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The map label for this gene is ndk

Identifier: 169628696

GI number: 169628696

Start: 1636740

End: 1637150

Strand: Direct

Name: ndk

Synonym: MAB_1606

Alternate gene names: 169628696

Gene position: 1636740-1637150 (Clockwise)

Preceding gene: 169628695

Following gene: 169628697

Centisome position: 32.3

GC content: 66.67

Gene sequence:

>411_bases
GTGACTGAGCGGACTCTGGTTTTGATCAAGCCCGATGGTGTGCGACGGGGACTTGTCGGTGAGGTGTTGAATCGGATCGA
GCGCAAGGGCCTGACACTGGCCGCGCTCGAGCTGAAGAACGTCGATGACGCGACGGCCCGGGCCCATTACGCCGAGCACG
CGGAGAAGCCGTTCTTCGGCTCGCTGCTGGAGTTCATCACCTCGGGTCCGCTCGTGGCGGCAGTGCTGGAAGGTCCGCGT
GCTATCGCCGCGTTCCGCCAGATCGCCGGCGGCACCGATCCGGTGGAGAAGGCGGCGACCGGCAGCATCCGCGGCGACTT
CGCCCTGGAGACCCAGGAGAACCTGGTGCACGGTTCCGACTCGCCCGAGTCCGCTGCGCGTGAGATCGCGCTGTGGTTCC
CTGCGCTCTGA

Upstream 100 bases:

>100_bases
CTGCTCATCTGGTACATGCGCAACCAGGTCCGCGACCGTCAGAGCCGCGGCGAGCTGCCGGGTCAGCAGGGCAGCGCTAC
CGACCAGTAGGCTGTCGCCC

Downstream 100 bases:

>100_bases
CCCAATCGATCTGATCTGAAACCCACGAGTGTGCGGTTTGCGTCGGTTCCTCCGGGAATCTCGACGTAAACCGCACACTC
GATTACGTATATGGGTCGCC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 136; Mature: 135

Protein sequence:

>136_residues
MTERTLVLIKPDGVRRGLVGEVLNRIERKGLTLAALELKNVDDATARAHYAEHAEKPFFGSLLEFITSGPLVAAVLEGPR
AIAAFRQIAGGTDPVEKAATGSIRGDFALETQENLVHGSDSPESAAREIALWFPAL

Sequences:

>Translated_136_residues
MTERTLVLIKPDGVRRGLVGEVLNRIERKGLTLAALELKNVDDATARAHYAEHAEKPFFGSLLEFITSGPLVAAVLEGPR
AIAAFRQIAGGTDPVEKAATGSIRGDFALETQENLVHGSDSPESAAREIALWFPAL
>Mature_135_residues
TERTLVLIKPDGVRRGLVGEVLNRIERKGLTLAALELKNVDDATARAHYAEHAEKPFFGSLLEFITSGPLVAAVLEGPRA
IAAFRQIAGGTDPVEKAATGSIRGDFALETQENLVHGSDSPESAAREIALWFPAL

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=133, Percent_Identity=51.8796992481203, Blast_Score=141, Evalue=1e-34,
Organism=Homo sapiens, GI4557797, Length=132, Percent_Identity=44.6969696969697, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI38045913, Length=132, Percent_Identity=44.6969696969697, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI66392227, Length=131, Percent_Identity=44.2748091603053, Blast_Score=129, Evalue=6e-31,
Organism=Homo sapiens, GI66392205, Length=131, Percent_Identity=44.2748091603053, Blast_Score=129, Evalue=6e-31,
Organism=Homo sapiens, GI4505409, Length=131, Percent_Identity=44.2748091603053, Blast_Score=129, Evalue=6e-31,
Organism=Homo sapiens, GI66392192, Length=131, Percent_Identity=44.2748091603053, Blast_Score=129, Evalue=6e-31,
Organism=Homo sapiens, GI66392203, Length=131, Percent_Identity=44.2748091603053, Blast_Score=129, Evalue=7e-31,
Organism=Homo sapiens, GI4826862, Length=131, Percent_Identity=47.3282442748092, Blast_Score=129, Evalue=9e-31,
Organism=Homo sapiens, GI37574614, Length=135, Percent_Identity=34.8148148148148, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI7019465, Length=135, Percent_Identity=34.8148148148148, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI5031951, Length=134, Percent_Identity=39.5522388059701, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI30023828, Length=138, Percent_Identity=32.6086956521739, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=30.3703703703704, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1788866, Length=131, Percent_Identity=45.0381679389313, Blast_Score=117, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17506807, Length=132, Percent_Identity=47.7272727272727, Blast_Score=133, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322783, Length=132, Percent_Identity=50, Blast_Score=141, Evalue=3e-35,
Organism=Drosophila melanogaster, GI45549037, Length=131, Percent_Identity=45.0381679389313, Blast_Score=132, Evalue=7e-32,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=30.5970149253731, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_MYCA9 (B1MMX9)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001702345.1
- ProteinModelPortal:   B1MMX9
- SMR:   B1MMX9
- EnsemblBacteria:   EBMYCT00000007749
- GeneID:   5964126
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_1606
- GeneTree:   EBGT00050000015870
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   MABS561007:MAB_1606-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 14576; Mature: 14445

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 10-10 BINDING 58-58 BINDING 86-86 BINDING 92-92 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERTLVLIKPDGVRRGLVGEVLNRIERKGLTLAALELKNVDDATARAHYAEHAEKPFFG
CCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCHHH
SLLEFITSGPLVAAVLEGPRAIAAFRQIAGGTDPVEKAATGSIRGDFALETQENLVHGSD
HHHHHHHCCCHHEEHHCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCEEECCHHHHCCCCC
SPESAAREIALWFPAL
CHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TERTLVLIKPDGVRRGLVGEVLNRIERKGLTLAALELKNVDDATARAHYAEHAEKPFFG
CCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCHHH
SLLEFITSGPLVAAVLEGPRAIAAFRQIAGGTDPVEKAATGSIRGDFALETQENLVHGSD
HHHHHHHCCCHHEEHHCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCEEECCHHHHCCCCC
SPESAAREIALWFPAL
CHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA