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The map label for this gene is rio1 [H]

Identifier: 170024713

GI number: 170024713

Start: 2719920

End: 2720771

Strand: Direct

Name: rio1 [H]

Synonym: YPK_2488

Alternate gene names: 170024713

Gene position: 2719920-2720771 (Clockwise)

Preceding gene: 170024712

Following gene: 170024714

Centisome position: 58.0

GC content: 48.83

Gene sequence:

>852_bases
ATGAAAATTCCAAAACGAATCCAACCGCTGGTTGATGACGGCTTGGTTGACGAAGTCATCCGTCGTTTGAAAAGTGGCAA
AGAAGCTGATGTGTATGTTGTCCGTTGCGGGTCAGACATACGCTGCGCTAAAGTTTATAAAGAAGCAGAGAACCGCAGTT
TCAAACAAGCGGTTCAATATCAAGAAGGGCGTAAGGTCCGTAATAGCCGTGATGCCCGGGCAATGGCTAAAGGCTCTAAA
TTTGGCCGCAAACAGCAAGAGGAAACCTGGCAAACTGCCGAGGTGGATGCGTTGTTCCTGTTAGCTAATGCCGGAGTGCG
CGTTCCACAGCCTTACACCTGTCTTGATGGCGTTTTACTGATGGAACTGGTCACTGATGAAGATGGCCTCGCGGCACCCA
GACTCAGTGACGTGCCGTTATCTAAAGAGCAGGCCTTGGCTGACCATGAAATCATGATCCAATACGTGGTGCGGATGTTA
TGCGCAGGTCTGGTACACGGTGATCTTTCAGAATTTAATGTGTTAATGGATAAAGATGGCCCGGTTATTATCGATCTGCC
GCAGGCGGTTAATGCGGCCGCCAATAACCATGCTAAAGCCATGCTTGAGCGGGATGTTGCCAATATGACCCACTATTATG
GTCAATATGCCCCCGAGTTACTGAATCGCAAGTATGCCAAGGAAATGTGGGCGCTTTATGAAGACGGTAAACTTCATCCA
GATACGCCTCTCACCGGGAACTTTGCAGAAAGCACTCAGGCAGCGGATGTCGACGCTGTATTAGATGAAATTAAAGCTGT
TATTGCCGAAGAGCAAGAACGTCTGCGCGAGGCTCAAGAGCACAACAACTAA

Upstream 100 bases:

>100_bases
CTCAGTAAAAACCCACCCGTTAACGACTCCGGGTGGTAAACTGAAGAAAAATTCGGCCGAAGCCATTCCATCGAGGGCTT
AAATAGGGTACAAGGACGCC

Downstream 100 bases:

>100_bases
ATAAAGTAGACCCTCTAGGTAAATCAAGCCCTCTAAGAAGATCAAAAAACAACCTCTGGAGCAGCGGCCTTCCCTGCTCC
TCCTCCCCATCCCTGATAAT

Product: hypothetical protein

Products: NA

Alternate protein names: AfRio1 [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MKIPKRIQPLVDDGLVDEVIRRLKSGKEADVYVVRCGSDIRCAKVYKEAENRSFKQAVQYQEGRKVRNSRDARAMAKGSK
FGRKQQEETWQTAEVDALFLLANAGVRVPQPYTCLDGVLLMELVTDEDGLAAPRLSDVPLSKEQALADHEIMIQYVVRML
CAGLVHGDLSEFNVLMDKDGPVIIDLPQAVNAAANNHAKAMLERDVANMTHYYGQYAPELLNRKYAKEMWALYEDGKLHP
DTPLTGNFAESTQAADVDAVLDEIKAVIAEEQERLREAQEHNN

Sequences:

>Translated_283_residues
MKIPKRIQPLVDDGLVDEVIRRLKSGKEADVYVVRCGSDIRCAKVYKEAENRSFKQAVQYQEGRKVRNSRDARAMAKGSK
FGRKQQEETWQTAEVDALFLLANAGVRVPQPYTCLDGVLLMELVTDEDGLAAPRLSDVPLSKEQALADHEIMIQYVVRML
CAGLVHGDLSEFNVLMDKDGPVIIDLPQAVNAAANNHAKAMLERDVANMTHYYGQYAPELLNRKYAKEMWALYEDGKLHP
DTPLTGNFAESTQAADVDAVLDEIKAVIAEEQERLREAQEHNN
>Mature_283_residues
MKIPKRIQPLVDDGLVDEVIRRLKSGKEADVYVVRCGSDIRCAKVYKEAENRSFKQAVQYQEGRKVRNSRDARAMAKGSK
FGRKQQEETWQTAEVDALFLLANAGVRVPQPYTCLDGVLLMELVTDEDGLAAPRLSDVPLSKEQALADHEIMIQYVVRML
CAGLVHGDLSEFNVLMDKDGPVIIDLPQAVNAAANNHAKAMLERDVANMTHYYGQYAPELLNRKYAKEMWALYEDGKLHP
DTPLTGNFAESTQAADVDAVLDEIKAVIAEEQERLREAQEHNN

Specific function: Autophosphorylation of the rio1 protein is not necessary for maintenance of kinase activity. Prefers ATP over GTP. The yeast ortholog is involved in ribosome biogenesis [H]

COG id: COG1718

COG function: function code TD; Serine/threonine protein kinase involved in cell cycle control

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI23510356, Length=270, Percent_Identity=27.7777777777778, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI23510358, Length=195, Percent_Identity=28.7179487179487, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24662811, Length=212, Percent_Identity=31.6037735849057, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356879, Length=212, Percent_Identity=31.6037735849057, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR018934
- InterPro:   IPR000687
- InterPro:   IPR018935 [H]

Pfam domain/function: PF01163 RIO1 [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 31742; Mature: 31742

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00109 PROTEIN_KINASE_TYR ; PS01245 RIO1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIPKRIQPLVDDGLVDEVIRRLKSGKEADVYVVRCGSDIRCAKVYKEAENRSFKQAVQY
CCCCHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCHHHHHHHHH
QEGRKVRNSRDARAMAKGSKFGRKQQEETWQTAEVDALFLLANAGVRVPQPYTCLDGVLL
HHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHH
MELVTDEDGLAAPRLSDVPLSKEQALADHEIMIQYVVRMLCAGLVHGDLSEFNVLMDKDG
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEECCCC
PVIIDLPQAVNAAANNHAKAMLERDVANMTHYYGQYAPELLNRKYAKEMWALYEDGKLHP
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DTPLTGNFAESTQAADVDAVLDEIKAVIAEEQERLREAQEHNN
CCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIPKRIQPLVDDGLVDEVIRRLKSGKEADVYVVRCGSDIRCAKVYKEAENRSFKQAVQY
CCCCHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCHHHHHHHHH
QEGRKVRNSRDARAMAKGSKFGRKQQEETWQTAEVDALFLLANAGVRVPQPYTCLDGVLL
HHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHH
MELVTDEDGLAAPRLSDVPLSKEQALADHEIMIQYVVRMLCAGLVHGDLSEFNVLMDKDG
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEECCCC
PVIIDLPQAVNAAANNHAKAMLERDVANMTHYYGQYAPELLNRKYAKEMWALYEDGKLHP
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DTPLTGNFAESTQAADVDAVLDEIKAVIAEEQERLREAQEHNN
CCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]