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The map label for this gene is comEC [H]

Identifier: 169628717

GI number: 169628717

Start: 1655804

End: 1657321

Strand: Direct

Name: comEC [H]

Synonym: MAB_1627

Alternate gene names: 169628717

Gene position: 1655804-1657321 (Clockwise)

Preceding gene: 169628716

Following gene: 169628723

Centisome position: 32.68

GC content: 68.25

Gene sequence:

>1518_bases
GTGACGTCGGCGGGTGCTGATGAGCCAGTACTGGATCTCCGGTTGGTGCCGCCCGCGCTCGCCGCCTGGGCTGCAACTGC
TACTGGAATTCTCTGGCCGACAGGCTATTTCACGGCAGCGGCGTTGGGCATAGGCGCGATCTGGGTGCGGCTGAGCCGGC
GTCGATGGAACGGGGCGGTTGCCGCCGCGGTGGCGAGCATCCTCATCGCGGGGATGGGATTCTCGGTGGCTGCCGCGATA
CGGCACCATGGGGTGCAGAACCATCCCCTGCGATCCCGGGTGGGGCAGATCGTCACGGCGCAGCTGCGGGTGACCGACGA
TCCGAGGAGCGTCACGGGCGGTCGCGCGATGATGCGCGCCGACCTGGTCGGTTTGGGTGATCCGGTGCAGGGGATGACAG
GTGCGGTGCTGGTTTTCGGATCCTCCTCTCTGCTGGGCCGGGTCGCGGTCGGTGACACGGTGCGGGCGCGCGCGGCCGTT
GCCCGCCCCGGTCGCCGTGACTTGACGGTGGCAACGCTCACTGTGGTGGCGGAGCCCTCGATCTTCGGGCATTCGCCGAT
TCATGGTGTGGCCAACGGTATTCGTGATCGTTTTGTCGACGTTTCTCGAAACGCGCTGCCGGCCGGCGAGGCCGCGCTAC
TACCGGGCCTGGTGCTGGGGGACACCAGCGCGCTCGACGCGCAGACGGTGGCGATGTTTCGTACGTCCGGGCTCACGCAT
CTGATGGCGGTCTCGGGGGCCAACGTATCCATCGTGTGCGGGGCGGTGCTGCTGCTGGGCCGGCTGATCGGCCTGCGGAC
CTCGGTGGTGTTGGCGGGGTTGGTGCTTGTGGGCTTCGTCATTCTGGTGCGGCCATCGCCGAGCGTACTGCGAGCCGCGG
TGATGGGTGCGATCGGTCTGCTGGGCGTGCTGACGGCACGCCGCCGTCAAGCCATACCTGCCTTGGCCGCAACAATTTTG
GTCCTCCTCGCGGTATCGCCGGGGCTGGCCGTCGACATCGGCTTCGCGTTGTCGGTGGTGGCCACCGCGGCTCTGGTGGT
GTTGGCGCCGCGCTGGTCGATGCGCCTGACGGCGCGGGGCTGGCCCAAGCCGCTGGCCGATGCGCTGTGCGTCGCGGTCG
CCGCCCAGCTGGTGACCGCGCCTGTGATCGCGGCGATCTCGGGCAGCGTAAGCATGGCCTCGATAGCGGCCAATGTGCTC
GCGGGGCTGGTGATCGTGCCCATTACCGTGCTCGGTACCGCGGCCGCGGCTCTCACGGTCGTCTCACCGCAGGTGGCCGG
GCTGCTGGCGAGGTTTTGCGGGCCCGAATTGTGGTGGCTGCTGCGGGTCGCCGATTACGCGTCCGCAGGTGGTACAACAG
CGATTCCGGTGCCCGCCGGCGTGCTCGGCTTCGCTGTTGTAGCTGTGCTGCTTGGTATTGCGGTGTGGTTGTGGCGCCGG
CGGTGGTTCCGTGGGCTTGTCTGGACCGGGGTGCTGTGTGCGCTTGCGCTGATGATTTCGGCGAGAGTGGTGAGCTAG

Upstream 100 bases:

>100_bases
GGCGATCCGAGCACGGGAAGTTCACCAGCATCGACCAGCTCGCGGAGGTGGACGGGATCGGTCCCTCGCGGCTGGACAAG
TTGCGCGATTTCGTGGTGTT

Downstream 100 bases:

>100_bases
CCGGGCTACACCCCGGACAGGGTGAGTTGGCGCTGAGGCGCGGGCGCCGTGGAAGTTTCATGACGGCGCCAGCAGTGGCG
AAGCACGCGCAGCACGAACG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MTSAGADEPVLDLRLVPPALAAWAATATGILWPTGYFTAAALGIGAIWVRLSRRRWNGAVAAAVASILIAGMGFSVAAAI
RHHGVQNHPLRSRVGQIVTAQLRVTDDPRSVTGGRAMMRADLVGLGDPVQGMTGAVLVFGSSSLLGRVAVGDTVRARAAV
ARPGRRDLTVATLTVVAEPSIFGHSPIHGVANGIRDRFVDVSRNALPAGEAALLPGLVLGDTSALDAQTVAMFRTSGLTH
LMAVSGANVSIVCGAVLLLGRLIGLRTSVVLAGLVLVGFVILVRPSPSVLRAAVMGAIGLLGVLTARRRQAIPALAATIL
VLLAVSPGLAVDIGFALSVVATAALVVLAPRWSMRLTARGWPKPLADALCVAVAAQLVTAPVIAAISGSVSMASIAANVL
AGLVIVPITVLGTAAAALTVVSPQVAGLLARFCGPELWWLLRVADYASAGGTTAIPVPAGVLGFAVVAVLLGIAVWLWRR
RWFRGLVWTGVLCALALMISARVVS

Sequences:

>Translated_505_residues
MTSAGADEPVLDLRLVPPALAAWAATATGILWPTGYFTAAALGIGAIWVRLSRRRWNGAVAAAVASILIAGMGFSVAAAI
RHHGVQNHPLRSRVGQIVTAQLRVTDDPRSVTGGRAMMRADLVGLGDPVQGMTGAVLVFGSSSLLGRVAVGDTVRARAAV
ARPGRRDLTVATLTVVAEPSIFGHSPIHGVANGIRDRFVDVSRNALPAGEAALLPGLVLGDTSALDAQTVAMFRTSGLTH
LMAVSGANVSIVCGAVLLLGRLIGLRTSVVLAGLVLVGFVILVRPSPSVLRAAVMGAIGLLGVLTARRRQAIPALAATIL
VLLAVSPGLAVDIGFALSVVATAALVVLAPRWSMRLTARGWPKPLADALCVAVAAQLVTAPVIAAISGSVSMASIAANVL
AGLVIVPITVLGTAAAALTVVSPQVAGLLARFCGPELWWLLRVADYASAGGTTAIPVPAGVLGFAVVAVLLGIAVWLWRR
RWFRGLVWTGVLCALALMISARVVS
>Mature_504_residues
TSAGADEPVLDLRLVPPALAAWAATATGILWPTGYFTAAALGIGAIWVRLSRRRWNGAVAAAVASILIAGMGFSVAAAIR
HHGVQNHPLRSRVGQIVTAQLRVTDDPRSVTGGRAMMRADLVGLGDPVQGMTGAVLVFGSSSLLGRVAVGDTVRARAAVA
RPGRRDLTVATLTVVAEPSIFGHSPIHGVANGIRDRFVDVSRNALPAGEAALLPGLVLGDTSALDAQTVAMFRTSGLTHL
MAVSGANVSIVCGAVLLLGRLIGLRTSVVLAGLVLVGFVILVRPSPSVLRAAVMGAIGLLGVLTARRRQAIPALAATILV
LLAVSPGLAVDIGFALSVVATAALVVLAPRWSMRLTARGWPKPLADALCVAVAAQLVTAPVIAAISGSVSMASIAANVLA
GLVIVPITVLGTAAAALTVVSPQVAGLLARFCGPELWWLLRVADYASAGGTTAIPVPAGVLGFAVVAVLLGIAVWLWRRR
WFRGLVWTGVLCALALMISARVVS

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 51607; Mature: 51476

Theoretical pI: Translated: 12.20; Mature: 12.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAGADEPVLDLRLVPPALAAWAATATGILWPTGYFTAAALGIGAIWVRLSRRRWNGAV
CCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHH
AAAVASILIAGMGFSVAAAIRHHGVQNHPLRSRVGQIVTAQLRVTDDPRSVTGGRAMMRA
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHEEEEEEECCCCCCCCCCHHHHHH
DLVGLGDPVQGMTGAVLVFGSSSLLGRVAVGDTVRARAAVARPGRRDLTVATLTVVAEPS
HHHCCCCCCCCCCCEEEEECCCHHHEEHHCCCHHHHHHHHCCCCCCCEEEEEEEEEECCC
IFGHSPIHGVANGIRDRFVDVSRNALPAGEAALLPGLVLGDTSALDAQTVAMFRTSGLTH
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEECCCCCCCHHHHHHHHHCCCHH
LMAVSGANVSIVCGAVLLLGRLIGLRTSVVLAGLVLVGFVILVRPSPSVLRAAVMGAIGL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LGVLTARRRQAIPALAATILVLLAVSPGLAVDIGFALSVVATAALVVLAPRWSMRLTARG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCCEEEECCC
WPKPLADALCVAVAAQLVTAPVIAAISGSVSMASIAANVLAGLVIVPITVLGTAAAALTV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSPQVAGLLARFCGPELWWLLRVADYASAGGTTAIPVPAGVLGFAVVAVLLGIAVWLWRR
CCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHH
RWFRGLVWTGVLCALALMISARVVS
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSAGADEPVLDLRLVPPALAAWAATATGILWPTGYFTAAALGIGAIWVRLSRRRWNGAV
CCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHH
AAAVASILIAGMGFSVAAAIRHHGVQNHPLRSRVGQIVTAQLRVTDDPRSVTGGRAMMRA
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHEEEEEEECCCCCCCCCCHHHHHH
DLVGLGDPVQGMTGAVLVFGSSSLLGRVAVGDTVRARAAVARPGRRDLTVATLTVVAEPS
HHHCCCCCCCCCCCEEEEECCCHHHEEHHCCCHHHHHHHHCCCCCCCEEEEEEEEEECCC
IFGHSPIHGVANGIRDRFVDVSRNALPAGEAALLPGLVLGDTSALDAQTVAMFRTSGLTH
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEECCCCCCCHHHHHHHHHCCCHH
LMAVSGANVSIVCGAVLLLGRLIGLRTSVVLAGLVLVGFVILVRPSPSVLRAAVMGAIGL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LGVLTARRRQAIPALAATILVLLAVSPGLAVDIGFALSVVATAALVVLAPRWSMRLTARG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCCCEEEECCC
WPKPLADALCVAVAAQLVTAPVIAAISGSVSMASIAANVLAGLVIVPITVLGTAAAALTV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSPQVAGLLARFCGPELWWLLRVADYASAGGTTAIPVPAGVLGFAVVAVLLGIAVWLWRR
CCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHH
RWFRGLVWTGVLCALALMISARVVS
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]