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The map label for this gene is hisQ [H]

Identifier: 170023780

GI number: 170023780

Start: 1701611

End: 1702297

Strand: Direct

Name: hisQ [H]

Synonym: YPK_1539

Alternate gene names: 170023780

Gene position: 1701611-1702297 (Clockwise)

Preceding gene: 170023779

Following gene: 170023781

Centisome position: 36.29

GC content: 49.49

Gene sequence:

>687_bases
ATGCTGGATGGATATTCCAAACTGATATTTGAAGGTGCGCTGGTGACACTGGAGTTAGCATTGTTCTCGGTGCTGCTGTC
AGTGGTTATCGGCTTGATGGGGGCCGGTGGCAAGTTATCGTCAAACCGGTTGGTATCGGGCTTGTTTGAGTGCTACACCA
CACTGATCCGTGGCGTACCTGATTTGGTTTTGATGCTGCTTATCTTCTACGGTTTGCAGATTACCCTCAATAGCATTACC
GAGTCCCTTGGTTTTGCACAAATTGATATTGACCCTCTCTCTGCCGGGGTTATCACCCTTGGCTTTATCTATGGCGCTTA
CTTCACTGAAACGTTTCGTGGCGCTTATATGGCGGTCTCTAAAGGGCAAATTGAGGCCGCGACGGCCTTTGGTTTTACCT
CCAGCCAGATCTTTCGTCGCATTATGTTCCCAGCCATGATGCGCTATGCGTTGCCGGGCATTGGTAATAATTGGCAAGTG
ATCCTGAAAGCGACGGCGCTGGTGTCAATTTTAGGCTTGAATGACGTGGTCAAAGCCACCCAATTGGCGGGAAAAGGCAC
TTATCAGCCGTTTTTCTTTGCTTTGGTTGCTGGTGCGATTTATCTGTTCTTTACCACTCTCTCTAACGGTGTCTTGTGGT
GGCTGGAAAGGCGCTATTCCCATGGGGTGAAGAGGGCTGAGCTATGA

Upstream 100 bases:

>100_bases
ATTAATCCTTTTTGTCGTCGTGGCCTCTGTCGATTGTGGCAGGGGCTAACATACCGTAATTAACCAGACTCCTCACTCAG
TAAAACAGGATAACCCACAG

Downstream 100 bases:

>100_bases
TTGAAATCTTACATCAATATTGGCAGGCATTACTTTGGAGTGATGGCTACCGCTTTACCGGCATGGCGGTCACTCTCTGG
TTATTAATTTCTTCGGTCGT

Product: polar amino acid ABC transporter inner membrane subunit

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MLDGYSKLIFEGALVTLELALFSVLLSVVIGLMGAGGKLSSNRLVSGLFECYTTLIRGVPDLVLMLLIFYGLQITLNSIT
ESLGFAQIDIDPLSAGVITLGFIYGAYFTETFRGAYMAVSKGQIEAATAFGFTSSQIFRRIMFPAMMRYALPGIGNNWQV
ILKATALVSILGLNDVVKATQLAGKGTYQPFFFALVAGAIYLFFTTLSNGVLWWLERRYSHGVKRAEL

Sequences:

>Translated_228_residues
MLDGYSKLIFEGALVTLELALFSVLLSVVIGLMGAGGKLSSNRLVSGLFECYTTLIRGVPDLVLMLLIFYGLQITLNSIT
ESLGFAQIDIDPLSAGVITLGFIYGAYFTETFRGAYMAVSKGQIEAATAFGFTSSQIFRRIMFPAMMRYALPGIGNNWQV
ILKATALVSILGLNDVVKATQLAGKGTYQPFFFALVAGAIYLFFTTLSNGVLWWLERRYSHGVKRAEL
>Mature_228_residues
MLDGYSKLIFEGALVTLELALFSVLLSVVIGLMGAGGKLSSNRLVSGLFECYTTLIRGVPDLVLMLLIFYGLQITLNSIT
ESLGFAQIDIDPLSAGVITLGFIYGAYFTETFRGAYMAVSKGQIEAATAFGFTSSQIFRRIMFPAMMRYALPGIGNNWQV
ILKATALVSILGLNDVVKATQLAGKGTYQPFFFALVAGAIYLFFTTLSNGVLWWLERRYSHGVKRAEL

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=228, Percent_Identity=77.6315789473684, Blast_Score=359, Evalue=1e-101,
Organism=Escherichia coli, GI1787087, Length=224, Percent_Identity=36.6071428571429, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1788645, Length=222, Percent_Identity=32.8828828828829, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787030, Length=212, Percent_Identity=27.8301886792453, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788226, Length=219, Percent_Identity=29.6803652968037, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1786873, Length=210, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786874, Length=186, Percent_Identity=27.9569892473118, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 24890; Mature: 24890

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDGYSKLIFEGALVTLELALFSVLLSVVIGLMGAGGKLSSNRLVSGLFECYTTLIRGVP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCH
DLVLMLLIFYGLQITLNSITESLGFAQIDIDPLSAGVITLGFIYGAYFTETFRGAYMAVS
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHEEEC
KGQIEAATAFGFTSSQIFRRIMFPAMMRYALPGIGNNWQVILKATALVSILGLNDVVKAT
CCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QLAGKGTYQPFFFALVAGAIYLFFTTLSNGVLWWLERRYSHGVKRAEL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLDGYSKLIFEGALVTLELALFSVLLSVVIGLMGAGGKLSSNRLVSGLFECYTTLIRGVP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCH
DLVLMLLIFYGLQITLNSITESLGFAQIDIDPLSAGVITLGFIYGAYFTETFRGAYMAVS
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHEEEC
KGQIEAATAFGFTSSQIFRRIMFPAMMRYALPGIGNNWQVILKATALVSILGLNDVVKAT
CCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QLAGKGTYQPFFFALVAGAIYLFFTTLSNGVLWWLERRYSHGVKRAEL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]