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The map label for this gene is mntH

Identifier: 170023680

GI number: 170023680

Start: 1590772

End: 1592001

Strand: Direct

Name: mntH

Synonym: YPK_1439

Alternate gene names: 170023680

Gene position: 1590772-1592001 (Clockwise)

Preceding gene: 170023675

Following gene: 170023684

Centisome position: 33.92

GC content: 48.7

Gene sequence:

>1230_bases
ATGCTTAATGGCCGTGCTGTCGATACATCTCGTCGCCCATTAAGGAAGATTAAACTCTCCTTGATGGGGCCTGCTTTTAT
TGCTGCCATTGCTTATATTGATCCCGGCAATTTCGCGACTAATATTCAGGCGGGGGCCACGTTTGGCTATACCTTGCTAT
GGGTTGTCGTGTGGGCCAACGTCATGGCGATGTTAGTCCAGCTGCTGTCCGCCAAGCTGGGTATCGCTACCGGTAAAAAT
TTGGCTGAGCATATCCGGGACCGTTTCCCTCGTCCAGTGGTATGGGCCTACTGGGTGCAAGCCGAAATTATCGTGATGGC
GACCGATTTGGCTGAGTTTATCGGGGCGGCTATTGGCTTTAAATTGCTGTTTGGTGTGACGCTACTGCAAGGGGCGGTGC
TGACAGGTATTGCCACCTTTCTTATTCTTATGTTGCAAAATAGGGGGCAAAAGCCTCTCGAATTGGTGATTGGTGGGCTG
CTATTGTTTGTCGCCGCGGCTTATATTGTTGAACTGATCTTCTCTCAGCCAGATATTGCGGCTCTTGGCCGTGGGATGCT
GATCCCAAATTTACCTGATGGTAACGCCGTATTTTTAGCTGCGGGGGTGTTGGGGGCGACTATTATGCCGCATGTGATTT
ACCTGCATTCAGCATTAACACAAACCGGGGGGGAAGAGTCTAAAACTGAGCGCTATGCCTCGACCAAGTTTGATGTAGCG
ATTGCCATGACGATTGCGGGCTTTGTTAATTTGGCGATGATGGCAACCGCCGCTGCGGCTTTTCATTTCAATGGTTATGA
GAACATTGCTGAAATCGAAGAGGCTTATATAACCTTGCAGCCGCTGTTGGGTAATGCTGCGGCCACTGTTTTTGGTTTGA
GCTTAATCGCCGCCGGGCTTTCATCAACGGTCGTGGGTACGCTGGCGGGGCAAGTGGTCATGCAGGGTTTTGTGCGGTTT
TATATTCCAATGTGGGTGCGCCGTATAGTCACTATGTTGCCTTCTTTTATTGTTATTTTAGCTGGGATGGATGCGACACA
GATATTGGTGATGAGTCAGGTTTTACTGAGTTTTGGTATTGCACTGGCACTGGTGCCATTATTGGTTTTCACCGGTAATA
AAGAGTTGATGGGGGAGCTGGTTGATACAAAAACCACCCAGATTTTAGGTAAATTGGTGGTTCTGATCGTGGTTGGGTTA
AATGCCTATTTACTGATTAGCCTGCTTTAG

Upstream 100 bases:

>100_bases
AGATAATTCCATTATCACAAATGCGCTTGATAATTATTCTCATTTAAAAGATAGTAGGGGTAAATAATAACCGTGCACTT
TCCAAGGGGGTAAGTCTGAC

Downstream 100 bases:

>100_bases
ACTTAATAATGAACGTTGTCAGGCGTGTCGATCCGATAATAATTCCATGAAAACCCGCCTGACAGGCTTTATTGAGCGAT
GACAATGTCTATTTAGTCAT

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MLNGRAVDTSRRPLRKIKLSLMGPAFIAAIAYIDPGNFATNIQAGATFGYTLLWVVVWANVMAMLVQLLSAKLGIATGKN
LAEHIRDRFPRPVVWAYWVQAEIIVMATDLAEFIGAAIGFKLLFGVTLLQGAVLTGIATFLILMLQNRGQKPLELVIGGL
LLFVAAAYIVELIFSQPDIAALGRGMLIPNLPDGNAVFLAAGVLGATIMPHVIYLHSALTQTGGEESKTERYASTKFDVA
IAMTIAGFVNLAMMATAAAAFHFNGYENIAEIEEAYITLQPLLGNAAATVFGLSLIAAGLSSTVVGTLAGQVVMQGFVRF
YIPMWVRRIVTMLPSFIVILAGMDATQILVMSQVLLSFGIALALVPLLVFTGNKELMGELVDTKTTQILGKLVVLIVVGL
NAYLLISLL

Sequences:

>Translated_409_residues
MLNGRAVDTSRRPLRKIKLSLMGPAFIAAIAYIDPGNFATNIQAGATFGYTLLWVVVWANVMAMLVQLLSAKLGIATGKN
LAEHIRDRFPRPVVWAYWVQAEIIVMATDLAEFIGAAIGFKLLFGVTLLQGAVLTGIATFLILMLQNRGQKPLELVIGGL
LLFVAAAYIVELIFSQPDIAALGRGMLIPNLPDGNAVFLAAGVLGATIMPHVIYLHSALTQTGGEESKTERYASTKFDVA
IAMTIAGFVNLAMMATAAAAFHFNGYENIAEIEEAYITLQPLLGNAAATVFGLSLIAAGLSSTVVGTLAGQVVMQGFVRF
YIPMWVRRIVTMLPSFIVILAGMDATQILVMSQVLLSFGIALALVPLLVFTGNKELMGELVDTKTTQILGKLVVLIVVGL
NAYLLISLL
>Mature_409_residues
MLNGRAVDTSRRPLRKIKLSLMGPAFIAAIAYIDPGNFATNIQAGATFGYTLLWVVVWANVMAMLVQLLSAKLGIATGKN
LAEHIRDRFPRPVVWAYWVQAEIIVMATDLAEFIGAAIGFKLLFGVTLLQGAVLTGIATFLILMLQNRGQKPLELVIGGL
LLFVAAAYIVELIFSQPDIAALGRGMLIPNLPDGNAVFLAAGVLGATIMPHVIYLHSALTQTGGEESKTERYASTKFDVA
IAMTIAGFVNLAMMATAAAAFHFNGYENIAEIEEAYITLQPLLGNAAATVFGLSLIAAGLSSTVVGTLAGQVVMQGFVRF
YIPMWVRRIVTMLPSFIVILAGMDATQILVMSQVLLSFGIALALVPLLVFTGNKELMGELVDTKTTQILGKLVVLIVVGL
NAYLLISLL

Specific function: H(+)-stimulated, highly selective, manganese uptake system

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family

Homologues:

Organism=Homo sapiens, GI109255241, Length=437, Percent_Identity=33.1807780320366, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI295293167, Length=432, Percent_Identity=30.3240740740741, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI295293175, Length=432, Percent_Identity=30.3240740740741, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI295293173, Length=432, Percent_Identity=30.3240740740741, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI10835169, Length=432, Percent_Identity=30.3240740740741, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI295293171, Length=432, Percent_Identity=30.3240740740741, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI295293169, Length=432, Percent_Identity=30.3240740740741, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI295293178, Length=432, Percent_Identity=30.3240740740741, Blast_Score=162, Evalue=7e-40,
Organism=Escherichia coli, GI1788736, Length=406, Percent_Identity=77.5862068965517, Blast_Score=617, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI193210616, Length=442, Percent_Identity=29.8642533936652, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17569473, Length=393, Percent_Identity=31.0432569974555, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71999499, Length=447, Percent_Identity=29.5302013422819, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71993856, Length=220, Percent_Identity=37.7272727272727, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323062, Length=390, Percent_Identity=32.8205128205128, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6324450, Length=438, Percent_Identity=29.6803652968037, Blast_Score=179, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6321841, Length=411, Percent_Identity=30.1703163017032, Blast_Score=154, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24648607, Length=436, Percent_Identity=30.9633027522936, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI281362176, Length=436, Percent_Identity=30.9633027522936, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24648609, Length=436, Percent_Identity=30.9633027522936, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI45553443, Length=412, Percent_Identity=31.3106796116505, Blast_Score=205, Evalue=6e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MNTH_YERP3 (A7FGC8)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400306.1
- ProteinModelPortal:   A7FGC8
- STRING:   A7FGC8
- GeneID:   5385394
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1327
- eggNOG:   COG1914
- HOGENOM:   HBG312498
- OMA:   AYIVELV
- ProtClustDB:   PRK00701
- BioCyc:   YPSE349747:YPSIP31758_1327-MONOMER
- HAMAP:   MF_00221
- InterPro:   IPR023056
- InterPro:   IPR001046
- PANTHER:   PTHR11706
- PRINTS:   PR00447
- TIGRFAMs:   TIGR01197

Pfam domain/function: PF01566 Nramp

EC number: NA

Molecular weight: Translated: 43743; Mature: 43743

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x149be6a8)-; HASH(0x16f985b4)-; HASH(0x17382970)-; HASH(0xca2db30)-; HASH(0x16eb163c)-; HASH(0x16eedf50)-; HASH(0x17207634)-; HASH(0x1738acc4)-; HASH(0x1730125c)-; HASH(0x170ffb7c)-; HASH(0x170898c8)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure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HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA