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The map label for this gene is cobB [H]

Identifier: 169823993

GI number: 169823993

Start: 344242

End: 344982

Strand: Direct

Name: cobB [H]

Synonym: FMG_0296

Alternate gene names: 169823993

Gene position: 344242-344982 (Clockwise)

Preceding gene: 169823992

Following gene: 169823994

Centisome position: 19.15

GC content: 36.71

Gene sequence:

>741_bases
ATGAATGATGTTGAAAGATTAAAACAAATTGTAGAACAAAGTGACAAAATCGTGTTTTTCGGTGGGGCAGGAGTGTCCAC
TGCATCTGGAATTCCAGATTTTAGATCTGCAACTGGACTTTACAACAAGAAAAACGACAGCGATTTTTCGCCGGAATATA
TGTTGAGCCATGAATTTTTTGTGACACATCCAGATTTGTTTCAAGATTATGTTTTGGAAAATTTGATTATCGATGGAGTA
AAGCCGAATAATGCACATCTTTCTTTGAGGAAATTAGAAAAAGCAAACAAATTACTCGGCGTTATCACACAAAACATCGA
CAGCCTGGATACGATGGCTGGTACGAAAAATATCGCAGAAATTCACGGGAATTTGAGAGATTATTACTGTGTAAATTGCG
GTGCAAAATACGATTTGGACTATTACAAACAAAACAGACCTTGCAAATGTGAAAAATGTGGCGGCGTTGTGCGTCCGGAT
GTCACATTGTATGGAGAAGTTCCACCACAAAGTGAATTTGCAAAAGCAATAAATTGGATTAACAAGGCAGACACGATGAT
TGTAGCTGGAAGTTCGCTTGTTGTGTATCCTGCAAGTGGTCTTATCAATTATTTTCGAGGAGATAATTTGATACTAATTA
ATCTAGATCGTACAAGCTACGATAATATGGCAAATATCGTGATTCATGACGATATTGCAAAAACTTTAGAATATGTGACG
AGGGATATTGATGAAAGATAA

Upstream 100 bases:

>100_bases
CCAAGAAGATTGCTGGGCTGTTTCATGATATTTTTATCGGTGATGATATTGGCGGTTTCAATGAGATTTCAAGAAAGAAA
AGCAAGGGAAGCGATAAATA

Downstream 100 bases:

>100_bases
AATTAAAAATTATTTGCAAAAAGTTTACGGAGTGGATTTTTTCTCAAAAACAATGATAGTATTCGCTCTGATACTTTCTT
TTATTAATTTAAAATTTAAA

Product: Sir2 family transcriptional regulator

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MNDVERLKQIVEQSDKIVFFGGAGVSTASGIPDFRSATGLYNKKNDSDFSPEYMLSHEFFVTHPDLFQDYVLENLIIDGV
KPNNAHLSLRKLEKANKLLGVITQNIDSLDTMAGTKNIAEIHGNLRDYYCVNCGAKYDLDYYKQNRPCKCEKCGGVVRPD
VTLYGEVPPQSEFAKAINWINKADTMIVAGSSLVVYPASGLINYFRGDNLILINLDRTSYDNMANIVIHDDIAKTLEYVT
RDIDER

Sequences:

>Translated_246_residues
MNDVERLKQIVEQSDKIVFFGGAGVSTASGIPDFRSATGLYNKKNDSDFSPEYMLSHEFFVTHPDLFQDYVLENLIIDGV
KPNNAHLSLRKLEKANKLLGVITQNIDSLDTMAGTKNIAEIHGNLRDYYCVNCGAKYDLDYYKQNRPCKCEKCGGVVRPD
VTLYGEVPPQSEFAKAINWINKADTMIVAGSSLVVYPASGLINYFRGDNLILINLDRTSYDNMANIVIHDDIAKTLEYVT
RDIDER
>Mature_246_residues
MNDVERLKQIVEQSDKIVFFGGAGVSTASGIPDFRSATGLYNKKNDSDFSPEYMLSHEFFVTHPDLFQDYVLENLIIDGV
KPNNAHLSLRKLEKANKLLGVITQNIDSLDTMAGTKNIAEIHGNLRDYYCVNCGAKYDLDYYKQNRPCKCEKCGGVVRPD
VTLYGEVPPQSEFAKAINWINKADTMIVAGSSLVVYPASGLINYFRGDNLILINLDRTSYDNMANIVIHDDIAKTLEYVT
RDIDER

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI13775602, Length=204, Percent_Identity=34.8039215686275, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI13775600, Length=204, Percent_Identity=34.8039215686275, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI6912662, Length=278, Percent_Identity=28.0575539568345, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI300797705, Length=205, Percent_Identity=34.1463414634146, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI6912660, Length=226, Percent_Identity=33.1858407079646, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI300795542, Length=242, Percent_Identity=29.3388429752066, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI63054862, Length=205, Percent_Identity=34.6341463414634, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI300797577, Length=243, Percent_Identity=29.2181069958848, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI7657575, Length=214, Percent_Identity=31.7757009345794, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI6912664, Length=261, Percent_Identity=27.9693486590038, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI13787215, Length=247, Percent_Identity=28.7449392712551, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI300797597, Length=239, Percent_Identity=27.6150627615063, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI7706712, Length=261, Percent_Identity=26.0536398467433, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI308199517, Length=220, Percent_Identity=31.3636363636364, Blast_Score=96, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17541892, Length=211, Percent_Identity=32.7014218009479, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17567771, Length=277, Percent_Identity=27.4368231046931, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71990482, Length=287, Percent_Identity=25.0871080139373, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71990487, Length=289, Percent_Identity=24.9134948096886, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17505510, Length=254, Percent_Identity=24.8031496062992, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6325242, Length=255, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6320163, Length=262, Percent_Identity=28.6259541984733, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324504, Length=263, Percent_Identity=29.6577946768061, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324599, Length=306, Percent_Identity=25.1633986928105, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320397, Length=245, Percent_Identity=24.8979591836735, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24648389, Length=241, Percent_Identity=31.9502074688797, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI28571445, Length=267, Percent_Identity=26.9662921348315, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17137536, Length=225, Percent_Identity=30.2222222222222, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24645650, Length=255, Percent_Identity=24.3137254901961, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24650933, Length=250, Percent_Identity=25.2, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27634; Mature: 27634

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDVERLKQIVEQSDKIVFFGGAGVSTASGIPDFRSATGLYNKKNDSDFSPEYMLSHEFF
CCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEECCEEE
VTHPDLFQDYVLENLIIDGVKPNNAHLSLRKLEKANKLLGVITQNIDSLDTMAGTKNIAE
EECHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHH
IHGNLRDYYCVNCGAKYDLDYYKQNRPCKCEKCGGVVRPDVTLYGEVPPQSEFAKAINWI
HHCCCCEEEEEECCCCCCCHHHHCCCCCCHHHCCCCCCCCEEEEECCCCHHHHHHHHHHH
NKADTMIVAGSSLVVYPASGLINYFRGDNLILINLDRTSYDNMANIVIHDDIAKTLEYVT
CCCCEEEEECCEEEEECCHHHHHHHCCCCEEEEEECCCCCCCEEEEEEEHHHHHHHHHHH
RDIDER
HHHCCC
>Mature Secondary Structure
MNDVERLKQIVEQSDKIVFFGGAGVSTASGIPDFRSATGLYNKKNDSDFSPEYMLSHEFF
CCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEECCEEE
VTHPDLFQDYVLENLIIDGVKPNNAHLSLRKLEKANKLLGVITQNIDSLDTMAGTKNIAE
EECHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHH
IHGNLRDYYCVNCGAKYDLDYYKQNRPCKCEKCGGVVRPDVTLYGEVPPQSEFAKAINWI
HHCCCCEEEEEECCCCCCCHHHHCCCCCCHHHCCCCCCCCEEEEECCCCHHHHHHHHHHH
NKADTMIVAGSSLVVYPASGLINYFRGDNLILINLDRTSYDNMANIVIHDDIAKTLEYVT
CCCCEEEEECCEEEEECCHHHHHHHCCCCEEEEEECCCCCCCEEEEEEEHHHHHHHHHHH
RDIDER
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]