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The map label for this gene is selB [H]

Identifier: 16766967

GI number: 16766967

Start: 3870846

End: 3872696

Strand: Reverse

Name: selB [H]

Synonym: STM3682

Alternate gene names: 16766967

Gene position: 3872696-3870846 (Counterclockwise)

Preceding gene: 16766968

Following gene: 16766965

Centisome position: 79.73

GC content: 57.1

Gene sequence:

>1851_bases
ATGATTATTGCAACTGCCGGACACGTAGACCACGGTAAAACGACGTTGCTCCAGGCGATTACCGGGGTCAATGCCGATCG
CCTGCCGGAAGAGAAAAAACGCGGGATGACTATCGATCTGGGCTACGCCTATTGGCCGCAGCCGGATGGTCGTGTGCTGG
GCTTTATCGATGTGCCTGGGCATGAAAAATTCCTCTCTAACATGCTGGCGGGCGTAGGCGGTATCGATCACGCTTTGCTG
GTGGTCGCCTGTGATGACGGCGTCATGGCGCAAACGCGCGAGCATTTACAGATCCTACAACTGACGGGTAATCTCCAGCT
CACCGTCGCGCTGACCAAAGCCGATCGCGTGGACGAGGCGCGTATCGGTGAAGTACGTGAAGAGGTACTGGCGGCGCTCG
ACAACTATGGCTTCGCCGATACCGTTTTATTTGTCACCGCCGCCAATGAAGGACGCGGTATTGCAGAACTTCGCGCTCAT
TTACAGCAGCTTCCTGCACGTTCGCACGCCGCGCAGCATCGCTTCCGCCTGGCTATCGACCGTGCGTTTACGGTGAAAGG
GGCGGGACTGGTGGTGACCGGAACGGCGCTGAGCGGAGAGGTAAACGTGGGCGATACGCTATGGTTGACCGGCGTTAATA
CGCCGATGCGCGTACGAAGTCTACACGCGCAAAATCAGCCCACTGACCATGCGTATGCCGGGCAACGTATTGCGCTCAAT
ATTGCGGGCGATGCGGAGAAGGAGCAGCTTAACCGCGGCGACTGGCTGCTTTCCGATGCGCCGGTGGGGGAGGCTTTTTC
CCGGGTGATCGTTTCTCTGGCGCTTCATGCGCCGCTTTCCCAATGGCAACCGCTACATATTCACCATGCTGCCAGCCATG
TGACCGGTCGCGTCTCTTTGCTGGAAGGCGGGCTGGCCGAGCTGATCTTTGATACGCCGTTGTGGCTGGCCGATAATGAC
AGACTGGTGCTGCGTGATATTTCCGCACGTGCCACCCTTGCCGGCGCACGCGTGGTGACGCTTAAGGCGCCGCGTCGCGG
TAAACGTAAGCCAGATTATTTGCACTGGCTTTCAACGCTTGCCGCCGCGCAGGACGATAGCGCGGCGTTGGCCATTCATC
TGGAACGCGGCGCCGTCAACCTGCCGGATTTCGGTTGGGCGCGTCAGCTTAATCCTCTCGGTATGCGTCAGCTTATTGAG
CAACATGGTTTTATCCAGGCTGGAGACAATTTGTTAAGCGCGCCCGTCGCCGCCCGCTGGCAGCGTAAGATTCTTGATAC
GCTGGCGACCTACCACGAACAGCACCGCGATGAACCGGGGCCGGGACGCGAGCGTTTACGCCGCATGGCCCTGCCGATGG
AGGATGAAGCGCTGGTTCTGATGCTGATCGAGCGGATGCGCGACGACGGCCTGATTCATAGCCATCACGGTTGGTTGCAT
CTGCCGGATCATAAAGCGGGATTTAGCGATGAGCAGCAGGCCGTCTGGCAAAAAGTCGAACCGCTATTTGGCGATGAACC
CTGGTGGGTACGCGATCTGGCGAAAGAGACCGGAACGGAAGAACAATTGATGCGGCTGGTGCTGCGGCAGGCGGCACAGC
AAGGCATCATTACCGCGATCGTAAAAGATCGGTACTATCGTAACGATCGGATTGTCGCTTTCGCCAATATGATCCGCGAG
CTGGATCAAGAGAGAGGATCAACCTGTGCGGCGGATTTTCGCGACAGGCTGAATGTAGGGCGGAAACTGGCCATTCAGAT
CCTTGAATATTTTGACCGGATTGGATTTACACGACGTCGTGGGAATGATCATTTATTACGTGATGCGTTATTATTTCCGC
AAAAAGAATGA

Upstream 100 bases:

>100_bases
TGCTGCCTGTACCGGTCATTGGCCGAATTTATGATGGCCGTTTATGGCTGGATATGCGCTGTCTTGAAGACGAAAGCCGG
TTTATGGAGATGATGCTGAA

Downstream 100 bases:

>100_bases
AATGGTTAAATTAAATAACAAATGAAGCAATACAATTATTGCGTTGCTTTATAAAAAGCACATCAGGAAATGAACCAGAT
GTGCTTTTTATTTTTCTGGC

Product: selenocysteinyl-tRNA-specific translation factor

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 616; Mature: 616

Protein sequence:

>616_residues
MIIATAGHVDHGKTTLLQAITGVNADRLPEEKKRGMTIDLGYAYWPQPDGRVLGFIDVPGHEKFLSNMLAGVGGIDHALL
VVACDDGVMAQTREHLQILQLTGNLQLTVALTKADRVDEARIGEVREEVLAALDNYGFADTVLFVTAANEGRGIAELRAH
LQQLPARSHAAQHRFRLAIDRAFTVKGAGLVVTGTALSGEVNVGDTLWLTGVNTPMRVRSLHAQNQPTDHAYAGQRIALN
IAGDAEKEQLNRGDWLLSDAPVGEAFSRVIVSLALHAPLSQWQPLHIHHAASHVTGRVSLLEGGLAELIFDTPLWLADND
RLVLRDISARATLAGARVVTLKAPRRGKRKPDYLHWLSTLAAAQDDSAALAIHLERGAVNLPDFGWARQLNPLGMRQLIE
QHGFIQAGDNLLSAPVAARWQRKILDTLATYHEQHRDEPGPGRERLRRMALPMEDEALVLMLIERMRDDGLIHSHHGWLH
LPDHKAGFSDEQQAVWQKVEPLFGDEPWWVRDLAKETGTEEQLMRLVLRQAAQQGIITAIVKDRYYRNDRIVAFANMIRE
LDQERGSTCAADFRDRLNVGRKLAIQILEYFDRIGFTRRRGNDHLLRDALLFPQKE

Sequences:

>Translated_616_residues
MIIATAGHVDHGKTTLLQAITGVNADRLPEEKKRGMTIDLGYAYWPQPDGRVLGFIDVPGHEKFLSNMLAGVGGIDHALL
VVACDDGVMAQTREHLQILQLTGNLQLTVALTKADRVDEARIGEVREEVLAALDNYGFADTVLFVTAANEGRGIAELRAH
LQQLPARSHAAQHRFRLAIDRAFTVKGAGLVVTGTALSGEVNVGDTLWLTGVNTPMRVRSLHAQNQPTDHAYAGQRIALN
IAGDAEKEQLNRGDWLLSDAPVGEAFSRVIVSLALHAPLSQWQPLHIHHAASHVTGRVSLLEGGLAELIFDTPLWLADND
RLVLRDISARATLAGARVVTLKAPRRGKRKPDYLHWLSTLAAAQDDSAALAIHLERGAVNLPDFGWARQLNPLGMRQLIE
QHGFIQAGDNLLSAPVAARWQRKILDTLATYHEQHRDEPGPGRERLRRMALPMEDEALVLMLIERMRDDGLIHSHHGWLH
LPDHKAGFSDEQQAVWQKVEPLFGDEPWWVRDLAKETGTEEQLMRLVLRQAAQQGIITAIVKDRYYRNDRIVAFANMIRE
LDQERGSTCAADFRDRLNVGRKLAIQILEYFDRIGFTRRRGNDHLLRDALLFPQKE
>Mature_616_residues
MIIATAGHVDHGKTTLLQAITGVNADRLPEEKKRGMTIDLGYAYWPQPDGRVLGFIDVPGHEKFLSNMLAGVGGIDHALL
VVACDDGVMAQTREHLQILQLTGNLQLTVALTKADRVDEARIGEVREEVLAALDNYGFADTVLFVTAANEGRGIAELRAH
LQQLPARSHAAQHRFRLAIDRAFTVKGAGLVVTGTALSGEVNVGDTLWLTGVNTPMRVRSLHAQNQPTDHAYAGQRIALN
IAGDAEKEQLNRGDWLLSDAPVGEAFSRVIVSLALHAPLSQWQPLHIHHAASHVTGRVSLLEGGLAELIFDTPLWLADND
RLVLRDISARATLAGARVVTLKAPRRGKRKPDYLHWLSTLAAAQDDSAALAIHLERGAVNLPDFGWARQLNPLGMRQLIE
QHGFIQAGDNLLSAPVAARWQRKILDTLATYHEQHRDEPGPGRERLRRMALPMEDEALVLMLIERMRDDGLIHSHHGWLH
LPDHKAGFSDEQQAVWQKVEPLFGDEPWWVRDLAKETGTEEQLMRLVLRQAAQQGIITAIVKDRYYRNDRIVAFANMIRE
LDQERGSTCAADFRDRLNVGRKLAIQILEYFDRIGFTRRRGNDHLLRDALLFPQKE

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=280, Percent_Identity=32.1428571428571, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI54607086, Length=285, Percent_Identity=25.9649122807018, Blast_Score=106, Evalue=8e-23,
Organism=Homo sapiens, GI223555963, Length=374, Percent_Identity=25.9358288770053, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI5729864, Length=374, Percent_Identity=25.9358288770053, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI53729339, Length=250, Percent_Identity=29.6, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI53729337, Length=250, Percent_Identity=29.6, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI46094014, Length=381, Percent_Identity=23.6220472440945, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI194018520, Length=298, Percent_Identity=24.1610738255034, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI194097354, Length=298, Percent_Identity=24.1610738255034, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI194018522, Length=302, Percent_Identity=23.841059602649, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI2367247, Length=615, Percent_Identity=85.0406504065041, Blast_Score=1065, Evalue=0.0,
Organism=Escherichia coli, GI1790412, Length=369, Percent_Identity=28.4552845528455, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1789737, Length=369, Percent_Identity=28.4552845528455, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789108, Length=334, Percent_Identity=27.5449101796407, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1789559, Length=96, Percent_Identity=39.5833333333333, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25141371, Length=230, Percent_Identity=35.2173913043478, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17556456, Length=375, Percent_Identity=27.4666666666667, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17506081, Length=262, Percent_Identity=27.4809160305344, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI115532067, Length=304, Percent_Identity=26.6447368421053, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI115532065, Length=304, Percent_Identity=26.6447368421053, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17552884, Length=406, Percent_Identity=24.8768472906404, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17569207, Length=406, Percent_Identity=24.8768472906404, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71994658, Length=234, Percent_Identity=30.7692307692308, Blast_Score=76, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324761, Length=303, Percent_Identity=32.6732673267327, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6325337, Length=407, Percent_Identity=24.0786240786241, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319594, Length=407, Percent_Identity=24.0786240786241, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320377, Length=281, Percent_Identity=24.1992882562278, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324550, Length=121, Percent_Identity=31.404958677686, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921738, Length=264, Percent_Identity=32.1969696969697, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI281363316, Length=288, Percent_Identity=30.9027777777778, Blast_Score=116, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17864358, Length=288, Percent_Identity=30.9027777777778, Blast_Score=116, Evalue=6e-26,
Organism=Drosophila melanogaster, GI19922690, Length=260, Percent_Identity=31.5384615384615, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI45550900, Length=378, Percent_Identity=22.4867724867725, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17137380, Length=351, Percent_Identity=24.5014245014245, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI45553807, Length=317, Percent_Identity=25.5520504731861, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45553816, Length=317, Percent_Identity=25.5520504731861, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24651721, Length=317, Percent_Identity=25.5520504731861, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17864154, Length=317, Percent_Identity=25.5520504731861, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28572034, Length=149, Percent_Identity=34.8993288590604, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 68652; Mature: 68652

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIATAGHVDHGKTTLLQAITGVNADRLPEEKKRGMTIDLGYAYWPQPDGRVLGFIDVPG
CEEEECCCCCCCHHHHHHHHHCCCHHCCCHHHHCCCEEEECEEECCCCCCCEEEEEECCC
HEKFLSNMLAGVGGIDHALLVVACDDGVMAQTREHLQILQLTGNLQLTVALTKADRVDEA
HHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHEEEEECCCEEEEEEEECCCCCCHH
RIGEVREEVLAALDNYGFADTVLFVTAANEGRGIAELRAHLQQLPARSHAAQHRFRLAID
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHEEEE
RAFTVKGAGLVVTGTALSGEVNVGDTLWLTGVNTPMRVRSLHAQNQPTDHAYAGQRIALN
EEEEEECCCEEEEECEECCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCCEEEEE
IAGDAEKEQLNRGDWLLSDAPVGEAFSRVIVSLALHAPLSQWQPLHIHHAASHVTGRVSL
ECCCCCHHHCCCCCEEECCCCHHHHHHHHHHHHHHHCCHHHCCCEEEEHHHHHHHCCHHH
LEGGLAELIFDTPLWLADNDRLVLRDISARATLAGARVVTLKAPRRGKRKPDYLHWLSTL
HHCCHHHHHHCCCCEEECCCEEEEEECCCHHEECCCEEEEEECCCCCCCCCHHHHHHHHH
AAAQDDSAALAIHLERGAVNLPDFGWARQLNPLGMRQLIEQHGFIQAGDNLLSAPVAARW
HHCCCCCCEEEEEEECCCCCCCCCCHHHCCCHHHHHHHHHHCCCEECCCCHHCCHHHHHH
QRKILDTLATYHEQHRDEPGPGRERLRRMALPMEDEALVLMLIERMRDDGLIHSHHGWLH
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEECCCCEEE
LPDHKAGFSDEQQAVWQKVEPLFGDEPWWVRDLAKETGTEEQLMRLVLRQAAQQGIITAI
CCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHH
VKDRYYRNDRIVAFANMIRELDQERGSTCAADFRDRLNVGRKLAIQILEYFDRIGFTRRR
HHHHHHCCCCCHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEECC
GNDHLLRDALLFPQKE
CCCHHHHHHHCCCCCC
>Mature Secondary Structure
MIIATAGHVDHGKTTLLQAITGVNADRLPEEKKRGMTIDLGYAYWPQPDGRVLGFIDVPG
CEEEECCCCCCCHHHHHHHHHCCCHHCCCHHHHCCCEEEECEEECCCCCCCEEEEEECCC
HEKFLSNMLAGVGGIDHALLVVACDDGVMAQTREHLQILQLTGNLQLTVALTKADRVDEA
HHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHEEEEECCCEEEEEEEECCCCCCHH
RIGEVREEVLAALDNYGFADTVLFVTAANEGRGIAELRAHLQQLPARSHAAQHRFRLAID
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHEEEE
RAFTVKGAGLVVTGTALSGEVNVGDTLWLTGVNTPMRVRSLHAQNQPTDHAYAGQRIALN
EEEEEECCCEEEEECEECCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCCEEEEE
IAGDAEKEQLNRGDWLLSDAPVGEAFSRVIVSLALHAPLSQWQPLHIHHAASHVTGRVSL
ECCCCCHHHCCCCCEEECCCCHHHHHHHHHHHHHHHCCHHHCCCEEEEHHHHHHHCCHHH
LEGGLAELIFDTPLWLADNDRLVLRDISARATLAGARVVTLKAPRRGKRKPDYLHWLSTL
HHCCHHHHHHCCCCEEECCCEEEEEECCCHHEECCCEEEEEECCCCCCCCCHHHHHHHHH
AAAQDDSAALAIHLERGAVNLPDFGWARQLNPLGMRQLIEQHGFIQAGDNLLSAPVAARW
HHCCCCCCEEEEEEECCCCCCCCCCHHHCCCHHHHHHHHHHCCCEECCCCHHCCHHHHHH
QRKILDTLATYHEQHRDEPGPGRERLRRMALPMEDEALVLMLIERMRDDGLIHSHHGWLH
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEECCCCEEE
LPDHKAGFSDEQQAVWQKVEPLFGDEPWWVRDLAKETGTEEQLMRLVLRQAAQQGIITAI
CCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHH
VKDRYYRNDRIVAFANMIRELDQERGSTCAADFRDRLNVGRKLAIQILEYFDRIGFTRRR
HHHHHHCCCCCHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEECC
GNDHLLRDALLFPQKE
CCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2531290; 8041620; 9278503; 2140572 [H]