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The map label for this gene is hisG [H]

Identifier: 169629218

GI number: 169629218

Start: 2144529

End: 2145398

Strand: Direct

Name: hisG [H]

Synonym: MAB_2132

Alternate gene names: 169629218

Gene position: 2144529-2145398 (Clockwise)

Preceding gene: 169629217

Following gene: 169629219

Centisome position: 42.32

GC content: 65.86

Gene sequence:

>870_bases
ATGACCAGTACCAACGGTGCTCTGCGCGTCGCGGTCCCCAACAAGGGGGCGCTCAGTGAAGCCGCATCGGAAATCCTGTC
CGAGGCGGGCTATCGGCGGCGTGGTGACGCCAAGGACCTAACCGTGCTCGACCCGCAGAACGACGTCGAGTTCTTCTTCT
TGAGGCCCAAGGACATAGCCATCTATGTCGGTTCGGGTGAGCTTGATCTCGGCATCACCGGCCGCGATCTCATGATGGAC
TCCGATGCGCCGGTGACCGAGCGGCTCGCGCTGGGATTCGGGGGCTCGACCTTCCGGTACGCCGCGCCCGCAGGGCGGGA
CTGGACGATCTACGACATCGCGGGAAAGAGAATCGCCACCGCGTACCCCAACTTGGTCCGAAAGGATCTGGCCGCCAAAG
GCATCGAAGCCGAGGTCATCCGGCTGGACGGTGCCGTCGAGATTTCCATCCAGCTCGGGGTGGCCGATGTGATCGCCGAT
ATCGTCGGCACCGGCCGCACCCTGCGCCAGCATGGGCTGGTTGCCTTCGGTGAGTCGTTGTGCGATTCGGAGGCGGTGCT
GATCGAGCGGGAGAACGCCGATCCGGCAACGGAATCGGCTCGTACACAGCTGACGACGCGTATCCAGGGGGTGGTGTTCG
GCCAGCAGTACCTCATGCTCGACTACGACTGCCCGCGCGCGGTCCTGGACGAGGCTCTTAAGGTGACGCCGGGCCTGGAG
TCGCCGACGTTGGCACCGCTGGCAGACGAGGCATGGGTGGCGGTCCGCGCCCTCGCCCCGCGCAAGGGCGTCAACACCAC
CATGGACGCGCTGGCCGCCATCGGCGCCAAGGCCATCCTTGCCTCGGAGGTCCGCTTCTTCCGGGCGTAG

Upstream 100 bases:

>100_bases
GAATCGCTTGCCGAAGAGGTGAGCCAGTTGCTCTATTGGGCGCAGGTGCTGCTGATCGCGCGCGGCCTCACCCTCGACGA
CGTCTACCGAAAGCTCTGAG

Downstream 100 bases:

>100_bases
TTTTCATTCGTGAACAGACGCCTGGTGCGGGGCATCTTGGCGTTTTGGTGCACTAAGCGTCTGCTCGGCAATACGATGGC
GCTATGGCGTTGCAGGTCCT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MTSTNGALRVAVPNKGALSEAASEILSEAGYRRRGDAKDLTVLDPQNDVEFFFLRPKDIAIYVGSGELDLGITGRDLMMD
SDAPVTERLALGFGGSTFRYAAPAGRDWTIYDIAGKRIATAYPNLVRKDLAAKGIEAEVIRLDGAVEISIQLGVADVIAD
IVGTGRTLRQHGLVAFGESLCDSEAVLIERENADPATESARTQLTTRIQGVVFGQQYLMLDYDCPRAVLDEALKVTPGLE
SPTLAPLADEAWVAVRALAPRKGVNTTMDALAAIGAKAILASEVRFFRA

Sequences:

>Translated_289_residues
MTSTNGALRVAVPNKGALSEAASEILSEAGYRRRGDAKDLTVLDPQNDVEFFFLRPKDIAIYVGSGELDLGITGRDLMMD
SDAPVTERLALGFGGSTFRYAAPAGRDWTIYDIAGKRIATAYPNLVRKDLAAKGIEAEVIRLDGAVEISIQLGVADVIAD
IVGTGRTLRQHGLVAFGESLCDSEAVLIERENADPATESARTQLTTRIQGVVFGQQYLMLDYDCPRAVLDEALKVTPGLE
SPTLAPLADEAWVAVRALAPRKGVNTTMDALAAIGAKAILASEVRFFRA
>Mature_288_residues
TSTNGALRVAVPNKGALSEAASEILSEAGYRRRGDAKDLTVLDPQNDVEFFFLRPKDIAIYVGSGELDLGITGRDLMMDS
DAPVTERLALGFGGSTFRYAAPAGRDWTIYDIAGKRIATAYPNLVRKDLAAKGIEAEVIRLDGAVEISIQLGVADVIADI
VGTGRTLRQHGLVAFGESLCDSEAVLIERENADPATESARTQLTTRIQGVVFGQQYLMLDYDCPRAVLDEALKVTPGLES
PTLAPLADEAWVAVRALAPRKGVNTTMDALAAIGAKAILASEVRFFRA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=293, Percent_Identity=33.1058020477816, Blast_Score=134, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6320896, Length=288, Percent_Identity=33.6805555555556, Blast_Score=138, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 30913; Mature: 30781

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTNGALRVAVPNKGALSEAASEILSEAGYRRRGDAKDLTVLDPQNDVEFFFLRPKDIA
CCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCEEEEECCCEEE
IYVGSGELDLGITGRDLMMDSDAPVTERLALGFGGSTFRYAAPAGRDWTIYDIAGKRIAT
EEEECCCEEEEECCCCEEECCCCCHHHHHEECCCCCCEEEECCCCCCEEEEECCCCEEEH
AYPNLVRKDLAAKGIEAEVIRLDGAVEISIQLGVADVIADIVGTGRTLRQHGLVAFGESL
HHHHHHHHHHHHCCCCEEEEEECCEEEEEEEECHHHHHHHHHCCCHHHHHCCHHHHHHHH
CDSEAVLIERENADPATESARTQLTTRIQGVVFGQQYLMLDYDCPRAVLDEALKVTPGLE
CCCCEEEEEECCCCCCHHHHHHHHHHHHEEEEECCEEEEEECCCCHHHHHHHHCCCCCCC
SPTLAPLADEAWVAVRALAPRKGVNTTMDALAAIGAKAILASEVRFFRA
CCCCCCCCCCHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSTNGALRVAVPNKGALSEAASEILSEAGYRRRGDAKDLTVLDPQNDVEFFFLRPKDIA
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCEEEEECCCEEE
IYVGSGELDLGITGRDLMMDSDAPVTERLALGFGGSTFRYAAPAGRDWTIYDIAGKRIAT
EEEECCCEEEEECCCCEEECCCCCHHHHHEECCCCCCEEEECCCCCCEEEEECCCCEEEH
AYPNLVRKDLAAKGIEAEVIRLDGAVEISIQLGVADVIADIVGTGRTLRQHGLVAFGESL
HHHHHHHHHHHHCCCCEEEEEECCEEEEEEEECHHHHHHHHHCCCHHHHHCCHHHHHHHH
CDSEAVLIERENADPATESARTQLTTRIQGVVFGQQYLMLDYDCPRAVLDEALKVTPGLE
CCCCEEEEEECCCCCCHHHHHHHHHHHHEEEEECCEEEEEECCCCHHHHHHHHCCCCCCC
SPTLAPLADEAWVAVRALAPRKGVNTTMDALAAIGAKAILASEVRFFRA
CCCCCCCCCCHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA