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The map label for this gene is gnd [H]

Identifier: 169833368

GI number: 169833368

Start: 437206

End: 438630

Strand: Direct

Name: gnd [H]

Synonym: SPH_0482

Alternate gene names: 169833368

Gene position: 437206-438630 (Clockwise)

Preceding gene: 169833975

Following gene: 169832776

Centisome position: 19.47

GC content: 42.88

Gene sequence:

>1425_bases
ATGACAAAAGCTAACTTTGGTGTCGTAGGTATGGCCGTAATGGGTCGTAACCTTGCCCTTAATATTGAATCTCGTGGTTA
CACAGTTGCTATCTACAACCGTAGTAAAGAAAAAACTGAAGATGTAATTGCTTGCCATCCTGAAAAGAACTTTGTACCAA
GCTATGACGTTGAAAGTTTTGTAAACTCAATCGAAAGACCTCGTCGTATCATGCTCATGGTTCAAGCTGGACCTGGTACA
GATGCGACTATTCAAGCCCTTCTTCCACACCTTGACAAGGGTGATATCTTGATCGACGGAGGAAACACTTTCTACAAAGA
TACAATCCGTCGTAATGAAGAATTGGCAAACTCAGGTATCAACTTTATCGGTACTGGGGTTTCTGGTGGTGAAAAAGGTG
CCCTTGAAGGTCCTTCTATCATGCCTGGTGGACAAAAAGAAGCTTATGAATTGGTTGCGGATGTTCTTGAAGAAATCTCA
GCTAAAGCACCAGAAGATGGCAAACCATGTGTGACTTACATCGGTCCTGATGGAGCTGGTCACTATGTGAAAATGGTTCA
CAACGGTATAGAGTATGGTGATATGCAATTGATCGCAGAAAGCTATGACTTGATGCAACACTTGCTAGGCCTTTCTGCAG
AAGACATGGCTGAAATCTTTACTGAGTGGAACAAGGGTGAATTGGACAGCTACTTGATCGAAATCACAGCTGATATCTTG
AGCCGTAAAGATGATGAAGGTCAAGATGGACCAATCGTAGACTACATCCTTGATGCTGCAGGTAACAAGGGAACTGGTAA
ATGGACTAGCCAATCATCACTTGACCTTGGTGTACCATTGTCACTCATCACTGAGTCAGTATTTGCCCGTTACATTTCAA
CTTACAAAGAAGAACGTGTACATGCTAGCAAGGTGCTTCCAAAACCAGCCGCCTTCAAATTTGAAGGAGACAAGGCTGAA
TTGATTGAAAAAATCCGTCAAGCCCTTTACTTCTCAAAAATCATTTCATACGCACAAGGTTTTGCACAATTGCGTGTAGC
TTCTAAAGAAAATAACTGGAACTTGCCATTTGCGGACATCGCATCTATCTGGCGTGATGGCTGTATCATCCGTTCTCGTT
TCTTGCAAAAGATTACAGATGCTTACAACCGTGATGCAGACCTTGCTAACCTTCTTTTGGATGAGTACTTCTTGGATGTT
ACTGCTAAGTACCAACAAGCAGTGCGTGATATCGTAGCTCTTGCTGTTCAAGCTGGTGTGCCAGTGCCAACTTTCTCAGC
AGCTATTACTTACTTTGATAGCTACCGTTCAGCTGACCTTCCAGCTAACTTGATCCAAGCGCAACGTGATTACTTTGGTG
CCCACACTTACCAACGTAAAGACAAAGAAGGAACCTTCCACTACTCTTGGTATGACGAAAAATAA

Upstream 100 bases:

>100_bases
TCATGCGGATGACTTGGACTACTAAGCAGTCGTTACAAAATTCTTTCTTTTCAAAAGTAAAAATGATAAAATAAAACAAA
TCAAACAAGAGGAGTGTCAA

Downstream 100 bases:

>100_bases
GTAGGTCAGCCATGGGGAAACGGATTTTATTACTTGAGAAAGAACGAAATCTAGCTCATTTTTTAAGTTTGGAACTCCAG
AAAGAGCAGTATCGGGTTGA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MTKANFGVVGMAVMGRNLALNIESRGYTVAIYNRSKEKTEDVIACHPEKNFVPSYDVESFVNSIERPRRIMLMVQAGPGT
DATIQALLPHLDKGDILIDGGNTFYKDTIRRNEELANSGINFIGTGVSGGEKGALEGPSIMPGGQKEAYELVADVLEEIS
AKAPEDGKPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAESYDLMQHLLGLSAEDMAEIFTEWNKGELDSYLIEITADIL
SRKDDEGQDGPIVDYILDAAGNKGTGKWTSQSSLDLGVPLSLITESVFARYISTYKEERVHASKVLPKPAAFKFEGDKAE
LIEKIRQALYFSKIISYAQGFAQLRVASKENNWNLPFADIASIWRDGCIIRSRFLQKITDAYNRDADLANLLLDEYFLDV
TAKYQQAVRDIVALAVQAGVPVPTFSAAITYFDSYRSADLPANLIQAQRDYFGAHTYQRKDKEGTFHYSWYDEK

Sequences:

>Translated_474_residues
MTKANFGVVGMAVMGRNLALNIESRGYTVAIYNRSKEKTEDVIACHPEKNFVPSYDVESFVNSIERPRRIMLMVQAGPGT
DATIQALLPHLDKGDILIDGGNTFYKDTIRRNEELANSGINFIGTGVSGGEKGALEGPSIMPGGQKEAYELVADVLEEIS
AKAPEDGKPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAESYDLMQHLLGLSAEDMAEIFTEWNKGELDSYLIEITADIL
SRKDDEGQDGPIVDYILDAAGNKGTGKWTSQSSLDLGVPLSLITESVFARYISTYKEERVHASKVLPKPAAFKFEGDKAE
LIEKIRQALYFSKIISYAQGFAQLRVASKENNWNLPFADIASIWRDGCIIRSRFLQKITDAYNRDADLANLLLDEYFLDV
TAKYQQAVRDIVALAVQAGVPVPTFSAAITYFDSYRSADLPANLIQAQRDYFGAHTYQRKDKEGTFHYSWYDEK
>Mature_473_residues
TKANFGVVGMAVMGRNLALNIESRGYTVAIYNRSKEKTEDVIACHPEKNFVPSYDVESFVNSIERPRRIMLMVQAGPGTD
ATIQALLPHLDKGDILIDGGNTFYKDTIRRNEELANSGINFIGTGVSGGEKGALEGPSIMPGGQKEAYELVADVLEEISA
KAPEDGKPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAESYDLMQHLLGLSAEDMAEIFTEWNKGELDSYLIEITADILS
RKDDEGQDGPIVDYILDAAGNKGTGKWTSQSSLDLGVPLSLITESVFARYISTYKEERVHASKVLPKPAAFKFEGDKAEL
IEKIRQALYFSKIISYAQGFAQLRVASKENNWNLPFADIASIWRDGCIIRSRFLQKITDAYNRDADLANLLLDEYFLDVT
AKYQQAVRDIVALAVQAGVPVPTFSAAITYFDSYRSADLPANLIQAQRDYFGAHTYQRKDKEGTFHYSWYDEK

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=472, Percent_Identity=51.271186440678, Blast_Score=478, Evalue=1e-135,
Organism=Escherichia coli, GI1788341, Length=472, Percent_Identity=70.1271186440678, Blast_Score=679, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=474, Percent_Identity=50.210970464135, Blast_Score=494, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6321695, Length=462, Percent_Identity=51.0822510822511, Blast_Score=481, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6321977, Length=457, Percent_Identity=51.6411378555799, Blast_Score=471, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24639279, Length=468, Percent_Identity=50.2136752136752, Blast_Score=463, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52622; Mature: 52491

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKANFGVVGMAVMGRNLALNIESRGYTVAIYNRSKEKTEDVIACHPEKNFVPSYDVESF
CCCCCCCCEEHHHHCCCEEEEEECCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHH
VNSIERPRRIMLMVQAGPGTDATIQALLPHLDKGDILIDGGNTFYKDTIRRNEELANSGI
HHHHCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCC
NFIGTGVSGGEKGALEGPSIMPGGQKEAYELVADVLEEISAKAPEDGKPCVTYIGPDGAG
CEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCC
HYVKMVHNGIEYGDMQLIAESYDLMQHLLGLSAEDMAEIFTEWNKGELDSYLIEITADIL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
SRKDDEGQDGPIVDYILDAAGNKGTGKWTSQSSLDLGVPLSLITESVFARYISTYKEERV
CCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
HASKVLPKPAAFKFEGDKAELIEKIRQALYFSKIISYAQGFAQLRVASKENNWNLPFADI
HHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCHHHH
ASIWRDGCIIRSRFLQKITDAYNRDADLANLLLDEYFLDVTAKYQQAVRDIVALAVQAGV
HHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PVPTFSAAITYFDSYRSADLPANLIQAQRDYFGAHTYQRKDKEGTFHYSWYDEK
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHCCCCCCCCEEEECCCCC
>Mature Secondary Structure 
TKANFGVVGMAVMGRNLALNIESRGYTVAIYNRSKEKTEDVIACHPEKNFVPSYDVESF
CCCCCCCEEHHHHCCCEEEEEECCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHH
VNSIERPRRIMLMVQAGPGTDATIQALLPHLDKGDILIDGGNTFYKDTIRRNEELANSGI
HHHHCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCC
NFIGTGVSGGEKGALEGPSIMPGGQKEAYELVADVLEEISAKAPEDGKPCVTYIGPDGAG
CEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCC
HYVKMVHNGIEYGDMQLIAESYDLMQHLLGLSAEDMAEIFTEWNKGELDSYLIEITADIL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
SRKDDEGQDGPIVDYILDAAGNKGTGKWTSQSSLDLGVPLSLITESVFARYISTYKEERV
CCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
HASKVLPKPAAFKFEGDKAELIEKIRQALYFSKIISYAQGFAQLRVASKENNWNLPFADI
HHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCHHHH
ASIWRDGCIIRSRFLQKITDAYNRDADLANLLLDEYFLDVTAKYQQAVRDIVALAVQAGV
HHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PVPTFSAAITYFDSYRSADLPANLIQAQRDYFGAHTYQRKDKEGTFHYSWYDEK
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHCCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]