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The map label for this gene is dnaX [H]

Identifier: 169627413

GI number: 169627413

Start: 310222

End: 312261

Strand: Direct

Name: dnaX [H]

Synonym: MAB_0309

Alternate gene names: 169627413

Gene position: 310222-312261 (Clockwise)

Preceding gene: 169627409

Following gene: 169627419

Centisome position: 6.12

GC content: 68.28

Gene sequence:

>2040_bases
ATGGCGGGCGCACGTAACCGTCTGTGGGCGCCGGTACCCTTGCTCTCCGTGGCCCTGTACCGCAAGTATCGCCCGGCGAC
CTTCGCCGAAGTCGTCGGCCAGGAGCATGTCACCGGACCGTTGACCACTGCCCTGGATGCCGGCCGGATCAATCACGCCT
ATTTGTTCTCGGGGCCCCGCGGTTGCGGCAAGACGTCTTCTGCCCGCATCCTGGCCCGCTCCCTGAACTGTGTGCAGGGA
CCCACCTCGACGCCGTGCGGAACGTGTGAATCCTGTGTCGCGTTGGCGCCCAACGGTTCGGGCAATGTCGATGTCATCGA
GCTCGACGCCGCCAGCCACGGCGGTGTCGATGACACCCGTGAGCTACGCGACCGTGCCTTCTACGCGCCGGCTCAATCGC
GCTACCGCATCTTCATCATCGATGAGGCGCACATGGTCACCACGGCGGGCTTCAACGCGCTACTCAAGATCGTCGAGGAG
CCGCCCGAGCACCTGATCTTCGTCTTCGCCACCACCGAGCCGGAGAAGGTGCTGCCCACCATCCGGTCGCGGACCCACCA
CTATCCGTTCCGTCTGCTGGCACCCAAGACGATGCGTACGCTCGTCGAAGGCATCTGCGCGCAAGAGAACGTGTCCGTTG
ACGACCCGGTGTACCCATTGGTGATCCGGGCCGGCGCCGGCTCTCCGCGTGACACCTTGTCGGTACTCGATCAGCTGCTT
GCCGGGGCCGATGAGGAACGCGTCACCTATCAGCGGGCACTCTCGCTGTTGGGTGTCACCGATATCGCGTTGATCGACGA
TGCGGTGGATGCGCTTGCCGCCGGTGACGGCGCCGCGGTGTTCGGTGCGATTGAGGGTGTGATGGATGCCGGGCACGATC
CACGCCGGTTCGGCACCGATTTGCTTGAGCGCTTCCGCGACCTGATTGTGCTGCAGGCTGTTCCGGATGCGGTGGAGCGT
GGGGTGGTGGATGCGCCGCAGGATGTGCTTGAGCGCATGCGTGAGCAAGCCGAGCGCATCGGTCCCGCCACCTTGACCAG
GTATGCCGAGGTGTTGCATGCGGGTCTGGGGGAGATGCGCGGTGCGACAGCGCCGCGGCTGCTGTTGGAAGTGGTGTGTG
CGAGGCTGCTACTGCCCTCGGCTACCGATGCGGAATCGGCGGTGCTGCAACGTGTCGAGCGCATCGAGAAGCGGCTGGAC
ATGTCGGTGCCGGAGGCGGACGGCGCCAGCGCCGCGCCACGCTTTGTCCGTAAATCTCAAGCGGCTGCTGCCCCGGCCGC
GGAAACTGCTGCGTCACCCGCTCCGGCGCCCCAACCTCCCCGCCCGGCCCCTGAACCACCCGCGCCGATACCCGGCCCGG
CGCCTGAGCCGCCCGCGCCACGTCCGGAACCCGAGCCGGCCCCTGAGCCCGAGCCGGCTCCGGAACCCACGCCAATCCCT
GAGCCACCCGCGCCGGAACCAGCTCCCGAGCCAGAGCCGGAGCCGGCCCCAGTACCGGAGCCCGAACCTGCTCGTGAACC
GCGTCAGCCCGGTGCGCTGGACACCACCGCTGTGCGCAATGCCTGGGCGGAGATCCGCGCCAAGGTGCGGGATCGGAGCC
GCACCACCGAGGTCATGCTGTCGGGCGCCACTGTGCGCGCCATCGATGGCAACACCCTTGTGCTGTCGCACGATTCGCCG
CCACTAGCCAAGCGCATCACCGAGTCGCGCAATGCCGAGGTCATCCGCGAGGCGTTGAGGGATGCGCTCGGTGTCAACTG
GGAGATCCGCTGCGACGTGGGCAGCGCCGAGGCCGCCGCGCCCGCTGCGTCGCGTCCCGCCAAGGCCGCCCCACGCGTGG
TGACGCGGCCCAGCCGTCCCACGCCCGATCCCGAGCCGGTTCCGGAGCCTGAGCCCGAGCCGCCGTCGCCCGAGGACGAG
GAGGAGCAGATGCTCGCCGAGGCCGGGCAGAGCGAGGCTGGGCCTCGGCGCGATCCGGAAGAGGTCGCGCTGGAGCTACT
TCAGAACGAGCTGGGCGCCCGTAAGATCGACCCCAATTAG

Upstream 100 bases:

>100_bases
GGCGGTTGCTCCGGCGGCCAGCACAGTTGTGGCGCTCACCTTATTGGTAGGCATGAGCGGACACTAGCAAACAATATGAC
CGGCGGCGACCGCTGGGCTC

Downstream 100 bases:

>100_bases
GGCTGCCACCATGGGCGCAGCGGCAACTCGGAGCCGCCTCGCTCGTCGAGTTTCGTGGCCAGCACCTGGTGCAGCTGAAC
CACGTTGCGCTCGAAGCCCA

Product: DNA polymerase III, subunit gamma/tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 679; Mature: 678

Protein sequence:

>679_residues
MAGARNRLWAPVPLLSVALYRKYRPATFAEVVGQEHVTGPLTTALDAGRINHAYLFSGPRGCGKTSSARILARSLNCVQG
PTSTPCGTCESCVALAPNGSGNVDVIELDAASHGGVDDTRELRDRAFYAPAQSRYRIFIIDEAHMVTTAGFNALLKIVEE
PPEHLIFVFATTEPEKVLPTIRSRTHHYPFRLLAPKTMRTLVEGICAQENVSVDDPVYPLVIRAGAGSPRDTLSVLDQLL
AGADEERVTYQRALSLLGVTDIALIDDAVDALAAGDGAAVFGAIEGVMDAGHDPRRFGTDLLERFRDLIVLQAVPDAVER
GVVDAPQDVLERMREQAERIGPATLTRYAEVLHAGLGEMRGATAPRLLLEVVCARLLLPSATDAESAVLQRVERIEKRLD
MSVPEADGASAAPRFVRKSQAAAAPAAETAASPAPAPQPPRPAPEPPAPIPGPAPEPPAPRPEPEPAPEPEPAPEPTPIP
EPPAPEPAPEPEPEPAPVPEPEPAREPRQPGALDTTAVRNAWAEIRAKVRDRSRTTEVMLSGATVRAIDGNTLVLSHDSP
PLAKRITESRNAEVIREALRDALGVNWEIRCDVGSAEAAAPAASRPAKAAPRVVTRPSRPTPDPEPVPEPEPEPPSPEDE
EEQMLAEAGQSEAGPRRDPEEVALELLQNELGARKIDPN

Sequences:

>Translated_679_residues
MAGARNRLWAPVPLLSVALYRKYRPATFAEVVGQEHVTGPLTTALDAGRINHAYLFSGPRGCGKTSSARILARSLNCVQG
PTSTPCGTCESCVALAPNGSGNVDVIELDAASHGGVDDTRELRDRAFYAPAQSRYRIFIIDEAHMVTTAGFNALLKIVEE
PPEHLIFVFATTEPEKVLPTIRSRTHHYPFRLLAPKTMRTLVEGICAQENVSVDDPVYPLVIRAGAGSPRDTLSVLDQLL
AGADEERVTYQRALSLLGVTDIALIDDAVDALAAGDGAAVFGAIEGVMDAGHDPRRFGTDLLERFRDLIVLQAVPDAVER
GVVDAPQDVLERMREQAERIGPATLTRYAEVLHAGLGEMRGATAPRLLLEVVCARLLLPSATDAESAVLQRVERIEKRLD
MSVPEADGASAAPRFVRKSQAAAAPAAETAASPAPAPQPPRPAPEPPAPIPGPAPEPPAPRPEPEPAPEPEPAPEPTPIP
EPPAPEPAPEPEPEPAPVPEPEPAREPRQPGALDTTAVRNAWAEIRAKVRDRSRTTEVMLSGATVRAIDGNTLVLSHDSP
PLAKRITESRNAEVIREALRDALGVNWEIRCDVGSAEAAAPAASRPAKAAPRVVTRPSRPTPDPEPVPEPEPEPPSPEDE
EEQMLAEAGQSEAGPRRDPEEVALELLQNELGARKIDPN
>Mature_678_residues
AGARNRLWAPVPLLSVALYRKYRPATFAEVVGQEHVTGPLTTALDAGRINHAYLFSGPRGCGKTSSARILARSLNCVQGP
TSTPCGTCESCVALAPNGSGNVDVIELDAASHGGVDDTRELRDRAFYAPAQSRYRIFIIDEAHMVTTAGFNALLKIVEEP
PEHLIFVFATTEPEKVLPTIRSRTHHYPFRLLAPKTMRTLVEGICAQENVSVDDPVYPLVIRAGAGSPRDTLSVLDQLLA
GADEERVTYQRALSLLGVTDIALIDDAVDALAAGDGAAVFGAIEGVMDAGHDPRRFGTDLLERFRDLIVLQAVPDAVERG
VVDAPQDVLERMREQAERIGPATLTRYAEVLHAGLGEMRGATAPRLLLEVVCARLLLPSATDAESAVLQRVERIEKRLDM
SVPEADGASAAPRFVRKSQAAAAPAAETAASPAPAPQPPRPAPEPPAPIPGPAPEPPAPRPEPEPAPEPEPAPEPTPIPE
PPAPEPAPEPEPEPAPVPEPEPAREPRQPGALDTTAVRNAWAEIRAKVRDRSRTTEVMLSGATVRAIDGNTLVLSHDSPP
LAKRITESRNAEVIREALRDALGVNWEIRCDVGSAEAAAPAASRPAKAAPRVVTRPSRPTPDPEPVPEPEPEPPSPEDEE
EQMLAEAGQSEAGPRRDPEEVALELLQNELGARKIDPN

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=359, Percent_Identity=39.8328690807799, Blast_Score=249, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6324039, Length=292, Percent_Identity=26.027397260274, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322528, Length=287, Percent_Identity=24.7386759581882, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 72571; Mature: 72439

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGARNRLWAPVPLLSVALYRKYRPATFAEVVGQEHVTGPLTTALDAGRINHAYLFSGPR
CCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCHHCCCCHHHHHHCCCCCEEEEECCCC
GCGKTSSARILARSLNCVQGPTSTPCGTCESCVALAPNGSGNVDVIELDAASHGGVDDTR
CCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHEEECCCCCCCEEEEEECCCCCCCCCHHH
ELRDRAFYAPAQSRYRIFIIDEAHMVTTAGFNALLKIVEEPPEHLIFVFATTEPEKVLPT
HHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHH
IRSRTHHYPFRLLAPKTMRTLVEGICAQENVSVDDPVYPLVIRAGAGSPRDTLSVLDQLL
HHHCCCCCCEEEECHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
AGADEERVTYQRALSLLGVTDIALIDDAVDALAAGDGAAVFGAIEGVMDAGHDPRRFGTD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHH
LLERFRDLIVLQAVPDAVERGVVDAPQDVLERMREQAERIGPATLTRYAEVLHAGLGEMR
HHHHHHHHHHHHHCHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
GATAPRLLLEVVCARLLLPSATDAESAVLQRVERIEKRLDMSVPEADGASAAPRFVRKSQ
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
AAAAPAAETAASPAPAPQPPRPAPEPPAPIPGPAPEPPAPRPEPEPAPEPEPAPEPTPIP
HHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
EPPAPEPAPEPEPEPAPVPEPEPAREPRQPGALDTTAVRNAWAEIRAKVRDRSRTTEVML
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEE
SGATVRAIDGNTLVLSHDSPPLAKRITESRNAEVIREALRDALGVNWEIRCDVGSAEAAA
CCCEEEEECCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCHHCC
PAASRPAKAAPRVVTRPSRPTPDPEPVPEPEPEPPSPEDEEEQMLAEAGQSEAGPRRDPE
CCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHH
EVALELLQNELGARKIDPN
HHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AGARNRLWAPVPLLSVALYRKYRPATFAEVVGQEHVTGPLTTALDAGRINHAYLFSGPR
CCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCHHCCCCHHHHHHCCCCCEEEEECCCC
GCGKTSSARILARSLNCVQGPTSTPCGTCESCVALAPNGSGNVDVIELDAASHGGVDDTR
CCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHEEECCCCCCCEEEEEECCCCCCCCCHHH
ELRDRAFYAPAQSRYRIFIIDEAHMVTTAGFNALLKIVEEPPEHLIFVFATTEPEKVLPT
HHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHH
IRSRTHHYPFRLLAPKTMRTLVEGICAQENVSVDDPVYPLVIRAGAGSPRDTLSVLDQLL
HHHCCCCCCEEEECHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
AGADEERVTYQRALSLLGVTDIALIDDAVDALAAGDGAAVFGAIEGVMDAGHDPRRFGTD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHH
LLERFRDLIVLQAVPDAVERGVVDAPQDVLERMREQAERIGPATLTRYAEVLHAGLGEMR
HHHHHHHHHHHHHCHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
GATAPRLLLEVVCARLLLPSATDAESAVLQRVERIEKRLDMSVPEADGASAAPRFVRKSQ
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
AAAAPAAETAASPAPAPQPPRPAPEPPAPIPGPAPEPPAPRPEPEPAPEPEPAPEPTPIP
HHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
EPPAPEPAPEPEPEPAPVPEPEPAREPRQPGALDTTAVRNAWAEIRAKVRDRSRTTEVML
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEE
SGATVRAIDGNTLVLSHDSPPLAKRITESRNAEVIREALRDALGVNWEIRCDVGSAEAAA
CCCEEEEECCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCHHCC
PAASRPAKAAPRVVTRPSRPTPDPEPVPEPEPEPPSPEDEEEQMLAEAGQSEAGPRRDPE
CCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHH
EVALELLQNELGARKIDPN
HHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]