Click here to switch to the map view.

The map label for this gene is xdhD [H]

Identifier: 169824203

GI number: 169824203

Start: 570340

End: 572613

Strand: Direct

Name: xdhD [H]

Synonym: FMG_0506

Alternate gene names: 169824203

Gene position: 570340-572613 (Clockwise)

Preceding gene: 169824202

Following gene: 169824204

Centisome position: 31.73

GC content: 35.27

Gene sequence:

>2274_bases
ATGAAGATAAATAAAGATTTCAAGAAAATAGATTCAAATTCATTAGTTACTGGTAAACCTGTCTACACAGAAGATTTGAA
AGATCCTAATGCACTAATAATTAAGTTGATGAGAAGTCCTTATGCGAGATGCGAAATTTTAGAAATCGACAAATCAAAGG
CAGAAGCGATGGATGGAATTGTTGCAGTGTACACTTATGAGGATGTTTTTGATAATAAATTTACTTTGGCAGGACAATCT
TATCCAGAACCAAGTCCATACGATATGTCGATTTTATCAAAAAATATAAGATACATGAAAGAGCCTGTAGCAATCGTTGT
TGGAGTTAACGAAAAAGTTTGTAATCAAGCTATGAAGAGAATCAAAGTAAAATACGATGTCAAAGAGCCACTACTTGATT
ACACGAAAGCTATCGATAACGAAATCGTAGTTCACGAAGAAGACGTGTTCTTTAATGGTCCAACGAAAGTTTTCGGTTAC
AATACGAGAAGAAATCTTGTTGGTGAAAAGAAAGAATCATGGGGAGAAGATATTGACAAGGTAATGAGTGAGTGTGATGT
TGTATTGGAAGATACTTTTACAACAAAAGCACAAGCGCATTGTATGATGGAAACTTACAGATCGTATTGCTACATGGATC
AATTCGATAGATTGTGTTGCATTTCATCTACACAAGTGCCATTTCACATCAAAAGACAATTATCCGTTGCTCTTGGAATT
AGCGATTCAAGAATCAGAATTATAAAACCAAGAGTTGGTGGAGGATTTGGTGGAAAACAAACAAGTGTCACAGAAATTTA
TCCTGGATTTGTAACATTGAAGACAGGAAAGCCATCAATTCTTGTATTTGACAGGGAAGAAACTTTTGAAGCTTCAAATT
CTCGTCACCAAATGAAAGTTAAAGTAAAAATTGGCGCAAAAAAAGATGGTACGATTGAAGCGTGTGATATTTATGCACTA
TCTGATCAAGGAGCTTATGGATATCACGCATTTACCACTTTGAATTTGGTTGGTAACAAAACTCTTCCGTTATACAGTAG
AATGAGAGCCGCGAGATTTTTCGGACAAGTTGTCTACACTAATAAACTTCCTGGTGGAGCTTTCCGTGGTTACGGTGCAG
TTCAAGGAACATTTGCACTAGAATCTATGGTAAACAAATTAGCCAAAGAATTAAACATGGATCCTGTCGAGCTTAGACTT
AAAAACACTGTTCGAGAAGGAGAAAAAACTCTTGCTTACGGAATAGATGTCAAAAGTTGCAAATTAAATGAATGTATCGA
AAAGGGAAGAGAAATGATTGAATGGGATAAATATTATCCGTTCAAAGAAGAAAAAGATAAAATAATTTCAGTTGGAATGG
CAATCGCCCAACAAGGAAGTGGAATTCAAAATGTCGACACTTCTACTGTTGAGGTGAGATTAAACGAACAAGGCGACTAT
ACATTATTGATGAGTCCTACAGATGTTGGACAAGGCACTGATTCTATCATGGTGAATTTGGCAAACGAAGTGTTGCAATG
CGGAATGGACAATATAATTCCGATAATTGCAGATACTGATATAACTCCATACGATCCAGGTAGTTATGCATCAAGTGGTG
TGTATATAACTGGTGGAGCAGTTGTTCGTGCTTGCGAAAATTTATTAAACAAAATCAAAAAACGTGTTGCAATGAGATTT
GAAACTTCTGTTGAATGGTTAGAAATCAGAGATCAAGCAGTTTATTTGCAAAATAAGAAATTAATTGCAATTAAAGATTT
GGCGAGAGATTTGTCAACTGGTCCAAATGGTATGCAATTAATCGGAGTAGGAAATTTCGATTCAAAAACATCACCACCAC
CATATATGGCAGGATTTGTAAAAATTAGTATTGACAAATTAACAGGAGAAATCAAAGTAGAAGATTATGCAGCAGTTGTC
GATTGCGGAACTGTTATGAATACCAAATTAGCGACAGTTCAAGTCGAAGGTGGAATTGGTCAATCTATAGGATATGCCTT
GTATGAAGATTCATTGTGGGATGATGAAGGAAGATTAAAAGAACATTCTTTTATTTCGTATAATTTGCCTTCTAGAAAAG
ACATCGGAAATATCCACGTTGATTTTTGTGAAAGTTATGAACCTACAGGTCCATTCGGCGCAAAATCAATTGGAGAAATA
GTTTCAAACACACCTGCACCAGCTATTAATGGAGCGATATTGAATGCAATTAGTTGCACTTTTGATACTCTTCCAATAAA
AGCTGAAGATGTTTTATTAAAAATGTATGAATAG

