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The map label for this gene is ffh [H]

Identifier: 169824222

GI number: 169824222

Start: 590052

End: 591392

Strand: Direct

Name: ffh [H]

Synonym: FMG_0525

Alternate gene names: 169824222

Gene position: 590052-591392 (Clockwise)

Preceding gene: 169824221

Following gene: 169824223

Centisome position: 32.82

GC content: 34.08

Gene sequence:

>1341_bases
ATGATATTTGAAAATTTGTCCGATAAATTACAAAATGCCTTGTCAAAATTGACCAACAGAGGAAAGCTAACAGAAAAAGA
TATAGATGTTGCAATGAGAGAAGTTAAACTTGCTTTATTGGAAGCGGACGTTAACTATAAAGTTGTCAAAGATTTTATCT
CTCAGGTAAAAGAACGTGCTATTGATTCTTCTGTTTTGGAAAGTCTTACTCCAGGTCAACAAGTTATCAAGATAGTTAAT
GAAGAATTAACTAAAATGATGGGTGAAAAGGAAGAAAAACTTAACGTTTCACCGATGAAGCCTACAGTAATTATGCTTTG
TGGCTTGCAAGGGGCTGGTAAAACAACTCATGCCGGAAAGCTTGCATTAAATTTGAAAAACAAAAACAAAAGCGTACTAC
TTGTAGCGTGTGATATTTACAGACCTGCTGCCATCAAACAACTTCAAGTTGTCGGTGGGAAAGTTGGGGTAGAAGTTTTT
GAGATGGGACAGATAAATCCTGTTGAAATTTCTAAAAAAGCAATCGAAGAAGCTAAAAGAAAGAACATTGATTATGTAAT
TATAGATACTGCCGGTCGTCTTCACATTGACGATACTTTGATGGATGAGCTGAAAAATATTAAACAAGAAGTGAATCCTT
CAGATATTTTGTTAGTTGTAGATGCGATGACTGGACAAGATGCAGTGAATGTTGCAGCTAAGTTTAACGAAGATTTGGAT
ATTACAGGAATTATACTTACAAAGTTAGACGGTGATGCAAGAGGTGGTGCTGCTTTATCAATCAGACAAGTAGCTGATAA
GCCTATTAAATTTATAGGTGTAGGTGAAAAACTTGGAGATTTAGAGCCATTCCATCCGGATAGAATGGCATCTCGTATCT
TGGGAATGGGAGATGTTCTTAGCCTTATCGAAAAAGCGCAAAATCAATTTGACGAGAAAAAGGCAAAAGAGTTAGAAGAA
AAGATTAAAGCTCAAAGTTTTGACTTTAATGATTTTCTTGACCAAATGCAGCAAATTAAAAAAATGGGACCTATGCAAGA
TATTCTTGCAATGATTCCTGGTGTAGATAGCAAAATGCTTAAACAAGTTAATTTCGACAATAAAGAATTTGACAAGATTG
AAGCGATTATAAAATCTATGACCAAACAAGAAAGAGAAAATCCAGATATCATTAGCATATCTAGAAGAAAAAGAATTGCT
AAAGGATGCGGTCAAGATCAAGTAGCGGTTAATAAACTTTTGAAACAATTTAAAGAAATGAAAGTTATGATGAAAAATAT
GGGAGCGCTACAGAAGAAATTTGGCAAAAAAGGTAAAATGAAAATGCCTTTTTTTAGATAA

Upstream 100 bases:

>100_bases
AATGATCTTTTCTCTTTGTCACCAGAAATCAAAAGCAAAGAAATTGAAAATATCATTATAGATATAGAAGATTTCTTAAA
TGATTTAGAGGATGTGGAAA

Downstream 100 bases:

>100_bases
TAAGTTATGGAGGTAAATTATGTCAGTAAAAATTAGATTGAAAAGAATGGGAGCAAAGAAGAAACCATTTTATAGAATAG
TTGTCGCAGATTCAAGATGT

Product: signal recognition particle

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MIFENLSDKLQNALSKLTNRGKLTEKDIDVAMREVKLALLEADVNYKVVKDFISQVKERAIDSSVLESLTPGQQVIKIVN
EELTKMMGEKEEKLNVSPMKPTVIMLCGLQGAGKTTHAGKLALNLKNKNKSVLLVACDIYRPAAIKQLQVVGGKVGVEVF
EMGQINPVEISKKAIEEAKRKNIDYVIIDTAGRLHIDDTLMDELKNIKQEVNPSDILLVVDAMTGQDAVNVAAKFNEDLD
ITGIILTKLDGDARGGAALSIRQVADKPIKFIGVGEKLGDLEPFHPDRMASRILGMGDVLSLIEKAQNQFDEKKAKELEE
KIKAQSFDFNDFLDQMQQIKKMGPMQDILAMIPGVDSKMLKQVNFDNKEFDKIEAIIKSMTKQERENPDIISISRRKRIA
KGCGQDQVAVNKLLKQFKEMKVMMKNMGALQKKFGKKGKMKMPFFR

Sequences:

>Translated_446_residues
MIFENLSDKLQNALSKLTNRGKLTEKDIDVAMREVKLALLEADVNYKVVKDFISQVKERAIDSSVLESLTPGQQVIKIVN
EELTKMMGEKEEKLNVSPMKPTVIMLCGLQGAGKTTHAGKLALNLKNKNKSVLLVACDIYRPAAIKQLQVVGGKVGVEVF
EMGQINPVEISKKAIEEAKRKNIDYVIIDTAGRLHIDDTLMDELKNIKQEVNPSDILLVVDAMTGQDAVNVAAKFNEDLD
ITGIILTKLDGDARGGAALSIRQVADKPIKFIGVGEKLGDLEPFHPDRMASRILGMGDVLSLIEKAQNQFDEKKAKELEE
KIKAQSFDFNDFLDQMQQIKKMGPMQDILAMIPGVDSKMLKQVNFDNKEFDKIEAIIKSMTKQERENPDIISISRRKRIA
KGCGQDQVAVNKLLKQFKEMKVMMKNMGALQKKFGKKGKMKMPFFR
>Mature_446_residues
MIFENLSDKLQNALSKLTNRGKLTEKDIDVAMREVKLALLEADVNYKVVKDFISQVKERAIDSSVLESLTPGQQVIKIVN
EELTKMMGEKEEKLNVSPMKPTVIMLCGLQGAGKTTHAGKLALNLKNKNKSVLLVACDIYRPAAIKQLQVVGGKVGVEVF
EMGQINPVEISKKAIEEAKRKNIDYVIIDTAGRLHIDDTLMDELKNIKQEVNPSDILLVVDAMTGQDAVNVAAKFNEDLD
ITGIILTKLDGDARGGAALSIRQVADKPIKFIGVGEKLGDLEPFHPDRMASRILGMGDVLSLIEKAQNQFDEKKAKELEE
KIKAQSFDFNDFLDQMQQIKKMGPMQDILAMIPGVDSKMLKQVNFDNKEFDKIEAIIKSMTKQERENPDIISISRRKRIA
KGCGQDQVAVNKLLKQFKEMKVMMKNMGALQKKFGKKGKMKMPFFR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=453, Percent_Identity=34.878587196468, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI226371618, Length=398, Percent_Identity=34.1708542713568, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI89061728, Length=166, Percent_Identity=37.3493975903614, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI295424842, Length=211, Percent_Identity=33.6492890995261, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI23308697, Length=211, Percent_Identity=33.6492890995261, Blast_Score=115, Evalue=8e-26,
Organism=Escherichia coli, GI1788963, Length=431, Percent_Identity=52.2041763341067, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI1789874, Length=253, Percent_Identity=39.5256916996047, Blast_Score=166, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17539958, Length=452, Percent_Identity=31.1946902654867, Blast_Score=234, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI193206261, Length=256, Percent_Identity=32.03125, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=458, Percent_Identity=32.9694323144105, Blast_Score=226, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6320498, Length=261, Percent_Identity=31.0344827586207, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17647949, Length=453, Percent_Identity=32.0088300220751, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24641198, Length=266, Percent_Identity=31.203007518797, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49864; Mature: 49864

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFENLSDKLQNALSKLTNRGKLTEKDIDVAMREVKLALLEADVNYKVVKDFISQVKERA
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IDSSVLESLTPGQQVIKIVNEELTKMMGEKEEKLNVSPMKPTVIMLCGLQGAGKTTHAGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEECCCCCCCCCCCCE
LALNLKNKNKSVLLVACDIYRPAAIKQLQVVGGKVGVEVFEMGQINPVEISKKAIEEAKR
EEEEEECCCCEEEEEEECCCCCHHHHHHHHHCCHHCHHHHHCCCCCHHHHHHHHHHHHHH
KNIDYVIIDTAGRLHIDDTLMDELKNIKQEVNPSDILLVVDAMTGQDAVNVAAKFNEDLD
CCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCC
ITGIILTKLDGDARGGAALSIRQVADKPIKFIGVGEKLGDLEPFHPDRMASRILGMGDVL
EEEEEEEEECCCCCCCCEEEHHHHHCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHHH
SLIEKAQNQFDEKKAKELEEKIKAQSFDFNDFLDQMQQIKKMGPMQDILAMIPGVDSKML
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHH
KQVNFDNKEFDKIEAIIKSMTKQERENPDIISISRRKRIAKGCGQDQVAVNKLLKQFKEM
HHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHH
KVMMKNMGALQKKFGKKGKMKMPFFR
HHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MIFENLSDKLQNALSKLTNRGKLTEKDIDVAMREVKLALLEADVNYKVVKDFISQVKERA
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IDSSVLESLTPGQQVIKIVNEELTKMMGEKEEKLNVSPMKPTVIMLCGLQGAGKTTHAGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEECCCCCCCCCCCCE
LALNLKNKNKSVLLVACDIYRPAAIKQLQVVGGKVGVEVFEMGQINPVEISKKAIEEAKR
EEEEEECCCCEEEEEEECCCCCHHHHHHHHHCCHHCHHHHHCCCCCHHHHHHHHHHHHHH
KNIDYVIIDTAGRLHIDDTLMDELKNIKQEVNPSDILLVVDAMTGQDAVNVAAKFNEDLD
CCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCC
ITGIILTKLDGDARGGAALSIRQVADKPIKFIGVGEKLGDLEPFHPDRMASRILGMGDVL
EEEEEEEEECCCCCCCCEEEHHHHHCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHHH
SLIEKAQNQFDEKKAKELEEKIKAQSFDFNDFLDQMQQIKKMGPMQDILAMIPGVDSKML
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHH
KQVNFDNKEFDKIEAIIKSMTKQERENPDIISISRRKRIAKGCGQDQVAVNKLLKQFKEM
HHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHH
KVMMKNMGALQKKFGKKGKMKMPFFR
HHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]