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The map label for this gene is astC [H]

Identifier: 170024458

GI number: 170024458

Start: 2471837

End: 2473177

Strand: Reverse

Name: astC [H]

Synonym: YPK_2229

Alternate gene names: 170024458

Gene position: 2473177-2471837 (Counterclockwise)

Preceding gene: 170024459

Following gene: 170024457

Centisome position: 52.74

GC content: 51.3

Gene sequence:

>1341_bases
ATGGTTAACAGAATAAGCGATTTTTGTTGGGGGGCAGAGATTCACTCTGATGATGAGTTTCTAAACCTACTATTTACGCT
GATTAAAGGGGGCAATATGGAGCAGCCAAGTCCTGTCACTCGTCAGTCTTTTGATGAATGGATCGTACCCACCTATGCGC
CAGCAGATTTTATCGTGGTAAGGGGGGAAGGGTCGACATTGTGGGATCAACAAGGTAAATCGTATATCGATTTTGCGGGT
GGTATTGCGGTAAATGCCTTGGGGCATGGGCACCCGGCAGTAAGGGCCGCATTGATTGAGCAGGCTGATAAAGTCTGGCA
TTTGGGCAATGGCTACACCAATGAGCCGGTATTACGTCTGGCGAAGCAGTTGATCGATGCGACCTTTGCAGAAAAAGTGT
TTTTCTGTAATTCCGGTGCGGAGGCCAATGAGGCGGCACTGAAGCTGGCGCGCAAGTATGCGCTGGATAATTTTGCCAAT
AAAGCGGGTCAGCAAGGTGAGAAGAACCAAATTGTGGCGTTTAGAAATGCGTTTCATGGCCGCACGCTGTTTACGGTCTC
AGCGGGTGGGCAGCCTAAATACTCGCAAGATTTTGCTCCCCTGCCAGGCGGTATCCATCACGGTATTTTTAATGACCTTG
CTTCAGCGGAACACCTGATCACCGATCAAACCTGTGCGGTTATTGTGGAACCCATTCAGGGTGAGGGCGGCGTGCTACCT
GCGGATAAAGAGTTCCTGCACGGTTTGCGGGCGCTGTGCGATCGCCATAATGCATTGCTGATTTTTGATGAAATACAAAC
CGGGGTGGGGCGTACCGGAGAACTCTACGCTTATATGCACTATGGGGTGTCCCCAGATGTGCTGACCAGTGCCAAAGCGT
TGGGAGGCGGTTTTCCCATTGGCGCAATGCTGACTACCACAAAATATGCCAGTGCGCTCAGTGTCGGTAGCCATGGCACG
ACCTTCGGGGGGAACCCGCTGGCCTGTGCCGTCGCGGGCACCGTTCTGTCATTGATTAATCAACCTACGCTATTAGCCGG
TGTTAAAGCACGCCACCAGTGGTTTATCGATGAACTGGCTGAAATCAATGCCCGGCATAACGTTTTCGCTGAAATCCGCG
GGCGTGGTCTGCTGATCGGGTGTGTGCTCAATGCCCAATATGCGGGCAAATCTAAAGAGATTGTTCAGGCCGCCGCTCAA
TACGGGCTTATTGCCCTGATTGCTGGCCCTGACGTTGTACGTTTTGCTCCATCGCTGATTATTTCGCCGAAGGAGATTAA
AGAAGGCTTAGCTCGACTCGCCATGGGGATTGAACAGGTTTGTCAAAAAGTTACGTCGTAA

Upstream 100 bases:

>100_bases
TGCCTGTTTTAATGGGGAATATACAATTTATTCACATTCTGAGCGGTGTGGCACGAAAGCTGCTGTACACTTTATATCAG
GTGAATATATTTCATTCGTT

Downstream 100 bases:

>100_bases
CGTTTATGCCGTAGGCAAGGGACTCGAATATGATGAAAGTGCGCCCGGTAGAGCGCCGCGATCTGGCTGATATCTTTGAA
CTGGCCGGTAAAACAGGCGT

Product: bifunctional succinylornithine transaminase/acetylornithine transaminase

Products: NA

Alternate protein names: Succinylornithine aminotransferase [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MVNRISDFCWGAEIHSDDEFLNLLFTLIKGGNMEQPSPVTRQSFDEWIVPTYAPADFIVVRGEGSTLWDQQGKSYIDFAG
GIAVNALGHGHPAVRAALIEQADKVWHLGNGYTNEPVLRLAKQLIDATFAEKVFFCNSGAEANEAALKLARKYALDNFAN
KAGQQGEKNQIVAFRNAFHGRTLFTVSAGGQPKYSQDFAPLPGGIHHGIFNDLASAEHLITDQTCAVIVEPIQGEGGVLP
ADKEFLHGLRALCDRHNALLIFDEIQTGVGRTGELYAYMHYGVSPDVLTSAKALGGGFPIGAMLTTTKYASALSVGSHGT
TFGGNPLACAVAGTVLSLINQPTLLAGVKARHQWFIDELAEINARHNVFAEIRGRGLLIGCVLNAQYAGKSKEIVQAAAQ
YGLIALIAGPDVVRFAPSLIISPKEIKEGLARLAMGIEQVCQKVTS

Sequences:

>Translated_446_residues
MVNRISDFCWGAEIHSDDEFLNLLFTLIKGGNMEQPSPVTRQSFDEWIVPTYAPADFIVVRGEGSTLWDQQGKSYIDFAG
GIAVNALGHGHPAVRAALIEQADKVWHLGNGYTNEPVLRLAKQLIDATFAEKVFFCNSGAEANEAALKLARKYALDNFAN
KAGQQGEKNQIVAFRNAFHGRTLFTVSAGGQPKYSQDFAPLPGGIHHGIFNDLASAEHLITDQTCAVIVEPIQGEGGVLP
ADKEFLHGLRALCDRHNALLIFDEIQTGVGRTGELYAYMHYGVSPDVLTSAKALGGGFPIGAMLTTTKYASALSVGSHGT
TFGGNPLACAVAGTVLSLINQPTLLAGVKARHQWFIDELAEINARHNVFAEIRGRGLLIGCVLNAQYAGKSKEIVQAAAQ
YGLIALIAGPDVVRFAPSLIISPKEIKEGLARLAMGIEQVCQKVTS
>Mature_446_residues
MVNRISDFCWGAEIHSDDEFLNLLFTLIKGGNMEQPSPVTRQSFDEWIVPTYAPADFIVVRGEGSTLWDQQGKSYIDFAG
GIAVNALGHGHPAVRAALIEQADKVWHLGNGYTNEPVLRLAKQLIDATFAEKVFFCNSGAEANEAALKLARKYALDNFAN
KAGQQGEKNQIVAFRNAFHGRTLFTVSAGGQPKYSQDFAPLPGGIHHGIFNDLASAEHLITDQTCAVIVEPIQGEGGVLP
ADKEFLHGLRALCDRHNALLIFDEIQTGVGRTGELYAYMHYGVSPDVLTSAKALGGGFPIGAMLTTTKYASALSVGSHGT
TFGGNPLACAVAGTVLSLINQPTLLAGVKARHQWFIDELAEINARHNVFAEIRGRGLLIGCVLNAQYAGKSKEIVQAAAQ
YGLIALIAGPDVVRFAPSLIISPKEIKEGLARLAMGIEQVCQKVTS

Specific function: Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=382, Percent_Identity=35.3403141361257, Blast_Score=212, Evalue=7e-55,
Organism=Homo sapiens, GI284507298, Length=296, Percent_Identity=36.1486486486487, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI13994255, Length=433, Percent_Identity=27.7136258660508, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI37574042, Length=436, Percent_Identity=27.2935779816514, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI226442705, Length=436, Percent_Identity=27.0642201834862, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI24119277, Length=435, Percent_Identity=25.9770114942529, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI226442709, Length=401, Percent_Identity=27.6807980049875, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI188536080, Length=415, Percent_Identity=24.3373493975904, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI38679950, Length=415, Percent_Identity=24.3373493975904, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI38679946, Length=415, Percent_Identity=24.3373493975904, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1788044, Length=409, Percent_Identity=68.9486552567237, Blast_Score=591, Evalue=1e-170,
Organism=Escherichia coli, GI1789759, Length=406, Percent_Identity=58.3743842364532, Blast_Score=500, Evalue=1e-143,
Organism=Escherichia coli, GI1789016, Length=410, Percent_Identity=35.3658536585366, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI145693181, Length=331, Percent_Identity=37.1601208459215, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1787560, Length=395, Percent_Identity=34.4303797468354, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1786349, Length=320, Percent_Identity=33.125, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1786991, Length=298, Percent_Identity=35.2348993288591, Blast_Score=135, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI25144271, Length=382, Percent_Identity=33.2460732984293, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI32564660, Length=441, Percent_Identity=29.4784580498866, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25144274, Length=260, Percent_Identity=34.2307692307692, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI71992977, Length=437, Percent_Identity=27.6887871853547, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=419, Percent_Identity=25.0596658711217, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71981843, Length=169, Percent_Identity=30.7692307692308, Blast_Score=81, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6324432, Length=408, Percent_Identity=41.421568627451, Blast_Score=291, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6323470, Length=426, Percent_Identity=33.3333333333333, Blast_Score=206, Evalue=8e-54,
Organism=Saccharomyces cerevisiae, GI6324386, Length=350, Percent_Identity=29.1428571428571, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321456, Length=374, Percent_Identity=27.2727272727273, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI21357415, Length=383, Percent_Identity=34.2036553524804, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI28574759, Length=439, Percent_Identity=30.2961275626424, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI161085790, Length=373, Percent_Identity=32.171581769437, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21356575, Length=364, Percent_Identity=27.1978021978022, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281366494, Length=281, Percent_Identity=28.1138790035587, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24667139, Length=281, Percent_Identity=28.1138790035587, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24667143, Length=281, Percent_Identity=28.1138790035587, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR017652 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.81 [H]

Molecular weight: Translated: 47854; Mature: 47854

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNRISDFCWGAEIHSDDEFLNLLFTLIKGGNMEQPSPVTRQSFDEWIVPTYAPADFIVV
CCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEE
RGEGSTLWDQQGKSYIDFAGGIAVNALGHGHPAVRAALIEQADKVWHLGNGYTNEPVLRL
ECCCCEEHHHCCCCEEEECCCEEEECCCCCCHHHHHHHHHHHHHEEECCCCCCCCHHHHH
AKQLIDATFAEKVFFCNSGAEANEAALKLARKYALDNFANKAGQQGEKNQIVAFRNAFHG
HHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCC
RTLFTVSAGGQPKYSQDFAPLPGGIHHGIFNDLASAEHLITDQTCAVIVEPIQGEGGVLP
CEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
ADKEFLHGLRALCDRHNALLIFDEIQTGVGRTGELYAYMHYGVSPDVLTSAKALGGGFPI
CCHHHHHHHHHHHCCCCEEEEEECHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCH
GAMLTTTKYASALSVGSHGTTFGGNPLACAVAGTVLSLINQPTLLAGVKARHQWFIDELA
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
EINARHNVFAEIRGRGLLIGCVLNAQYAGKSKEIVQAAAQYGLIALIAGPDVVRFAPSLI
HHCCCCCCCEEECCCEEEEEEEEECCCCCCHHHHHHHHHHCCEEEEEECCCHHHHCHHHE
ISPKEIKEGLARLAMGIEQVCQKVTS
ECHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVNRISDFCWGAEIHSDDEFLNLLFTLIKGGNMEQPSPVTRQSFDEWIVPTYAPADFIVV
CCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEE
RGEGSTLWDQQGKSYIDFAGGIAVNALGHGHPAVRAALIEQADKVWHLGNGYTNEPVLRL
ECCCCEEHHHCCCCEEEECCCEEEECCCCCCHHHHHHHHHHHHHEEECCCCCCCCHHHHH
AKQLIDATFAEKVFFCNSGAEANEAALKLARKYALDNFANKAGQQGEKNQIVAFRNAFHG
HHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCC
RTLFTVSAGGQPKYSQDFAPLPGGIHHGIFNDLASAEHLITDQTCAVIVEPIQGEGGVLP
CEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
ADKEFLHGLRALCDRHNALLIFDEIQTGVGRTGELYAYMHYGVSPDVLTSAKALGGGFPI
CCHHHHHHHHHHHCCCCEEEEEECHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCH
GAMLTTTKYASALSVGSHGTTFGGNPLACAVAGTVLSLINQPTLLAGVKARHQWFIDELA
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
EINARHNVFAEIRGRGLLIGCVLNAQYAGKSKEIVQAAAQYGLIALIAGPDVVRFAPSLI
HHCCCCCCCEEECCCEEEEEEEEECCCCCCHHHHHHHHHHCCEEEEEECCCHHHHCHHHE
ISPKEIKEGLARLAMGIEQVCQKVTS
ECHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA