Click here to switch to the map view.

The map label for this gene is prcB

Identifier: 169629258

GI number: 169629258

Start: 2186669

End: 2187547

Strand: Direct

Name: prcB

Synonym: MAB_2172

Alternate gene names: 169629258

Gene position: 2186669-2187547 (Clockwise)

Preceding gene: 169629257

Following gene: 169629259

Centisome position: 43.15

GC content: 65.3

Gene sequence:

>879_bases
GTGATCTGGCGCGACGACGCGATCGCCAGCCAGCCCGCCGGACAGCACTTCCGCAATTCGCACCTTTCCTCGTTCTCGGA
GTATCTGAGGGCCCAGGCCCCAGAGTTGCTTCCGGCGCTGGGGAAGGCGTCTGCTGACGTGATCGGGAACTTGCCCCATG
GCACCACCATTGTCGCGCTCACCTACCGCGGTGGGGTGCTGATCGCGGGCGATCGGCGCGCTACCCAGGGCAACTACATC
GCCAACCGCGACATCGACAAGGTGCAGATCACCGACAACTACTCGGCGACCGGTATCGCGGGAACCGCCGCTATCGCGGT
CGAATTCGCACGGCTCTACGCCGTGGAATTGGAGCACTACGAGAAGCTGGAAGGGGTGCAGCTGACCTTCAACGGCAAGG
CCAACCGGCTCTCGGCACTGGTGCGCGGCAATCTCGCGGCGGCCATGCAAGGCTTGGTGGCAGTGCCGCTGTTGGTGGGC
TACGACCTCGACGATCCCAACGGGGAAACCGCTGGCCGCATCGTGTCTTTCGACGTCGCCGGTGGTTGGCATGTGGAGAG
CGACGGCTATCAGGCGGTGGGTTCGGGCTCGGTCTTTGCGAAGTCGTCCATCAAGAAGCTGTACAGGCCCGGCGGCGATG
CGCTGACCGCGCTCGCGGTCGCGGTAGAGGCGCTTTACGATGCCGCCGACGATGATTCGGCAACGGGCGGGCCGGATCTG
GTGCGCCGGGTGTTCCCCACGGCCATTCGGATCGACTCCGGGGGAGCGGTTCGCGTCCCCGAGGCCGATATCGAGAGGAT
CGCGCGCGAAGTCATCGCGAAGCGGACCGAGGCGGCACGGGAAGAAGCTGACTTGCGTGAATCGGGTGGTGACTCATGA

Upstream 100 bases:

>100_bases
AGCTGGCGGAGGACACTGACGATCTGCTCGATGAGATCGACGATGTGCTGGAAGAGAACGCCGAGGACTTCGTGCGGGCG
TACGTCCAAAAGGGTGGCCA

Downstream 100 bases:

>100_bases
CCTTTCCGTACTACGCCTCGGTCGAGCAGCTCATGCGCGACCGTTCGGAATTGGCGCGCAAGGGCATCAGCCGGGGCCGT
TCGGTAGTGGCACTGACCTA

Product: proteasome (beta subunit) PrcB

Products: NA

Alternate protein names: 20S proteasome beta subunit; Proteasome core protein PrcB

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MIWRDDAIASQPAGQHFRNSHLSSFSEYLRAQAPELLPALGKASADVIGNLPHGTTIVALTYRGGVLIAGDRRATQGNYI
ANRDIDKVQITDNYSATGIAGTAAIAVEFARLYAVELEHYEKLEGVQLTFNGKANRLSALVRGNLAAAMQGLVAVPLLVG
YDLDDPNGETAGRIVSFDVAGGWHVESDGYQAVGSGSVFAKSSIKKLYRPGGDALTALAVAVEALYDAADDDSATGGPDL
VRRVFPTAIRIDSGGAVRVPEADIERIAREVIAKRTEAAREEADLRESGGDS

Sequences:

>Translated_292_residues
MIWRDDAIASQPAGQHFRNSHLSSFSEYLRAQAPELLPALGKASADVIGNLPHGTTIVALTYRGGVLIAGDRRATQGNYI
ANRDIDKVQITDNYSATGIAGTAAIAVEFARLYAVELEHYEKLEGVQLTFNGKANRLSALVRGNLAAAMQGLVAVPLLVG
YDLDDPNGETAGRIVSFDVAGGWHVESDGYQAVGSGSVFAKSSIKKLYRPGGDALTALAVAVEALYDAADDDSATGGPDL
VRRVFPTAIRIDSGGAVRVPEADIERIAREVIAKRTEAAREEADLRESGGDS
>Mature_292_residues
MIWRDDAIASQPAGQHFRNSHLSSFSEYLRAQAPELLPALGKASADVIGNLPHGTTIVALTYRGGVLIAGDRRATQGNYI
ANRDIDKVQITDNYSATGIAGTAAIAVEFARLYAVELEHYEKLEGVQLTFNGKANRLSALVRGNLAAAMQGLVAVPLLVG
YDLDDPNGETAGRIVSFDVAGGWHVESDGYQAVGSGSVFAKSSIKKLYRPGGDALTALAVAVEALYDAADDDSATGGPDL
VRRVFPTAIRIDSGGAVRVPEADIERIAREVIAKRTEAAREEADLRESGGDS

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1B family

Homologues:

Organism=Homo sapiens, GI4506201, Length=191, Percent_Identity=29.3193717277487, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI20130281, Length=243, Percent_Identity=27.5720164609054, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSB_MYCA9 (B1MAI2)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001702907.1
- ProteinModelPortal:   B1MAI2
- SMR:   B1MAI2
- MEROPS:   T01.005
- EnsemblBacteria:   EBMYCT00000006915
- GeneID:   5964685
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_2172
- GeneTree:   EBGT00050000016799
- HOGENOM:   HBG322409
- OMA:   FQVELEH
- GO:   GO:0005737
- HAMAP:   MF_02113_B
- InterPro:   IPR022483
- InterPro:   IPR001353
- TIGRFAMs:   TIGR03690

Pfam domain/function: PF00227 Proteasome

EC number: =3.4.25.1

Molecular weight: Translated: 30881; Mature: 30881

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00854 PROTEASOME_B_1; PS51476 PROTEASOME_B_2

Important sites: ACT_SITE 55-55

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIWRDDAIASQPAGQHFRNSHLSSFSEYLRAQAPELLPALGKASADVIGNLPHGTTIVAL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHCCCCCCCEEEEE
TYRGGVLIAGDRRATQGNYIANRDIDKVQITDNYSATGIAGTAAIAVEFARLYAVELEHY
EECCCEEEECCCCCCCCCEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EKLEGVQLTFNGKANRLSALVRGNLAAAMQGLVAVPLLVGYDLDDPNGETAGRIVSFDVA
HHCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECC
GGWHVESDGYQAVGSGSVFAKSSIKKLYRPGGDALTALAVAVEALYDAADDDSATGGPDL
CCEEECCCCCEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHH
VRRVFPTAIRIDSGGAVRVPEADIERIAREVIAKRTEAAREEADLRESGGDS
HHHHCCCEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIWRDDAIASQPAGQHFRNSHLSSFSEYLRAQAPELLPALGKASADVIGNLPHGTTIVAL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHCCCCCCCEEEEE
TYRGGVLIAGDRRATQGNYIANRDIDKVQITDNYSATGIAGTAAIAVEFARLYAVELEHY
EECCCEEEECCCCCCCCCEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EKLEGVQLTFNGKANRLSALVRGNLAAAMQGLVAVPLLVGYDLDDPNGETAGRIVSFDVA
HHCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECC
GGWHVESDGYQAVGSGSVFAKSSIKKLYRPGGDALTALAVAVEALYDAADDDSATGGPDL
CCEEECCCCCEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHH
VRRVFPTAIRIDSGGAVRVPEADIERIAREVIAKRTEAAREEADLRESGGDS
HHHHCCCEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA