Click here to switch to the map view.

The map label for this gene is menE [H]

Identifier: 169629625

GI number: 169629625

Start: 2586679

End: 2588325

Strand: Reverse

Name: menE [H]

Synonym: MAB_2539c

Alternate gene names: 169629625

Gene position: 2588325-2586679 (Counterclockwise)

Preceding gene: 169629626

Following gene: 169629624

Centisome position: 51.08

GC content: 63.69

Gene sequence:

>1647_bases
ATGCCGAATAACCTGCGCGAGAGCCTGCGGCAGTGGGGTGCTGCGATACCTGCTGCCGTTACCTCGGGCGCCTTTACTCC
GGTGAGCCCCCGCGCCCTGGCCTCGCTGGTCCGTAGTTTTTGGCAGTTCGGGCCCACGCCCGCGATGTTGTTGGCAGCCA
GTGCGATTCGTTTTCCTGACCGGGCCGCGCTGATCGACGATTCCGGGCAGCTCACCTATCGTGACCTCCAACGGCGGGCC
GAGGCCGTAGCTGCTGCGGTGTACGCGCGCACCCCGTCGGCACCGAGGTCGGTAGGGATCATCTGCCGTAACCACCGGGG
CTTCGCCGAATCCATGCTGGCCGGTGCCCAGCTCGGGGCGGAGCTGGTCTTCATCAACACCGAATTGACACCCCAGCAGC
TGGGGGCGATCCTGCAACGTCATGAACCCGACGTGCTGGTGTACGACGACGAATACTCGCAGGCTGTCGAGGAATCTCAG
TACCAGGGACTGCGAGTATTGGCGTGGCGTGAAAACCCGCAAGAAAATCGCCTGACGCTGGATTCTTTGGCAGATCAGCA
CCATCCGAAACCGCCGCCGGTACGCCGCCCCGTCAAGTTGACTCTTCTCACCTCCGGCACCACCGGGTTGGCCAAGGGCG
TGCCACGTGCCATCAAGCCCCGCCAATTGGCACTCATGTGCGTAACCGCGATGGCCACGGTGCGGCTGCGCTCCCGGGAC
CGTGTGTTGGTGGCGCCACCGTTCTTCCATGGTTTCGGGCTGGCCGCGCTGCTAGGCCCGTTGGCGCTCGGTGGAACGGT
GATGTGCCGACGACGATTCGACGCTCAGCAGGCCATGACGGACATCCGCCGGCAGCGCGTCACGGTGCTGATGGCGGTGC
CCGTCATGTTGCAGCGGATACTTGCGCTCGCCGACCTCGATCGTCGAGATGCGCGGCAACTGTCACTGCGGATGATCGTC
ACCGGAGCGGCCCCGATCTCCTCGTCAACGGTATCCGGCGTGCTGGAAGCGTTCGGGCCGATTCTGGTCAATGGGTACGG
CTCCACCGAGGCCGGCGTGGTGGCCATCGCCTCCCCCAAAGACCTGGTCGCCTCGCCGAATACCATCGGGCGCACTGCCC
TTGGGGTATCCGTGCGAATCCTGCGGGAGGATCGCCGGCCGGCCGCGCCCGGCGAGACCGGGATGATCTTCGTACGTGGC
GGGCTAGAGTACGAGGGATACACCCCCGACAAGGCCACGCGGCCGACCGCCAAGGAGATCGTTGACGGGCATGTAAATAC
CGGCGATATGGGACATTTCGATGCCGACGGCAGGCTGTACATCGATGGCCGTTCCGACGACATGATTGTCTCCGGCGGCG
AAAATGTCTTCCCCGGTGAAGTGGAGGACCGCCTGACCACGTACCCCGGTATTACCGATGCCGTCGTCATCGGGGTACCC
GATGACGACTTCGGGCAGGTATTGCATGCATTCGTTGTCGCTGCTGACGGAGCACCCGCTCCATCCGAGGAAGTACTGAA
GACTCATGTCCGACAAGGATTGGAACGCTACAAGGTTCCGAAGCGGTTCATCGTGCTGGACGAGATACCGCGCAACGCGA
GCGGCAAAGTGCTTCGCGCAAAACTGAATTCACCTGGCGCGTGCTGA

Upstream 100 bases:

>100_bases
GTCTATCGCCGGCTGGGCGATACCCAGGCTTCACTGGCGCGGGTAACGGCCGGACAATCGACCACCACGCGCATTGACGC
CCCGGAAAGGATCGGCGTAC

Downstream 100 bases:

>100_bases
GCGCCACCGACGCCTGAGGACAACGATGTCTGACACCCCTGCGATCACCCGCCGCGACCGTGACCGGTTCTACGAGCCGC
CCCATCTCGATGATGGCGGT

Product: fatty-acid-CoA ligase FadD

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MPNNLRESLRQWGAAIPAAVTSGAFTPVSPRALASLVRSFWQFGPTPAMLLAASAIRFPDRAALIDDSGQLTYRDLQRRA
EAVAAAVYARTPSAPRSVGIICRNHRGFAESMLAGAQLGAELVFINTELTPQQLGAILQRHEPDVLVYDDEYSQAVEESQ
YQGLRVLAWRENPQENRLTLDSLADQHHPKPPPVRRPVKLTLLTSGTTGLAKGVPRAIKPRQLALMCVTAMATVRLRSRD
RVLVAPPFFHGFGLAALLGPLALGGTVMCRRRFDAQQAMTDIRRQRVTVLMAVPVMLQRILALADLDRRDARQLSLRMIV
TGAAPISSSTVSGVLEAFGPILVNGYGSTEAGVVAIASPKDLVASPNTIGRTALGVSVRILREDRRPAAPGETGMIFVRG
GLEYEGYTPDKATRPTAKEIVDGHVNTGDMGHFDADGRLYIDGRSDDMIVSGGENVFPGEVEDRLTTYPGITDAVVIGVP
DDDFGQVLHAFVVAADGAPAPSEEVLKTHVRQGLERYKVPKRFIVLDEIPRNASGKVLRAKLNSPGAC

Sequences:

>Translated_548_residues
MPNNLRESLRQWGAAIPAAVTSGAFTPVSPRALASLVRSFWQFGPTPAMLLAASAIRFPDRAALIDDSGQLTYRDLQRRA
EAVAAAVYARTPSAPRSVGIICRNHRGFAESMLAGAQLGAELVFINTELTPQQLGAILQRHEPDVLVYDDEYSQAVEESQ
YQGLRVLAWRENPQENRLTLDSLADQHHPKPPPVRRPVKLTLLTSGTTGLAKGVPRAIKPRQLALMCVTAMATVRLRSRD
RVLVAPPFFHGFGLAALLGPLALGGTVMCRRRFDAQQAMTDIRRQRVTVLMAVPVMLQRILALADLDRRDARQLSLRMIV
TGAAPISSSTVSGVLEAFGPILVNGYGSTEAGVVAIASPKDLVASPNTIGRTALGVSVRILREDRRPAAPGETGMIFVRG
GLEYEGYTPDKATRPTAKEIVDGHVNTGDMGHFDADGRLYIDGRSDDMIVSGGENVFPGEVEDRLTTYPGITDAVVIGVP
DDDFGQVLHAFVVAADGAPAPSEEVLKTHVRQGLERYKVPKRFIVLDEIPRNASGKVLRAKLNSPGAC
>Mature_547_residues
PNNLRESLRQWGAAIPAAVTSGAFTPVSPRALASLVRSFWQFGPTPAMLLAASAIRFPDRAALIDDSGQLTYRDLQRRAE
AVAAAVYARTPSAPRSVGIICRNHRGFAESMLAGAQLGAELVFINTELTPQQLGAILQRHEPDVLVYDDEYSQAVEESQY
QGLRVLAWRENPQENRLTLDSLADQHHPKPPPVRRPVKLTLLTSGTTGLAKGVPRAIKPRQLALMCVTAMATVRLRSRDR
VLVAPPFFHGFGLAALLGPLALGGTVMCRRRFDAQQAMTDIRRQRVTVLMAVPVMLQRILALADLDRRDARQLSLRMIVT
GAAPISSSTVSGVLEAFGPILVNGYGSTEAGVVAIASPKDLVASPNTIGRTALGVSVRILREDRRPAAPGETGMIFVRGG
LEYEGYTPDKATRPTAKEIVDGHVNTGDMGHFDADGRLYIDGRSDDMIVSGGENVFPGEVEDRLTTYPGITDAVVIGVPD
DDFGQVLHAFVVAADGAPAPSEEVLKTHVRQGLERYKVPKRFIVLDEIPRNASGKVLRAKLNSPGAC

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI187761345, Length=533, Percent_Identity=27.5797373358349, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI187761343, Length=533, Percent_Identity=27.5797373358349, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI156151445, Length=548, Percent_Identity=25, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI38505220, Length=281, Percent_Identity=29.1814946619217, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI122937307, Length=275, Percent_Identity=32, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI42544132, Length=450, Percent_Identity=24.6666666666667, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI58082049, Length=427, Percent_Identity=27.1662763466042, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI115511026, Length=395, Percent_Identity=25.0632911392405, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI157311624, Length=427, Percent_Identity=25.9953161592506, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI157311622, Length=427, Percent_Identity=25.9953161592506, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI62865631, Length=537, Percent_Identity=24.0223463687151, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI13325055, Length=537, Percent_Identity=24.0223463687151, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI40807357, Length=481, Percent_Identity=26.1954261954262, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI28416953, Length=471, Percent_Identity=23.9915074309979, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI13375727, Length=536, Percent_Identity=23.8805970149254, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI253970489, Length=419, Percent_Identity=24.3436754176611, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI8923896, Length=399, Percent_Identity=24.0601503759398, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1788107, Length=572, Percent_Identity=25.6993006993007, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI221142682, Length=506, Percent_Identity=26.6798418972332, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI145693145, Length=345, Percent_Identity=29.8550724637681, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1786810, Length=521, Percent_Identity=23.6084452975048, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1789201, Length=355, Percent_Identity=29.5774647887324, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790505, Length=394, Percent_Identity=22.3350253807107, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786529, Length=471, Percent_Identity=25.0530785562633, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788595, Length=344, Percent_Identity=25.2906976744186, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786801, Length=528, Percent_Identity=24.4318181818182, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32563687, Length=493, Percent_Identity=30.0202839756592, Blast_Score=172, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17558820, Length=500, Percent_Identity=29, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17559526, Length=358, Percent_Identity=28.7709497206704, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17531443, Length=351, Percent_Identity=27.9202279202279, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17557194, Length=403, Percent_Identity=26.5508684863524, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17560308, Length=364, Percent_Identity=28.8461538461538, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17538037, Length=355, Percent_Identity=27.6056338028169, Blast_Score=115, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17560140, Length=340, Percent_Identity=27.0588235294118, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71985884, Length=349, Percent_Identity=26.647564469914, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71994690, Length=353, Percent_Identity=27.1954674220963, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71994694, Length=353, Percent_Identity=27.1954674220963, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71994703, Length=353, Percent_Identity=27.1954674220963, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71996755, Length=504, Percent_Identity=22.6190476190476, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25141359, Length=504, Percent_Identity=23.8095238095238, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319699, Length=520, Percent_Identity=24.8076923076923, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6323182, Length=413, Percent_Identity=24.9394673123487, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319264, Length=386, Percent_Identity=24.6113989637306, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21355181, Length=499, Percent_Identity=26.6533066132265, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI20130357, Length=346, Percent_Identity=27.7456647398844, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24581924, Length=315, Percent_Identity=30.1587301587302, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI18859661, Length=351, Percent_Identity=29.6296296296296, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24648260, Length=346, Percent_Identity=28.3236994219653, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21356947, Length=505, Percent_Identity=25.3465346534653, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI19922652, Length=536, Percent_Identity=23.6940298507463, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24648676, Length=537, Percent_Identity=25.512104283054, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24653035, Length=342, Percent_Identity=25.7309941520468, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356441, Length=493, Percent_Identity=22.7180527383367, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24648253, Length=472, Percent_Identity=21.6101694915254, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI161076582, Length=351, Percent_Identity=25.0712250712251, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355225, Length=368, Percent_Identity=26.3586956521739, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24656500, Length=353, Percent_Identity=24.0793201133144, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24648255, Length=472, Percent_Identity=21.3983050847458, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24648257, Length=362, Percent_Identity=25.1381215469613, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573631, Length=554, Percent_Identity=25.0902527075812, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI20130353, Length=554, Percent_Identity=25.0902527075812, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21358303, Length=184, Percent_Identity=27.1739130434783, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281365686, Length=489, Percent_Identity=20.8588957055215, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 59190; Mature: 59059

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNNLRESLRQWGAAIPAAVTSGAFTPVSPRALASLVRSFWQFGPTPAMLLAASAIRFPD
CCCHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
RAALIDDSGQLTYRDLQRRAEAVAAAVYARTPSAPRSVGIICRNHRGFAESMLAGAQLGA
CEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCC
ELVFINTELTPQQLGAILQRHEPDVLVYDDEYSQAVEESQYQGLRVLAWRENPQENRLTL
EEEEEECCCCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHCCEEEEEECCCCCCCCEEH
DSLADQHHPKPPPVRRPVKLTLLTSGTTGLAKGVPRAIKPRQLALMCVTAMATVRLRSRD
HHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCC
RVLVAPPFFHGFGLAALLGPLALGGTVMCRRRFDAQQAMTDIRRQRVTVLMAVPVMLQRI
CEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALADLDRRDARQLSLRMIVTGAAPISSSTVSGVLEAFGPILVNGYGSTEAGVVAIASPK
HHHHCCCHHHHHHEEEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCH
DLVASPNTIGRTALGVSVRILREDRRPAAPGETGMIFVRGGLEYEGYTPDKATRPTAKEI
HHCCCCCCCCCHHHHHEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHH
VDGHVNTGDMGHFDADGRLYIDGRSDDMIVSGGENVFPGEVEDRLTTYPGITDAVVIGVP
HCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHHHCCCCCCCEEEEECC
DDDFGQVLHAFVVAADGAPAPSEEVLKTHVRQGLERYKVPKRFIVLDEIPRNASGKVLRA
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEE
KLNSPGAC
ECCCCCCC
>Mature Secondary Structure 
PNNLRESLRQWGAAIPAAVTSGAFTPVSPRALASLVRSFWQFGPTPAMLLAASAIRFPD
CCHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
RAALIDDSGQLTYRDLQRRAEAVAAAVYARTPSAPRSVGIICRNHRGFAESMLAGAQLGA
CEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHCCC
ELVFINTELTPQQLGAILQRHEPDVLVYDDEYSQAVEESQYQGLRVLAWRENPQENRLTL
EEEEEECCCCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHCCEEEEEECCCCCCCCEEH
DSLADQHHPKPPPVRRPVKLTLLTSGTTGLAKGVPRAIKPRQLALMCVTAMATVRLRSRD
HHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCC
RVLVAPPFFHGFGLAALLGPLALGGTVMCRRRFDAQQAMTDIRRQRVTVLMAVPVMLQRI
CEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALADLDRRDARQLSLRMIVTGAAPISSSTVSGVLEAFGPILVNGYGSTEAGVVAIASPK
HHHHCCCHHHHHHEEEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCH
DLVASPNTIGRTALGVSVRILREDRRPAAPGETGMIFVRGGLEYEGYTPDKATRPTAKEI
HHCCCCCCCCCHHHHHEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHH
VDGHVNTGDMGHFDADGRLYIDGRSDDMIVSGGENVFPGEVEDRLTTYPGITDAVVIGVP
HCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHHHCCCCCCCEEEEECC
DDDFGQVLHAFVVAADGAPAPSEEVLKTHVRQGLERYKVPKRFIVLDEIPRNASGKVLRA
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEE
KLNSPGAC
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA