Click here to switch to the map view.

The map label for this gene is tdk

Identifier: 170024308

GI number: 170024308

Start: 2304407

End: 2304997

Strand: Reverse

Name: tdk

Synonym: YPK_2073

Alternate gene names: 170024308

Gene position: 2304997-2304407 (Counterclockwise)

Preceding gene: 170024310

Following gene: 170024306

Centisome position: 49.15

GC content: 45.85

Gene sequence:

>591_bases
ATGGCTCAACTTTACTTTTATTACTCTGCAATGAACGCGGGGAAATCCACAGCACTTCTACAGTCCTCATATAACTACCA
AGAACGAGGTATGCGCACCTTGGTGTTTACGGCTGAGATAGATAACCGCTTTGGTGTCGGAACGGTAAGTTCACGCATTG
GCCTCTCTTCTCAGGCCCAGCTCTATAATAGCGGGACATCATTGTTATCTATTATCGCCGCTGAGCACCAGGACACACCT
ATTCATTGTATTCTATTGGATGAATGTCAATTTCTGACTAAAGAGCAGGTCCAGGAACTCTGTCAGGTTGTTGATGAATT
ACATCTTCCTGTTCTTTGCTACGGCCTGCGGACTGATTTTCTCGGCGAATTATTTCCCGGTAGTAAATATTTACTGGCGT
GGGCGGACAAATTAGTGGAGTTGAAAACCATTTGTCATTGCGGTCGTAAAGCAAACATGGTTCTTCGCCTGGATGAGCAG
GGGAGAGCGGTACACAATGGTGAACAGGTCGTTATTGGTGGCAATGAAAGCTATGTTTCTGTCTGCCGCCGCCATTATAA
AGAAGCAATTAAAGCCGCCTGCTGTTCGTAG

Upstream 100 bases:

>100_bases
TATAGCAGAGTAATGGGTTCAACGCAGAGTCTGAGTTTATGATAAACTGAATACATATTGTCAATATGATTATTTATTAT
ACCATTGGAGTGACGGGCCC

Downstream 100 bases:

>100_bases
TATCCCTAATCACTAATTAGTGACAGTAGAATACCTCACTGGCTTTATTATATGATCAGTGGGGTATTGGGCTCTTCGCC
AGTTCATTGCCTTACAAAGC

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MAQLYFYYSAMNAGKSTALLQSSYNYQERGMRTLVFTAEIDNRFGVGTVSSRIGLSSQAQLYNSGTSLLSIIAAEHQDTP
IHCILLDECQFLTKEQVQELCQVVDELHLPVLCYGLRTDFLGELFPGSKYLLAWADKLVELKTICHCGRKANMVLRLDEQ
GRAVHNGEQVVIGGNESYVSVCRRHYKEAIKAACCS

Sequences:

>Translated_196_residues
MAQLYFYYSAMNAGKSTALLQSSYNYQERGMRTLVFTAEIDNRFGVGTVSSRIGLSSQAQLYNSGTSLLSIIAAEHQDTP
IHCILLDECQFLTKEQVQELCQVVDELHLPVLCYGLRTDFLGELFPGSKYLLAWADKLVELKTICHCGRKANMVLRLDEQ
GRAVHNGEQVVIGGNESYVSVCRRHYKEAIKAACCS
>Mature_195_residues
AQLYFYYSAMNAGKSTALLQSSYNYQERGMRTLVFTAEIDNRFGVGTVSSRIGLSSQAQLYNSGTSLLSIIAAEHQDTPI
HCILLDECQFLTKEQVQELCQVVDELHLPVLCYGLRTDFLGELFPGSKYLLAWADKLVELKTICHCGRKANMVLRLDEQG
RAVHNGEQVVIGGNESYVSVCRRHYKEAIKAACCS

Specific function: Phosphorylates Both Thymidine And Deoxyuridine. [C]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family

Homologues:

Organism=Escherichia coli, GI1787490, Length=191, Percent_Identity=76.4397905759162, Blast_Score=311, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KITH_YERPE (Q8ZEJ1)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AD0265
- RefSeq:   NP_669456.1
- RefSeq:   NP_993315.1
- RefSeq:   YP_002347150.1
- ProteinModelPortal:   Q8ZEJ1
- SMR:   Q8ZEJ1
- GeneID:   1147092
- GeneID:   1175011
- GeneID:   2763462
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO2176
- KEGG:   ypk:y2145
- KEGG:   ypm:YP_1975
- HOGENOM:   HBG522108
- OMA:   FRYGAMN
- ProtClustDB:   PRK04296
- BioCyc:   YPES187410:Y2145-MONOMER
- BioCyc:   YPES214092:YPO2176-MONOMER
- BRENDA:   2.7.1.21
- GO:   GO:0005737
- HAMAP:   MF_00124
- InterPro:   IPR001267
- InterPro:   IPR020633
- InterPro:   IPR020634
- PANTHER:   PTHR11441
- PIRSF:   PIRSF035805

Pfam domain/function: PF00265 TK

EC number: =2.7.1.21

Molecular weight: Translated: 21897; Mature: 21766

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: ACT_SITE 88-88

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLYFYYSAMNAGKSTALLQSSYNYQERGMRTLVFTAEIDNRFGVGTVSSRIGLSSQAQ
CCEEEEEEEECCCCCHHHHHHCCCCHHHCCCEEEEEEEECCCCCCCCCHHHHCCCCCHHH
LYNSGTSLLSIIAAEHQDTPIHCILLDECQFLTKEQVQELCQVVDELHLPVLCYGLRTDF
HHHCCHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHH
LGELFPGSKYLLAWADKLVELKTICHCGRKANMVLRLDEQGRAVHNGEQVVIGGNESYVS
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCEEEECCCHHHHH
VCRRHYKEAIKAACCS
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AQLYFYYSAMNAGKSTALLQSSYNYQERGMRTLVFTAEIDNRFGVGTVSSRIGLSSQAQ
CEEEEEEEECCCCCHHHHHHCCCCHHHCCCEEEEEEEECCCCCCCCCHHHHCCCCCHHH
LYNSGTSLLSIIAAEHQDTPIHCILLDECQFLTKEQVQELCQVVDELHLPVLCYGLRTDF
HHHCCHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHH
LGELFPGSKYLLAWADKLVELKTICHCGRKANMVLRLDEQGRAVHNGEQVVIGGNESYVS
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCEEEECCCHHHHH
VCRRHYKEAIKAACCS
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430