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The map label for this gene is ethA [H]

Identifier: 169629380

GI number: 169629380

Start: 2341486

End: 2342967

Strand: Reverse

Name: ethA [H]

Synonym: MAB_2294c

Alternate gene names: 169629380

Gene position: 2342967-2341486 (Counterclockwise)

Preceding gene: 169629381

Following gene: 169629378

Centisome position: 46.24

GC content: 61.47

Gene sequence:

>1482_bases
ATGTCGGACATGCCGAGAGATGAATTAGTAGACGTTCTCATCGTCGGCGCCGGGATATCCGGTATCAATGCCGCTATCCG
ATTGAGCGGCGCCGGCCGCAGCTTTCACATCGTCGAGCGCCGCGAGCGCATCGGCGGGACCTGGGACCTGTTCCGCTACC
CCGGAATCCGCTCCGACAGCGATATCTATACGCTCAGTTTCGGGTACCACCCCTGGCATGAACGCAACACCATCGCCGAT
GGCGCGGACATTCGCGACTATCTGGAGCACGCGGCCAGCGACTACGACATCGACGGGCATATCACCTTCTCGGCCAAGGT
CACCAGCGCCGATTTCGGGACCGATACCGACATCTGGTCGGTGCGCGTCGACACACCGGCCGGCCCGACGACTTACCGCG
CCAAGTTCCTGTACCTGTGCACCGGCTACTACAACTACGACGACGGCTACACCCCGGAATTCCCGGGGGTGGAGAAGTTC
GCCGGGCGATTGATCCATCCCCAACATTGGCCAGATGACCTGGATTGCTCCGGCAAGGAGATCACTGTCATCGGCAGCGG
CGCGACCGCGATCACCCTGGTGCCGTCGTTGGCGCGCGCCGGGGCCAAGGTGAATATGCTGCAGCGTTCCCCCAGCTATA
TCTACCCGATCGCCCGAGTTGACGCGGTTGTCGATGTGATGCGAAAAGTCTTTCCACTCAGCATTGTTCAGCATTTCGCA
CGCATCTGGCTGGGCGGATTCAACTGGATCATGTATCAGGTATGCCGCAAGGCACCCGGCTTCGCGAAGTGGTTCCTCAG
ACGGCGCATCACCAAACTGCTCCCTGCGGGCTACCCGGTCGACGTGCATTTCGCACCCCGCTACAACCCGTGGGATCAAC
GCGTATGCGCGGATACCGACGGCGACCTCTTCGAGGCCATCAGCAATGGAGGGGTCCGGATGGTCACCGACACCATCGAC
ACCTTCACGTCCGCGGGAATCCGGTTGGGCTCGGGCCAGGAGTTGCCTGCCGATGTGATCATCACTGCCACAGGGCTGAA
TCTGCAGATCTTCGGCGGCATCGCGCTGAGCGTGGACGGCTCCCCTGTGGACGCGCCGAATCGGTTCATCTACAAGGGCT
ATCTGATCGAGGGAGTACCGAACGCCGCCTGGAGCGTCGGATACACCAATGCGTCATGGACACTGCGTGCCGACTTGAGC
GCGCGTGCCGTGGTGCGACTTCTCGACTACATGGATCGACACGGTTACACCCACGCCTATCCGGACCGGCACGGCGAGGA
ACTCGAGGCCCGGCCCTTCTTCAACCTGTCGTCGGGGTACGTGACCCGCGGTGACGCACACATGCCCCGCTCGGGAGTTT
CGGGGCCATGGGCAATCCGGCACAATTACGTACTGGATTTCCTTGCGTTCCATCGTGATCGGATTGACGAAAACATGCAG
TTCGGCATCGCGAAGTCCAAGGCCGTGTCTTCGGCGGCTTAG

Upstream 100 bases:

>100_bases
GGCCGCGCCGATCTTGCAAGCACTCGCGGGCTATCGGGCTTCCCTCTCGGGGTAGCGTGATGGGCCAGATGTTGTCTCAT
CAATGACGATCAGGAGCATC

Downstream 100 bases:

>100_bases
TTCCTGGGCGAGAACTGCGGATCATCTAGGTGCGCGAGGTACTCGAGCACCCGCAGGAATGCACCGCGATCGACGGAAGA
TACCCCAGCCAGGATCCGAT

Product: monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MSDMPRDELVDVLIVGAGISGINAAIRLSGAGRSFHIVERRERIGGTWDLFRYPGIRSDSDIYTLSFGYHPWHERNTIAD
GADIRDYLEHAASDYDIDGHITFSAKVTSADFGTDTDIWSVRVDTPAGPTTYRAKFLYLCTGYYNYDDGYTPEFPGVEKF
AGRLIHPQHWPDDLDCSGKEITVIGSGATAITLVPSLARAGAKVNMLQRSPSYIYPIARVDAVVDVMRKVFPLSIVQHFA
RIWLGGFNWIMYQVCRKAPGFAKWFLRRRITKLLPAGYPVDVHFAPRYNPWDQRVCADTDGDLFEAISNGGVRMVTDTID
TFTSAGIRLGSGQELPADVIITATGLNLQIFGGIALSVDGSPVDAPNRFIYKGYLIEGVPNAAWSVGYTNASWTLRADLS
ARAVVRLLDYMDRHGYTHAYPDRHGEELEARPFFNLSSGYVTRGDAHMPRSGVSGPWAIRHNYVLDFLAFHRDRIDENMQ
FGIAKSKAVSSAA

Sequences:

>Translated_493_residues
MSDMPRDELVDVLIVGAGISGINAAIRLSGAGRSFHIVERRERIGGTWDLFRYPGIRSDSDIYTLSFGYHPWHERNTIAD
GADIRDYLEHAASDYDIDGHITFSAKVTSADFGTDTDIWSVRVDTPAGPTTYRAKFLYLCTGYYNYDDGYTPEFPGVEKF
AGRLIHPQHWPDDLDCSGKEITVIGSGATAITLVPSLARAGAKVNMLQRSPSYIYPIARVDAVVDVMRKVFPLSIVQHFA
RIWLGGFNWIMYQVCRKAPGFAKWFLRRRITKLLPAGYPVDVHFAPRYNPWDQRVCADTDGDLFEAISNGGVRMVTDTID
TFTSAGIRLGSGQELPADVIITATGLNLQIFGGIALSVDGSPVDAPNRFIYKGYLIEGVPNAAWSVGYTNASWTLRADLS
ARAVVRLLDYMDRHGYTHAYPDRHGEELEARPFFNLSSGYVTRGDAHMPRSGVSGPWAIRHNYVLDFLAFHRDRIDENMQ
FGIAKSKAVSSAA
>Mature_492_residues
SDMPRDELVDVLIVGAGISGINAAIRLSGAGRSFHIVERRERIGGTWDLFRYPGIRSDSDIYTLSFGYHPWHERNTIADG
ADIRDYLEHAASDYDIDGHITFSAKVTSADFGTDTDIWSVRVDTPAGPTTYRAKFLYLCTGYYNYDDGYTPEFPGVEKFA
GRLIHPQHWPDDLDCSGKEITVIGSGATAITLVPSLARAGAKVNMLQRSPSYIYPIARVDAVVDVMRKVFPLSIVQHFAR
IWLGGFNWIMYQVCRKAPGFAKWFLRRRITKLLPAGYPVDVHFAPRYNPWDQRVCADTDGDLFEAISNGGVRMVTDTIDT
FTSAGIRLGSGQELPADVIITATGLNLQIFGGIALSVDGSPVDAPNRFIYKGYLIEGVPNAAWSVGYTNASWTLRADLSA
RAVVRLLDYMDRHGYTHAYPDRHGEELEARPFFNLSSGYVTRGDAHMPRSGVSGPWAIRHNYVLDFLAFHRDRIDENMQF
GIAKSKAVSSAA

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503759, Length=217, Percent_Identity=24.8847926267281, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25150462, Length=249, Percent_Identity=24.0963855421687, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 54784; Mature: 54653

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDMPRDELVDVLIVGAGISGINAAIRLSGAGRSFHIVERRERIGGTWDLFRYPGIRSDS
CCCCCHHHHEEEEEEECCCCCCCEEEEEECCCCEEEEEHHHHHCCCCEEHHCCCCCCCCC
DIYTLSFGYHPWHERNTIADGADIRDYLEHAASDYDIDGHITFSAKVTSADFGTDTDIWS
CEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEEEEEEECCCCCCCCEEE
VRVDTPAGPTTYRAKFLYLCTGYYNYDDGYTPEFPGVEKFAGRLIHPQHWPDDLDCSGKE
EEECCCCCCCCEEEEEEEEEEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCE
ITVIGSGATAITLVPSLARAGAKVNMLQRSPSYIYPIARVDAVVDVMRKVFPLSIVQHFA
EEEEECCCEEEEEHHHHHHCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
RIWLGGFNWIMYQVCRKAPGFAKWFLRRRITKLLPAGYPVDVHFAPRYNPWDQRVCADTD
HHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEECCCC
GDLFEAISNGGVRMVTDTIDTFTSAGIRLGSGQELPADVIITATGLNLQIFGGIALSVDG
CHHHHHHHCCCEEEEEHHHHHHHHCCEEECCCCCCCCEEEEEEECCEEEEEEEEEEEECC
SPVDAPNRFIYKGYLIEGVPNAAWSVGYTNASWTLRADLSARAVVRLLDYMDRHGYTHAY
CCCCCCCCEEEEEEEEECCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCC
PDRHGEELEARPFFNLSSGYVTRGDAHMPRSGVSGPWAIRHNYVLDFLAFHRDRIDENMQ
CCCCCCCCCCCCCEECCCCEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCHH
FGIAKSKAVSSAA
CCCHHHHHHCCCC
>Mature Secondary Structure 
SDMPRDELVDVLIVGAGISGINAAIRLSGAGRSFHIVERRERIGGTWDLFRYPGIRSDS
CCCCHHHHEEEEEEECCCCCCCEEEEEECCCCEEEEEHHHHHCCCCEEHHCCCCCCCCC
DIYTLSFGYHPWHERNTIADGADIRDYLEHAASDYDIDGHITFSAKVTSADFGTDTDIWS
CEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEEEEEEECCCCCCCCEEE
VRVDTPAGPTTYRAKFLYLCTGYYNYDDGYTPEFPGVEKFAGRLIHPQHWPDDLDCSGKE
EEECCCCCCCCEEEEEEEEEEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCE
ITVIGSGATAITLVPSLARAGAKVNMLQRSPSYIYPIARVDAVVDVMRKVFPLSIVQHFA
EEEEECCCEEEEEHHHHHHCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
RIWLGGFNWIMYQVCRKAPGFAKWFLRRRITKLLPAGYPVDVHFAPRYNPWDQRVCADTD
HHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEECCCC
GDLFEAISNGGVRMVTDTIDTFTSAGIRLGSGQELPADVIITATGLNLQIFGGIALSVDG
CHHHHHHHCCCEEEEEHHHHHHHHCCEEECCCCCCCCEEEEEEECCEEEEEEEEEEEECC
SPVDAPNRFIYKGYLIEGVPNAAWSVGYTNASWTLRADLSARAVVRLLDYMDRHGYTHAY
CCCCCCCCEEEEEEEEECCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCC
PDRHGEELEARPFFNLSSGYVTRGDAHMPRSGVSGPWAIRHNYVLDFLAFHRDRIDENMQ
CCCCCCCCCCCCCEECCCCEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCHH
FGIAKSKAVSSAA
CCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]