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The map label for this gene is cysJ [H]

Identifier: 16766254

GI number: 16766254

Start: 3090711

End: 3092510

Strand: Reverse

Name: cysJ [H]

Synonym: STM2948

Alternate gene names: 16766254

Gene position: 3092510-3090711 (Counterclockwise)

Preceding gene: 16766256

Following gene: 16766253

Centisome position: 63.67

GC content: 57.5

Gene sequence:

>1800_bases
ATGACGACACCGGCTCCACTGACTGGGTTGCTTCCGCTTAATCCGGAGCAACTGGCGCGCCTTCAGGCCGCGACAACCGA
CCTTACTCCCGAACAGCTTGCCTGGGTCTCCGGCTATTTTTGGGGCGTACTGAACCCGCGCTCAGGCGCTGTTGCCGTCA
CGCCTGTTCCTGAGCGGAAGATGCCGCGGGTTACGCTTATCTCCGCTTCGCAAACCGGCAATGCGCGTCGTGTGGCGGAA
GCGCTGCGTGATGATCTGCTGGCGGCCAACCTTAATGTGACACTGGTGAACGCCGGCGACTACAAATTCAAACAGATTGC
CAGTGAAAAACTGTTGGTGATAGTGACGTCCACCCAGGGAGAAGGCGAGCCGCCGGAAGAGGCCGTCGCGCTGCATAAAT
TCCTGTTCTCCAAAAAAGCGCCGAAACTGGAAAACACCGCTTTTGCCGTGTTTAGCCTCGGCGACACCTCTTATGAATTT
TTCTGCCAGTCCGGAAAAGATTTCGACAGCAAACTGGCGGAACTGGGCGGTGAACGTCTGCTCGACCGTGTCGATGCTGA
CGTTGAATATCAGGCAGCTGCCAGCGAATGGCGCGCCCGCGTGGTTGATGTTCTGAAGTCTCGCGCACCTGTCGCGGCAC
CTTCGCAATCCGTCGCTACTGGCGCGGTAAACGACATCCACACCAGCCCCTATACTAAAGACGCGCCGCTGATCGCGACC
CTCTCCGTGAATCAGAAAATCACCGGTCGCAACTCGGAAAAAGATGTGCGTCATATTGAGATTGATTTAGGCGACTCCGG
CCTGCGCTATCAGCCGGGCGATGCGCTGGGCGTCTGGTATCAGAACGATCCGGCTCTGGTGAAGGAGCTGGTTGAGTTGC
TGTGGCTGAAGGGCGATGAGCCGGTGACGGTTGACGGTAAAACCCTGCCGCTCGCCGAAGCGCTGGAGTGGCACTTCGAG
CTGACGGTGAATACCGCCAACATTGTTGAGAACTACGCGACCCTGACGCGCAGTGAGTCGCTGTTGCCATTAGTGGGCGA
CAAAGCGCAGCTCCAGCATTACGCCGCGACCACGCCCATTGTTGATATGGTGCGTTTCTCTCCGGCACAGCTGGATGCTC
AGGCGCTAATCGACCTGCTGCGTCCGCTAACGCCGCGTCTGTACTCCATCGCCTCCGCACAGGCTGAAGTGGAGAGCGAA
GTGCATATCACCGTTGGCGTGGTTCGTTATGACATTGAAGGCCGCGCCCGCGCCGGTGGCGCTTCCAGCTTCCTCGCCGA
CCGCGTGGAAGAAGAGGGCGAAGTTCGCGTCTTTATTGAGCATAACGATAACTTCCGCCTGCCAGCTAACCCGGAAACGC
CGGTGATCATGATTGGCCCCGGTACCGGCATCGCGCCGTTCCGCTCCTTTATGCAACAGCGCGCGGCGGAAGGGGTGGAA
GGTAAGAACTGGTTGTTCTTCGGCAACCCGCACTTTACCGAAGATTTCCTCTATCAGGTGGAGTGGCAGCGCTACGTGAA
AGAGGGGGTGTTAAGCCGTATCGATCTCGCCTGGTCACGCGATCAAAAAGAAAAAATTTACGTACAAGACAAGCTGCGTG
AACAGGGCGCCGAGCTGTGGCGCTGGATCAATGATGGCGCGCATATTTATGTCTGCGGCGACGCCAGGCGCATGGCCGCA
GATGTCGAAAAAGCATTGCTGGAAGTGATCGCTGAATTCGGCGGTATGGACCTCGAATCGGCAGATGAATATTTAAGTGA
GCTGCGCGTAGAGCGCCGTTATCAGCGAGATGTCTACTAA

Upstream 100 bases:

>100_bases
AGTCACGTATTTATGTACGCTCCTGGGGCGCGATCAGCTTACGGCGAACTTGAATGATTTTGTGTATAGATCCGCTTTGC
TTACTGGAACATAACGACGC

Downstream 100 bases:

>100_bases
TGAGCGAAAAACATCCAGGCCCACTGGTGGTCGAAGGTAAACTGTCCGATGCCGAGCGCATGAAGCTGGAAAGCAACTAT
CTGCGCGGCACCATTGCGGA

Product: sulfite reductase subunit alpha

Products: NA

Alternate protein names: SiR-FP [H]

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MTTPAPLTGLLPLNPEQLARLQAATTDLTPEQLAWVSGYFWGVLNPRSGAVAVTPVPERKMPRVTLISASQTGNARRVAE
ALRDDLLAANLNVTLVNAGDYKFKQIASEKLLVIVTSTQGEGEPPEEAVALHKFLFSKKAPKLENTAFAVFSLGDTSYEF
FCQSGKDFDSKLAELGGERLLDRVDADVEYQAAASEWRARVVDVLKSRAPVAAPSQSVATGAVNDIHTSPYTKDAPLIAT
LSVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDEPVTVDGKTLPLAEALEWHFE
LTVNTANIVENYATLTRSESLLPLVGDKAQLQHYAATTPIVDMVRFSPAQLDAQALIDLLRPLTPRLYSIASAQAEVESE
VHITVGVVRYDIEGRARAGGASSFLADRVEEEGEVRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRSFMQQRAAEGVE
GKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLSRIDLAWSRDQKEKIYVQDKLREQGAELWRWINDGAHIYVCGDARRMAA
DVEKALLEVIAEFGGMDLESADEYLSELRVERRYQRDVY

Sequences:

>Translated_599_residues
MTTPAPLTGLLPLNPEQLARLQAATTDLTPEQLAWVSGYFWGVLNPRSGAVAVTPVPERKMPRVTLISASQTGNARRVAE
ALRDDLLAANLNVTLVNAGDYKFKQIASEKLLVIVTSTQGEGEPPEEAVALHKFLFSKKAPKLENTAFAVFSLGDTSYEF
FCQSGKDFDSKLAELGGERLLDRVDADVEYQAAASEWRARVVDVLKSRAPVAAPSQSVATGAVNDIHTSPYTKDAPLIAT
LSVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDEPVTVDGKTLPLAEALEWHFE
LTVNTANIVENYATLTRSESLLPLVGDKAQLQHYAATTPIVDMVRFSPAQLDAQALIDLLRPLTPRLYSIASAQAEVESE
VHITVGVVRYDIEGRARAGGASSFLADRVEEEGEVRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRSFMQQRAAEGVE
GKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLSRIDLAWSRDQKEKIYVQDKLREQGAELWRWINDGAHIYVCGDARRMAA
DVEKALLEVIAEFGGMDLESADEYLSELRVERRYQRDVY
>Mature_598_residues
TTPAPLTGLLPLNPEQLARLQAATTDLTPEQLAWVSGYFWGVLNPRSGAVAVTPVPERKMPRVTLISASQTGNARRVAEA
LRDDLLAANLNVTLVNAGDYKFKQIASEKLLVIVTSTQGEGEPPEEAVALHKFLFSKKAPKLENTAFAVFSLGDTSYEFF
CQSGKDFDSKLAELGGERLLDRVDADVEYQAAASEWRARVVDVLKSRAPVAAPSQSVATGAVNDIHTSPYTKDAPLIATL
SVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDEPVTVDGKTLPLAEALEWHFEL
TVNTANIVENYATLTRSESLLPLVGDKAQLQHYAATTPIVDMVRFSPAQLDAQALIDLLRPLTPRLYSIASAQAEVESEV
HITVGVVRYDIEGRARAGGASSFLADRVEEEGEVRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRSFMQQRAAEGVEG
KNWLFFGNPHFTEDFLYQVEWQRYVKEGVLSRIDLAWSRDQKEKIYVQDKLREQGAELWRWINDGAHIYVCGDARRMAAD
VEKALLEVIAEFGGMDLESADEYLSELRVERRYQRDVY

Specific function: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow f

COG id: COG0369

COG function: function code P; Sulfite reductase, alpha subunit (flavoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 flavodoxin-like domain [H]

Homologues:

Organism=Homo sapiens, GI127139033, Length=601, Percent_Identity=30.6156405990017, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI7657393, Length=595, Percent_Identity=30.4201680672269, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI221316709, Length=595, Percent_Identity=30.2521008403361, Blast_Score=227, Evalue=3e-59,
Organism=Homo sapiens, GI221316705, Length=604, Percent_Identity=29.9668874172185, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI24041029, Length=598, Percent_Identity=30.4347826086957, Blast_Score=219, Evalue=7e-57,
Organism=Homo sapiens, GI221316707, Length=525, Percent_Identity=30.0952380952381, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI10835173, Length=655, Percent_Identity=28.8549618320611, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI40254422, Length=652, Percent_Identity=27.1472392638037, Blast_Score=166, Evalue=8e-41,
Organism=Homo sapiens, GI169790956, Length=420, Percent_Identity=27.6190476190476, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI169790958, Length=420, Percent_Identity=27.6190476190476, Blast_Score=155, Evalue=8e-38,
Organism=Escherichia coli, GI1789123, Length=599, Percent_Identity=90.8180300500835, Blast_Score=1120, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17554134, Length=593, Percent_Identity=30.5227655986509, Blast_Score=230, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17566446, Length=589, Percent_Identity=25.8064516129032, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17531441, Length=395, Percent_Identity=25.3164556962025, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321832, Length=640, Percent_Identity=29.21875, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6321143, Length=399, Percent_Identity=30.3258145363409, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6325305, Length=627, Percent_Identity=23.6044657097289, Blast_Score=140, Evalue=8e-34,
Organism=Drosophila melanogaster, GI17137192, Length=600, Percent_Identity=28.5, Blast_Score=216, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24582192, Length=511, Percent_Identity=29.9412915851272, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24583543, Length=528, Percent_Identity=30.6818181818182, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI78706872, Length=528, Percent_Identity=30.6818181818182, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI78706876, Length=528, Percent_Identity=30.6818181818182, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24660907, Length=596, Percent_Identity=25.3355704697987, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24660903, Length=596, Percent_Identity=25.3355704697987, Blast_Score=148, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010199
- InterPro:   IPR003097
- InterPro:   IPR017927
- InterPro:   IPR001094
- InterPro:   IPR008254
- InterPro:   IPR001709
- InterPro:   IPR023173
- InterPro:   IPR001433
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00667 FAD_binding_1; PF00258 Flavodoxin_1; PF00175 NAD_binding_1 [H]

EC number: =1.8.1.2 [H]

Molecular weight: Translated: 66485; Mature: 66354

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS50902 FLAVODOXIN_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPAPLTGLLPLNPEQLARLQAATTDLTPEQLAWVSGYFWGVLNPRSGAVAVTPVPERK
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHEEEEEECCCCCEEEECCCCCCC
MPRVTLISASQTGNARRVAEALRDDLLAANLNVTLVNAGDYKFKQIASEKLLVIVTSTQG
CCEEEEEECCCCCCHHHHHHHHHHHHEEECCCEEEEECCCCHHHHHCCCCEEEEEECCCC
EGEPPEEAVALHKFLFSKKAPKLENTAFAVFSLGDTSYEFFCQSGKDFDSKLAELGGERL
CCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEHHCCCCCCHHHHHHHHCHHHH
LDRVDADVEYQAAASEWRARVVDVLKSRAPVAAPSQSVATGAVNDIHTSPYTKDAPLIAT
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
LSVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDE
EECCCEECCCCCCCCCEEEEEEECCCCCEECCCCEEEEEECCCHHHHHHHHHHHHCCCCC
PVTVDGKTLPLAEALEWHFELTVNTANIVENYATLTRSESLLPLVGDKAQLQHYAATTPI
CEEECCCCCCHHHHHEEEEEEEEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCH
VDMVRFSPAQLDAQALIDLLRPLTPRLYSIASAQAEVESEVHITVGVVRYDIEGRARAGG
HHHHHCCCHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCC
ASSFLADRVEEEGEVRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRSFMQQRAAEGVE
HHHHHHHHHCCCCCEEEEEEECCCEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCC
GKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLSRIDLAWSRDQKEKIYVQDKLREQGAELW
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHH
RWINDGAHIYVCGDARRMAADVEKALLEVIAEFGGMDLESADEYLSELRVERRYQRDVY
HHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTPAPLTGLLPLNPEQLARLQAATTDLTPEQLAWVSGYFWGVLNPRSGAVAVTPVPERK
CCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHEEEEEECCCCCEEEECCCCCCC
MPRVTLISASQTGNARRVAEALRDDLLAANLNVTLVNAGDYKFKQIASEKLLVIVTSTQG
CCEEEEEECCCCCCHHHHHHHHHHHHEEECCCEEEEECCCCHHHHHCCCCEEEEEECCCC
EGEPPEEAVALHKFLFSKKAPKLENTAFAVFSLGDTSYEFFCQSGKDFDSKLAELGGERL
CCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEHHCCCCCCHHHHHHHHCHHHH
LDRVDADVEYQAAASEWRARVVDVLKSRAPVAAPSQSVATGAVNDIHTSPYTKDAPLIAT
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
LSVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDE
EECCCEECCCCCCCCCEEEEEEECCCCCEECCCCEEEEEECCCHHHHHHHHHHHHCCCCC
PVTVDGKTLPLAEALEWHFELTVNTANIVENYATLTRSESLLPLVGDKAQLQHYAATTPI
CEEECCCCCCHHHHHEEEEEEEEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCH
VDMVRFSPAQLDAQALIDLLRPLTPRLYSIASAQAEVESEVHITVGVVRYDIEGRARAGG
HHHHHCCCHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCC
ASSFLADRVEEEGEVRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRSFMQQRAAEGVE
HHHHHHHHHCCCCCEEEEEEECCCEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCC
GKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLSRIDLAWSRDQKEKIYVQDKLREQGAELW
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHH
RWINDGAHIYVCGDARRMAADVEKALLEVIAEFGGMDLESADEYLSELRVERRYQRDVY
HHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA