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The map label for this gene is mmlH [H]

Identifier: 170024728

GI number: 170024728

Start: 2737001

End: 2738341

Strand: Direct

Name: mmlH [H]

Synonym: YPK_2503

Alternate gene names: 170024728

Gene position: 2737001-2738341 (Clockwise)

Preceding gene: 170024727

Following gene: 170024730

Centisome position: 58.37

GC content: 52.2

Gene sequence:

>1341_bases
ATGAACATCTATAAAAAAATATCTGCTGATGGCTGGCAGCCGCAGCAATTAACAATCAAAGATGTCAAATTCGCCACATG
GCTCGCCTTCTTCGCCTGGGTATTCGCCGTTTACGACTTTATTCTGTTCGGTACCCTGCTACCGGAAATTGGTGATCATT
TTGGTTGGGATGAAATAGAACAGGCTAAGTTAGCGACTTGGGTCGCCGCTGGAGGTGCTGTTGTGGCGCTGACTGTCGGC
CCCATCGTTGACAGGTTGGGGCGGCGTTTGGGCATTGTGTTTACTGTCACCGGTGCGGCGATATCCTCTCTGTTGACCGC
AATCGGGGGCGCATGGGGCAAAGGCGTATTGGTCGGTATTCGTTCGATAGCGGGGCTAGGCTTCGCCGAGCAAACGGTGA
ATGCGACGTATCTCACCGAAATGTATGCCGCCATTAACGACCCAATATTAAATCGGCACAAAGGATTTATTTATAGTCTG
GTACAAGGGGGGTGGCCAGTTGGCGCACTGGTCGCCTCAGGGCTGTCAGCACTGTTGATGCCGATTATCGGCTGGCAAGG
GAGTTTTATTTTTGCCGCAGTTCCTTCGTTTATTATTGCCCTGCTGGCCCTAAAACTAAAAGAAACCCCACAATTTCAAA
TCCACCAGCACATCCGTCGGTTAACGGAAGCTGGCCAGCCAGAAAAGGCCCGTCAGGTGGCAAAAGATTATCATTTTGAG
TATGCCGATCATCAACGTACCGGCCTGTCAGCCATTTTTCGTGGCACATCACTGCGCACCACACTGGTACTCGGCGGAGC
CTTAATGATCAACTGGTTTGCTATTCAGATTTTCGGGGTGCTCGGCACCACGGTTATCACGAAGGTACACGATGTCTCCT
TTGAGAGTTCACTCTGGGTTCTGGTGCTTTCTAACCTGGTGGGCTATTGCGGTTATCTGGCGCATGGTTGGTTAGGGGAT
CGTTTCGGCCGCCGGAATATCATTGCTCTAGGTTGGATGCTCGGTGGTTTATCGTTGGCCACCATGCTCTATGGGCCAGC
CGATTTTTCCCTCATCGTTATCCTGTACAGCGCAGGCCTATTTTTCCTGATAGGGCCATATTCTGCCGCCCTATTCTTCT
TTAGTGAGAGTTTTCCCACCGCCATCCGTGCCACTGCTGGCGCATTTATCATCGCCATGGGGCCTATCGGTGCCATTATT
GCCAGCATGGGGGCGACCAGCATTCTCAGCAGCGGAGGCAACTGGCAGACCGCAGCCCTGTTATTCGGTGCCATCCCCTG
CTTTATCTCTGGCGTCATTATGCTGTTTGCCCACCACGTGGCACCGCAGAGTGTGAAGTAA

Upstream 100 bases:

>100_bases
TACGTTTCGTGACCTTTGATGAGATTGCTGACGACTACTTGCGCCGTATGCCGCGCAAAATTTGATCCTGAGGCATCCTA
TTGAACGAGTGATAACAACC

Downstream 100 bases:

>100_bases
TTCGATGGGGGACACCGGCTCATATTCTCAGACGCTGGGCCGGTAGCGCCATAACCAACGGCCCGTGGACATGCGGCGAT
AAAACAACACCCCCCGGACC

Product: major facilitator transporter

Products: Proton [Cytoplasm]; N-acetylneuraminate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MNIYKKISADGWQPQQLTIKDVKFATWLAFFAWVFAVYDFILFGTLLPEIGDHFGWDEIEQAKLATWVAAGGAVVALTVG
PIVDRLGRRLGIVFTVTGAAISSLLTAIGGAWGKGVLVGIRSIAGLGFAEQTVNATYLTEMYAAINDPILNRHKGFIYSL
VQGGWPVGALVASGLSALLMPIIGWQGSFIFAAVPSFIIALLALKLKETPQFQIHQHIRRLTEAGQPEKARQVAKDYHFE
YADHQRTGLSAIFRGTSLRTTLVLGGALMINWFAIQIFGVLGTTVITKVHDVSFESSLWVLVLSNLVGYCGYLAHGWLGD
RFGRRNIIALGWMLGGLSLATMLYGPADFSLIVILYSAGLFFLIGPYSAALFFFSESFPTAIRATAGAFIIAMGPIGAII
ASMGATSILSSGGNWQTAALLFGAIPCFISGVIMLFAHHVAPQSVK

Sequences:

>Translated_446_residues
MNIYKKISADGWQPQQLTIKDVKFATWLAFFAWVFAVYDFILFGTLLPEIGDHFGWDEIEQAKLATWVAAGGAVVALTVG
PIVDRLGRRLGIVFTVTGAAISSLLTAIGGAWGKGVLVGIRSIAGLGFAEQTVNATYLTEMYAAINDPILNRHKGFIYSL
VQGGWPVGALVASGLSALLMPIIGWQGSFIFAAVPSFIIALLALKLKETPQFQIHQHIRRLTEAGQPEKARQVAKDYHFE
YADHQRTGLSAIFRGTSLRTTLVLGGALMINWFAIQIFGVLGTTVITKVHDVSFESSLWVLVLSNLVGYCGYLAHGWLGD
RFGRRNIIALGWMLGGLSLATMLYGPADFSLIVILYSAGLFFLIGPYSAALFFFSESFPTAIRATAGAFIIAMGPIGAII
ASMGATSILSSGGNWQTAALLFGAIPCFISGVIMLFAHHVAPQSVK
>Mature_446_residues
MNIYKKISADGWQPQQLTIKDVKFATWLAFFAWVFAVYDFILFGTLLPEIGDHFGWDEIEQAKLATWVAAGGAVVALTVG
PIVDRLGRRLGIVFTVTGAAISSLLTAIGGAWGKGVLVGIRSIAGLGFAEQTVNATYLTEMYAAINDPILNRHKGFIYSL
VQGGWPVGALVASGLSALLMPIIGWQGSFIFAAVPSFIIALLALKLKETPQFQIHQHIRRLTEAGQPEKARQVAKDYHFE
YADHQRTGLSAIFRGTSLRTTLVLGGALMINWFAIQIFGVLGTTVITKVHDVSFESSLWVLVLSNLVGYCGYLAHGWLGD
RFGRRNIIALGWMLGGLSLATMLYGPADFSLIVILYSAGLFFLIGPYSAALFFFSESFPTAIRATAGAFIIAMGPIGAII
ASMGATSILSSGGNWQTAALLFGAIPCFISGVIMLFAHHVAPQSVK

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=415, Percent_Identity=24.578313253012, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI32564663, Length=404, Percent_Identity=23.2673267326733, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48016; Mature: 48016

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; N-acetylneuraminate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + N-acetylneuraminate [Periplasm] = Proton [Cytoplasm] + N-acetylneuraminate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]