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The map label for this gene is maeA [H]

Identifier: 170024787

GI number: 170024787

Start: 2811624

End: 2813321

Strand: Direct

Name: maeA [H]

Synonym: YPK_2562

Alternate gene names: 170024787

Gene position: 2811624-2813321 (Clockwise)

Preceding gene: 170024786

Following gene: 170024788

Centisome position: 59.96

GC content: 48.23

Gene sequence:

>1698_bases
ATGGAACTTGAATACGAAAGTAAGCGCCCCCTGTACATCCCCTACGCTGGTCCAATATTGCTGGAGTTCCCACTTCTCAA
TAAAGGCAGTGCTTTTACCAATGATGAGCGTAATCATTTCAATCTACATGGCCTATTGCCAGAAGCGGTTGAAACCATTG
AAGAGCAAGCAGAGCGGGCTTACCGCCAGTATCAGGATTTTAAAAACGACGACGATAAGCATATTTATCTGCGCAATATT
CAGGATACCAATGAAACGCTGTTTTATCGTCTGCTAGAAGCTCACCTAAGTGAGATGATGCCAATTATCTACACCCCAAC
CGTTGGGGAAGCGTGTGAGCACTTTTCTGATATTTATCGCCGTGCACGCGGGTTATTTATTTCCTATCCGAACCGCGAAC
ACATTGATGACATGCTACAAAATGCCACCAAACAAAATGTTAAGGTTATCGTCGTCACTGATGGCGAGCGTATTCTGGGC
CTTGGCGACCAAGGTATCGGCGGTATGGGTATCCCAATAGGTAAATTATCGTTGTATACCGCATGCGGCGGCATTAGCCC
AGCCTACACGTTGCCCGTAGTACTTGATGTCGGGACAAATAACCCACAACGGTTGAATGACCCACTGTATATGGGCTGGC
GTCATCCACGAATCTCCGGTGACGAGTACTATGCATTTGTTGATGAATTTATTCAGGCGGTAAAACGTCGTTGGCCAAAT
GTCTTGTTGCAGTTTGAAGATTTTGCACAGAAAAATGCCACCCCGCTGCTAAACCGCTATCGCGATGAATTATGCTGTTT
CAATGATGATATACAAGGGACCGCGGCAGTCACTCTGGGTAGCCTGATTGCCGCCAGCCATGCTGCGGGTAGCCAACTGC
GCGACCAAACAGTCACCTTCCTTGGTGCTGGTTCCGCGGGTTGTGGTATTGCCGAGCAGATCATCGCTCAAATGATGTCA
GAGGGCTTAAGCGAAATACAAGCTCGAGCGCGGATCTTTATGGTCGACCGGTTTGGTCTGCTGACAGATAAACTGCCTAA
CTTGCTCGATTTCCAAAGTAAATTGGTACAAAAAAGTGACGACCTACACCACTGGAATCTGCACAATGATGCGATTTCAT
TACTTGATGTTGTCCGTAATGCCAAACCAACCGTACTCATTGGGGTTTCAGGTCAACCAGGGCTGTTTACTGAAGAGTTG
ATCCGTGAAATGCACAGCCATTGCGCCCGGCCTATCGTCATGCCATTGTCTAACCCAACATCACGGGTTGAAGCCCGACC
AGAAGATATTATCAACTGGACCGATGGCGCGGCACTGGTTGCCACAGGTAGCCCATTCCCACCAGTCAGTTATAAAGAAA
AACTGTATCCTATTGCTCAATGTAATAACTCTTACATCTTCCCCGGTATCGGCTTGGGTGTATTGGCATCTGGTGCGAGC
CGTGTCACGGATGGCATGTTAATGGCTGCCAGCCGGGCATTAGCAGAGAGCTCACCACTCGCACGTCATGGCGAAGGGGC
CTTACTGCCTAATATCGATGATATTCAGGCGGTATCGAAAGCTATCGCAATGCGGGTCGGTCAAGCCGCTCAATTACAAG
GTGTTGCTATTGTGACTTCGGAAGAAGCGTTGTCTAAAGCCATTGAGCACAATTATTGGCAACCACAGTACCGTAGCTAT
AAACGCACCTCGTTTTGA

Upstream 100 bases:

>100_bases
GCAATTGTCATAATTTGCTAACAAATGCTGTACATATTTTTCTTATCTTTTAGGATCGGGGTAACAATTGCTATTTGATA
ACGTTTAAGAGTAAGAACTC

Downstream 100 bases:

>100_bases
ATATAATCCGGCCTGTGCTATACCGCAGGCCGGGTACTCAGATGCTATCCACCACCGTTTTTCTACCGTGGTCACTTTTA
ACAAAAACAGCGTTGAACAA

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MELEYESKRPLYIPYAGPILLEFPLLNKGSAFTNDERNHFNLHGLLPEAVETIEEQAERAYRQYQDFKNDDDKHIYLRNI
QDTNETLFYRLLEAHLSEMMPIIYTPTVGEACEHFSDIYRRARGLFISYPNREHIDDMLQNATKQNVKVIVVTDGERILG
LGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDVGTNNPQRLNDPLYMGWRHPRISGDEYYAFVDEFIQAVKRRWPN
VLLQFEDFAQKNATPLLNRYRDELCCFNDDIQGTAAVTLGSLIAASHAAGSQLRDQTVTFLGAGSAGCGIAEQIIAQMMS
EGLSEIQARARIFMVDRFGLLTDKLPNLLDFQSKLVQKSDDLHHWNLHNDAISLLDVVRNAKPTVLIGVSGQPGLFTEEL
IREMHSHCARPIVMPLSNPTSRVEARPEDIINWTDGAALVATGSPFPPVSYKEKLYPIAQCNNSYIFPGIGLGVLASGAS
RVTDGMLMAASRALAESSPLARHGEGALLPNIDDIQAVSKAIAMRVGQAAQLQGVAIVTSEEALSKAIEHNYWQPQYRSY
KRTSF

Sequences:

>Translated_565_residues
MELEYESKRPLYIPYAGPILLEFPLLNKGSAFTNDERNHFNLHGLLPEAVETIEEQAERAYRQYQDFKNDDDKHIYLRNI
QDTNETLFYRLLEAHLSEMMPIIYTPTVGEACEHFSDIYRRARGLFISYPNREHIDDMLQNATKQNVKVIVVTDGERILG
LGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDVGTNNPQRLNDPLYMGWRHPRISGDEYYAFVDEFIQAVKRRWPN
VLLQFEDFAQKNATPLLNRYRDELCCFNDDIQGTAAVTLGSLIAASHAAGSQLRDQTVTFLGAGSAGCGIAEQIIAQMMS
EGLSEIQARARIFMVDRFGLLTDKLPNLLDFQSKLVQKSDDLHHWNLHNDAISLLDVVRNAKPTVLIGVSGQPGLFTEEL
IREMHSHCARPIVMPLSNPTSRVEARPEDIINWTDGAALVATGSPFPPVSYKEKLYPIAQCNNSYIFPGIGLGVLASGAS
RVTDGMLMAASRALAESSPLARHGEGALLPNIDDIQAVSKAIAMRVGQAAQLQGVAIVTSEEALSKAIEHNYWQPQYRSY
KRTSF
>Mature_565_residues
MELEYESKRPLYIPYAGPILLEFPLLNKGSAFTNDERNHFNLHGLLPEAVETIEEQAERAYRQYQDFKNDDDKHIYLRNI
QDTNETLFYRLLEAHLSEMMPIIYTPTVGEACEHFSDIYRRARGLFISYPNREHIDDMLQNATKQNVKVIVVTDGERILG
LGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDVGTNNPQRLNDPLYMGWRHPRISGDEYYAFVDEFIQAVKRRWPN
VLLQFEDFAQKNATPLLNRYRDELCCFNDDIQGTAAVTLGSLIAASHAAGSQLRDQTVTFLGAGSAGCGIAEQIIAQMMS
EGLSEIQARARIFMVDRFGLLTDKLPNLLDFQSKLVQKSDDLHHWNLHNDAISLLDVVRNAKPTVLIGVSGQPGLFTEEL
IREMHSHCARPIVMPLSNPTSRVEARPEDIINWTDGAALVATGSPFPPVSYKEKLYPIAQCNNSYIFPGIGLGVLASGAS
RVTDGMLMAASRALAESSPLARHGEGALLPNIDDIQAVSKAIAMRVGQAAQLQGVAIVTSEEALSKAIEHNYWQPQYRSY
KRTSF

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=542, Percent_Identity=43.5424354243542, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI62420882, Length=560, Percent_Identity=41.6071428571429, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI62420880, Length=560, Percent_Identity=41.6071428571429, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI239049447, Length=560, Percent_Identity=41.6071428571429, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI4505145, Length=554, Percent_Identity=41.5162454873646, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI270265879, Length=463, Percent_Identity=44.7084233261339, Blast_Score=378, Evalue=1e-105,
Organism=Escherichia coli, GI87081919, Length=565, Percent_Identity=74.8672566371681, Blast_Score=872, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17537199, Length=543, Percent_Identity=43.8305709023941, Blast_Score=420, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6322823, Length=559, Percent_Identity=44.9016100178891, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24646386, Length=516, Percent_Identity=45.3488372093023, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24646388, Length=516, Percent_Identity=45.3488372093023, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI281362674, Length=540, Percent_Identity=43.8888888888889, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI21356279, Length=540, Percent_Identity=43.8888888888889, Blast_Score=440, Evalue=1e-123,
Organism=Drosophila melanogaster, GI281362672, Length=540, Percent_Identity=43.8888888888889, Blast_Score=440, Evalue=1e-123,
Organism=Drosophila melanogaster, GI78707242, Length=539, Percent_Identity=38.5899814471243, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI78707238, Length=539, Percent_Identity=38.5899814471243, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI78707240, Length=507, Percent_Identity=39.2504930966469, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI78707232, Length=503, Percent_Identity=37.9721669980119, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI281363505, Length=503, Percent_Identity=37.9721669980119, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI78707236, Length=503, Percent_Identity=37.9721669980119, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI281363503, Length=501, Percent_Identity=37.7245508982036, Blast_Score=358, Evalue=4e-99,
Organism=Drosophila melanogaster, GI19922384, Length=538, Percent_Identity=31.0408921933086, Blast_Score=268, Evalue=5e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 62829; Mature: 62829

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELEYESKRPLYIPYAGPILLEFPLLNKGSAFTNDERNHFNLHGLLPEAVETIEEQAERA
CCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHH
YRQYQDFKNDDDKHIYLRNIQDTNETLFYRLLEAHLSEMMPIIYTPTVGEACEHFSDIYR
HHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHH
RARGLFISYPNREHIDDMLQNATKQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYT
HHCCCEEECCCHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHH
ACGGISPAYTLPVVLDVGTNNPQRLNDPLYMGWRHPRISGDEYYAFVDEFIQAVKRRWPN
HHCCCCCCEEEEEEEECCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCH
VLLQFEDFAQKNATPLLNRYRDELCCFNDDIQGTAAVTLGSLIAASHAAGSQLRDQTVTF
HEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHCEEEE
LGAGSAGCGIAEQIIAQMMSEGLSEIQARARIFMVDRFGLLTDKLPNLLDFQSKLVQKSD
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHCCHHHHHHHHHHHCCC
DLHHWNLHNDAISLLDVVRNAKPTVLIGVSGQPGLFTEELIREMHSHCARPIVMPLSNPT
CCCEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCCH
SRVEARPEDIINWTDGAALVATGSPFPPVSYKEKLYPIAQCNNSYIFPGIGLGVLASGAS
HHHCCCHHHHCCCCCCCEEEECCCCCCCCCHHHHCCHHHHCCCCEECCCCCHHHHHCCHH
RVTDGMLMAASRALAESSPLARHGEGALLPNIDDIQAVSKAIAMRVGQAAQLQGVAIVTS
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCCEEEEEC
EEALSKAIEHNYWQPQYRSYKRTSF
HHHHHHHHHCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MELEYESKRPLYIPYAGPILLEFPLLNKGSAFTNDERNHFNLHGLLPEAVETIEEQAERA
CCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHH
YRQYQDFKNDDDKHIYLRNIQDTNETLFYRLLEAHLSEMMPIIYTPTVGEACEHFSDIYR
HHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHH
RARGLFISYPNREHIDDMLQNATKQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYT
HHCCCEEECCCHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHH
ACGGISPAYTLPVVLDVGTNNPQRLNDPLYMGWRHPRISGDEYYAFVDEFIQAVKRRWPN
HHCCCCCCEEEEEEEECCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCH
VLLQFEDFAQKNATPLLNRYRDELCCFNDDIQGTAAVTLGSLIAASHAAGSQLRDQTVTF
HEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHCEEEE
LGAGSAGCGIAEQIIAQMMSEGLSEIQARARIFMVDRFGLLTDKLPNLLDFQSKLVQKSD
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHCCHHHHHHHHHHHCCC
DLHHWNLHNDAISLLDVVRNAKPTVLIGVSGQPGLFTEELIREMHSHCARPIVMPLSNPT
CCCEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCCH
SRVEARPEDIINWTDGAALVATGSPFPPVSYKEKLYPIAQCNNSYIFPGIGLGVLASGAS
HHHCCCHHHHCCCCCCCEEEECCCCCCCCCHHHHCCHHHHCCCCEECCCCCHHHHHCCHH
RVTDGMLMAASRALAESSPLARHGEGALLPNIDDIQAVSKAIAMRVGQAAQLQGVAIVTS
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCCEEEEEC
EEALSKAIEHNYWQPQYRSYKRTSF
HHHHHHHHHCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA