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The map label for this gene is uhpC

Identifier: 16767072

GI number: 16767072

Start: 3987714

End: 3989042

Strand: Reverse

Name: uhpC

Synonym: STM3788

Alternate gene names: 16767072

Gene position: 3989042-3987714 (Counterclockwise)

Preceding gene: 16767073

Following gene: 16767071

Centisome position: 82.12

GC content: 59.67

Gene sequence:

>1329_bases
ATGCTTTCGTTTTTAAAAGCCCCGGCCAACGCGCCGCTCATCACCGATAAGCACGAGGTTGACGCCCGCTATCGCTACTG
GCGGCGGCATATCCTGATCACCATTTGGTTGGGTTACGCGCTGTTCTATTTCACCCGTAAAAGCTTTAACGCCGCCGCGC
CGGAAATCCTTGCCAGCGGCATTCTGACCCGCAGCGATATCGGCCTGCTGGCGACGCTGTTTTACATCACCTACGGGGTG
TCGAAATTTGTCTCCGGCATCGTTAGCGATCGCTCTAACGCTCGCTATTTTATGGGCATCGGGCTGATTGCGACTGGCGT
AGTGAATATTCTGTTCGGCTTCTCGACCTCGCTGTGGGCCTTTGCTCTGCTATGGGCGCTGAACGCCTTTTTCCAGGGGT
TTGGATCGCCGGTTTGCGCCCGTTTGCTGACTGCCTGGTACTCGCGTACCGAGCGCGGCGGCTGGTGGGCGTTATGGAAT
ACCGCGCACAATGTCGGCGGGGCGCTGATCCCTCTCGTTATGGCCGCTGTCGCCCTGCATTATGGCTGGCGCGTCGGAAT
GATGGTGGCCGGGTTGCTTGCCATCGGGGTGGGCATGGTCCTCTGCTGGCGGCTGCGCGACCGTCCGCAGGCGATTGGTT
TACCGCCGGTAGGCGACTGGCGGCACGATGCGCTGGAGGTCGCCCAACAGCAAGAGGGCGCGGGGCTAAGTCGCAAAGAA
ATCCTCGCTAAATATGTGCTGTTGAATCCCTATATCTGGCTGCTTTCGTTGTGTTATGTCTTAGTGTACGTGGTGCGCGC
GGCGATCAACGACTGGGGCAACCTGTATATGTCCGAGACGCTGGGCGTAGATTTGGTCACGGCCAACACGGCAGTATCGA
TGTTTGAGCTGGGTGGATTTATCGGTGCGCTGGTGGCGGGCTGGGGCTCGGACAAACTCTTCAACGGCAACCGCGGACCG
ATGAATTTAATCTTCGCCGCCGGGATTTTGCTCTCTGTGGGTTCGCTGTGGCTGATGCCGTTCGCCAGCTACGTGATGCA
GGCGGCCTGTTTCTTCACCACCGGTTTCTTTGTCTTCGGCCCGCAGATGCTCATTGGCATGGCGGCGGCGGAGTGCTCGC
ATAAAGAGGCGGCGGGCGCGGCCACCGGCTTTGTCGGCCTGTTCGCCTATCTCGGCGCGTCGCTTTCCGGCTGGCCGTTA
GCGAAAGTGCTGGAGATCTGGCACTGGACCGGTTTTTTTGCGGTCATCGCCATCGCGGCGGGGATCTCCGCGCTATTGCT
GTTGCCATTTCTGAACGCTCAGGCCCCACGCGAGACCCACGAAGCGTGA

Upstream 100 bases:

>100_bases
CGAACGCGTGTCGGCGCTCGGCGGGACGCTAACCATCTCTTGTACCCACGGTACGCGGGTGAGCGTCTCGTTGCCCCAGC
GTTACGTTTAAGGAAGGATA

Downstream 100 bases:

>100_bases
TACACCTCACCTTTTTGCGCTGAATGGGGCAAAACTAAGAAATTTTCCCGGTTTTGCCTGGACGCTGTCGCAGGCCACTT
TTCCTGTGGATTTTTACAAT

Product: regulatory protein UhpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MLSFLKAPANAPLITDKHEVDARYRYWRRHILITIWLGYALFYFTRKSFNAAAPEILASGILTRSDIGLLATLFYITYGV
SKFVSGIVSDRSNARYFMGIGLIATGVVNILFGFSTSLWAFALLWALNAFFQGFGSPVCARLLTAWYSRTERGGWWALWN
TAHNVGGALIPLVMAAVALHYGWRVGMMVAGLLAIGVGMVLCWRLRDRPQAIGLPPVGDWRHDALEVAQQQEGAGLSRKE
ILAKYVLLNPYIWLLSLCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVSMFELGGFIGALVAGWGSDKLFNGNRGP
MNLIFAAGILLSVGSLWLMPFASYVMQAACFFTTGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPL
AKVLEIWHWTGFFAVIAIAAGISALLLLPFLNAQAPRETHEA

Sequences:

>Translated_442_residues
MLSFLKAPANAPLITDKHEVDARYRYWRRHILITIWLGYALFYFTRKSFNAAAPEILASGILTRSDIGLLATLFYITYGV
SKFVSGIVSDRSNARYFMGIGLIATGVVNILFGFSTSLWAFALLWALNAFFQGFGSPVCARLLTAWYSRTERGGWWALWN
TAHNVGGALIPLVMAAVALHYGWRVGMMVAGLLAIGVGMVLCWRLRDRPQAIGLPPVGDWRHDALEVAQQQEGAGLSRKE
ILAKYVLLNPYIWLLSLCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVSMFELGGFIGALVAGWGSDKLFNGNRGP
MNLIFAAGILLSVGSLWLMPFASYVMQAACFFTTGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPL
AKVLEIWHWTGFFAVIAIAAGISALLLLPFLNAQAPRETHEA
>Mature_442_residues
MLSFLKAPANAPLITDKHEVDARYRYWRRHILITIWLGYALFYFTRKSFNAAAPEILASGILTRSDIGLLATLFYITYGV
SKFVSGIVSDRSNARYFMGIGLIATGVVNILFGFSTSLWAFALLWALNAFFQGFGSPVCARLLTAWYSRTERGGWWALWN
TAHNVGGALIPLVMAAVALHYGWRVGMMVAGLLAIGVGMVLCWRLRDRPQAIGLPPVGDWRHDALEVAQQQEGAGLSRKE
ILAKYVLLNPYIWLLSLCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVSMFELGGFIGALVAGWGSDKLFNGNRGP
MNLIFAAGILLSVGSLWLMPFASYVMQAACFFTTGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPL
AKVLEIWHWTGFFAVIAIAAGISALLLLPFLNAQAPRETHEA

Specific function: UhpC is required for uhpT expression, it may act jointly with the uhpB signaling protein

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family

Homologues:

Organism=Homo sapiens, GI256219598, Length=440, Percent_Identity=29.3181818181818, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI4503847, Length=440, Percent_Identity=29.3181818181818, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI256219483, Length=440, Percent_Identity=29.3181818181818, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI256219543, Length=454, Percent_Identity=28.4140969162996, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI256219564, Length=371, Percent_Identity=28.0323450134771, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI46361976, Length=411, Percent_Identity=23.3576642335766, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI14150047, Length=291, Percent_Identity=23.3676975945017, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI223717983, Length=470, Percent_Identity=23.4042553191489, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI38093649, Length=470, Percent_Identity=23.4042553191489, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI87082310, Length=438, Percent_Identity=90.6392694063927, Blast_Score=818, Evalue=0.0,
Organism=Escherichia coli, GI1788573, Length=447, Percent_Identity=35.1230425055928, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI2367259, Length=462, Percent_Identity=30.7359307359307, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI2367379, Length=362, Percent_Identity=21.5469613259669, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17542316, Length=461, Percent_Identity=23.8611713665944, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI133930953, Length=448, Percent_Identity=23.4375, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI133901856, Length=453, Percent_Identity=22.5165562913907, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI133901854, Length=453, Percent_Identity=22.5165562913907, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24656861, Length=414, Percent_Identity=26.8115942028986, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24656866, Length=414, Percent_Identity=26.8115942028986, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI45550478, Length=414, Percent_Identity=26.8115942028986, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UHPC_SALTY (P27669)

Other databases:

- EMBL:   M89480
- EMBL:   AE006468
- PIR:   C41853
- RefSeq:   NP_462687.1
- ProteinModelPortal:   P27669
- SMR:   P27669
- GeneID:   1255312
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM3788
- NMPDR:   fig|99287.1.peg.3662
- HOGENOM:   HBG559184
- OMA:   WILSISY
- ProtClustDB:   PRK11663
- BioCyc:   STYP99287:STM3788-MONOMER
- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159
- TIGRFAMs:   TIGR00881

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 48255; Mature: 48255

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS00942 GLPT; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf7ed014)-; HASH(0x11663ce0)-; HASH(0x129ec8d4)-; HASH(0x110aa068)-; HASH(0x12b23044)-; HASH(0x12703bc0)-; HASH(0x125f16e8)-; HASH(0x12b3a00c)-; HASH(0x12ae8680)-; HASH(0x12930c94)-;

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSFLKAPANAPLITDKHEVDARYRYWRRHILITIWLGYALFYFTRKSFNAAAPEILASG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ILTRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGVVNILFGFSTSLWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
FALLWALNAFFQGFGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPLVMAAVALH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHCCHHHHHHHHHHHHHH
YGWRVGMMVAGLLAIGVGMVLCWRLRDRPQAIGLPPVGDWRHDALEVAQQQEGAGLSRKE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHH
ILAKYVLLNPYIWLLSLCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVSMFELGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHH
IGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQAACFFTTGFFVFG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPLAKVLEIWHWTGFFAVIAIAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GISALLLLPFLNAQAPRETHEA
HHHHHHHHHHHCCCCCCCCCCH
>Mature Secondary Structure
MLSFLKAPANAPLITDKHEVDARYRYWRRHILITIWLGYALFYFTRKSFNAAAPEILASG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ILTRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGVVNILFGFSTSLWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
FALLWALNAFFQGFGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPLVMAAVALH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHCCHHHHHHHHHHHHHH
YGWRVGMMVAGLLAIGVGMVLCWRLRDRPQAIGLPPVGDWRHDALEVAQQQEGAGLSRKE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHH
ILAKYVLLNPYIWLLSLCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVSMFELGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHH
IGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQAACFFTTGFFVFG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPLAKVLEIWHWTGFFAVIAIAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GISALLLLPFLNAQAPRETHEA
HHHHHHHHHHHCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1569007; 11677609