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The map label for this gene is pcp

Identifier: 169824051

GI number: 169824051

Start: 408729

End: 409370

Strand: Direct

Name: pcp

Synonym: FMG_0354

Alternate gene names: 169824051

Gene position: 408729-409370 (Clockwise)

Preceding gene: 169824050

Following gene: 169824052

Centisome position: 22.74

GC content: 34.27

Gene sequence:

>642_bases
ATGAAAATTTTAGTTTCAGGTTTTGATCCATTTGGTGGTGAAAAAATCAACCCTGCTATTGAATCAGTTAAGCTATTGCC
AGATTCAATTAAAGGAAATGAAATAATCAAAATAGAAATTCCTACAGTTATTGGAAAAAGTGTAGATAAATTAAAAGAAA
AGATAAAAGAAGTTAAACCAGATGTTGTAATATCAGTGGGACAAGCTGGTGGACGTGAAGACATCACTGTAGAAAGAGTT
GCAATCAATGTTGACGATTGTAGAATTAAGGATAACGAAGGAAACCAACCAATCGACGAAAAAATTGCCGAAGATGGTCC
TGATGCGTACTTGTTGACTCTACCAATCAAAGCAATGGTTGAAAACATAAAATCAGCAAACATTCCAGCATCTGTGTCAA
ACACTGCAGGAACATTCATATGTAACCATGTTGCATACGGAATGGCTCATGTAAGAGCTACTGAATATCCTAATATGAGA
ACTGGATTTATTCACATTCCATTCTTACCAGAACAAGTTTTGAATAAACCACACACTGCTTCAATGAATTTGGATACAAT
TGCAAAAGCATTGGAAAAAGCAATTGAAGCTGTAATAGACAATGATGAAGATATCAAAGTTACAGGTGGAAAAACTCATT
AA

Upstream 100 bases:

>100_bases
ATAAAAACGGAGTTATTAAAGCGCAACTTCCAGTTGCTTTAGCTCTAATAGTTGTTCATGTTGTATTATTAATGATATTA
GCATTTTAGGAGGTAAATTT

Downstream 100 bases:

>100_bases
AAATTTTTTGGAAAATCATTAATAGTTTAATTGAAGAACTTCGAAACATTTAAAGTTTCGAGGTTCTTTTTTATTTGCAA
ATGAATTTTCGTTTTTGTTT

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MKILVSGFDPFGGEKINPAIESVKLLPDSIKGNEIIKIEIPTVIGKSVDKLKEKIKEVKPDVVISVGQAGGREDITVERV
AINVDDCRIKDNEGNQPIDEKIAEDGPDAYLLTLPIKAMVENIKSANIPASVSNTAGTFICNHVAYGMAHVRATEYPNMR
TGFIHIPFLPEQVLNKPHTASMNLDTIAKALEKAIEAVIDNDEDIKVTGGKTH

Sequences:

>Translated_213_residues
MKILVSGFDPFGGEKINPAIESVKLLPDSIKGNEIIKIEIPTVIGKSVDKLKEKIKEVKPDVVISVGQAGGREDITVERV
AINVDDCRIKDNEGNQPIDEKIAEDGPDAYLLTLPIKAMVENIKSANIPASVSNTAGTFICNHVAYGMAHVRATEYPNMR
TGFIHIPFLPEQVLNKPHTASMNLDTIAKALEKAIEAVIDNDEDIKVTGGKTH
>Mature_213_residues
MKILVSGFDPFGGEKINPAIESVKLLPDSIKGNEIIKIEIPTVIGKSVDKLKEKIKEVKPDVVISVGQAGGREDITVERV
AINVDDCRIKDNEGNQPIDEKIAEDGPDAYLLTLPIKAMVENIKSANIPASVSNTAGTFICNHVAYGMAHVRATEYPNMR
TGFIHIPFLPEQVLNKPHTASMNLDTIAKALEKAIEAVIDNDEDIKVTGGKTH

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCP_FINM2 (B0S415)

Other databases:

- EMBL:   AP008971
- RefSeq:   YP_001691662.1
- ProteinModelPortal:   B0S415
- SMR:   B0S415
- MEROPS:   C15.001
- GeneID:   6019366
- GenomeReviews:   AP008971_GR
- KEGG:   fma:FMG_0354
- HOGENOM:   HBG360405
- OMA:   NTAGTYV
- ProtClustDB:   CLSK2307041
- BioCyc:   FMAG334413:FMG_0354-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00417
- InterPro:   IPR000816
- InterPro:   IPR016125
- Gene3D:   G3DSA:3.40.630.20
- PANTHER:   PTHR23402
- PIRSF:   PIRSF015592
- PRINTS:   PR00706
- TIGRFAMs:   TIGR00504

Pfam domain/function: PF01470 Peptidase_C15; SSF53182 Peptidase_C15-like

EC number: =3.4.19.3

Molecular weight: Translated: 23119; Mature: 23119

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS01334 PYRASE_CYS; PS01333 PYRASE_GLU

Important sites: ACT_SITE 78-78 ACT_SITE 141-141 ACT_SITE 165-165

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVSGFDPFGGEKINPAIESVKLLPDSIKGNEIIKIEIPTVIGKSVDKLKEKIKEVKP
CEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHCCC
DVVISVGQAGGREDITVERVAINVDDCRIKDNEGNQPIDEKIAEDGPDAYLLTLPIKAMV
CEEEEECCCCCCCCEEEEEEEEECCCEEEECCCCCCCHHHHHHCCCCCEEEEEECHHHHH
ENIKSANIPASVSNTAGTFICNHVAYGMAHVRATEYPNMRTGFIHIPFLPEQVLNKPHTA
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCCCCEEECCCCCHHHCCCCCCC
SMNLDTIAKALEKAIEAVIDNDEDIKVTGGKTH
CCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
>Mature Secondary Structure
MKILVSGFDPFGGEKINPAIESVKLLPDSIKGNEIIKIEIPTVIGKSVDKLKEKIKEVKP
CEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHCCC
DVVISVGQAGGREDITVERVAINVDDCRIKDNEGNQPIDEKIAEDGPDAYLLTLPIKAMV
CEEEEECCCCCCCCEEEEEEEEECCCEEEECCCCCCCHHHHHHCCCCCEEEEEECHHHHH
ENIKSANIPASVSNTAGTFICNHVAYGMAHVRATEYPNMRTGFIHIPFLPEQVLNKPHTA
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCCCCEEECCCCCHHHCCCCCCC
SMNLDTIAKALEKAIEAVIDNDEDIKVTGGKTH
CCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA