Click here to switch to the map view.

The map label for this gene is ilvC [H]

Identifier: 169832888

GI number: 169832888

Start: 500637

End: 501659

Strand: Direct

Name: ilvC [H]

Synonym: SPH_0553

Alternate gene names: 169832888

Gene position: 500637-501659 (Clockwise)

Preceding gene: 169834441

Following gene: 169833952

Centisome position: 22.29

GC content: 39.98

Gene sequence:

>1023_bases
ATGACAGTTCAAATGGAATATGAAAAAGATGTTAAAGTAGCAGCACTTGACGGTAAAAAAATCGCCGTTATCGGTTATGG
TTCACAAGGACATGCACATGCTCAAAACTTGCGTGATTCAGGTCGTGACGTTATTATCGGTGTACGTCCAGGTAAATCTT
TTGATAAAGCAAAAGAAGATGGATTTGATACTTACACAGTAGTAGAAGCTACTAAGTTGGCTGATGTTATCATGATCTTG
GCGCCAGACGAAATTCAACAAGAATTGTACGAAGCAGAAATCGCTCCAAACTTGGAAGCTGGAAACGCAGTTGGATTTGC
CCATGGTTTCAACATCCACTTTGAATTTATCAAAGTTCCTGCGGATGTAGATGTCTTCATGTGTGCTCCTAAAGGACCAG
GACACTTGGTACGTCGTACTTACGAAGAAGGATTTGGTGTTCCAGCTCTTTATGCAGTATACCAAGATGCAACAGGAAAT
GCTAAAAACATTGCTATGGACTGGTGTAAAGGTGTTGGAGCGGCTCGTGTAGGTCTTCTTGAAACAACTTACAAAGAAGA
AACTGAAGAAGATTTGTTTGGTGAACAAGCTGTACTTTGTGGTGGTTTGACTGCCCTTATCGAAGCAGGTTTCGAAGTCT
TGACAGAAGCAGGTTACGCTCCAGAATTGGCTTACTTTGAAGTTCTTCACGAAATGAAATTGATCGTTGACTTGATCTAC
GAAGGTGGATTCAAGAAAATGCGTCAATCTATTTCAAACACTGCTGAATACGGTGACTATGTATCAGGTCCACGTGTAAT
CACTGAACAAGTTAAAGAAAATATGAAGGCTGTCTTGGCAGACATCCAAAATGGTAAATTTGCAAATGACTTTGTAAATG
ACTATAAAGCTGGACGTCCAAAATTGACTGCTTACCGTGAACAAGCAGCTAACCTTGAAATTGAAAAAGTTGGTGCAGAA
TTGCGTAAAGCAATGCCATTCGTTGGTAAAAACGACGATGATGCATTCAAAATCTATAACTAA

Upstream 100 bases:

>100_bases
CTCGAACGGGTGCAACTGGATTTACCCGCGATTAAAAATCCAACTTAAATTTATTAAACCAGCCTAAAAGGCAATAAATA
ATAGAAAAGAGAGAAAAGCT

Downstream 100 bases:

>100_bases
TTAGAAATATATAGCGCTGGAGATGATTTTATGAAAAAGATTATGAGAAAAATTGCATCGTTATTATTGGTTCTAGTTGT
ATAATGTAATTACACCGTCG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MTVQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGRDVIIGVRPGKSFDKAKEDGFDTYTVVEATKLADVIMIL
APDEIQQELYEAEIAPNLEAGNAVGFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTYEEGFGVPALYAVYQDATGN
AKNIAMDWCKGVGAARVGLLETTYKEETEEDLFGEQAVLCGGLTALIEAGFEVLTEAGYAPELAYFEVLHEMKLIVDLIY
EGGFKKMRQSISNTAEYGDYVSGPRVITEQVKENMKAVLADIQNGKFANDFVNDYKAGRPKLTAYREQAANLEIEKVGAE
LRKAMPFVGKNDDDAFKIYN

Sequences:

>Translated_340_residues
MTVQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGRDVIIGVRPGKSFDKAKEDGFDTYTVVEATKLADVIMIL
APDEIQQELYEAEIAPNLEAGNAVGFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTYEEGFGVPALYAVYQDATGN
AKNIAMDWCKGVGAARVGLLETTYKEETEEDLFGEQAVLCGGLTALIEAGFEVLTEAGYAPELAYFEVLHEMKLIVDLIY
EGGFKKMRQSISNTAEYGDYVSGPRVITEQVKENMKAVLADIQNGKFANDFVNDYKAGRPKLTAYREQAANLEIEKVGAE
LRKAMPFVGKNDDDAFKIYN
>Mature_339_residues
TVQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGRDVIIGVRPGKSFDKAKEDGFDTYTVVEATKLADVIMILA
PDEIQQELYEAEIAPNLEAGNAVGFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTYEEGFGVPALYAVYQDATGNA
KNIAMDWCKGVGAARVGLLETTYKEETEEDLFGEQAVLCGGLTALIEAGFEVLTEAGYAPELAYFEVLHEMKLIVDLIYE
GGFKKMRQSISNTAEYGDYVSGPRVITEQVKENMKAVLADIQNGKFANDFVNDYKAGRPKLTAYREQAANLEIEKVGAEL
RKAMPFVGKNDDDAFKIYN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=312, Percent_Identity=33.974358974359, Blast_Score=159, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323387, Length=303, Percent_Identity=35.3135313531353, Blast_Score=148, Evalue=1e-36,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 37379; Mature: 37248

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGRDVIIGVRPGKSFDKAKED
CEEEEECCCCCEEEEECCCEEEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHC
GFDTYTVVEATKLADVIMILAPDEIQQELYEAEIAPNLEAGNAVGFAHGFNIHFEFIKVP
CCCEEEEHHHHHHHEEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEEECCEEEEEEEEEC
ADVDVFMCAPKGPGHLVRRTYEEGFGVPALYAVYQDATGNAKNIAMDWCKGVGAARVGLL
CCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCCHHHHHHH
ETTYKEETEEDLFGEQAVLCGGLTALIEAGFEVLTEAGYAPELAYFEVLHEMKLIVDLIY
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGFKKMRQSISNTAEYGDYVSGPRVITEQVKENMKAVLADIQNGKFANDFVNDYKAGRP
HCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
KLTAYREQAANLEIEKVGAELRKAMPFVGKNDDDAFKIYN
CHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCEEECC
>Mature Secondary Structure 
TVQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGRDVIIGVRPGKSFDKAKED
EEEEECCCCCEEEEECCCEEEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHC
GFDTYTVVEATKLADVIMILAPDEIQQELYEAEIAPNLEAGNAVGFAHGFNIHFEFIKVP
CCCEEEEHHHHHHHEEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEEECCEEEEEEEEEC
ADVDVFMCAPKGPGHLVRRTYEEGFGVPALYAVYQDATGNAKNIAMDWCKGVGAARVGLL
CCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCCHHHHHHH
ETTYKEETEEDLFGEQAVLCGGLTALIEAGFEVLTEAGYAPELAYFEVLHEMKLIVDLIY
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGFKKMRQSISNTAEYGDYVSGPRVITEQVKENMKAVLADIQNGKFANDFVNDYKAGRP
HCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
KLTAYREQAANLEIEKVGAELRKAMPFVGKNDDDAFKIYN
CHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA