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The map label for this gene is cysM [H]

Identifier: 170023654

GI number: 170023654

Start: 1556479

End: 1557357

Strand: Direct

Name: cysM [H]

Synonym: YPK_1412

Alternate gene names: 170023654

Gene position: 1556479-1557357 (Clockwise)

Preceding gene: 170023653

Following gene: 170023655

Centisome position: 33.19

GC content: 54.15

Gene sequence:

>879_bases
GTGACAACCCTGGAACACTGCATCGGCCATACACCATTGGTGAAACTACAACGCTTAAGCCAAGGGCTAAATGCGGAGAT
TTGGGTCAAACTGGAAGGGAACAATCCGGCCGGTTCGGTTAAAGATAGAGCCGCGCTGGCGATGATCCAGCAGGCAGAGT
TACGTGGTGATATTGCCCCCGGTGATGTCCTGATTGAAGCGACCAGTGGAAATACCGGGATTGCCTTGGCGATGATTGCC
GCCATGAAAGGCTATCACTTGAAGTTACTGATGCCAGAAAACATGAGTCAGGAACGTCAGGCGGCGATGCGGGCTTACGG
CGCGGAACTGATTCTGGTTAGCCGTGAACAGGGGATGGAAGGGGCGCGTGATCTGGCGTTAACCATGCAGGAGAACGGCG
AAGGTAACGTGCTGGATCAATTTAATAATGCGGATAATCCCTATGCGCATTTTACGGGGACCGGGCCGGAAATTTGGCAG
CAAACGGCGGGTAAAGTGAGCCACTTTGTCTCCAGTATGGGGACCACCGGTACGATCACCGGTGTCAGCCAGTATCTAAA
AAGCCAAAATCCGCAGGTGAAGGTTATCGGCCTGCAACCAGCAGAAGGCTGCAGTATTCCGGGGATCCGCCGGTGGTCAG
CGGAATATATACCGGGTATTTTCCGCCCCGAGCTGGTGGATCAGGTGTTGGATATCACGCAGAGTGTCGCAGAGCAAACC
ATGCGGCGGTTGGCGAAAGAAGAGGGGATATTCTGTGGCGTCAGTTCTGGTGGTGCGGTGGCTGGGGCGCTGCGGATCGC
GGTAGATAACCCTGATGCGGTGATTGTGGCGATTATCTGTGACCGTGGTGACCGCTATTTATCAACTGGGGTTTTTTAA

Upstream 100 bases:

>100_bases
GCAAACCCTGATGAGCTGACAGGCGTCAGTCATTCGGGTTCATGAGAGCGGCGAACACCGTTGCAACGTCAAGGGCCAAG
GGTATTTAAAGGTAATAAAT

Downstream 100 bases:

>100_bases
GTAAGGGGGGCTAAATTTTTCCTCCACTTAAGTCTGGTGAGGGCTGTTTATGACAGCCCGAATATTCAATCAAGATATAG
CATTTTTATTGAAAACCTAT

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTTLEHCIGHTPLVKLQRLSQGLNAEIWVKLEGNNPAGSVKDRAALAMIQQAELRGDIAPGDVLIEATSGNTGIALAMIA
AMKGYHLKLLMPENMSQERQAAMRAYGAELILVSREQGMEGARDLALTMQENGEGNVLDQFNNADNPYAHFTGTGPEIWQ
QTAGKVSHFVSSMGTTGTITGVSQYLKSQNPQVKVIGLQPAEGCSIPGIRRWSAEYIPGIFRPELVDQVLDITQSVAEQT
MRRLAKEEGIFCGVSSGGAVAGALRIAVDNPDAVIVAIICDRGDRYLSTGVF

Sequences:

>Translated_292_residues
MTTLEHCIGHTPLVKLQRLSQGLNAEIWVKLEGNNPAGSVKDRAALAMIQQAELRGDIAPGDVLIEATSGNTGIALAMIA
AMKGYHLKLLMPENMSQERQAAMRAYGAELILVSREQGMEGARDLALTMQENGEGNVLDQFNNADNPYAHFTGTGPEIWQ
QTAGKVSHFVSSMGTTGTITGVSQYLKSQNPQVKVIGLQPAEGCSIPGIRRWSAEYIPGIFRPELVDQVLDITQSVAEQT
MRRLAKEEGIFCGVSSGGAVAGALRIAVDNPDAVIVAIICDRGDRYLSTGVF
>Mature_291_residues
TTLEHCIGHTPLVKLQRLSQGLNAEIWVKLEGNNPAGSVKDRAALAMIQQAELRGDIAPGDVLIEATSGNTGIALAMIAA
MKGYHLKLLMPENMSQERQAAMRAYGAELILVSREQGMEGARDLALTMQENGEGNVLDQFNNADNPYAHFTGTGPEIWQQ
TAGKVSHFVSSMGTTGTITGVSQYLKSQNPQVKVIGLQPAEGCSIPGIRRWSAEYIPGIFRPELVDQVLDITQSVAEQTM
RRLAKEEGIFCGVSSGGAVAGALRIAVDNPDAVIVAIICDRGDRYLSTGVF

Specific function: Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=278, Percent_Identity=38.4892086330935, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI295821200, Length=278, Percent_Identity=38.4892086330935, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI4557415, Length=278, Percent_Identity=38.4892086330935, Blast_Score=176, Evalue=2e-44,
Organism=Escherichia coli, GI2367138, Length=292, Percent_Identity=76.027397260274, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI1788754, Length=305, Percent_Identity=44.2622950819672, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17562970, Length=296, Percent_Identity=42.5675675675676, Blast_Score=225, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI32566674, Length=291, Percent_Identity=43.298969072165, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI115535073, Length=296, Percent_Identity=42.9054054054054, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17535051, Length=296, Percent_Identity=42.2297297297297, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17561720, Length=296, Percent_Identity=41.2162162162162, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=37.7358490566038, Blast_Score=143, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI25147552, Length=285, Percent_Identity=35.7894736842105, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17534315, Length=306, Percent_Identity=35.6209150326797, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17539800, Length=331, Percent_Identity=23.8670694864048, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=313, Percent_Identity=35.7827476038339, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321449, Length=324, Percent_Identity=30.2469135802469, Blast_Score=124, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24643623, Length=281, Percent_Identity=40.2135231316726, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI20129101, Length=281, Percent_Identity=40.2135231316726, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 31323; Mature: 31192

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLEHCIGHTPLVKLQRLSQGLNAEIWVKLEGNNPAGSVKDRAALAMIQQAELRGDIAP
CCCHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCC
GDVLIEATSGNTGIALAMIAAMKGYHLKLLMPENMSQERQAAMRAYGAELILVSREQGME
CCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCC
GARDLALTMQENGEGNVLDQFNNADNPYAHFTGTGPEIWQQTAGKVSHFVSSMGTTGTIT
CHHHEEEEEECCCCCCCHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHH
GVSQYLKSQNPQVKVIGLQPAEGCSIPGIRRWSAEYIPGIFRPELVDQVLDITQSVAEQT
HHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHH
MRRLAKEEGIFCGVSSGGAVAGALRIAVDNPDAVIVAIICDRGDRYLSTGVF
HHHHHHHCCCEEEECCCCCEEEEEEEEECCCCEEEEEEEECCCCCCHHCCCC
>Mature Secondary Structure 
TTLEHCIGHTPLVKLQRLSQGLNAEIWVKLEGNNPAGSVKDRAALAMIQQAELRGDIAP
CCHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCC
GDVLIEATSGNTGIALAMIAAMKGYHLKLLMPENMSQERQAAMRAYGAELILVSREQGME
CCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCC
GARDLALTMQENGEGNVLDQFNNADNPYAHFTGTGPEIWQQTAGKVSHFVSSMGTTGTIT
CHHHEEEEEECCCCCCCHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHH
GVSQYLKSQNPQVKVIGLQPAEGCSIPGIRRWSAEYIPGIFRPELVDQVLDITQSVAEQT
HHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHH
MRRLAKEEGIFCGVSSGGAVAGALRIAVDNPDAVIVAIICDRGDRYLSTGVF
HHHHHHHCCCEEEECCCCCEEEEEEEEECCCCEEEEEEEECCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2188958; 9205837; 9278503 [H]