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The map label for this gene is sbcB [H]

Identifier: 170024741

GI number: 170024741

Start: 2754811

End: 2756241

Strand: Direct

Name: sbcB [H]

Synonym: YPK_2516

Alternate gene names: 170024741

Gene position: 2754811-2756241 (Clockwise)

Preceding gene: 170024738

Following gene: 170024745

Centisome position: 58.74

GC content: 49.41

Gene sequence:

>1431_bases
ATGTCAGATAAAAATAAGCAACCAACATTTTACGTCCACGATTATGAAACCTTCGGCCAGCGGCCAGCCTTGGATAGACC
TGCGCAATTTGCCGGGGTACGTACCGATCTGGATTTCAATCTCGTCGAAGAGCCATTGGTCATTTACTGCAAGCCCGCAG
ATGATTATCTGCCACAGCCCGAAGCGGTGATGATAACCGGTATTACCCCCCAACATGCTTTAGCCAACGGGGTCAATGAA
GCTGAGTTTTCCCGCCAAATACACCAGGCCTTTTCGGTACCCGGCACCTGTATCCTCGGCTACAACAATATTCGTTTTGA
TGATGAAGTCAGTCGCAACATTTTCTATCGTAATTTTTATGATCCCTATGCCTACAGTTGGCAGGGGGGAAATTCCCGTT
GGGATCTGTTGGATGTGATGCGCGCCTGCTATGCCCTGCGCCCAGAAGGTATTGTTTGGCCCGAAAATGATGATGGCCTG
CCCAGCTTTAAACTGGAACATTTGACCAAAGCCAATGGCGTCGAACATTTACAGGCACATGATGCGATGTCCGATGTCTA
CGCCACCATTGCAATGGCAAAATTGGTGAAACAGGCCCAACCCCGTCTGTTTGATTATCTGTATCAGCACCGCAGTAAGC
ATAAGATCAATGCGTTGATTGATATCGCGGAGATGACACCACTGGTTCATGTGTCTGGCATGTTTGGTGCCGCACGGGGC
AACACCAGTTGGGTGGCACCGCTGGCCTGGCACCCCGAGAATAAAAATGCGGTAATTATGTGCGATCTGGCCGGGGATAT
GTCCCCATTACTGGAGTTGGACAGCGATACATTGCGCGAACGTCTGTATACCCGCCGTGACAAGCTCCAAGCCCAAGAGT
CGGCAATCCCTATCAAACTGGTACATATCAATAAATGTCCGGTATTGGCTCCTGCAAAAACTCTGCTGCCCGAGAATGCT
GATCGCTTGGGGATTGATCGCCAGCGTTGTTTGCAAAATCTGCAACTGCTGCGGCAAAACCCGCAGGTGCGTGAAAAAGT
GGTCGCGCTGTTTGCACAAGCTGAGCCATTCGCGGTTACCGATGATGTGGATACACAGTTGTATAACGGCTTTTTCAGTG
ATGCTGACCGCGCCACCATGAAGATTATCCAGCAAACTGAGCCACAAAATCTGCCAGCACTGGATTTGACATTTCAGGAC
CCACGGTTGGAGGCCCTGCTATTCCGCTTCCGCGCCCGTAACTACCCAAATACCTTGAATAACAGTGAACAACAGCGTTG
GTTACAGCATCGCCGTGAAGCGCTTAGCCCTGAGCGGGTACAAGATTATGTTTTGCAACTGGAACAATTTTATAACCAGT
ATGAAGACGATAAAGAGAAACTTGCGCTGCTAAAAGCGTTGTTTGAATATGCCAAGGGATTAGTGAGTTAA

Upstream 100 bases:

>100_bases
ATGATATTCTAGCGTCAACGTCATCCGTCGCTGCGGGTTGCCTTCTGCAAGCAGATCCCACCCGAATATGACCACGATAA
ATGAAGGGTTAAACCGAATA

Downstream 100 bases:

>100_bases
TATTTGCAGATAAAACGCCGCCAGAGAGCTGAGATTATTGGGCTGCCTGTGCGGCAGTGAACAGCTCTCGTCTCCCTGGC
CGTCCAGCGTGTAATTTCTA

Product: exonuclease I

Products: NA

Alternate protein names: Exonuclease I; DNA deoxyribophosphodiesterase; dRPase [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSDKNKQPTFYVHDYETFGQRPALDRPAQFAGVRTDLDFNLVEEPLVIYCKPADDYLPQPEAVMITGITPQHALANGVNE
AEFSRQIHQAFSVPGTCILGYNNIRFDDEVSRNIFYRNFYDPYAYSWQGGNSRWDLLDVMRACYALRPEGIVWPENDDGL
PSFKLEHLTKANGVEHLQAHDAMSDVYATIAMAKLVKQAQPRLFDYLYQHRSKHKINALIDIAEMTPLVHVSGMFGAARG
NTSWVAPLAWHPENKNAVIMCDLAGDMSPLLELDSDTLRERLYTRRDKLQAQESAIPIKLVHINKCPVLAPAKTLLPENA
DRLGIDRQRCLQNLQLLRQNPQVREKVVALFAQAEPFAVTDDVDTQLYNGFFSDADRATMKIIQQTEPQNLPALDLTFQD
PRLEALLFRFRARNYPNTLNNSEQQRWLQHRREALSPERVQDYVLQLEQFYNQYEDDKEKLALLKALFEYAKGLVS

Sequences:

>Translated_476_residues
MSDKNKQPTFYVHDYETFGQRPALDRPAQFAGVRTDLDFNLVEEPLVIYCKPADDYLPQPEAVMITGITPQHALANGVNE
AEFSRQIHQAFSVPGTCILGYNNIRFDDEVSRNIFYRNFYDPYAYSWQGGNSRWDLLDVMRACYALRPEGIVWPENDDGL
PSFKLEHLTKANGVEHLQAHDAMSDVYATIAMAKLVKQAQPRLFDYLYQHRSKHKINALIDIAEMTPLVHVSGMFGAARG
NTSWVAPLAWHPENKNAVIMCDLAGDMSPLLELDSDTLRERLYTRRDKLQAQESAIPIKLVHINKCPVLAPAKTLLPENA
DRLGIDRQRCLQNLQLLRQNPQVREKVVALFAQAEPFAVTDDVDTQLYNGFFSDADRATMKIIQQTEPQNLPALDLTFQD
PRLEALLFRFRARNYPNTLNNSEQQRWLQHRREALSPERVQDYVLQLEQFYNQYEDDKEKLALLKALFEYAKGLVS
>Mature_475_residues
SDKNKQPTFYVHDYETFGQRPALDRPAQFAGVRTDLDFNLVEEPLVIYCKPADDYLPQPEAVMITGITPQHALANGVNEA
EFSRQIHQAFSVPGTCILGYNNIRFDDEVSRNIFYRNFYDPYAYSWQGGNSRWDLLDVMRACYALRPEGIVWPENDDGLP
SFKLEHLTKANGVEHLQAHDAMSDVYATIAMAKLVKQAQPRLFDYLYQHRSKHKINALIDIAEMTPLVHVSGMFGAARGN
TSWVAPLAWHPENKNAVIMCDLAGDMSPLLELDSDTLRERLYTRRDKLQAQESAIPIKLVHINKCPVLAPAKTLLPENAD
RLGIDRQRCLQNLQLLRQNPQVREKVVALFAQAEPFAVTDDVDTQLYNGFFSDADRATMKIIQQTEPQNLPALDLTFQDP
RLEALLFRFRARNYPNTLNNSEQQRWLQHRREALSPERVQDYVLQLEQFYNQYEDDKEKLALLKALFEYAKGLVS

Specific function: Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease AP lyase [H]

COG id: COG2925

COG function: function code L; Exonuclease I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1788321, Length=475, Percent_Identity=73.4736842105263, Blast_Score=746, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013620
- InterPro:   IPR013520
- InterPro:   IPR012337 [H]

Pfam domain/function: PF00929 Exonuc_X-T; PF08411 Exonuc_X-T_C [H]

EC number: =3.1.11.1 [H]

Molecular weight: Translated: 54650; Mature: 54518

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKNKQPTFYVHDYETFGQRPALDRPAQFAGVRTDLDFNLVEEPLVIYCKPADDYLPQP
CCCCCCCCEEEEECHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
EAVMITGITPQHALANGVNEAEFSRQIHQAFSVPGTCILGYNNIRFDDEVSRNIFYRNFY
CEEEEECCCHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHEEECCC
DPYAYSWQGGNSRWDLLDVMRACYALRPEGIVWPENDDGLPSFKLEHLTKANGVEHLQAH
CCCCEEECCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCHHHHHHH
DAMSDVYATIAMAKLVKQAQPRLFDYLYQHRSKHKINALIDIAEMTPLVHVSGMFGAARG
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCCCCCC
NTSWVAPLAWHPENKNAVIMCDLAGDMSPLLELDSDTLRERLYTRRDKLQAQESAIPIKL
CCCEEEEEEECCCCCCEEEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEE
VHINKCPVLAPAKTLLPENADRLGIDRQRCLQNLQLLRQNPQVREKVVALFAQAEPFAVT
EEECCCCCCCCHHHHCCCCCHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEC
DDVDTQLYNGFFSDADRATMKIIQQTEPQNLPALDLTFQDPRLEALLFRFRARNYPNTLN
CCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCC
NSEQQRWLQHRREALSPERVQDYVLQLEQFYNQYEDDKEKLALLKALFEYAKGLVS
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDKNKQPTFYVHDYETFGQRPALDRPAQFAGVRTDLDFNLVEEPLVIYCKPADDYLPQP
CCCCCCCEEEEECHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
EAVMITGITPQHALANGVNEAEFSRQIHQAFSVPGTCILGYNNIRFDDEVSRNIFYRNFY
CEEEEECCCHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHEEECCC
DPYAYSWQGGNSRWDLLDVMRACYALRPEGIVWPENDDGLPSFKLEHLTKANGVEHLQAH
CCCCEEECCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCHHHHHHH
DAMSDVYATIAMAKLVKQAQPRLFDYLYQHRSKHKINALIDIAEMTPLVHVSGMFGAARG
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCCCCCC
NTSWVAPLAWHPENKNAVIMCDLAGDMSPLLELDSDTLRERLYTRRDKLQAQESAIPIKL
CCCEEEEEEECCCCCCEEEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEE
VHINKCPVLAPAKTLLPENADRLGIDRQRCLQNLQLLRQNPQVREKVVALFAQAEPFAVT
EEECCCCCCCCHHHHCCCCCHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEC
DDVDTQLYNGFFSDADRATMKIIQQTEPQNLPALDLTFQDPRLEALLFRFRARNYPNTLN
CCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCC
NSEQQRWLQHRREALSPERVQDYVLQLEQFYNQYEDDKEKLALLKALFEYAKGLVS
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3539937; 9097040; 9278503; 1329027 [H]