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The map label for this gene is aspS [H]

Identifier: 170024382

GI number: 170024382

Start: 2378180

End: 2379976

Strand: Reverse

Name: aspS [H]

Synonym: YPK_2148

Alternate gene names: 170024382

Gene position: 2379976-2378180 (Counterclockwise)

Preceding gene: 170024387

Following gene: 170024381

Centisome position: 50.75

GC content: 51.09

Gene sequence:

>1797_bases
ATGCGTACTGAATATTGCGGGCAGTTGAATCTGTCCCACGTGGGCCAAAGCGTTACACTTTGTGGTTGGGTTAACCGTCG
TCGTGATCTGGGTGGCCTGATTTTTATTGATATGCGCGATCGCGAAGGCATCGTTCAGGTATTCTTCGATCCAGACCATA
AAGCCGCTTTTGAACAAGCTTCTGAGTTGCGTAATGAGTTCTGTATTCAGATTACCGGTACTGTGCGTGCACGTCCTGAC
AGTCAAATCAATAAAGATATGTCCACCGGTGAAGTGGAAATCTTTGCTAACACGCTGAATATCATTAATCGCTCCGAGCC
ATTGCCGTTAGATTCCAATCAAATCAACAGTGAAGAGCAGCGGTTGAAATATCGCTATCTGGATCTGCGCCGCCCGGAAA
TGGCTGATCGCTTGAAGTCCCGTGCCAAAATCACCAGTTTTGTACGCCGCTTCATGGACGATCATGGCTTCCTGGATATC
GAAACCCCGATGTTGACCAAAGCGACACCGGAAGGCGCCCGTGACTATCTGGTGCCAAGCCGTGTGCATAAAGGCAAGTT
TTACGCTTTGCCACAGTCTCCTCAGCTTTTCAAACAGTTGCTGATGATGTCTGGCTTTGACCGTTACTATCAGATCGTAA
AATGCTTCCGTGACGAAGATTTACGTGCTGACCGCCAGCCTGAATTTACCCAGATCGATGTTGAAACTTCGTTCATGAGC
GCAGATCAAGTGCGTGAAGTGATGGAAAAATTGGTCCGTGAATTGTGGCAGGAAACCAAAGGCGTTGATCTGGGTGATTT
CCCGGTAATGACCTTTGCTGAAGCGATGCGTCGTTATGGTTCCGATAAGCCAGACCTGCGTAACCCACTGGAATTAGTGG
ATGTCGCCTCTCTGGTTAAAGATGTTGAATTTAAAGTGTTCTCCGGTCCGGCCAATGATGCCAAAGGGCGAGTGGCTGCG
CTACGTGTACCGGGGGGCGCGCAACTTAGCCGCAAACAAATTGATGAGTATGGTCAGTTTGTCGGTATTTATGGTGCGAA
AGGCTTGGCATGGCTGAAGGTCAATGACCGTGCTGCAGGTCTTGAAGGGGTACAAAGCCCGATAGCCAAATTCCTCAGTT
CTGAAGTGTTGGACGCCATTTTGGTGGCCACTCAGGCGGAAAGTGGCGATATCCTGTTCTTCGGCGCGGACAGTTACAAG
ATTGTGACCGATGCGATGGGGGCGTTGCGTCTGAAAGTAGGGCGTGATCTCGAGTTGACGCGTCTGGGGACATGGGCACC
GTTATGGGTGGTTGATTTCCCAATGTTTGAAGATGATAGCGAAGGCGGCCTGACGGCCATGCATCATCCATTCACCGCCC
CAAAAGATATGAGCCCGGAACAACTGGCCGCAGCACCAACCACCGCTATCGCCAATGCTTACGACATGGTGATCAACGGC
TATGAAGTGGGCGGGGGTTCTGTGCGTATTCATCGCACTGAAATGCAGCAAACGGTCTTTGGTATTCTGGGCATCACTGA
GGATGAACAGCGTGAGAAGTTTGGCTTCTTGCTGGATGCGCTGAAATTTGGCACCCCGCCACATGCGGGCCTGGCGTTTG
GTCTGGATCGTCTGGTCATGTTGTTGACCGGTACCGATAACATCCGTGACGTCATTGCCTTCCCTAAAACGACTGCGGCG
GCTTGTCTGATGACCGATGCGCCAAGTTTTGCCAACCCGGCCTCGTTGCAAGAGTTGTCCATTAGCGTGGTGGCGAAGAA
AGGCACTACAGATGCTGGGGCAGAAGAGAATCAGTAA

Upstream 100 bases:

>100_bases
TACCAAAACATTAGGTTTACCAGAATACAGGGTTCACCAGAAAATCGCCGCACGGAGAGTGCATAACGCGTGCGGCATCG
GCTGAGTAAAAGGATATTGT

Downstream 100 bases:

>100_bases
TGAATTATAAACGCCCCGAGTCGGTTCTGGTCGTCATCTATGCCAAATCCAGCGGGCGGGTGTTGATGTTGCAACGGCGC
GATGATCCTGATTTTTGGCA

Product: aspartyl-tRNA synthetase

Products: NA

Alternate protein names: Aspartate--tRNA ligase; AspRS [H]

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MRTEYCGQLNLSHVGQSVTLCGWVNRRRDLGGLIFIDMRDREGIVQVFFDPDHKAAFEQASELRNEFCIQITGTVRARPD
SQINKDMSTGEVEIFANTLNIINRSEPLPLDSNQINSEEQRLKYRYLDLRRPEMADRLKSRAKITSFVRRFMDDHGFLDI
ETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMS
ADQVREVMEKLVRELWQETKGVDLGDFPVMTFAEAMRRYGSDKPDLRNPLELVDVASLVKDVEFKVFSGPANDAKGRVAA
LRVPGGAQLSRKQIDEYGQFVGIYGAKGLAWLKVNDRAAGLEGVQSPIAKFLSSEVLDAILVATQAESGDILFFGADSYK
IVTDAMGALRLKVGRDLELTRLGTWAPLWVVDFPMFEDDSEGGLTAMHHPFTAPKDMSPEQLAAAPTTAIANAYDMVING
YEVGGGSVRIHRTEMQQTVFGILGITEDEQREKFGFLLDALKFGTPPHAGLAFGLDRLVMLLTGTDNIRDVIAFPKTTAA
ACLMTDAPSFANPASLQELSISVVAKKGTTDAGAEENQ

Sequences:

>Translated_598_residues
MRTEYCGQLNLSHVGQSVTLCGWVNRRRDLGGLIFIDMRDREGIVQVFFDPDHKAAFEQASELRNEFCIQITGTVRARPD
SQINKDMSTGEVEIFANTLNIINRSEPLPLDSNQINSEEQRLKYRYLDLRRPEMADRLKSRAKITSFVRRFMDDHGFLDI
ETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMS
ADQVREVMEKLVRELWQETKGVDLGDFPVMTFAEAMRRYGSDKPDLRNPLELVDVASLVKDVEFKVFSGPANDAKGRVAA
LRVPGGAQLSRKQIDEYGQFVGIYGAKGLAWLKVNDRAAGLEGVQSPIAKFLSSEVLDAILVATQAESGDILFFGADSYK
IVTDAMGALRLKVGRDLELTRLGTWAPLWVVDFPMFEDDSEGGLTAMHHPFTAPKDMSPEQLAAAPTTAIANAYDMVING
YEVGGGSVRIHRTEMQQTVFGILGITEDEQREKFGFLLDALKFGTPPHAGLAFGLDRLVMLLTGTDNIRDVIAFPKTTAA
ACLMTDAPSFANPASLQELSISVVAKKGTTDAGAEENQ
>Mature_598_residues
MRTEYCGQLNLSHVGQSVTLCGWVNRRRDLGGLIFIDMRDREGIVQVFFDPDHKAAFEQASELRNEFCIQITGTVRARPD
SQINKDMSTGEVEIFANTLNIINRSEPLPLDSNQINSEEQRLKYRYLDLRRPEMADRLKSRAKITSFVRRFMDDHGFLDI
ETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMS
ADQVREVMEKLVRELWQETKGVDLGDFPVMTFAEAMRRYGSDKPDLRNPLELVDVASLVKDVEFKVFSGPANDAKGRVAA
LRVPGGAQLSRKQIDEYGQFVGIYGAKGLAWLKVNDRAAGLEGVQSPIAKFLSSEVLDAILVATQAESGDILFFGADSYK
IVTDAMGALRLKVGRDLELTRLGTWAPLWVVDFPMFEDDSEGGLTAMHHPFTAPKDMSPEQLAAAPTTAIANAYDMVING
YEVGGGSVRIHRTEMQQTVFGILGITEDEQREKFGFLLDALKFGTPPHAGLAFGLDRLVMLLTGTDNIRDVIAFPKTTAA
ACLMTDAPSFANPASLQELSISVVAKKGTTDAGAEENQ

Specific function: Unknown

COG id: COG0173

COG function: function code J; Aspartyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI40789249, Length=610, Percent_Identity=40.327868852459, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI5031815, Length=251, Percent_Identity=25.8964143426295, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI194272210, Length=251, Percent_Identity=25.8964143426295, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI45439306, Length=266, Percent_Identity=25.9398496240602, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1788173, Length=586, Percent_Identity=82.2525597269625, Blast_Score=1019, Evalue=0.0,
Organism=Escherichia coli, GI1789256, Length=307, Percent_Identity=27.6872964169381, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1790571, Length=295, Percent_Identity=27.1186440677966, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32566633, Length=614, Percent_Identity=34.5276872964169, Blast_Score=316, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI71994340, Length=175, Percent_Identity=27.4285714285714, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17535925, Length=175, Percent_Identity=27.4285714285714, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17535927, Length=175, Percent_Identity=27.4285714285714, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17551876, Length=280, Percent_Identity=27.8571428571429, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325153, Length=646, Percent_Identity=34.0557275541796, Blast_Score=290, Evalue=6e-79,
Organism=Saccharomyces cerevisiae, GI6320242, Length=258, Percent_Identity=25.1937984496124, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321807, Length=253, Percent_Identity=27.6679841897233, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324256, Length=259, Percent_Identity=24.7104247104247, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323011, Length=337, Percent_Identity=26.1127596439169, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24584738, Length=603, Percent_Identity=35.6550580431177, Blast_Score=332, Evalue=4e-91,
Organism=Drosophila melanogaster, GI24640849, Length=253, Percent_Identity=28.4584980237154, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24640851, Length=253, Percent_Identity=28.4584980237154, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17136276, Length=239, Percent_Identity=27.6150627615063, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR020564
- InterPro:   IPR004524
- InterPro:   IPR018153
- InterPro:   IPR002312
- InterPro:   IPR004115
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF02938 GAD; PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.12 [H]

Molecular weight: Translated: 66659; Mature: 66659

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTEYCGQLNLSHVGQSVTLCGWVNRRRDLGGLIFIDMRDREGIVQVFFDPDHKAAFEQA
CCCCCCCCCCHHHCCCCEEEEEHHHHHCCCCCEEEEEEECCCCEEEEEECCCHHHHHHHH
SELRNEFCIQITGTVRARPDSQINKDMSTGEVEIFANTLNIINRSEPLPLDSNQINSEEQ
HHHHHCEEEEEEEEEECCCCHHHCCCCCCCEEEEEEEHHHHHCCCCCCCCCCCCCCCHHH
RLKYRYLDLRRPEMADRLKSRAKITSFVRRFMDDHGFLDIETPMLTKATPEGARDYLVPS
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCC
RVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMS
CCCCCEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHCC
ADQVREVMEKLVRELWQETKGVDLGDFPVMTFAEAMRRYGSDKPDLRNPLELVDVASLVK
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
DVEFKVFSGPANDAKGRVAALRVPGGAQLSRKQIDEYGQFVGIYGAKGLAWLKVNDRAAG
HCCEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHCEEEEECCCCEEEEEECCCCCC
LEGVQSPIAKFLSSEVLDAILVATQAESGDILFFGADSYKIVTDAMGALRLKVGRDLELT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEHHHHHHHHEEECCCCEEEE
RLGTWAPLWVVDFPMFEDDSEGGLTAMHHPFTAPKDMSPEQLAAAPTTAIANAYDMVING
ECCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCHHHHHHHHHHEEEE
YEVGGGSVRIHRTEMQQTVFGILGITEDEQREKFGFLLDALKFGTPPHAGLAFGLDRLVM
EEECCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEE
LLTGTDNIRDVIAFPKTTAAACLMTDAPSFANPASLQELSISVVAKKGTTDAGAEENQ
EEECCCCHHHHHCCCCHHHHHEEEECCCCCCCCCCHHHEEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MRTEYCGQLNLSHVGQSVTLCGWVNRRRDLGGLIFIDMRDREGIVQVFFDPDHKAAFEQA
CCCCCCCCCCHHHCCCCEEEEEHHHHHCCCCCEEEEEEECCCCEEEEEECCCHHHHHHHH
SELRNEFCIQITGTVRARPDSQINKDMSTGEVEIFANTLNIINRSEPLPLDSNQINSEEQ
HHHHHCEEEEEEEEEECCCCHHHCCCCCCCEEEEEEEHHHHHCCCCCCCCCCCCCCCHHH
RLKYRYLDLRRPEMADRLKSRAKITSFVRRFMDDHGFLDIETPMLTKATPEGARDYLVPS
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCC
RVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMS
CCCCCEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHCC
ADQVREVMEKLVRELWQETKGVDLGDFPVMTFAEAMRRYGSDKPDLRNPLELVDVASLVK
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
DVEFKVFSGPANDAKGRVAALRVPGGAQLSRKQIDEYGQFVGIYGAKGLAWLKVNDRAAG
HCCEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHCEEEEECCCCEEEEEECCCCCC
LEGVQSPIAKFLSSEVLDAILVATQAESGDILFFGADSYKIVTDAMGALRLKVGRDLELT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEHHHHHHHHEEECCCCEEEE
RLGTWAPLWVVDFPMFEDDSEGGLTAMHHPFTAPKDMSPEQLAAAPTTAIANAYDMVING
ECCCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCHHHHHHHHHHEEEE
YEVGGGSVRIHRTEMQQTVFGILGITEDEQREKFGFLLDALKFGTPPHAGLAFGLDRLVM
EEECCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEE
LLTGTDNIRDVIAFPKTTAAACLMTDAPSFANPASLQELSISVVAKKGTTDAGAEENQ
EEECCCCHHHHHCCCCHHHHHEEEECCCCCCCCCCHHHEEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA