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The map label for this gene is yegE [H]

Identifier: 170024695

GI number: 170024695

Start: 2705155

End: 2707236

Strand: Direct

Name: yegE [H]

Synonym: YPK_2470

Alternate gene names: 170024695

Gene position: 2705155-2707236 (Clockwise)

Preceding gene: 170024693

Following gene: 170024696

Centisome position: 57.69

GC content: 48.17

Gene sequence:

>2082_bases
ATGGCTTTGTACCCGGCATCATTTGACGATCATGTTTTCCGGTTATTAATTGAGGCCGTTGATGATTACGCCATATACAT
CATTGATGCCAAGGGGCACGTTCTGACCTGGAACAATGGCGCAGAACGCAATACCGGTTATTGTGCCGAAGAGGTTATCG
GTCAATCCTTCGAGCTGTTTTATACCCCGGAAGATTTAGTGAACGGCTTGTCAGTCAAAGGGCTTAAGCACGCTAATCAG
TTTGGTCATTACGAATCTCAAAGCTGGCGTGTGCGCAAAAATGGCAAACGTTTTTGGGGCAACGTCACTCTCAGTGCACT
TCATAACTCAGAAAATATTTTGCAGGGCTTTGTTCATGTTACCCGTGACCTGACCGACCAATGGCAGCGGGATAATGCAC
TGCGGAAAAGTGAAGAGCTGTTTCGTCATCTGATCAGTGAAGTGGAAGATTGTGCCATCTACATGATCGACACTGCGGGT
CGCATCCTTACCTGGAATAAAGGGGGGGAACGGCATGAAGGTTATACCCGTGAGGAGATAATCGGTGAGCACTTTACTCT
ATTATTTACGCAGGAGGACATTTCGGCGGGTGTACCGGAAAAATCACTCGCCAAGGCGGTAGCAGAAGGTAATTTCCAGA
CTGAAGGGTGGCATGTCCGTAAGAATAATATCCGTTATTGGGCCAGTGTCGCCATTAGCCCAATACACGATGACCAAGGA
AACTTATTGGGTTTCACCAAGATTGTCCGCGACTTGACTGAACGCCACCAACGTGAAGAAACATTGCGTATCAGCGAAGA
ACGCTTTCGCCTGATGGTTGATTCTGTTGAAGATTATGCCATTTTAATGCTAGACCCTTGGGGTCGGGTTAATACCTGGA
ATCACGGTGCACAACACAAGATTGGCTATGCCAGTAACGAGATTATCGGCCAGCATTTCGGCTGCCTCTTCTTGCCGGAA
GACCTTGTTGCAGGGCTACCAGGAAAACTGCTGAAAACAGCGGCGTCAGCGAGCCGTATAGAGTACGAAGGTTGGTTGGT
TCGTAAAGATATTACCCGCTATTGGGCGCTTACCGTGATTACAGCGATACATGACCATAACGGTAAACTGTTGGGTTATA
CCAAACTCATCCGTGATATTAGTGAGCGAAAACAACGCGAAGATGCCCTGCGCGCCAGTGAAGCTGCCCGCTATGAAGAG
CGCGAACAGTTACATCAAGTTCTGTCATCCATTCCTGATGGGATTATCTCTCTCAATAGTGAAGGCCGGGTGGTATTAAT
GAACCCGAAAGCTGAAGAGATGACGGGCTGTAGGCAGAATGAATCCTGTGGTTTACCGATTGAAGAGGTCTTTATTTTGT
GGTCTCCACTACAGGATAAAAATCAATTAGAGGCCTTCAGTCAATGCCTGGCTGAAGGACGACAGACCCTATTACCAGAA
GGCCATTATCTGGTATCTCGCTGGGGAGAACGCCAAGAAATACGCTGTTCAGCTTCACCAATACGTGATCGTGACAATAT
TGTTACTGGCGCCGTCGTGGTATTCCAAGATGTCACCCGTGCACGCCATGAACAGCGGGCGCTGCAATACCAGGCTAGCC
ATGACATGCTCACCGGGTTAATTAACCGCCGACGATTGGAAGAGCGATTGACACTAGCGATTAATCAATTAGCTCATGAC
GGGCAACATATACTTTGCTATGTCGATTTAGACTATTTCAAAGATGTGAATGATAATGCGGGTCACGAAGCGGGGGATAT
GGTGCTGAGAATGGTCGCACAAACCATGCAACAAGCGGTGCGAGAAAACGATATTGTTGCCCGTTTAGGCGGGGATGAAT
TTGCGATTGTGCTCTTTAATTGCCCCAGTAAATCTGCGGCAGAAATACTGGAACAGGTCGTGGCGGATATTGCCGCCATC
CAGTTTCATTGGCACGGACAATCTTATGTCCTTACTGCCAGTCTGGGGGCAATACCATTGACCCAACAAACTGAATCCGC
TTCGCAAGCGATGCGTTTGGCCGATATTGCCTGCTACAAGGCCAAACATGCTGGCCGCAACCAATTGTCACTCACCTCTT
GA

Upstream 100 bases:

>100_bases
GACAGGCGCAATATCGTTCCCCCTTTATAAATTAAATATTCTCGCTGTCGCACGACTCAACCAACGATTGGTTGAATAAA
CATTCAAGGAAAAGATAGGA

Downstream 100 bases:

>100_bases
GGTATATTGCGGGTGGCTATCATGTCACCTGCAATGTTTTTATGATTGGCCCATCCCTCTGCTCAGCATGAATACTGATG
CAGCCCAAAAGTGAATTAGC

Product: PAS/PAC sensor-containing diguanylate cyclase

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 693; Mature: 692

Protein sequence:

>693_residues
MALYPASFDDHVFRLLIEAVDDYAIYIIDAKGHVLTWNNGAERNTGYCAEEVIGQSFELFYTPEDLVNGLSVKGLKHANQ
FGHYESQSWRVRKNGKRFWGNVTLSALHNSENILQGFVHVTRDLTDQWQRDNALRKSEELFRHLISEVEDCAIYMIDTAG
RILTWNKGGERHEGYTREEIIGEHFTLLFTQEDISAGVPEKSLAKAVAEGNFQTEGWHVRKNNIRYWASVAISPIHDDQG
NLLGFTKIVRDLTERHQREETLRISEERFRLMVDSVEDYAILMLDPWGRVNTWNHGAQHKIGYASNEIIGQHFGCLFLPE
DLVAGLPGKLLKTAASASRIEYEGWLVRKDITRYWALTVITAIHDHNGKLLGYTKLIRDISERKQREDALRASEAARYEE
REQLHQVLSSIPDGIISLNSEGRVVLMNPKAEEMTGCRQNESCGLPIEEVFILWSPLQDKNQLEAFSQCLAEGRQTLLPE
GHYLVSRWGERQEIRCSASPIRDRDNIVTGAVVVFQDVTRARHEQRALQYQASHDMLTGLINRRRLEERLTLAINQLAHD
GQHILCYVDLDYFKDVNDNAGHEAGDMVLRMVAQTMQQAVRENDIVARLGGDEFAIVLFNCPSKSAAEILEQVVADIAAI
QFHWHGQSYVLTASLGAIPLTQQTESASQAMRLADIACYKAKHAGRNQLSLTS

Sequences:

>Translated_693_residues
MALYPASFDDHVFRLLIEAVDDYAIYIIDAKGHVLTWNNGAERNTGYCAEEVIGQSFELFYTPEDLVNGLSVKGLKHANQ
FGHYESQSWRVRKNGKRFWGNVTLSALHNSENILQGFVHVTRDLTDQWQRDNALRKSEELFRHLISEVEDCAIYMIDTAG
RILTWNKGGERHEGYTREEIIGEHFTLLFTQEDISAGVPEKSLAKAVAEGNFQTEGWHVRKNNIRYWASVAISPIHDDQG
NLLGFTKIVRDLTERHQREETLRISEERFRLMVDSVEDYAILMLDPWGRVNTWNHGAQHKIGYASNEIIGQHFGCLFLPE
DLVAGLPGKLLKTAASASRIEYEGWLVRKDITRYWALTVITAIHDHNGKLLGYTKLIRDISERKQREDALRASEAARYEE
REQLHQVLSSIPDGIISLNSEGRVVLMNPKAEEMTGCRQNESCGLPIEEVFILWSPLQDKNQLEAFSQCLAEGRQTLLPE
GHYLVSRWGERQEIRCSASPIRDRDNIVTGAVVVFQDVTRARHEQRALQYQASHDMLTGLINRRRLEERLTLAINQLAHD
GQHILCYVDLDYFKDVNDNAGHEAGDMVLRMVAQTMQQAVRENDIVARLGGDEFAIVLFNCPSKSAAEILEQVVADIAAI
QFHWHGQSYVLTASLGAIPLTQQTESASQAMRLADIACYKAKHAGRNQLSLTS
>Mature_692_residues
ALYPASFDDHVFRLLIEAVDDYAIYIIDAKGHVLTWNNGAERNTGYCAEEVIGQSFELFYTPEDLVNGLSVKGLKHANQF
GHYESQSWRVRKNGKRFWGNVTLSALHNSENILQGFVHVTRDLTDQWQRDNALRKSEELFRHLISEVEDCAIYMIDTAGR
ILTWNKGGERHEGYTREEIIGEHFTLLFTQEDISAGVPEKSLAKAVAEGNFQTEGWHVRKNNIRYWASVAISPIHDDQGN
LLGFTKIVRDLTERHQREETLRISEERFRLMVDSVEDYAILMLDPWGRVNTWNHGAQHKIGYASNEIIGQHFGCLFLPED
LVAGLPGKLLKTAASASRIEYEGWLVRKDITRYWALTVITAIHDHNGKLLGYTKLIRDISERKQREDALRASEAARYEER
EQLHQVLSSIPDGIISLNSEGRVVLMNPKAEEMTGCRQNESCGLPIEEVFILWSPLQDKNQLEAFSQCLAEGRQTLLPEG
HYLVSRWGERQEIRCSASPIRDRDNIVTGAVVVFQDVTRARHEQRALQYQASHDMLTGLINRRRLEERLTLAINQLAHDG
QHILCYVDLDYFKDVNDNAGHEAGDMVLRMVAQTMQQAVRENDIVARLGGDEFAIVLFNCPSKSAAEILEQVVADIAAIQ
FHWHGQSYVLTASLGAIPLTQQTESASQAMRLADIACYKAKHAGRNQLSLTS

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=575, Percent_Identity=28.1739130434783, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1786584, Length=177, Percent_Identity=32.7683615819209, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI87081881, Length=319, Percent_Identity=26.0188087774295, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1787541, Length=291, Percent_Identity=30.2405498281787, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI87082007, Length=170, Percent_Identity=35.8823529411765, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI87081977, Length=167, Percent_Identity=34.1317365269461, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1787262, Length=233, Percent_Identity=26.1802575107296, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI145693134, Length=187, Percent_Identity=31.0160427807487, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1787802, Length=171, Percent_Identity=31.5789473684211, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87081974, Length=100, Percent_Identity=36, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1788956, Length=153, Percent_Identity=34.640522875817, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1787056, Length=161, Percent_Identity=31.6770186335404, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788085, Length=162, Percent_Identity=31.4814814814815, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI1787816, Length=163, Percent_Identity=30.0613496932515, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 78691; Mature: 78560

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALYPASFDDHVFRLLIEAVDDYAIYIIDAKGHVLTWNNGAERNTGYCAEEVIGQSFELF
CCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCEEEECCCCCCCCCCCHHHHCCCCEEEE
YTPEDLVNGLSVKGLKHANQFGHYESQSWRVRKNGKRFWGNVTLSALHNSENILQGFVHV
ECHHHHHCCCCCCCHHHHHHCCCCCCCCCEEECCCCEEECCEEEEEECCCHHHHHHHHHH
TRDLTDQWQRDNALRKSEELFRHLISEVEDCAIYMIDTAGRILTWNKGGERHEGYTREEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCEEEEECCCCCCCCCCCHHHH
IGEHFTLLFTQEDISAGVPEKSLAKAVAEGNFQTEGWHVRKNNIRYWASVAISPIHDDQG
CCCCEEEEEEECHHHCCCCHHHHHHHHHCCCCCCCCEEEECCCEEEEEEEEEEEEECCCC
NLLGFTKIVRDLTERHQREETLRISEERFRLMVDSVEDYAILMLDPWGRVNTWNHGAQHK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCC
IGYASNEIIGQHFGCLFLPEDLVAGLPGKLLKTAASASRIEYEGWLVRKDITRYWALTVI
CCCCCCHHHHHHCCEEEECHHHHCCCCHHHHHHHHHHCCEEECCEEEHHHHHHHHHHHHH
TAIHDHNGKLLGYTKLIRDISERKQREDALRASEAARYEEREQLHQVLSSIPDGIISLNS
HHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
EGRVVLMNPKAEEMTGCRQNESCGLPIEEVFILWSPLQDKNQLEAFSQCLAEGRQTLLPE
CCEEEEECCCHHHHHCCCCCCCCCCCHHHHHEEECCCCCHHHHHHHHHHHHCCHHHCCCC
GHYLVSRWGERQEIRCSASPIRDRDNIVTGAVVVFQDVTRARHEQRALQYQASHDMLTGL
CCCHHHCCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INRRRLEERLTLAINQLAHDGQHILCYVDLDYFKDVNDNAGHEAGDMVLRMVAQTMQQAV
HHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
RENDIVARLGGDEFAIVLFNCPSKSAAEILEQVVADIAAIQFHWHGQSYVLTASLGAIPL
HCCCEEEEECCCEEEEEEEECCCHHHHHHHHHHHHHHHHEEEEECCCEEEEEEECCCCCC
TQQTESASQAMRLADIACYKAKHAGRNQLSLTS
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ALYPASFDDHVFRLLIEAVDDYAIYIIDAKGHVLTWNNGAERNTGYCAEEVIGQSFELF
CCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCEEEECCCCCCCCCCCHHHHCCCCEEEE
YTPEDLVNGLSVKGLKHANQFGHYESQSWRVRKNGKRFWGNVTLSALHNSENILQGFVHV
ECHHHHHCCCCCCCHHHHHHCCCCCCCCCEEECCCCEEECCEEEEEECCCHHHHHHHHHH
TRDLTDQWQRDNALRKSEELFRHLISEVEDCAIYMIDTAGRILTWNKGGERHEGYTREEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCEEEEECCCCCCCCCCCHHHH
IGEHFTLLFTQEDISAGVPEKSLAKAVAEGNFQTEGWHVRKNNIRYWASVAISPIHDDQG
CCCCEEEEEEECHHHCCCCHHHHHHHHHCCCCCCCCEEEECCCEEEEEEEEEEEEECCCC
NLLGFTKIVRDLTERHQREETLRISEERFRLMVDSVEDYAILMLDPWGRVNTWNHGAQHK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCC
IGYASNEIIGQHFGCLFLPEDLVAGLPGKLLKTAASASRIEYEGWLVRKDITRYWALTVI
CCCCCCHHHHHHCCEEEECHHHHCCCCHHHHHHHHHHCCEEECCEEEHHHHHHHHHHHHH
TAIHDHNGKLLGYTKLIRDISERKQREDALRASEAARYEEREQLHQVLSSIPDGIISLNS
HHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
EGRVVLMNPKAEEMTGCRQNESCGLPIEEVFILWSPLQDKNQLEAFSQCLAEGRQTLLPE
CCEEEEECCCHHHHHCCCCCCCCCCCHHHHHEEECCCCCHHHHHHHHHHHHCCHHHCCCC
GHYLVSRWGERQEIRCSASPIRDRDNIVTGAVVVFQDVTRARHEQRALQYQASHDMLTGL
CCCHHHCCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INRRRLEERLTLAINQLAHDGQHILCYVDLDYFKDVNDNAGHEAGDMVLRMVAQTMQQAV
HHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
RENDIVARLGGDEFAIVLFNCPSKSAAEILEQVVADIAAIQFHWHGQSYVLTASLGAIPL
HCCCEEEEECCCEEEEEEEECCCHHHHHHHHHHHHHHHHEEEEECCCEEEEEEECCCCCC
TQQTESASQAMRLADIACYKAKHAGRNQLSLTS
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]