAEGQIYDTNRFAVRLMLQQLGCQIIDLGVIRDDQHALRAAFQ
EEEEECCCCCCCHHCCHHHCCEEEECHHHHHHHHHHHHCCEEEEEEEEECHHHHHHHHHH
QADTAADLVISSGGVSVGEADYTKQILDELGDIGFWKLAIKPGKPFAFGKLSNAWFCGLP
HCCCHHHEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCEEECCC
GNPVSAALTFYQLVQPLLAKLSGHTEWHPPLRLKAKATTPLKKTPGRLDFQRGIFSSNAD
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHCCCCCCCC
GQLEVRTTGHQGSHIFSSFSQGNCFIVLERERGSVAVGESVEIELFNELLGGNRPFAIHH
CEEEEEECCCCCCHHHHHCCCCCEEEEEECCCCCEEECCCCHHHHHHHHHCCCCCEEEEC
PVGG
CCCC
>Mature Secondary Structure
MDHCNTSDLLSLEQALTKMLSQATPLPATEVIPLSEAAGRITASAITSPIAVPPFANSAM
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHCCCEEHHHHCCCCCCCCCCCCCC
DGYAVRWHELSDEIPLPVAGVAFAGAPFKDVWPEKTCIRIMTGAPLPKGADTVVMQEHAV
CCCEEEEEECCCCCCCCCCCCEECCCCHHHCCCCCCEEEEEECCCCCCCCCEEEEEHHHE
VSEQGVIFNSNIRIGQNIRLAGEDIQQGAAVFPAGVKLGAAQLPLLASLGITEIAVYRAL
ECCCCEEEECCEEECCEEEECCHHHHCCCEECCCCCCCCCHHCCHHHHCCHHHHHHHHHH
KVAIFSTGDELQPIGQPLAEGQIYDTNRFAVRLMLQQLGCQIIDLGVIRDDQHALRAAFQ
EEEEECCCCCCCHHCCHHHCCEEEECHHHHHHHHHHHHCCEEEEEEEEECHHHHHHHHHH
QADTAADLVISSGGVSVGEADYTKQILDELGDIGFWKLAIKPGKPFAFGKLSNAWFCGLP
HCCCHHHEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCEEECCC
GNPVSAALTFYQLVQPLLAKLSGHTEWHPPLRLKAKATTPLKKTPGRLDFQRGIFSSNAD
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHCCCCCCCC
GQLEVRTTGHQGSHIFSSFSQGNCFIVLERERGSVAVGESVEIELFNELLGGNRPFAIHH
CEEEEEECCCCCCHHHHHCCCCCEEEEEECCCCCEEECCCCHHHHHHHHHCCCCCEEEEC
PVGG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]