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The map label for this gene is lacF [H]

Identifier: 170023876

GI number: 170023876

Start: 1812789

End: 1813664

Strand: Direct

Name: lacF [H]

Synonym: YPK_1635

Alternate gene names: 170023876

Gene position: 1812789-1813664 (Clockwise)

Preceding gene: 170023875

Following gene: 170023877

Centisome position: 38.66

GC content: 41.32

Gene sequence:

>876_bases
ATGACTTTTTTAAAGCTTAAAGATAAACAGGTAGGCAGCGTATTAGCGGCCTCTTATCTGGGATATACCAGCATATTCTG
GTTTTATCCTTTTATTTGGCTCGCCGTTTTATCGCTAACTGAGTGGCGTTTTGTTGGTATTCCTACGTTCAATGGCCTGA
ATAACTTTATTCTGGTAATGCAAGATCCTTTGTTTTGGAAATCGATGCTGAACGTGATGCGTTTCTTAATGTATTACTTG
CCCATTGTATTTATCTCTTCATTCCTGTTCGCGTTTGGTTTACAGAAATTAAAATATGGCAGGACCTTTGTTGCATTAAG
TTTTTTACTGGCTAACGTCTCATCTGGCGTGGCCTATTCCATCGTGTTCTCTAAGATATTTAGTCAGAATGGGCCGCTGA
ATACCTTCTTATATGATTGGTTTGGATTTACGCTGCCTTGGTTAACCAGCCCGGACTTCGCCATGTTATCTATCGCTTTG
GTCGTTACCTGGAAATTTGTCGGGTACTACGGGTTGATTCTCTTTTCTGGGTTAAACAGTATTCCCAAAGAAATTTATTC
AGCAGCGGAATTAGATAATACTCGCACCATTAAGCGCTTGTTCCATATCACATTACCGATGATCAACCCGCAATTAATTA
TGGTGCTGGTTTTAGCCATTACGGTCTCCTTCGCTATTTTTACCGAGCCATATCTCATTACCGGTGGCGGGCCGCTTAAT
AGCACCACCACGCCAATGATCGTGATGTATGAAACCGCGTTTATGAAGATGCAACCAAGTTGGGCAGCGACCATGTCAAT
CTTTATCGCGCTCATCAGTTTTGGAATTATCTTGGGTGTCAGAAAATTGCTGGAAAGAAAGGTAGAGATTGTTTAA

Upstream 100 bases:

>100_bases
AACGCTAGGATTTTAAAGTCCTAATATTTTGGAATCCTAGCAGTAAGAATGAGTTAATTTCTTGCTTTCTGCATCAAAGT
GAGCCAGGTGGCCTTTCATT

Downstream 100 bases:

>100_bases
ATGAAAAAAAACATCAACAGTTTAATTATCCATCTGGTTATGTTTTCTCTGGCGCTTTCGTGGCTCTATCCCTATATCTG
GATGGTGCTTTCTTCCTTTA

Product: binding-protein-dependent transport systems inner membrane component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTFLKLKDKQVGSVLAASYLGYTSIFWFYPFIWLAVLSLTEWRFVGIPTFNGLNNFILVMQDPLFWKSMLNVMRFLMYYL
PIVFISSFLFAFGLQKLKYGRTFVALSFLLANVSSGVAYSIVFSKIFSQNGPLNTFLYDWFGFTLPWLTSPDFAMLSIAL
VVTWKFVGYYGLILFSGLNSIPKEIYSAAELDNTRTIKRLFHITLPMINPQLIMVLVLAITVSFAIFTEPYLITGGGPLN
STTTPMIVMYETAFMKMQPSWAATMSIFIALISFGIILGVRKLLERKVEIV

Sequences:

>Translated_291_residues
MTFLKLKDKQVGSVLAASYLGYTSIFWFYPFIWLAVLSLTEWRFVGIPTFNGLNNFILVMQDPLFWKSMLNVMRFLMYYL
PIVFISSFLFAFGLQKLKYGRTFVALSFLLANVSSGVAYSIVFSKIFSQNGPLNTFLYDWFGFTLPWLTSPDFAMLSIAL
VVTWKFVGYYGLILFSGLNSIPKEIYSAAELDNTRTIKRLFHITLPMINPQLIMVLVLAITVSFAIFTEPYLITGGGPLN
STTTPMIVMYETAFMKMQPSWAATMSIFIALISFGIILGVRKLLERKVEIV
>Mature_290_residues
TFLKLKDKQVGSVLAASYLGYTSIFWFYPFIWLAVLSLTEWRFVGIPTFNGLNNFILVMQDPLFWKSMLNVMRFLMYYLP
IVFISSFLFAFGLQKLKYGRTFVALSFLLANVSSGVAYSIVFSKIFSQNGPLNTFLYDWFGFTLPWLTSPDFAMLSIALV
VTWKFVGYYGLILFSGLNSIPKEIYSAAELDNTRTIKRLFHITLPMINPQLIMVLVLAITVSFAIFTEPYLITGGGPLNS
TTTPMIVMYETAFMKMQPSWAATMSIFIALISFGIILGVRKLLERKVEIV

Specific function: Part of the binding-protein-dependent transport system for lactose. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG1175

COG function: function code G; ABC-type sugar transport systems, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787570, Length=242, Percent_Identity=25.6198347107438, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789861, Length=287, Percent_Identity=24.0418118466899, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 33116; Mature: 32985

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFLKLKDKQVGSVLAASYLGYTSIFWFYPFIWLAVLSLTEWRFVGIPTFNGLNNFILVM
CCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEE
QDPLFWKSMLNVMRFLMYYLPIVFISSFLFAFGLQKLKYGRTFVALSFLLANVSSGVAYS
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHH
IVFSKIFSQNGPLNTFLYDWFGFTLPWLTSPDFAMLSIALVVTWKFVGYYGLILFSGLNS
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPKEIYSAAELDNTRTIKRLFHITLPMINPQLIMVLVLAITVSFAIFTEPYLITGGGPLN
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
STTTPMIVMYETAFMKMQPSWAATMSIFIALISFGIILGVRKLLERKVEIV
CCCCCEEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TFLKLKDKQVGSVLAASYLGYTSIFWFYPFIWLAVLSLTEWRFVGIPTFNGLNNFILVM
CEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEE
QDPLFWKSMLNVMRFLMYYLPIVFISSFLFAFGLQKLKYGRTFVALSFLLANVSSGVAYS
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHH
IVFSKIFSQNGPLNTFLYDWFGFTLPWLTSPDFAMLSIALVVTWKFVGYYGLILFSGLNS
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPKEIYSAAELDNTRTIKRLFHITLPMINPQLIMVLVLAITVSFAIFTEPYLITGGGPLN
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC
STTTPMIVMYETAFMKMQPSWAATMSIFIALISFGIILGVRKLLERKVEIV
CCCCCEEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1630315 [H]