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The map label for this gene is moeA [H]

Identifier: 169823989

GI number: 169823989

Start: 340691

End: 341872

Strand: Direct

Name: moeA [H]

Synonym: FMG_0292

Alternate gene names: 169823989

Gene position: 340691-341872 (Clockwise)

Preceding gene: 169823988

Following gene: 169823990

Centisome position: 18.95

GC content: 34.18

Gene sequence:

>1182_bases
ATGTTATTACAAGTAGAAAAAGCGAAGGAAATACTTAAAGAAAATATAAAAAAAGCATCTGAAATTGAAGAAATTGATAT
TGATGATGCTTATAACAGAGTTTTGGCGGAGGATGTGCTGGCGAAGTTCAACAATCCTCCTTATCCCAAAAGTGCAATGG
ATGGATACGCTGTAAGTAGCAAAGATTCTGACAAATTATCGAAAAAGAAAATTATCGGGACGAATTTTGCTGGAGATTGC
AATGATTTTGATTACGAAGAAAATACTTGCGTGAGAATTATGACAGGTGCATTTGTACCAAAAGGCTACGATGCAATTGT
AAAACAAGAAGACTGCGAAGTAGTGGATGGTTTTATTGAAATCAAAAAACCTTACGAGCCTTTTGATTATTACATCAAAG
AAGGCGAAGATGTGTCTGAAGGGGATTTGTTAATTCCTAAAAACACGAGGATTTCTTCGGTTCACTTGTCGATTTTGGCA
TCAAATGGATATGCAAAAGTTAAGGTTTACAGAAAATTAAAGGTAGCGCTATTATCGACAGGATCTGAATTGTTGTATCC
TGGGGATGATTATAAACCAGGAAAAATCTACAGCTCAACAACTTTTACATTAAAATCTATTTTAAAAAATTCAGGAGTAG
AAGTTGTCGAACAAAAAAACTGCATGGATGATGAACAATCAATCATACGTGAAGTAAAAAATCTGACACAAAAATCAGAT
GTTGTGATAACAACTGGTGGAGTAAGTGTTGGGGACAAAGATTTAATGGAATCATGTATGAAACAAATTGGAGAAGTTTT
GTTTCACAGAATTGCCATGAAACCAGGAACACCTGTGATGGCATCAAAAGTAGGTGACACAATTGTGTTGTCTTGTTCGG
GAAGTCCGTTTGCGGCTTTTTGTAATTTCGAAGTTTTATTTTGGGATTTGTACAATAAATATTATGGATTAAATGTAAAA
CAATTTGAAGAAGGAAAAGTTGTAGAAGGATCGATGAAACCATCGAAGCTTCAACGATACGTCAGATGTTTTGTAAAAGA
TTCCGAGATTACGATTTTTGATAAACACAAGAATTCTATGCTACAAGATTTGACTAATTGCAATGCGCTTTTGCTTCAAA
AACAAAACGAAAGCTTGGATGTGAATTCAAGCGTAGATTATATTTATTTGGGTGAAATATGA

Upstream 100 bases:

>100_bases
GCACTTATAGTTATTACTTTGGGTAATGTTTTGGGTGGAATTTTGATTCCAACAATGAGAAATATCAACACAAAATTAAA
AAGCGAATAAGGTTAAATAA

Downstream 100 bases:

>100_bases
GAGTTTCTGTAGGAATATTGGCCGGTGGAAAAAGTGAGAGAATGGGTCAAGACAAATTCGATTTGAACTTTTATGGGCAC
ACTTTTATCGAAGAATTGAT

Product: molybdenum cofactor biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MLLQVEKAKEILKENIKKASEIEEIDIDDAYNRVLAEDVLAKFNNPPYPKSAMDGYAVSSKDSDKLSKKKIIGTNFAGDC
NDFDYEENTCVRIMTGAFVPKGYDAIVKQEDCEVVDGFIEIKKPYEPFDYYIKEGEDVSEGDLLIPKNTRISSVHLSILA
SNGYAKVKVYRKLKVALLSTGSELLYPGDDYKPGKIYSSTTFTLKSILKNSGVEVVEQKNCMDDEQSIIREVKNLTQKSD
VVITTGGVSVGDKDLMESCMKQIGEVLFHRIAMKPGTPVMASKVGDTIVLSCSGSPFAAFCNFEVLFWDLYNKYYGLNVK
QFEEGKVVEGSMKPSKLQRYVRCFVKDSEITIFDKHKNSMLQDLTNCNALLLQKQNESLDVNSSVDYIYLGEI

Sequences:

>Translated_393_residues
MLLQVEKAKEILKENIKKASEIEEIDIDDAYNRVLAEDVLAKFNNPPYPKSAMDGYAVSSKDSDKLSKKKIIGTNFAGDC
NDFDYEENTCVRIMTGAFVPKGYDAIVKQEDCEVVDGFIEIKKPYEPFDYYIKEGEDVSEGDLLIPKNTRISSVHLSILA
SNGYAKVKVYRKLKVALLSTGSELLYPGDDYKPGKIYSSTTFTLKSILKNSGVEVVEQKNCMDDEQSIIREVKNLTQKSD
VVITTGGVSVGDKDLMESCMKQIGEVLFHRIAMKPGTPVMASKVGDTIVLSCSGSPFAAFCNFEVLFWDLYNKYYGLNVK
QFEEGKVVEGSMKPSKLQRYVRCFVKDSEITIFDKHKNSMLQDLTNCNALLLQKQNESLDVNSSVDYIYLGEI
>Mature_393_residues
MLLQVEKAKEILKENIKKASEIEEIDIDDAYNRVLAEDVLAKFNNPPYPKSAMDGYAVSSKDSDKLSKKKIIGTNFAGDC
NDFDYEENTCVRIMTGAFVPKGYDAIVKQEDCEVVDGFIEIKKPYEPFDYYIKEGEDVSEGDLLIPKNTRISSVHLSILA
SNGYAKVKVYRKLKVALLSTGSELLYPGDDYKPGKIYSSTTFTLKSILKNSGVEVVEQKNCMDDEQSIIREVKNLTQKSD
VVITTGGVSVGDKDLMESCMKQIGEVLFHRIAMKPGTPVMASKVGDTIVLSCSGSPFAAFCNFEVLFWDLYNKYYGLNVK
QFEEGKVVEGSMKPSKLQRYVRCFVKDSEITIFDKHKNSMLQDLTNCNALLLQKQNESLDVNSSVDYIYLGEI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=309, Percent_Identity=31.3915857605178, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI10880983, Length=309, Percent_Identity=31.3915857605178, Blast_Score=146, Evalue=3e-35,
Organism=Escherichia coli, GI1787049, Length=315, Percent_Identity=32.6984126984127, Blast_Score=192, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI25147659, Length=314, Percent_Identity=32.484076433121, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17562606, Length=222, Percent_Identity=25.2252252252252, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17136978, Length=316, Percent_Identity=30.0632911392405, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24638841, Length=316, Percent_Identity=30.0632911392405, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44076; Mature: 44076

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLQVEKAKEILKENIKKASEIEEIDIDDAYNRVLAEDVLAKFNNPPYPKSAMDGYAVSS
CCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHCCCCEECC
KDSDKLSKKKIIGTNFAGDCNDFDYEENTCVRIMTGAFVPKGYDAIVKQEDCEVVDGFIE
CCCHHHHHHHEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHCCCCHHHHHHHHH
IKKPYEPFDYYIKEGEDVSEGDLLIPKNTRISSVHLSILASNGYAKVKVYRKLKVALLST
CCCCCCCHHHHHCCCCCCCCCCEECCCCCCEEEEEEEEEECCCEEEEEEHHHHEEHHCCC
GSELLYPGDDYKPGKIYSSTTFTLKSILKNSGVEVVEQKNCMDDEQSIIREVKNLTQKSD
CCCEEECCCCCCCCEEECCHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCC
VVITTGGVSVGDKDLMESCMKQIGEVLFHRIAMKPGTPVMASKVGDTIVLSCSGSPFAAF
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEEEECCCCEEEE
CNFEVLFWDLYNKYYGLNVKQFEEGKVVEGSMKPSKLQRYVRCFVKDSEITIFDKHKNSM
ECCEEEEEEHHHHHHCCCCEEECCCCEEECCCCHHHHHHHHHHHEECCEEEEEECCHHHH
LQDLTNCNALLLQKQNESLDVNSSVDYIYLGEI
HHHHHCCCEEEEECCCCCCCCCCCCCEEEECCC
>Mature Secondary Structure
MLLQVEKAKEILKENIKKASEIEEIDIDDAYNRVLAEDVLAKFNNPPYPKSAMDGYAVSS
CCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHCCCCEECC
KDSDKLSKKKIIGTNFAGDCNDFDYEENTCVRIMTGAFVPKGYDAIVKQEDCEVVDGFIE
CCCHHHHHHHEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHCCCCHHHHHHHHH
IKKPYEPFDYYIKEGEDVSEGDLLIPKNTRISSVHLSILASNGYAKVKVYRKLKVALLST
CCCCCCCHHHHHCCCCCCCCCCEECCCCCCEEEEEEEEEECCCEEEEEEHHHHEEHHCCC
GSELLYPGDDYKPGKIYSSTTFTLKSILKNSGVEVVEQKNCMDDEQSIIREVKNLTQKSD
CCCEEECCCCCCCCEEECCHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCC
VVITTGGVSVGDKDLMESCMKQIGEVLFHRIAMKPGTPVMASKVGDTIVLSCSGSPFAAF
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEEEECCCCEEEE
CNFEVLFWDLYNKYYGLNVKQFEEGKVVEGSMKPSKLQRYVRCFVKDSEITIFDKHKNSM
ECCEEEEEEHHHHHHCCCCEEECCCCEEECCCCHHHHHHHHHHHEECCEEEEEECCHHHH
LQDLTNCNALLLQKQNESLDVNSSVDYIYLGEI
HHHHHCCCEEEEECCCCCCCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]