Upstream 100 bases:

>100_bases
ACAGATGAAGAAATCGAAGATTATTTGATGGGAAATTTATGTAGATGTACAGGTTATGCATCTCAAATGAGAGCTATTAA
GAAATATTTGGAGATTGACG

Downstream 100 bases:

>100_bases
ATTTTAAGTCAGAGGTTTCTAGCCTCTGATTTTTTTGTGGAAAAATATTTAAAAAATTTAACAATACATATATATAACAA
TTGTGAAAAAAATTAGCATT

Product: putative hypoxanthine oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 757; Mature: 757

Protein sequence:

>757_residues
MKINKDFKKIDSNSLVTGKPVYTEDLKDPNALIIKLMRSPYARCEILEIDKSKAEAMDGIVAVYTYEDVFDNKFTLAGQS
YPEPSPYDMSILSKNIRYMKEPVAIVVGVNEKVCNQAMKRIKVKYDVKEPLLDYTKAIDNEIVVHEEDVFFNGPTKVFGY
NTRRNLVGEKKESWGEDIDKVMSECDVVLEDTFTTKAQAHCMMETYRSYCYMDQFDRLCCISSTQVPFHIKRQLSVALGI
SDSRIRIIKPRVGGGFGGKQTSVTEIYPGFVTLKTGKPSILVFDREETFEASNSRHQMKVKVKIGAKKDGTIEACDIYAL
SDQGAYGYHAFTTLNLVGNKTLPLYSRMRAARFFGQVVYTNKLPGGAFRGYGAVQGTFALESMVNKLAKELNMDPVELRL
KNTVREGEKTLAYGIDVKSCKLNECIEKGREMIEWDKYYPFKEEKDKIISVGMAIAQQGSGIQNVDTSTVEVRLNEQGDY
TLLMSPTDVGQGTDSIMVNLANEVLQCGMDNIIPIIADTDITPYDPGSYASSGVYITGGAVVRACENLLNKIKKRVAMRF
ETSVEWLEIRDQAVYLQNKKLIAIKDLARDLSTGPNGMQLIGVGNFDSKTSPPPYMAGFVKISIDKLTGEIKVEDYAAVV
DCGTVMNTKLATVQVEGGIGQSIGYALYEDSLWDDEGRLKEHSFISYNLPSRKDIGNIHVDFCESYEPTGPFGAKSIGEI
VSNTPAPAINGAILNAISCTFDTLPIKAEDVLLKMYE

Sequences:

>Translated_757_residues
MKINKDFKKIDSNSLVTGKPVYTEDLKDPNALIIKLMRSPYARCEILEIDKSKAEAMDGIVAVYTYEDVFDNKFTLAGQS
YPEPSPYDMSILSKNIRYMKEPVAIVVGVNEKVCNQAMKRIKVKYDVKEPLLDYTKAIDNEIVVHEEDVFFNGPTKVFGY
NTRRNLVGEKKESWGEDIDKVMSECDVVLEDTFTTKAQAHCMMETYRSYCYMDQFDRLCCISSTQVPFHIKRQLSVALGI
SDSRIRIIKPRVGGGFGGKQTSVTEIYPGFVTLKTGKPSILVFDREETFEASNSRHQMKVKVKIGAKKDGTIEACDIYAL
SDQGAYGYHAFTTLNLVGNKTLPLYSRMRAARFFGQVVYTNKLPGGAFRGYGAVQGTFALESMVNKLAKELNMDPVELRL
KNTVREGEKTLAYGIDVKSCKLNECIEKGREMIEWDKYYPFKEEKDKIISVGMAIAQQGSGIQNVDTSTVEVRLNEQGDY
TLLMSPTDVGQGTDSIMVNLANEVLQCGMDNIIPIIADTDITPYDPGSYASSGVYITGGAVVRACENLLNKIKKRVAMRF
ETSVEWLEIRDQAVYLQNKKLIAIKDLARDLSTGPNGMQLIGVGNFDSKTSPPPYMAGFVKISIDKLTGEIKVEDYAAVV
DCGTVMNTKLATVQVEGGIGQSIGYALYEDSLWDDEGRLKEHSFISYNLPSRKDIGNIHVDFCESYEPTGPFGAKSIGEI
VSNTPAPAINGAILNAISCTFDTLPIKAEDVLLKMYE
>Mature_757_residues
MKINKDFKKIDSNSLVTGKPVYTEDLKDPNALIIKLMRSPYARCEILEIDKSKAEAMDGIVAVYTYEDVFDNKFTLAGQS
YPEPSPYDMSILSKNIRYMKEPVAIVVGVNEKVCNQAMKRIKVKYDVKEPLLDYTKAIDNEIVVHEEDVFFNGPTKVFGY
NTRRNLVGEKKESWGEDIDKVMSECDVVLEDTFTTKAQAHCMMETYRSYCYMDQFDRLCCISSTQVPFHIKRQLSVALGI
SDSRIRIIKPRVGGGFGGKQTSVTEIYPGFVTLKTGKPSILVFDREETFEASNSRHQMKVKVKIGAKKDGTIEACDIYAL
SDQGAYGYHAFTTLNLVGNKTLPLYSRMRAARFFGQVVYTNKLPGGAFRGYGAVQGTFALESMVNKLAKELNMDPVELRL
KNTVREGEKTLAYGIDVKSCKLNECIEKGREMIEWDKYYPFKEEKDKIISVGMAIAQQGSGIQNVDTSTVEVRLNEQGDY
TLLMSPTDVGQGTDSIMVNLANEVLQCGMDNIIPIIADTDITPYDPGSYASSGVYITGGAVVRACENLLNKIKKRVAMRF
ETSVEWLEIRDQAVYLQNKKLIAIKDLARDLSTGPNGMQLIGVGNFDSKTSPPPYMAGFVKISIDKLTGEIKVEDYAAVV
DCGTVMNTKLATVQVEGGIGQSIGYALYEDSLWDDEGRLKEHSFISYNLPSRKDIGNIHVDFCESYEPTGPFGAKSIGEI
VSNTPAPAINGAILNAISCTFDTLPIKAEDVLLKMYE

Specific function: Probably has no xanthine dehydrogenase activity; however deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=745, Percent_Identity=24.0268456375839, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI71773480, Length=725, Percent_Identity=23.0344827586207, Blast_Score=128, Evalue=2e-29,
Organism=Escherichia coli, GI1789246, Length=790, Percent_Identity=34.3037974683544, Blast_Score=440, Evalue=1e-124,
Organism=Escherichia coli, GI1789230, Length=764, Percent_Identity=30.3664921465969, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1786478, Length=777, Percent_Identity=23.9382239382239, Blast_Score=137, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17540638, Length=735, Percent_Identity=22.8571428571429, Blast_Score=162, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI32566215, Length=744, Percent_Identity=22.9838709677419, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17539860, Length=754, Percent_Identity=23.342175066313, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI17737937, Length=729, Percent_Identity=24.0054869684499, Blast_Score=172, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR001041
- InterPro:   IPR017699 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2; PF01799 Fer2_2 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 84224; Mature: 84224

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00659 GLYCOSYL_HYDROL_F5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKINKDFKKIDSNSLVTGKPVYTEDLKDPNALIIKLMRSPYARCEILEIDKSKAEAMDGI
CCCCCCHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHCCE
VAVYTYEDVFDNKFTLAGQSYPEPSPYDMSILSKNIRYMKEPVAIVVGVNEKVCNQAMKR
EEEEEEHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHH
IKVKYDVKEPLLDYTKAIDNEIVVHEEDVFFNGPTKVFGYNTRRNLVGEKKESWGEDIDK
EEEEECCHHHHHHHHHHCCCCEEEEECCEEECCCCEEEECCHHHHHCCCHHHHHHHHHHH
VMSECDVVLEDTFTTKAQAHCMMETYRSYCYMDQFDRLCCISSTQVPFHIKRQLSVALGI
HHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEEEEEEEEEC
SDSRIRIIKPRVGGGFGGKQTSVTEIYPGFVTLKTGKPSILVFDREETFEASNSRHQMKV
CCCEEEEEECCCCCCCCCCCCCCEEECCCEEEEECCCCEEEEEECHHHHCCCCCCEEEEE
KVKIGAKKDGTIEACDIYALSDQGAYGYHAFTTLNLVGNKTLPLYSRMRAARFFGQVVYT
EEEECCCCCCCEEEEEEEEECCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCEEEEE
NKLPGGAFRGYGAVQGTFALESMVNKLAKELNMDPVELRLKNTVREGEKTLAYGIDVKSC
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCC
KLNECIEKGREMIEWDKYYPFKEEKDKIISVGMAIAQQGSGIQNVDTSTVEVRLNEQGDY
CHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCE
TLLMSPTDVGQGTDSIMVNLANEVLQCGMDNIIPIIADTDITPYDPGSYASSGVYITGGA
EEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEEEECCH
VVRACENLLNKIKKRVAMRFETSVEWLEIRDQAVYLQNKKLIAIKDLARDLSTGPNGMQL
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEEECCCEEEHHHHHHHHHCCCCCEEE
IGVGNFDSKTSPPPYMAGFVKISIDKLTGEIKVEDYAAVVDCGTVMNTKLATVQVEGGIG
EEECCCCCCCCCCCCEEEEEEEEEECCCCEEEEECEEEEEECCHHHCCEEEEEEECCCCC
QSIGYALYEDSLWDDEGRLKEHSFISYNLPSRKDIGNIHVDFCESYEPTGPFGAKSIGEI
CCCCCEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHH
VSNTPAPAINGAILNAISCTFDTLPIKAEDVLLKMYE
HCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHEEEECC
>Mature Secondary Structure
MKINKDFKKIDSNSLVTGKPVYTEDLKDPNALIIKLMRSPYARCEILEIDKSKAEAMDGI
CCCCCCHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHCCE
VAVYTYEDVFDNKFTLAGQSYPEPSPYDMSILSKNIRYMKEPVAIVVGVNEKVCNQAMKR
EEEEEEHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHH
IKVKYDVKEPLLDYTKAIDNEIVVHEEDVFFNGPTKVFGYNTRRNLVGEKKESWGEDIDK
EEEEECCHHHHHHHHHHCCCCEEEEECCEEECCCCEEEECCHHHHHCCCHHHHHHHHHHH
VMSECDVVLEDTFTTKAQAHCMMETYRSYCYMDQFDRLCCISSTQVPFHIKRQLSVALGI
HHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEEEEEEEEEC
SDSRIRIIKPRVGGGFGGKQTSVTEIYPGFVTLKTGKPSILVFDREETFEASNSRHQMKV
CCCEEEEEECCCCCCCCCCCCCCEEECCCEEEEECCCCEEEEEECHHHHCCCCCCEEEEE
KVKIGAKKDGTIEACDIYALSDQGAYGYHAFTTLNLVGNKTLPLYSRMRAARFFGQVVYT
EEEECCCCCCCEEEEEEEEECCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCEEEEE
NKLPGGAFRGYGAVQGTFALESMVNKLAKELNMDPVELRLKNTVREGEKTLAYGIDVKSC
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCC
KLNECIEKGREMIEWDKYYPFKEEKDKIISVGMAIAQQGSGIQNVDTSTVEVRLNEQGDY
CHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCE
TLLMSPTDVGQGTDSIMVNLANEVLQCGMDNIIPIIADTDITPYDPGSYASSGVYITGGA
EEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEEEECCH
VVRACENLLNKIKKRVAMRFETSVEWLEIRDQAVYLQNKKLIAIKDLARDLSTGPNGMQL
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEEECCCEEEHHHHHHHHHCCCCCEEE
IGVGNFDSKTSPPPYMAGFVKISIDKLTGEIKVEDYAAVVDCGTVMNTKLATVQVEGGIG
EEECCCCCCCCCCCCEEEEEEEEEECCCCEEEEECEEEEEECCHHHCCEEEEEEECCCCC
QSIGYALYEDSLWDDEGRLKEHSFISYNLPSRKDIGNIHVDFCESYEPTGPFGAKSIGEI
CCCCCEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHH
VSNTPAPAINGAILNAISCTFDTLPIKAEDVLLKMYE
HCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Two 2Fe-2S centers [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]