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The map label for this gene is proA [H]

Identifier: 169628708

GI number: 169628708

Start: 1647810

End: 1649138

Strand: Direct

Name: proA [H]

Synonym: MAB_1618

Alternate gene names: 169628708

Gene position: 1647810-1649138 (Clockwise)

Preceding gene: 169628706

Following gene: 169628709

Centisome position: 32.52

GC content: 68.02

Gene sequence:

>1329_bases
ATGAGCGTTTCAACCAACGAGTTGGCTCCTGGAGCCGCGGGGTCGGCGGCGTCCGCTCCGGTGACCGAAGCGCCTGCGAC
AGCGGACCTGCGCGCGGGCGTTCATGACGCCGCTCGCCGGGCGCGTGTGGCCGCCCGCGACCTGGCCCGTCTGACAGCCG
ATGCGAAGAATTCCGCACTGCTCGCGGCCGCCGACGCGATCGTGGCGTCCACCGATTCGATCATCGCGGCCAATGCCGAC
GATCTGCGGCGCGCGCGGGACGCCGGCATCGGCGAGGCCATGCTCGATCGATTGGCCCTGGACACGGCCCGGGTGGCCGG
TATCGCCGACGGTTTGCGTCAGGTCGCGGGTCTGCCCGATCCGGTCGGCGAGATACTGCGTGGCTCCACCCGTCCCAATG
GGCTGCGATTGCGCCAGATCAGGGTGCCGCTCGGGGTGGTCGGCATGGTGTACGAGGGGCGCCCGAACGTCACGGTGGAC
GCATTCGGGTTGACCCTCAAGTCGGGCAACGCGGTGCTGCTCCGCGGCAGTTCCTCGGCGGCAACCTCCAACACCGAGCT
CGTGCGGGTGCTGCGCAGCTCACTGGTCGCCAGTGGCTTGCCCGCCGACACGGTCCAACTGCTCGACAGCCGGGACCGGG
TGACCGTGACTCACCTCATCCAGGCGCGCGGGCTCGTTGACGTGGTGATCCCGCGCGGTGGGGCCGGCCTCATCGACGCC
GTGGTGCGTGACGCGCAGGTACCCACCATCGAAACCGGGGTGGGCAACTGCCACGTGTACGTGCACGCCGATGCCGACCT
TGCGCTGGCTGAGCGGATTCTGTTGAACTCCAAGACCCGTCGGCCCAGTGTGTGTAATGCCGCGGAGACGCTGTTGATCG
ACCGGGCCATAGCGGAGGTCGCCGTCCCGCAGCTGGTCGGCGCCTTGCAGGCGGCCGGAGTGACCGTGCATGCCGATCTT
CCCGTGCCGGGCGTGGTGCCGGTGACCGAGGATGACTTCGGCACCGAATACCTGTCGTTGGACATCGCGGTCGCGCTGGT
TGATGGTCTCGACGCGGCGATCGAGCACATCGACCGGTACTCCAGTGGGCACACCGACGCCATCGTCACCACGAACCTCA
GTGCGGCCCAGGAATTCACCGATCGTGTGGACAGCGCCGCCGTGATGGTCAACGCCTCCACCGCGTTCACCGACGGCGAG
CAGTTCGGATTCGGTGCCGAGATCGGAATCTCCACCCAGAAGTTGCATGCCCGTGGTCCCATGGGGCTGCCCGAACTGAC
CACCACCAAGTGGATCGTCCTCGGCGACGGTCAGATCCGTCCCGCCTAA

Upstream 100 bases:

>100_bases
ATGTTGACGCTACCGAGGACGCATACCGTGGCTAACTCAGTCACCCGCCTAGGTTAGTCCTGGCGCAGCTACATTCCGGG
CACCCGGATACCCTGACACG

Downstream 100 bases:

>100_bases
CACCTGGAGTACCGTGTCTGACCCTCTTCGCCCGAGTGGCTCATCGCAGTCCCGAACCCAGACCGCGCCGCTGTTCACGA
GCATCGACGATGTCACCACA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MSVSTNELAPGAAGSAASAPVTEAPATADLRAGVHDAARRARVAARDLARLTADAKNSALLAAADAIVASTDSIIAANAD
DLRRARDAGIGEAMLDRLALDTARVAGIADGLRQVAGLPDPVGEILRGSTRPNGLRLRQIRVPLGVVGMVYEGRPNVTVD
AFGLTLKSGNAVLLRGSSSAATSNTELVRVLRSSLVASGLPADTVQLLDSRDRVTVTHLIQARGLVDVVIPRGGAGLIDA
VVRDAQVPTIETGVGNCHVYVHADADLALAERILLNSKTRRPSVCNAAETLLIDRAIAEVAVPQLVGALQAAGVTVHADL
PVPGVVPVTEDDFGTEYLSLDIAVALVDGLDAAIEHIDRYSSGHTDAIVTTNLSAAQEFTDRVDSAAVMVNASTAFTDGE
QFGFGAEIGISTQKLHARGPMGLPELTTTKWIVLGDGQIRPA

Sequences:

>Translated_442_residues
MSVSTNELAPGAAGSAASAPVTEAPATADLRAGVHDAARRARVAARDLARLTADAKNSALLAAADAIVASTDSIIAANAD
DLRRARDAGIGEAMLDRLALDTARVAGIADGLRQVAGLPDPVGEILRGSTRPNGLRLRQIRVPLGVVGMVYEGRPNVTVD
AFGLTLKSGNAVLLRGSSSAATSNTELVRVLRSSLVASGLPADTVQLLDSRDRVTVTHLIQARGLVDVVIPRGGAGLIDA
VVRDAQVPTIETGVGNCHVYVHADADLALAERILLNSKTRRPSVCNAAETLLIDRAIAEVAVPQLVGALQAAGVTVHADL
PVPGVVPVTEDDFGTEYLSLDIAVALVDGLDAAIEHIDRYSSGHTDAIVTTNLSAAQEFTDRVDSAAVMVNASTAFTDGE
QFGFGAEIGISTQKLHARGPMGLPELTTTKWIVLGDGQIRPA
>Mature_441_residues
SVSTNELAPGAAGSAASAPVTEAPATADLRAGVHDAARRARVAARDLARLTADAKNSALLAAADAIVASTDSIIAANADD
LRRARDAGIGEAMLDRLALDTARVAGIADGLRQVAGLPDPVGEILRGSTRPNGLRLRQIRVPLGVVGMVYEGRPNVTVDA
FGLTLKSGNAVLLRGSSSAATSNTELVRVLRSSLVASGLPADTVQLLDSRDRVTVTHLIQARGLVDVVIPRGGAGLIDAV
VRDAQVPTIETGVGNCHVYVHADADLALAERILLNSKTRRPSVCNAAETLLIDRAIAEVAVPQLVGALQAAGVTVHADLP
VPGVVPVTEDDFGTEYLSLDIAVALVDGLDAAIEHIDRYSSGHTDAIVTTNLSAAQEFTDRVDSAAVMVNASTAFTDGEQ
FGFGAEIGISTQKLHARGPMGLPELTTTKWIVLGDGQIRPA

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=412, Percent_Identity=36.1650485436893, Blast_Score=251, Evalue=7e-67,
Organism=Homo sapiens, GI62912457, Length=412, Percent_Identity=36.1650485436893, Blast_Score=251, Evalue=8e-67,
Organism=Escherichia coli, GI1786438, Length=408, Percent_Identity=47.7941176470588, Blast_Score=374, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17569967, Length=413, Percent_Identity=35.8353510895884, Blast_Score=254, Evalue=7e-68,
Organism=Caenorhabditis elegans, GI17569969, Length=413, Percent_Identity=35.8353510895884, Blast_Score=254, Evalue=9e-68,
Organism=Saccharomyces cerevisiae, GI6324899, Length=427, Percent_Identity=35.5971896955504, Blast_Score=261, Evalue=1e-70,
Organism=Drosophila melanogaster, GI21357643, Length=404, Percent_Identity=36.8811881188119, Blast_Score=251, Evalue=6e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45649; Mature: 45518

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSTNELAPGAAGSAASAPVTEAPATADLRAGVHDAARRARVAARDLARLTADAKNSAL
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEE
LAAADAIVASTDSIIAANADDLRRARDAGIGEAMLDRLALDTARVAGIADGLRQVAGLPD
EEEHHHHHCCCCCEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PVGEILRGSTRPNGLRLRQIRVPLGVVGMVYEGRPNVTVDAFGLTLKSGNAVLLRGSSSA
CHHHHHCCCCCCCCEEEEEEECCCEEEEEEEECCCCEEEEEEEEEEECCCEEEEECCCCC
ATSNTELVRVLRSSLVASGLPADTVQLLDSRDRVTVTHLIQARGLVDVVIPRGGAGLIDA
CCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEHHHHHHHCCCEEEEECCCCCHHHHH
VVRDAQVPTIETGVGNCHVYVHADADLALAERILLNSKTRRPSVCNAAETLLIDRAIAEV
HHHCCCCCEEECCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
AVPQLVGALQAAGVTVHADLPVPGVVPVTEDDFGTEYLSLDIAVALVDGLDAAIEHIDRY
HHHHHHHHHHHCCEEEEECCCCCCEEECCCCCCCCCEEEHEEEEHHHHHHHHHHHHHHHH
SSGHTDAIVTTNLSAAQEFTDRVDSAAVMVNASTAFTDGEQFGFGAEIGISTQKLHARGP
CCCCCCEEEEECHHHHHHHHHHHCCEEEEEECCCEECCCCCCCCCCEECCCHHHEECCCC
MGLPELTTTKWIVLGDGQIRPA
CCCCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure 
SVSTNELAPGAAGSAASAPVTEAPATADLRAGVHDAARRARVAARDLARLTADAKNSAL
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEE
LAAADAIVASTDSIIAANADDLRRARDAGIGEAMLDRLALDTARVAGIADGLRQVAGLPD
EEEHHHHHCCCCCEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PVGEILRGSTRPNGLRLRQIRVPLGVVGMVYEGRPNVTVDAFGLTLKSGNAVLLRGSSSA
CHHHHHCCCCCCCCEEEEEEECCCEEEEEEEECCCCEEEEEEEEEEECCCEEEEECCCCC
ATSNTELVRVLRSSLVASGLPADTVQLLDSRDRVTVTHLIQARGLVDVVIPRGGAGLIDA
CCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEHHHHHHHCCCEEEEECCCCCHHHHH
VVRDAQVPTIETGVGNCHVYVHADADLALAERILLNSKTRRPSVCNAAETLLIDRAIAEV
HHHCCCCCEEECCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
AVPQLVGALQAAGVTVHADLPVPGVVPVTEDDFGTEYLSLDIAVALVDGLDAAIEHIDRY
HHHHHHHHHHHCCEEEEECCCCCCEEECCCCCCCCCEEEHEEEEHHHHHHHHHHHHHHHH
SSGHTDAIVTTNLSAAQEFTDRVDSAAVMVNASTAFTDGEQFGFGAEIGISTQKLHARGP
CCCCCCEEEEECHHHHHHHHHHHCCEEEEEECCCEECCCCCCCCCCEECCCHHHEECCCC
MGLPELTTTKWIVLGDGQIRPA
CCCCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA