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The map label for this gene is patA [H]

Identifier: 169629365

GI number: 169629365

Start: 2327711

End: 2328988

Strand: Direct

Name: patA [H]

Synonym: MAB_2279

Alternate gene names: 169629365

Gene position: 2327711-2328988 (Clockwise)

Preceding gene: 169629364

Following gene: 169629366

Centisome position: 45.94

GC content: 63.38

Gene sequence:

>1278_bases
ATGTCAGTGACAGCAAGCCCGCAGGCACCGAGTGCCGCGCATATTGCACGGATATACAAAACGCATCTCAGCGGTGGCCG
GGCCACCCTGGGCGACATCTTCGGTGGCCACATCGAAACATCTTCCGACGGAGCGTGGCTCACCACGGCCGAAGGCACCC
GTTTCCTCAACGCCGGTGGCTACGGCGTCGCCCTCGCCGGCTATCGACACCCGGTTGTCGTCGACCACATTCGTAGGCAG
CTGGACCAGCACCCGGTGGCCTCCCGCATGTTCTATGAACCCGCCGCCGCCGAGGCGGCCGCAGCCCTGGCCGCCGTAAC
GCCCAAGGGCCTTGACCGGATTCATTTCGCATGTTCGGGGGCCGAGGCCACGGAGGCCGCCATGAAGCTCGCCCGCCTCA
ACGGGTGCCGGCGATTTATCTCGATGACGGGCGGATACCACGGAAAGACATTGGGCGCACTGTCCTTAACGGCCCGGGAA
GTGTTCCAGGCGCCGTTCCGACCACTGTTACCCGGTGTGAGCCATGTGCCGTACGGAGACCTCGCGGCGCTACGTACCGA
ACTCGCGATGAGTACGGCGCGCGCGTGCGTGATTGTAGAACCGGTACAGGGCGAGGCCGGCGTCATCATCCCTCCCGACG
GATATCTGGCGGGTCTGCGTGCGGTGTGCGACGAGTACGGGGCGCTGCTGGTCGCCGACGAAATCCAAACCGGACTCGGG
AGATTGGGGCAGTGGTGGGGTGTGGACCGGGAGCGTGTAATTCCGGATATCTTGTTGTCCGGCAAGATGCTCGGCGGTGG
CGTAATGCCTGTCTCGGCGGCCATCACCACCACCGAGTGTTTCCGTCAACTCGACCGTGACCCCTATCTGCACACCTCGA
CATTCTCAACCAGCCCACTGGGTATGGCGGCGGTCAGCGGAGCGTTGCGCGTGATCGCCGAGGAGAGATTGGTTGAGCGG
GCCGCGGAGCTCGGGCAGATCCTTTTGGACAGGATCAGCTCGGCAAGTGCGCAGTGGTTCGGCCCGGATCAGGTACAGGT
ACGCGGTCAAGGGCTGCTGATCGGCATTGAGTTCACAGACGCCTCGATCGTGGGAGACCTGCTGATCGAGCTCATCAGCA
ACAACATCATCGTCAACCACTCACTGAATTCGGATCACGTCCTGCGGTTGACACCGCCGGCCGTCATCACCGACGACGAC
GTCGAATTCCTCGTCCAGGGCTACCTCAACGCGATTGAGCAGGTGGCTATCCGTGCCAAGGCAGCACTGCCCGGCTGA

Upstream 100 bases:

>100_bases
CCTTTCATCCGCCCTCACGGCTGTCGCTGGCCGACGCGCTGGCCCGTGCGGCCATCGGCGAACCGTTGCGCCTGGACTAG
GTAGGGGAGAGGACATTGTC

Downstream 100 bases:

>100_bases
TCACACATAAGCACACAGAAGTAGGAAGGACCCCTTTATGCGTACTGCGCAACTGATCGTCGATTCCAGCTCCCACCCCG
ATGAGGCCTACCGCGCCATC

Product: ornithine aminotransferase

Products: NA

Alternate protein names: Putrescine--2-oxoglutaric acid transaminase; PAT; PATase [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSVTASPQAPSAAHIARIYKTHLSGGRATLGDIFGGHIETSSDGAWLTTAEGTRFLNAGGYGVALAGYRHPVVVDHIRRQ
LDQHPVASRMFYEPAAAEAAAALAAVTPKGLDRIHFACSGAEATEAAMKLARLNGCRRFISMTGGYHGKTLGALSLTARE
VFQAPFRPLLPGVSHVPYGDLAALRTELAMSTARACVIVEPVQGEAGVIIPPDGYLAGLRAVCDEYGALLVADEIQTGLG
RLGQWWGVDRERVIPDILLSGKMLGGGVMPVSAAITTTECFRQLDRDPYLHTSTFSTSPLGMAAVSGALRVIAEERLVER
AAELGQILLDRISSASAQWFGPDQVQVRGQGLLIGIEFTDASIVGDLLIELISNNIIVNHSLNSDHVLRLTPPAVITDDD
VEFLVQGYLNAIEQVAIRAKAALPG

Sequences:

>Translated_425_residues
MSVTASPQAPSAAHIARIYKTHLSGGRATLGDIFGGHIETSSDGAWLTTAEGTRFLNAGGYGVALAGYRHPVVVDHIRRQ
LDQHPVASRMFYEPAAAEAAAALAAVTPKGLDRIHFACSGAEATEAAMKLARLNGCRRFISMTGGYHGKTLGALSLTARE
VFQAPFRPLLPGVSHVPYGDLAALRTELAMSTARACVIVEPVQGEAGVIIPPDGYLAGLRAVCDEYGALLVADEIQTGLG
RLGQWWGVDRERVIPDILLSGKMLGGGVMPVSAAITTTECFRQLDRDPYLHTSTFSTSPLGMAAVSGALRVIAEERLVER
AAELGQILLDRISSASAQWFGPDQVQVRGQGLLIGIEFTDASIVGDLLIELISNNIIVNHSLNSDHVLRLTPPAVITDDD
VEFLVQGYLNAIEQVAIRAKAALPG
>Mature_424_residues
SVTASPQAPSAAHIARIYKTHLSGGRATLGDIFGGHIETSSDGAWLTTAEGTRFLNAGGYGVALAGYRHPVVVDHIRRQL
DQHPVASRMFYEPAAAEAAAALAAVTPKGLDRIHFACSGAEATEAAMKLARLNGCRRFISMTGGYHGKTLGALSLTAREV
FQAPFRPLLPGVSHVPYGDLAALRTELAMSTARACVIVEPVQGEAGVIIPPDGYLAGLRAVCDEYGALLVADEIQTGLGR
LGQWWGVDRERVIPDILLSGKMLGGGVMPVSAAITTTECFRQLDRDPYLHTSTFSTSPLGMAAVSGALRVIAEERLVERA
AELGQILLDRISSASAQWFGPDQVQVRGQGLLIGIEFTDASIVGDLLIELISNNIIVNHSLNSDHVLRLTPPAVITDDDV
EFLVQGYLNAIEQVAIRAKAALPG

Specific function: Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithi

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=372, Percent_Identity=34.4086021505376, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI284507298, Length=294, Percent_Identity=37.4149659863946, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI13994255, Length=460, Percent_Identity=29.7826086956522, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI37574042, Length=395, Percent_Identity=26.3291139240506, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI226442709, Length=373, Percent_Identity=26.5415549597855, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI226442705, Length=362, Percent_Identity=26.2430939226519, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI24119277, Length=406, Percent_Identity=24.8768472906404, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI188536080, Length=424, Percent_Identity=24.5283018867925, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI38679950, Length=424, Percent_Identity=24.5283018867925, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI38679946, Length=424, Percent_Identity=24.5283018867925, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI145693181, Length=386, Percent_Identity=40.9326424870466, Blast_Score=301, Evalue=6e-83,
Organism=Escherichia coli, GI1789759, Length=391, Percent_Identity=31.7135549872123, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1787560, Length=340, Percent_Identity=33.8235294117647, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1788044, Length=328, Percent_Identity=31.4024390243902, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1789016, Length=396, Percent_Identity=28.5353535353535, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1786991, Length=327, Percent_Identity=29.9694189602446, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786349, Length=346, Percent_Identity=31.7919075144509, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25144271, Length=375, Percent_Identity=28.5333333333333, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI25144274, Length=259, Percent_Identity=31.6602316602317, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI32564660, Length=427, Percent_Identity=27.4004683840749, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71992977, Length=399, Percent_Identity=24.812030075188, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17541228, Length=426, Percent_Identity=24.1784037558685, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323470, Length=401, Percent_Identity=31.6708229426434, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324432, Length=380, Percent_Identity=27.6315789473684, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6324386, Length=308, Percent_Identity=22.7272727272727, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357415, Length=372, Percent_Identity=32.5268817204301, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI28574759, Length=424, Percent_Identity=29.0094339622642, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI161085790, Length=425, Percent_Identity=28.4705882352941, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI21356575, Length=413, Percent_Identity=27.3607748184019, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI281366494, Length=353, Percent_Identity=23.7960339943343, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24667139, Length=353, Percent_Identity=23.7960339943343, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24667143, Length=353, Percent_Identity=23.7960339943343, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR017747
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.82 [H]

Molecular weight: Translated: 45073; Mature: 44942

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTASPQAPSAAHIARIYKTHLSGGRATLGDIFGGHIETSSDGAWLTTAEGTRFLNAGG
CCCCCCCCCCCHHHHHHHHHHHCCCCCEEHHHHCCCCEEECCCCCEEEECCCCEEEECCC
YGVALAGYRHPVVVDHIRRQLDQHPVASRMFYEPAAAEAAAALAAVTPKGLDRIHFACSG
CEEEECCCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHCCCCCCHHEEEEECC
AEATEAAMKLARLNGCRRFISMTGGYHGKTLGALSLTAREVFQAPFRPLLPGVSHVPYGD
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCCH
LAALRTELAMSTARACVIVEPVQGEAGVIIPPDGYLAGLRAVCDEYGALLVADEIQTGLG
HHHHHHHHHHHHCCEEEEEEECCCCCCEEECCCCHHHHHHHHHHHHCCEEEEHHHHHHHH
RLGQWWGVDRERVIPDILLSGKMLGGGVMPVSAAITTTECFRQLDRDPYLHTSTFSTSPL
HHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCC
GMAAVSGALRVIAEERLVERAAELGQILLDRISSASAQWFGPDQVQVRGQGLLIGIEFTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEEEECC
ASIVGDLLIELISNNIIVNHSLNSDHVLRLTPPAVITDDDVEFLVQGYLNAIEQVAIRAK
HHHHHHHHHHHHHCCEEEEECCCCCCEEEECCCCEECCCHHHHHHHHHHHHHHHHHHHHH
AALPG
HCCCC
>Mature Secondary Structure 
SVTASPQAPSAAHIARIYKTHLSGGRATLGDIFGGHIETSSDGAWLTTAEGTRFLNAGG
CCCCCCCCCCHHHHHHHHHHHCCCCCEEHHHHCCCCEEECCCCCEEEECCCCEEEECCC
YGVALAGYRHPVVVDHIRRQLDQHPVASRMFYEPAAAEAAAALAAVTPKGLDRIHFACSG
CEEEECCCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHCCCCCCHHEEEEECC
AEATEAAMKLARLNGCRRFISMTGGYHGKTLGALSLTAREVFQAPFRPLLPGVSHVPYGD
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCCH
LAALRTELAMSTARACVIVEPVQGEAGVIIPPDGYLAGLRAVCDEYGALLVADEIQTGLG
HHHHHHHHHHHHCCEEEEEEECCCCCCEEECCCCHHHHHHHHHHHHCCEEEEHHHHHHHH
RLGQWWGVDRERVIPDILLSGKMLGGGVMPVSAAITTTECFRQLDRDPYLHTSTFSTSPL
HHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCC
GMAAVSGALRVIAEERLVERAAELGQILLDRISSASAQWFGPDQVQVRGQGLLIGIEFTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEEEECC
ASIVGDLLIELISNNIIVNHSLNSDHVLRLTPPAVITDDDVEFLVQGYLNAIEQVAIRAK
HHHHHHHHHHHHHCCEEEEECCCCCCEEEECCCCEECCCHHHHHHHHHHHHHHHHHHHHH
AALPG
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA