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The map label for this gene is folE [H]

Identifier: 170024793

GI number: 170024793

Start: 2820526

End: 2821188

Strand: Reverse

Name: folE [H]

Synonym: YPK_2568

Alternate gene names: 170024793

Gene position: 2821188-2820526 (Counterclockwise)

Preceding gene: 170024794

Following gene: 170024792

Centisome position: 60.16

GC content: 45.25

Gene sequence:

>663_bases
ATGTCATCGCTAAGTAAAGAAGCTGAGTTGGTTCATCAAGCGCTGCTGGCCCGTGGTCTTGAAACCCCTTTACGTAAACC
AGAATTAGATGCCGAGACGCGCAAAACTCGGATTCAGGCCCATATGACAGAAGTCATGCATTTGCTGAATCTTGATTTAA
CCGACGATAGTCTGGCTGATACACCAAGACGCATTGCGAAGATGTATGTTGATGAGATTTTCTCCGGATTGGATTACGAA
AATTTCCCTAAAATCACACTGATTCAAAATAAAATGAAAGTTGATGAAATGGTAACGGTACGGGATATCACTCTGACCAG
CACCTGCGAACATCATTTTGTGACGATTGATGGGAAAGCCACCGTCGCTTATATTCCGAAAGACAGTGTCATTGGTTTGT
CGAAAATCAACCGTATCGTGCAGTTTTTTGCACAGCGTCCGCAAGTGCAGGAACGATTAACACAGCAGATCTTGCTCGCA
TTACAAACCCTGTTGGGTACCAATAATGTCGCAGTTTCTATTGATGCAGTTCATTATTGCGTTAAAGCACGTGGTATCCG
TGATGCGACCAGCGCGACGACCACCACATCATTAGGCGGGTTATTTAAATCCAGTCAGAATACGCGTCAGGAATTTCTGC
GTGCGGTTCGTCACCACGGCTGA

Upstream 100 bases:

>100_bases
TGGATAATCATTTCGCTCTCAATTAGAGTGAGAGCGAAATTCGGGTGTGACCCGCATCATGCTTGTCTTATCTGGATGCG
TAAGCCTGTTGGAGAAAAGA

Downstream 100 bases:

>100_bases
TTGGCTTTTTGCCAGAGGGAGGGCCTGTAGGCCCTCGAATACAGGATGTCGAGTATGCGTCAACGCATCGCAACGTTAGA
CAGTGCGCGGGGGCTGGCCA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MSSLSKEAELVHQALLARGLETPLRKPELDAETRKTRIQAHMTEVMHLLNLDLTDDSLADTPRRIAKMYVDEIFSGLDYE
NFPKITLIQNKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILLA
LQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHG

Sequences:

>Translated_220_residues
MSSLSKEAELVHQALLARGLETPLRKPELDAETRKTRIQAHMTEVMHLLNLDLTDDSLADTPRRIAKMYVDEIFSGLDYE
NFPKITLIQNKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILLA
LQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHG
>Mature_219_residues
SSLSKEAELVHQALLARGLETPLRKPELDAETRKTRIQAHMTEVMHLLNLDLTDDSLADTPRRIAKMYVDEIFSGLDYEN
FPKITLIQNKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILLAL
QTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHG

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=123, Percent_Identity=44.7154471544715, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI4503949, Length=123, Percent_Identity=44.7154471544715, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI66932970, Length=82, Percent_Identity=48.780487804878, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI66932972, Length=82, Percent_Identity=48.780487804878, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1788476, Length=222, Percent_Identity=89.1891891891892, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17560486, Length=189, Percent_Identity=37.5661375661376, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321706, Length=182, Percent_Identity=40.1098901098901, Blast_Score=127, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24656796, Length=122, Percent_Identity=45.0819672131148, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24656782, Length=122, Percent_Identity=45.0819672131148, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24656791, Length=122, Percent_Identity=45.0819672131148, Blast_Score=110, Evalue=7e-25,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 24715; Mature: 24584

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLSKEAELVHQALLARGLETPLRKPELDAETRKTRIQAHMTEVMHLLNLDLTDDSLAD
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
TPRRIAKMYVDEIFSGLDYENFPKITLIQNKMKVDEMVTVRDITLTSTCEHHFVTIDGKA
HHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHEEEECCCCCEEEEECCCE
TVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILLALQTLLGTNNVAVSIDAVHYC
EEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHH
VKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHG
HHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSLSKEAELVHQALLARGLETPLRKPELDAETRKTRIQAHMTEVMHLLNLDLTDDSLAD
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
TPRRIAKMYVDEIFSGLDYENFPKITLIQNKMKVDEMVTVRDITLTSTCEHHFVTIDGKA
HHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHEEEECCCCCEEEEECCCE
TVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILLALQTLLGTNNVAVSIDAVHYC
EEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHH
VKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHG
HHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA