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The map label for this gene is tdh [H]

Identifier: 16766993

GI number: 16766993

Start: 3902882

End: 3903907

Strand: Reverse

Name: tdh [H]

Synonym: STM3708

Alternate gene names: 16766993

Gene position: 3903907-3902882 (Counterclockwise)

Preceding gene: 16766994

Following gene: 16766992

Centisome position: 80.37

GC content: 53.61

Gene sequence:

>1026_bases
ATGAAAGCGTTATCCAAACTGAAAGCGGAAGAGGGCATCTGGATGACCGACGTTCCGGAACCGGAAGTCGGCCATAACGA
TTTGCTGATTAAAATCCGTAAAACAGCCATCTGCGGTACTGACGTTCACATCTATAACTGGGATGACTGGTCGCAAAAAA
CCATCCCGGTTCCGATGGTCGTGGGGCATGAATATGTCGGCGAAGTGGTCGGCATCGGTCAGGAAGTGAAAGGCTTTAAA
ATCGGCGATCGCGTCTCCGGCGAAGGTCACATCACCTGCGGTCATTGCCGCAACTGCCGCGGCGGTCGCACTCACCTGTG
TCGCAACACCACCGGCGTGGGCGTCAACCGTCCCGGCTGCTTTGCGGAATACCTGGTCATCCCGGCGTTCAATGCGTTTA
AAATCCCGGATAACATTTCTGATGATTTAGCCTCTATTTTCGACCCGTTTGGTAATGCGGTGCATACGGCGCTGTCTTTC
GATCTGGTCGGCGAAGATGTACTGGTATCGGGGGCGGGGCCAATCGGCGTAATGGCCGCCGCGGTGGCGAAACATGTCGG
CGCGCGTCATGTGGTGATTACTGACGTCAATGAATACCGTCTGGAGCTGGCGCGTAAAATGGGCGTCACCCGCGCGGTCA
ACGTCGCGAAAGAGAGCCTGAACGACGTTATGGCGGAGCTGGGAATGACCGAAGGGTTCGATGTGGGTCTGGAGATGTCC
GGCGCGCCGCCGGCGTTTCGTACCATGCTGGACACCATGAATCACGGCGGTCGTATTGCGATGCTGGGGATTCCGCCATC
AGATATGTCTATCGACTGGACAAAAGTTATCTTTAAGGGCTTGTTCATTAAAGGTATTTATGGTCGTGAGATGTTCGAAA
CGTGGTACAAAATGGCGGCGCTGATCCAGTCCGGTCTGGATCTGTCACCGATTATCACCCATCGTTTCTCTATTGATGAT
TTCCAGAAAGGTTTTGATGCCATGCGTTCAGGCCAGTCAGGAAAAGTTATTCTGAGCTGGGATTAA

Upstream 100 bases:

>100_bases
CCAGATGTCTGCGGCGCATACGCCTGAGCAAATTACGCGTGCGGTAGACGCGTTCACGCGTATTGGTAAACAACTGGGCG
TGATTGCCTGAGGATGTAAG

Downstream 100 bases:

>100_bases
TATGTATATACCCAAAATAATTCGAGTTGCTTAAAGGCGGCAAGGGAGTGAGTCCCCAGGAGCATAGATAACTATATGAC
TGGGGTGAACGACAAATCTG

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDDWSQKTIPVPMVVGHEYVGEVVGIGQEVKGFK
IGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSF
DLVGEDVLVSGAGPIGVMAAAVAKHVGARHVVITDVNEYRLELARKMGVTRAVNVAKESLNDVMAELGMTEGFDVGLEMS
GAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFSIDD
FQKGFDAMRSGQSGKVILSWD

Sequences:

>Translated_341_residues
MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDDWSQKTIPVPMVVGHEYVGEVVGIGQEVKGFK
IGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSF
DLVGEDVLVSGAGPIGVMAAAVAKHVGARHVVITDVNEYRLELARKMGVTRAVNVAKESLNDVMAELGMTEGFDVGLEMS
GAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFSIDD
FQKGFDAMRSGQSGKVILSWD
>Mature_341_residues
MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDDWSQKTIPVPMVVGHEYVGEVVGIGQEVKGFK
IGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSF
DLVGEDVLVSGAGPIGVMAAAVAKHVGARHVVITDVNEYRLELARKMGVTRAVNVAKESLNDVMAELGMTEGFDVGLEMS
GAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFSIDD
FQKGFDAMRSGQSGKVILSWD

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=334, Percent_Identity=27.2455089820359, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=25.201072386059, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI262073058, Length=353, Percent_Identity=26.9121813031161, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI71743840, Length=353, Percent_Identity=26.9121813031161, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI34577061, Length=350, Percent_Identity=24.5714285714286, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4501933, Length=373, Percent_Identity=23.8605898123324, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI156523966, Length=349, Percent_Identity=24.0687679083095, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4501939, Length=343, Percent_Identity=23.9067055393586, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI71565154, Length=347, Percent_Identity=25.6484149855908, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=97.3607038123167, Blast_Score=689, Evalue=0.0,
Organism=Escherichia coli, GI1788075, Length=366, Percent_Identity=30.327868852459, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1788073, Length=329, Percent_Identity=28.8753799392097, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1787863, Length=318, Percent_Identity=29.559748427673, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI87082125, Length=344, Percent_Identity=31.6860465116279, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI226510992, Length=330, Percent_Identity=27.8787878787879, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1788407, Length=340, Percent_Identity=26.4705882352941, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI87081918, Length=284, Percent_Identity=30.9859154929577, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786825, Length=400, Percent_Identity=28.25, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1790718, Length=321, Percent_Identity=26.4797507788162, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786552, Length=358, Percent_Identity=27.9329608938547, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1786518, Length=280, Percent_Identity=26.7857142857143, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=335, Percent_Identity=33.134328358209, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17562878, Length=334, Percent_Identity=31.7365269461078, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI71988145, Length=232, Percent_Identity=31.8965517241379, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI25146526, Length=374, Percent_Identity=25.668449197861, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=288, Percent_Identity=27.7777777777778, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=374, Percent_Identity=25.668449197861, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=273, Percent_Identity=26.7399267399267, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=353, Percent_Identity=25.2124645892351, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323099, Length=323, Percent_Identity=31.8885448916409, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322619, Length=307, Percent_Identity=28.9902280130293, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6319955, Length=307, Percent_Identity=28.6644951140065, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319258, Length=373, Percent_Identity=27.0777479892761, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6319257, Length=359, Percent_Identity=27.8551532033426, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=358, Percent_Identity=27.0949720670391, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=324, Percent_Identity=29.6296296296296, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=324, Percent_Identity=29.9382716049383, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=325, Percent_Identity=28.6153846153846, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=338, Percent_Identity=26.9230769230769, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323980, Length=260, Percent_Identity=30, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319949, Length=288, Percent_Identity=27.0833333333333, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737897, Length=332, Percent_Identity=25.9036144578313, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI17137530, Length=332, Percent_Identity=25.9036144578313, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI17737895, Length=377, Percent_Identity=25.7294429708223, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI45551930, Length=175, Percent_Identity=27.4285714285714, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45550770, Length=175, Percent_Identity=27.4285714285714, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221457811, Length=175, Percent_Identity=27.4285714285714, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37213; Mature: 37213

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDDWSQKTIPVPMV
CCHHHHHHHHCCCEECCCCCCCCCCCCEEEEEEEEEEECCEEEEEECCCCCCCCCCCEEE
VGHEYVGEVVGIGQEVKGFKIGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRPGC
ECHHHHHHHHCCCCCCCCEECCCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCCCH
FAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGVMAA
HHHHHEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCHHHHHHH
AVAKHVGARHVVITDVNEYRLELARKMGVTRAVNVAKESLNDVMAELGMTEGFDVGLEMS
HHHHHCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEC
GAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAA
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LIQSGLDLSPIITHRFSIDDFQKGFDAMRSGQSGKVILSWD
HHHCCCCCCHHHHEECCHHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MKALSKLKAEEGIWMTDVPEPEVGHNDLLIKIRKTAICGTDVHIYNWDDWSQKTIPVPMV
CCHHHHHHHHCCCEECCCCCCCCCCCCEEEEEEEEEEECCEEEEEECCCCCCCCCCCEEE
VGHEYVGEVVGIGQEVKGFKIGDRVSGEGHITCGHCRNCRGGRTHLCRNTTGVGVNRPGC
ECHHHHHHHHCCCCCCCCEECCCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCCCH
FAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGVMAA
HHHHHEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCHHHHHHH
AVAKHVGARHVVITDVNEYRLELARKMGVTRAVNVAKESLNDVMAELGMTEGFDVGLEMS
HHHHHCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEC
GAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAA
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LIQSGLDLSPIITHRFSIDDFQKGFDAMRSGQSGKVILSWD
HHHCCCCCCHHHHEECCHHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA