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The map label for this gene is ddc [H]

Identifier: 169628775

GI number: 169628775

Start: 1712042

End: 1713562

Strand: Direct

Name: ddc [H]

Synonym: MAB_1685

Alternate gene names: 169628775

Gene position: 1712042-1713562 (Clockwise)

Preceding gene: 169628774

Following gene: 169628776

Centisome position: 33.79

GC content: 67.06

Gene sequence:

>1521_bases
GTGACGGCCCATCAGAGTCCCTTCGTGCAGAGTCCCTTCGTGAGCGACTTTCTCACGGGCGACAGCGCGCACACGTACCG
CGAGGCCGTCGCGCTGGCGGCCGAACGGGCAAGTGTCACACTGGGCGGGGCCACCGCACCGGGACTGGTGGACGGCTATT
CCGCGCTCAAACGCGATGCCGAGCGGCTCGATCTCGACGATCCCGATGGGGTGGGGCTGAGCCGGGCACTGGACGAGGCT
ACGGGGTTGCTCGCCGAGAAATCAGTGGTGGTAACCCATCCCGCATACCTGGCGCACCTACATTGCCCACCCGCATTGCC
GTCGCTCGCCGCCGAGGTGCTGATCAGTGCGTTCAATCAATCGATGGACTCGTTTGACCAGGCGCCGGCCGCCACCGCGA
TCGAACAGCAGGTAGTGGAATACTTGTGCACCAGAATGGGTTACGGCCGCGAGTCGGACGGTACCTTCACCAGCGGAGGT
ACCCAGTCGAATCTGCAGGCGCTGCTGCTGGCGCGGGACCTGTTCGCGCGCAAGGCCGGATGGGATATCGCGGGCCTGGG
GCTGCCGCCCGAGTCCGGTACCTGGCGGGTGCTGTGCACCCGGCAGACACACTTCTCGGTGCAGCAGGCACTCCGGCTAC
TCGGACTGGGCACCTCCGCCATCATCGAGGTACCCACCGATGATGCGGGGCGGTTGCGGGCCGAGACGCTCGCCGGAATC
TTGCGGGACGCCGATCATGCGGGCACACCGGTGTTCGCGCTGGTGCTCACTGCCGGGACAACGGATTTCGGAGCGATTGA
CCCGCTCGAGGAAGCCACCGCGATTGCCCGGTCACACGGCATCTGGGTACACGTGGATGCCTGCGCGGGTGGCTGCCTGA
TCTTCAGCGCTCAGCACCGGCAGTTGCTGCGTGGTATCGAACAGGCCGACTCGGTCGCCATCGACTTCCACAAGCTGCTG
TTTCAGGCGATCAGTTGCAGCGCGCTGCTGGTGCGCAATCGGGAGAGCTTCGGCGTGCTTGCCGCGCACGCGGATTACCT
GAATCCCGCCAGCGACGCCGAGCACGATGTGCTGAATCTGGTCGGCAACTCGCTGCAGACCACCCGGCGTTTCGATGCGC
TCAAGGTGCTGGTCACGCTGCGGGCCGTGGGGCAGCGTCAGGTGGCCGCGATGATCGATGCCACTGTCGCTGCGGCGGCG
GCCGCGGCCCAGGTGGCTGCCGAGCATCCCGACCTGGAACTGGTGGCGCCGGTATGCACCAACACGGTGGTGCTGCGCTG
GCGGCGACCGGAGGCCACGCGCGACGCGCGTGACGACGTCAACGACGCGGTCCGCGCCGAGCTTGCCCACAGCGGTAGGG
CGATCGTGGGCCGGTCCGGTGCGGCCGGGGCGCAGGCGATCAAACTGACGTTCGTCAATCCTCTGGTCACGACCTCGATG
GCGGGCGCGATGGTCTCCGACATTGCCGCCCATGGCAACCGGATCTGGCGTGCGCGCACACCGGAGGTCAGTGCCGTATG
A

Upstream 100 bases:

>100_bases
ACGTGGTGCGGTTCCTGCCGCCACTGACGATCGACGAGCCGGATATCGCCGCTGCGCTCAACGCGTTTGACGCCGCACTC
AGTGCGGTGGAGCGCACGCG

Downstream 100 bases:

>100_bases
GCAACAACCTGGCGCGCGTCGAGCGCGTTGCGGCATCCGATGCTCGCTTCGCCTGGGCCAAGAACATCGAGTTCGCGATC
TTCGGGTTGGAGAACGACTT

Product: putative decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MTAHQSPFVQSPFVSDFLTGDSAHTYREAVALAAERASVTLGGATAPGLVDGYSALKRDAERLDLDDPDGVGLSRALDEA
TGLLAEKSVVVTHPAYLAHLHCPPALPSLAAEVLISAFNQSMDSFDQAPAATAIEQQVVEYLCTRMGYGRESDGTFTSGG
TQSNLQALLLARDLFARKAGWDIAGLGLPPESGTWRVLCTRQTHFSVQQALRLLGLGTSAIIEVPTDDAGRLRAETLAGI
LRDADHAGTPVFALVLTAGTTDFGAIDPLEEATAIARSHGIWVHVDACAGGCLIFSAQHRQLLRGIEQADSVAIDFHKLL
FQAISCSALLVRNRESFGVLAAHADYLNPASDAEHDVLNLVGNSLQTTRRFDALKVLVTLRAVGQRQVAAMIDATVAAAA
AAAQVAAEHPDLELVAPVCTNTVVLRWRRPEATRDARDDVNDAVRAELAHSGRAIVGRSGAAGAQAIKLTFVNPLVTTSM
AGAMVSDIAAHGNRIWRARTPEVSAV

Sequences:

>Translated_506_residues
MTAHQSPFVQSPFVSDFLTGDSAHTYREAVALAAERASVTLGGATAPGLVDGYSALKRDAERLDLDDPDGVGLSRALDEA
TGLLAEKSVVVTHPAYLAHLHCPPALPSLAAEVLISAFNQSMDSFDQAPAATAIEQQVVEYLCTRMGYGRESDGTFTSGG
TQSNLQALLLARDLFARKAGWDIAGLGLPPESGTWRVLCTRQTHFSVQQALRLLGLGTSAIIEVPTDDAGRLRAETLAGI
LRDADHAGTPVFALVLTAGTTDFGAIDPLEEATAIARSHGIWVHVDACAGGCLIFSAQHRQLLRGIEQADSVAIDFHKLL
FQAISCSALLVRNRESFGVLAAHADYLNPASDAEHDVLNLVGNSLQTTRRFDALKVLVTLRAVGQRQVAAMIDATVAAAA
AAAQVAAEHPDLELVAPVCTNTVVLRWRRPEATRDARDDVNDAVRAELAHSGRAIVGRSGAAGAQAIKLTFVNPLVTTSM
AGAMVSDIAAHGNRIWRARTPEVSAV
>Mature_505_residues
TAHQSPFVQSPFVSDFLTGDSAHTYREAVALAAERASVTLGGATAPGLVDGYSALKRDAERLDLDDPDGVGLSRALDEAT
GLLAEKSVVVTHPAYLAHLHCPPALPSLAAEVLISAFNQSMDSFDQAPAATAIEQQVVEYLCTRMGYGRESDGTFTSGGT
QSNLQALLLARDLFARKAGWDIAGLGLPPESGTWRVLCTRQTHFSVQQALRLLGLGTSAIIEVPTDDAGRLRAETLAGIL
RDADHAGTPVFALVLTAGTTDFGAIDPLEEATAIARSHGIWVHVDACAGGCLIFSAQHRQLLRGIEQADSVAIDFHKLLF
QAISCSALLVRNRESFGVLAAHADYLNPASDAEHDVLNLVGNSLQTTRRFDALKVLVTLRAVGQRQVAAMIDATVAAAAA
AAQVAAEHPDLELVAPVCTNTVVLRWRRPEATRDARDDVNDAVRAELAHSGRAIVGRSGAAGAQAIKLTFVNPLVTTSMA
GAMVSDIAAHGNRIWRARTPEVSAV

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197383062, Length=431, Percent_Identity=29.9303944315545, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI194294551, Length=356, Percent_Identity=32.3033707865169, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI58331246, Length=416, Percent_Identity=27.4038461538462, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI197276620, Length=425, Percent_Identity=28, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI4503875, Length=425, Percent_Identity=28, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI4503281, Length=371, Percent_Identity=25.6064690026954, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI132814448, Length=371, Percent_Identity=25.6064690026954, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI92110055, Length=405, Percent_Identity=25.679012345679, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71993062, Length=378, Percent_Identity=29.3650793650794, Blast_Score=151, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17555682, Length=378, Percent_Identity=29.3650793650794, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71993058, Length=328, Percent_Identity=31.7073170731707, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17534817, Length=380, Percent_Identity=25, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17534819, Length=380, Percent_Identity=25, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71981211, Length=437, Percent_Identity=20.3661327231121, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI133931025, Length=311, Percent_Identity=24.7588424437299, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71981217, Length=270, Percent_Identity=25.1851851851852, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356415, Length=409, Percent_Identity=29.0953545232274, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI17136594, Length=353, Percent_Identity=27.7620396600567, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24657193, Length=415, Percent_Identity=28.9156626506024, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24657185, Length=415, Percent_Identity=28.9156626506024, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24657188, Length=415, Percent_Identity=28.9156626506024, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24652373, Length=405, Percent_Identity=26.6666666666667, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24585139, Length=358, Percent_Identity=26.536312849162, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI221476190, Length=358, Percent_Identity=26.536312849162, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24585143, Length=358, Percent_Identity=26.536312849162, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI28573972, Length=395, Percent_Identity=25.5696202531646, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136190, Length=345, Percent_Identity=24.9275362318841, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24586044, Length=373, Percent_Identity=25.7372654155496, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585135, Length=207, Percent_Identity=27.536231884058, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 53449; Mature: 53318

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAHQSPFVQSPFVSDFLTGDSAHTYREAVALAAERASVTLGGATAPGLVDGYSALKRDA
CCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHH
ERLDLDDPDGVGLSRALDEATGLLAEKSVVVTHPAYLAHLHCPPALPSLAAEVLISAFNQ
HHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCHHEEEECCCCCHHHHHHHHHHHHHHH
SMDSFDQAPAATAIEQQVVEYLCTRMGYGRESDGTFTSGGTQSNLQALLLARDLFARKAG
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
WDIAGLGLPPESGTWRVLCTRQTHFSVQQALRLLGLGTSAIIEVPTDDAGRLRAETLAGI
CCEEECCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHH
LRDADHAGTPVFALVLTAGTTDFGAIDPLEEATAIARSHGIWVHVDACAGGCLIFSAQHR
HHCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCEEEEEHHHH
QLLRGIEQADSVAIDFHKLLFQAISCSALLVRNRESFGVLAAHADYLNPASDAEHDVLNL
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCCEEEECHHHCCCCCCCHHHHHHH
VGNSLQTTRRFDALKVLVTLRAVGQRQVAAMIDATVAAAAAAAQVAAEHPDLELVAPVCT
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHC
NTVVLRWRRPEATRDARDDVNDAVRAELAHSGRAIVGRSGAAGAQAIKLTFVNPLVTTSM
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEECHHHHHHH
AGAMVSDIAAHGNRIWRARTPEVSAV
HHHHHHHHHHCCCEEEEECCCCCCCC
>Mature Secondary Structure 
TAHQSPFVQSPFVSDFLTGDSAHTYREAVALAAERASVTLGGATAPGLVDGYSALKRDA
CCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHH
ERLDLDDPDGVGLSRALDEATGLLAEKSVVVTHPAYLAHLHCPPALPSLAAEVLISAFNQ
HHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCHHEEEECCCCCHHHHHHHHHHHHHHH
SMDSFDQAPAATAIEQQVVEYLCTRMGYGRESDGTFTSGGTQSNLQALLLARDLFARKAG
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
WDIAGLGLPPESGTWRVLCTRQTHFSVQQALRLLGLGTSAIIEVPTDDAGRLRAETLAGI
CCEEECCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHH
LRDADHAGTPVFALVLTAGTTDFGAIDPLEEATAIARSHGIWVHVDACAGGCLIFSAQHR
HHCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCEEEEEHHHH
QLLRGIEQADSVAIDFHKLLFQAISCSALLVRNRESFGVLAAHADYLNPASDAEHDVLNL
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCCEEEECHHHCCCCCCCHHHHHHH
VGNSLQTTRRFDALKVLVTLRAVGQRQVAAMIDATVAAAAAAAQVAAEHPDLELVAPVCT
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHC
NTVVLRWRRPEATRDARDDVNDAVRAELAHSGRAIVGRSGAAGAQAIKLTFVNPLVTTSM
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEECHHHHHHH
AGAMVSDIAAHGNRIWRARTPEVSAV
HHHHHHHHHHCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]