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The map label for this gene is fabH

Identifier: 169833814

GI number: 169833814

Start: 477996

End: 478970

Strand: Direct

Name: fabH

Synonym: SPH_0525

Alternate gene names: 169833814

Gene position: 477996-478970 (Clockwise)

Preceding gene: 169833599

Following gene: 169833707

Centisome position: 21.29

GC content: 43.18

Gene sequence:

>975_bases
ATGGCTTTTGCAAAAATAAGTCAGGTTGCTCATTATGTGCCAGAGCAAGTGGTTACAAATCACGACTTGGCTCAGATTAT
GGATACCAATGATGAGTGGATTTCAAGTCGAACGGGAATACGACAAAGGCATATTTCAAGAACAGAATCTACCAGTGATT
TGGCTACAGAGGTTGCTAAGAAACTGATGGCAAAAGCTGGAATAACAGGAGAAGAACTGGATTTTATCATCCTAGCTACC
ATTACTCCAGATTCGATGATGCCCTCTACAGCTGCTCGTGTTCAAGCTAATATTGGCGCTAATAAAGCCTTTGCTTTTGA
CTTAACCGCGGCTTGCAGTGGATTTGTATTTGCTCTTTCAACTGCTGAAAAGTTTATCGCTTCTGGTCGCTTTCAAAAAG
GCTTGGTGATTGGTAGTGAAACCCTCTCTAAGGCAGTCGATTGGTCGGATCGATCAACAGCTGTGTTGTTTGGAGATGGT
GCTGGTGGTGTCTTGTTAGAAGCTAGCGAGCAAGAGCATTTCTTAGCTGAGAGTCTCAATAGCGATGGAAGTCGCAGCGA
GTGTTTAACTTATGGGCATTCAGGTTTGCATTCTCCATTTTCAGATCAAGAAAGTGCAGATTCATTTTTGAAGATGGATG
GACGCACAGTCTTTGATTTTGCCATTCGAGATGTAGCCAAGTCTATCAAGCAGACTATTGATGAATCTCCTATAGAGGTG
ACAGACTTGGATTATCTGCTACTTCATCAAGCCAATGACCGTATTTTGGATAAGATGGCTAGAAAAATTGGTGTTGACCG
AGCCAAACTTCCAGCCAATATGATGGAATATGGCAATACCAGTGCAGCCAGTATCCCGATTTTACTTTCAGAGTGTGTAG
AACAAGGTCTCATCCCTTTAGATGGTAGCCAGACTGTTCTTCTATCAGGCTTCGGTGGAGGCTTGACCTGGGGCACGCTC
ATTCTTACAATTTAG

Upstream 100 bases:

>100_bases
CCATGGTAGAAAAAATTATTGATGGCATGAGCGAGGAAGAAATTGCTGTCATGGGTAAAGGCTTGACTAATCTTTACCAA
TTTTTGGAGGATTTGAAATA

Downstream 100 bases:

>100_bases
GTAATCATGTGGTGAACACATTGTTATAAAAAAACTATTTATTTTAAAGGAGTCCTATCATGGCAGTATTTGAAAAAGTA
CAAGAAATTATCGTTGAAGA

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MAFAKISQVAHYVPEQVVTNHDLAQIMDTNDEWISSRTGIRQRHISRTESTSDLATEVAKKLMAKAGITGEELDFIILAT
ITPDSMMPSTAARVQANIGANKAFAFDLTAACSGFVFALSTAEKFIASGRFQKGLVIGSETLSKAVDWSDRSTAVLFGDG
AGGVLLEASEQEHFLAESLNSDGSRSECLTYGHSGLHSPFSDQESADSFLKMDGRTVFDFAIRDVAKSIKQTIDESPIEV
TDLDYLLLHQANDRILDKMARKIGVDRAKLPANMMEYGNTSAASIPILLSECVEQGLIPLDGSQTVLLSGFGGGLTWGTL
ILTI

Sequences:

>Translated_324_residues
MAFAKISQVAHYVPEQVVTNHDLAQIMDTNDEWISSRTGIRQRHISRTESTSDLATEVAKKLMAKAGITGEELDFIILAT
ITPDSMMPSTAARVQANIGANKAFAFDLTAACSGFVFALSTAEKFIASGRFQKGLVIGSETLSKAVDWSDRSTAVLFGDG
AGGVLLEASEQEHFLAESLNSDGSRSECLTYGHSGLHSPFSDQESADSFLKMDGRTVFDFAIRDVAKSIKQTIDESPIEV
TDLDYLLLHQANDRILDKMARKIGVDRAKLPANMMEYGNTSAASIPILLSECVEQGLIPLDGSQTVLLSGFGGGLTWGTL
ILTI
>Mature_323_residues
AFAKISQVAHYVPEQVVTNHDLAQIMDTNDEWISSRTGIRQRHISRTESTSDLATEVAKKLMAKAGITGEELDFIILATI
TPDSMMPSTAARVQANIGANKAFAFDLTAACSGFVFALSTAEKFIASGRFQKGLVIGSETLSKAVDWSDRSTAVLFGDGA
GGVLLEASEQEHFLAESLNSDGSRSECLTYGHSGLHSPFSDQESADSFLKMDGRTVFDFAIRDVAKSIKQTIDESPIEVT
DLDYLLLHQANDRILDKMARKIGVDRAKLPANMMEYGNTSAASIPILLSECVEQGLIPLDGSQTVLLSGFGGGLTWGTLI
LTI

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=323, Percent_Identity=39.0092879256966, Blast_Score=240, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_STRP2 (Q04M58)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_815890.1
- ProteinModelPortal:   Q04M58
- SMR:   Q04M58
- STRING:   Q04M58
- EnsemblBacteria:   EBSTRT00000019880
- GeneID:   4441504
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_0380
- eggNOG:   COG0332
- GeneTree:   EBGT00050000027516
- HOGENOM:   HBG649927
- OMA:   YIVPHQA
- ProtClustDB:   PRK09352
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 34904; Mature: 34773

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: ACT_SITE 112-112 ACT_SITE 249-249 ACT_SITE 279-279

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFAKISQVAHYVPEQVVTNHDLAQIMDTNDEWISSRTGIRQRHISRTESTSDLATEVAK
CCHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHHHH
KLMAKAGITGEELDFIILATITPDSMMPSTAARVQANIGANKAFAFDLTAACSGFVFALS
HHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHH
TAEKFIASGRFQKGLVIGSETLSKAVDWSDRSTAVLFGDGAGGVLLEASEQEHFLAESLN
HHHHHHHCCCCCCCEEECHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHC
SDGSRSECLTYGHSGLHSPFSDQESADSFLKMDGRTVFDFAIRDVAKSIKQTIDESPIEV
CCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEE
TDLDYLLLHQANDRILDKMARKIGVDRAKLPANMMEYGNTSAASIPILLSECVEQGLIPL
ECCCEEEEECCCHHHHHHHHHHHCCCHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCCEEC
DGSQTVLLSGFGGGLTWGTLILTI
CCCCEEEEECCCCCCCCCEEEEEC
>Mature Secondary Structure 
AFAKISQVAHYVPEQVVTNHDLAQIMDTNDEWISSRTGIRQRHISRTESTSDLATEVAK
CHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHHHH
KLMAKAGITGEELDFIILATITPDSMMPSTAARVQANIGANKAFAFDLTAACSGFVFALS
HHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHH
TAEKFIASGRFQKGLVIGSETLSKAVDWSDRSTAVLFGDGAGGVLLEASEQEHFLAESLN
HHHHHHHCCCCCCCEEECHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHC
SDGSRSECLTYGHSGLHSPFSDQESADSFLKMDGRTVFDFAIRDVAKSIKQTIDESPIEV
CCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEE
TDLDYLLLHQANDRILDKMARKIGVDRAKLPANMMEYGNTSAASIPILLSECVEQGLIPL
ECCCEEEEECCCHHHHHHHHHHHCCCHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCCEEC
DGSQTVLLSGFGGGLTWGTLILTI
CCCCEEEEECCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA