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The map label for this gene is yfeD

Identifier: 170024051

GI number: 170024051

Start: 2011447

End: 2012340

Strand: Reverse

Name: yfeD

Synonym: YPK_1812

Alternate gene names: 170024051

Gene position: 2012340-2011447 (Counterclockwise)

Preceding gene: 170024052

Following gene: 170024050

Centisome position: 42.91

GC content: 46.76

Gene sequence:

>894_bases
ATGAATATGCTGTTCAGTTTGATCAGTGAGCCATTCGCCTACCCCTTTATGCAGCGGGCAATTGTCGCGGCAATCGTCAC
TGGTGTGGTCTGCGCGATACTCTCTTGCTACCTGGTACTCAAAGGGTGGTCGCTAATGGGAGATGCTATTTCTCATGCTG
TGCTGCCAGGGATTGTTCTGGCTTTTTGGCTCGGTATCCCTCTGGTCATCGGCGCTTTTGTCTCAGGGATATTTTGTGCC
GTGGCAACTGGCTATTTAAAAGAAAACAGCCGGGTTAAAGAAGATACCGTCATGGGGATTGTTTTTTCTGGCATGTTCGC
GTTCGGCTTAGTGCTGTTCTCCCGTATAGATACTGACCAGCACCTCAGCCACATTTTGTTCGGTAACATGCTGGGGATTT
CGCTGACAGAACTGAAACAGACCCTGTGGATCGCAGGTTTCACGCTATTGGTGGTGTTACTAAAGCGCAAAGACTTTATG
TTGTACTGTTTCGATCCAAACCATGCGCGGGTTATCGGGCTACCCGTTAAGTTTCTGCATTACGGTTTACTTTGCTTACT
GGCATTGACTATCGTCGCGTCATTGCAGGCAGTTGGCGTTATTCTCGTCATCGCCATGTTGATAGCGCCGGGTATTATCG
CCTTTATGATTTGTCGTAGTTTTGATCAAATGCTGGTTGTCGCGACACTGGTTTCAGTGGTCGCCTGTGTTTTAGGTACA
TTAATCAGTTTTCATATTGATGGTGCAACAGGCCCATGCATCGTGATTATTCAAGCTTTATTCTTTGTTGTCGCCCTCAT
TTACAACCATATAAAACCGATTAAAGACCGAAAAATGGCACCACTCACCAAGGCAGTAAATCCAGAAAATACAGCCCCAA
GTAACCTGCCATAG

Upstream 100 bases:

>100_bases
TGGCCTTCTTCTTTGCCCCCAAACACGGATTACTGGCAACCCGATACCGCACACGGTTGAAACGTCGTCATCCGCCGGTT
CATCTTCCGGAGGATAACCT

Downstream 100 bases:

>100_bases
CAGTGACGTTTCTATTTATATGCGGTGCTGTATGTCTATTATATAGCCCGCCTATTACCATCAACGAATGGCTGTCAGCA
TTAAGCCTGCGTGTTTTCTA

Product: ABC-3 protein

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MNMLFSLISEPFAYPFMQRAIVAAIVTGVVCAILSCYLVLKGWSLMGDAISHAVLPGIVLAFWLGIPLVIGAFVSGIFCA
VATGYLKENSRVKEDTVMGIVFSGMFAFGLVLFSRIDTDQHLSHILFGNMLGISLTELKQTLWIAGFTLLVVLLKRKDFM
LYCFDPNHARVIGLPVKFLHYGLLCLLALTIVASLQAVGVILVIAMLIAPGIIAFMICRSFDQMLVVATLVSVVACVLGT
LISFHIDGATGPCIVIIQALFFVVALIYNHIKPIKDRKMAPLTKAVNPENTAPSNLP

Sequences:

>Translated_297_residues
MNMLFSLISEPFAYPFMQRAIVAAIVTGVVCAILSCYLVLKGWSLMGDAISHAVLPGIVLAFWLGIPLVIGAFVSGIFCA
VATGYLKENSRVKEDTVMGIVFSGMFAFGLVLFSRIDTDQHLSHILFGNMLGISLTELKQTLWIAGFTLLVVLLKRKDFM
LYCFDPNHARVIGLPVKFLHYGLLCLLALTIVASLQAVGVILVIAMLIAPGIIAFMICRSFDQMLVVATLVSVVACVLGT
LISFHIDGATGPCIVIIQALFFVVALIYNHIKPIKDRKMAPLTKAVNPENTAPSNLP
>Mature_297_residues
MNMLFSLISEPFAYPFMQRAIVAAIVTGVVCAILSCYLVLKGWSLMGDAISHAVLPGIVLAFWLGIPLVIGAFVSGIFCA
VATGYLKENSRVKEDTVMGIVFSGMFAFGLVLFSRIDTDQHLSHILFGNMLGISLTELKQTLWIAGFTLLVVLLKRKDFM
LYCFDPNHARVIGLPVKFLHYGLLCLLALTIVASLQAVGVILVIAMLIAPGIIAFMICRSFDQMLVVATLVSVVACVLGT
LISFHIDGATGPCIVIIQALFFVVALIYNHIKPIKDRKMAPLTKAVNPENTAPSNLP

Specific function: Part of an ATP-driven transport system yfeABCD for chelated iron

COG id: COG1108

COG function: function code P; ABC-type Mn2+/Zn2+ transport systems, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-3 integral membrane protein family

Homologues:

Organism=Escherichia coli, GI1788166, Length=242, Percent_Identity=26.8595041322314, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YFED_YERPE (Q56955)

Other databases:

- EMBL:   U50597
- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AC0298
- RefSeq:   NP_669210.1
- RefSeq:   NP_993559.1
- RefSeq:   YP_002347406.1
- ProteinModelPortal:   Q56955
- GeneID:   1146841
- GeneID:   1175276
- GeneID:   2764741
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO2442
- KEGG:   ypk:y1894
- KEGG:   ypm:YP_2230
- HOGENOM:   HBG733179
- OMA:   PFQFPFM
- ProtClustDB:   CLSK870079
- BioCyc:   YPES187410:Y1894-MONOMER
- BioCyc:   YPES214092:YPO2442-MONOMER
- InterPro:   IPR001626

Pfam domain/function: PF00950 ABC-3

EC number: NA

Molecular weight: Translated: 32204; Mature: 32204

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x16f348cc)-; HASH(0x16f42aa0)-; HASH(0x16a37dc4)-; HASH(0x17cfb1b4)-; HASH(0x174f59fc)-; HASH(0x1764888c)-; HASH(0x162d2618)-; HASH(0x17cf9d44)-;

Cys/Met content:

2.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMLFSLISEPFAYPFMQRAIVAAIVTGVVCAILSCYLVLKGWSLMGDAISHAVLPGIVL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFWLGIPLVIGAFVSGIFCAVATGYLKENSRVKEDTVMGIVFSGMFAFGLVLFSRIDTDQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
HLSHILFGNMLGISLTELKQTLWIAGFTLLVVLLKRKDFMLYCFDPNHARVIGLPVKFLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCHHHHH
YGLLCLLALTIVASLQAVGVILVIAMLIAPGIIAFMICRSFDQMLVVATLVSVVACVLGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LISFHIDGATGPCIVIIQALFFVVALIYNHIKPIKDRKMAPLTKAVNPENTAPSNLP
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCH
>Mature Secondary Structure
MNMLFSLISEPFAYPFMQRAIVAAIVTGVVCAILSCYLVLKGWSLMGDAISHAVLPGIVL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFWLGIPLVIGAFVSGIFCAVATGYLKENSRVKEDTVMGIVFSGMFAFGLVLFSRIDTDQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
HLSHILFGNMLGISLTELKQTLWIAGFTLLVVLLKRKDFMLYCFDPNHARVIGLPVKFLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCHHHHH
YGLLCLLALTIVASLQAVGVILVIAMLIAPGIIAFMICRSFDQMLVVATLVSVVACVLGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LISFHIDGATGPCIVIIQALFFVVALIYNHIKPIKDRKMAPLTKAVNPENTAPSNLP
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9495751; 11586360; 12142430