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The map label for this gene is invG

Identifier: 16766204

GI number: 16766204

Start: 3041597

End: 3043285

Strand: Reverse

Name: invG

Synonym: STM2898

Alternate gene names: 16766204

Gene position: 3043285-3041597 (Counterclockwise)

Preceding gene: 16766205

Following gene: 16766203

Centisome position: 62.65

GC content: 46.42

Gene sequence:

>1689_bases
ATGAAGACACATATTCTTTTGGCCAGAGTGCTGGCATGTGCCGCGCTTGTTCTGGTTACACCTGGTTATTCTAGTGAAAA
AATACCTGTAACGGGAAGTGGGTTTGTTGCGAAAGACGATAGCCTGCGGACATTTTTCGATGCCATGGCGCTACAGCTAA
AGGAGCCTGTCATTGTTAGCAAAATGGCGGCACGAAAAAAAATTACGGGCAACTTTGAGTTTCACGATCCTAACGCATTA
CTGGAGAAGCTTTCCCTACAACTGGGGCTGATTTGGTATTTCGATGGGCAGGCTATCTATATTTATGACGCCAGTGAAAT
GCGCAATGCCGTGGTTTCTTTACGCAACGTCTCACTCAATGAGTTCAACAATTTTCTAAAACGCTCAGGTTTATATAACA
AAAATTACCCGCTACGTGGCGATAACCGTAAAGGAACATTCTATGTTTCAGGGCCACCCGTCTATGTTGATATGGTGGTC
AACGCCGCCACCATGATGGACAAGCAAAACGATGGTATTGAGCTGGGACGCCAGAAAATAGGGGTGATGCGTCTGAACAA
TACCTTCGTGGGCGATCGTACCTATAATCTGCGCGATCAGAAAATGGTTATTCCCGGTATTGCTACGGCCATTGAAAGGT
TATTGCAGGGAGAAGAGCAACCCTTAGGTAATATTGTCAGTAGCGAACCCCCGGCGATGCCAGCGTTTTCAGCGAATGGA
GAAAAAGGTAAAGCAGCAAATTATGCCGGTGGCATGAGTCTGCAGGAAGCTTTAAAGCAAAATGCCGCGGCGGGCAATAT
TAAAATCGTGGCCTATCCGGATACCAACAGTTTGTTAGTAAAGGGAACGGCTGAGCAGGTGCATTTTATCGAAATGCTGG
TTAAAGCGCTGGATGTCGCCAAACGTCACGTAGAATTATCCCTGTGGATTGTCGATCTTAATAAAAGCGATCTGGAGCGT
TTGGGCACTTCATGGAGCGGCAGCATAACTATTGGGGACAAACTTGGCGTGTCATTAAACCAGTCTTCAATAAGTACCCT
CGATGGCAGTCGATTCATCGCCGCGGTCAATGCGTTAGAAGAGAAGAAACAGGCGACGGTGGTTTCGCGCCCGGTATTAC
TGACTCAGGAAAATGTTCCCGCTATTTTTGATAACAACAGAACGTTTTACACCAAGCTGATTGGGGAACGTAATGTGGCG
CTTGAGCATGTAACATACGGAACAATGATCCGAGTGCTGCCCCGTTTTTCCGCAGATGGTCAGATAGAAATGTCGCTGGA
CATTGAAGATGGCAACGATAAGACGCCGCAATCTGATACTACCACCTCCGTAGATGCGTTACCCGAAGTCGGGCGAACGT
TAATTAGCACTATTGCGAGAGTGCCGCACGGAAAAAGTTTGCTGGTCGGGGGTTATACACGGGATGCAAATACCGATACT
GTCCAAAGTATTCCGTTTTTAGGCAAATTACCGCTTATTGGTAGCCTGTTCCGTTATTCCAGTAAGAATAAAAGTAATGT
TGTTCGTGTGTTCATGATTGAACCAAAAGAAATTGTCGACCCGTTAACGCCGGATGCCAGCGAATCGGTAAACAATATTC
TGAAGCAAAGCGGTGCCTGGAGTGGGGACGATAAGTTACAGAAATGGGTTCGTGTTTATCTGGATAGAGGTCAGGAGGCA
ATTAAATGA

Upstream 100 bases:

>100_bases
ATCATGGTTACTCATCGCCTTCACATTTTTCTAGTGAGATCAAAGAGCTGATCGGCGTTTCGCCGCGGAAATTATCAAAT
ATTATTCAATTGGCAGACAA

Downstream 100 bases:

>100_bases
TTCCTGGCTCAACCTCCGGTATTTCATTTTCCAGAATATTGTCCCGGCAGACATCTCATCAGGATGCGACCCAGCATACT
GATGCGCAACAGGCGGAAAT

Product: outer membrane secretin precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MKTHILLARVLACAALVLVTPGYSSEKIPVTGSGFVAKDDSLRTFFDAMALQLKEPVIVSKMAARKKITGNFEFHDPNAL
LEKLSLQLGLIWYFDGQAIYIYDASEMRNAVVSLRNVSLNEFNNFLKRSGLYNKNYPLRGDNRKGTFYVSGPPVYVDMVV
NAATMMDKQNDGIELGRQKIGVMRLNNTFVGDRTYNLRDQKMVIPGIATAIERLLQGEEQPLGNIVSSEPPAMPAFSANG
EKGKAANYAGGMSLQEALKQNAAAGNIKIVAYPDTNSLLVKGTAEQVHFIEMLVKALDVAKRHVELSLWIVDLNKSDLER
LGTSWSGSITIGDKLGVSLNQSSISTLDGSRFIAAVNALEEKKQATVVSRPVLLTQENVPAIFDNNRTFYTKLIGERNVA
LEHVTYGTMIRVLPRFSADGQIEMSLDIEDGNDKTPQSDTTTSVDALPEVGRTLISTIARVPHGKSLLVGGYTRDANTDT
VQSIPFLGKLPLIGSLFRYSSKNKSNVVRVFMIEPKEIVDPLTPDASESVNNILKQSGAWSGDDKLQKWVRVYLDRGQEA
IK

Sequences:

>Translated_562_residues
MKTHILLARVLACAALVLVTPGYSSEKIPVTGSGFVAKDDSLRTFFDAMALQLKEPVIVSKMAARKKITGNFEFHDPNAL
LEKLSLQLGLIWYFDGQAIYIYDASEMRNAVVSLRNVSLNEFNNFLKRSGLYNKNYPLRGDNRKGTFYVSGPPVYVDMVV
NAATMMDKQNDGIELGRQKIGVMRLNNTFVGDRTYNLRDQKMVIPGIATAIERLLQGEEQPLGNIVSSEPPAMPAFSANG
EKGKAANYAGGMSLQEALKQNAAAGNIKIVAYPDTNSLLVKGTAEQVHFIEMLVKALDVAKRHVELSLWIVDLNKSDLER
LGTSWSGSITIGDKLGVSLNQSSISTLDGSRFIAAVNALEEKKQATVVSRPVLLTQENVPAIFDNNRTFYTKLIGERNVA
LEHVTYGTMIRVLPRFSADGQIEMSLDIEDGNDKTPQSDTTTSVDALPEVGRTLISTIARVPHGKSLLVGGYTRDANTDT
VQSIPFLGKLPLIGSLFRYSSKNKSNVVRVFMIEPKEIVDPLTPDASESVNNILKQSGAWSGDDKLQKWVRVYLDRGQEA
IK
>Mature_562_residues
MKTHILLARVLACAALVLVTPGYSSEKIPVTGSGFVAKDDSLRTFFDAMALQLKEPVIVSKMAARKKITGNFEFHDPNAL
LEKLSLQLGLIWYFDGQAIYIYDASEMRNAVVSLRNVSLNEFNNFLKRSGLYNKNYPLRGDNRKGTFYVSGPPVYVDMVV
NAATMMDKQNDGIELGRQKIGVMRLNNTFVGDRTYNLRDQKMVIPGIATAIERLLQGEEQPLGNIVSSEPPAMPAFSANG
EKGKAANYAGGMSLQEALKQNAAAGNIKIVAYPDTNSLLVKGTAEQVHFIEMLVKALDVAKRHVELSLWIVDLNKSDLER
LGTSWSGSITIGDKLGVSLNQSSISTLDGSRFIAAVNALEEKKQATVVSRPVLLTQENVPAIFDNNRTFYTKLIGERNVA
LEHVTYGTMIRVLPRFSADGQIEMSLDIEDGNDKTPQSDTTTSVDALPEVGRTLISTIARVPHGKSLLVGGYTRDANTDT
VQSIPFLGKLPLIGSLFRYSSKNKSNVVRVFMIEPKEIVDPLTPDASESVNNILKQSGAWSGDDKLQKWVRVYLDRGQEA
IK

Specific function: Involved in the invasion of the cells of the intestinal epithelium. Could be necessary for the export of invasion related determinants

COG id: COG1450

COG function: function code NU; Type II secretory pathway, component PulD

Gene ontology:

Cell location: Cell outer membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP D family

Homologues:

Organism=Escherichia coli, GI1789793, Length=261, Percent_Identity=26.4367816091954, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): INVG_SALTY (P35672)

Other databases:

- EMBL:   X75302
- EMBL:   U08280
- EMBL:   AE006468
- PIR:   S54420
- RefSeq:   NP_461819.1
- DIP:   DIP-48517N
- PRIDE:   P35672
- GeneID:   1254421
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM2898
- NMPDR:   fig|99287.1.peg.2795
- HOGENOM:   HBG640696
- OMA:   VFLIQPR
- ProtClustDB:   PRK15339
- BioCyc:   STYP99287:STM2898-MONOMER
- GO:   GO:0009405
- InterPro:   IPR005644
- InterPro:   IPR004846
- InterPro:   IPR004845
- InterPro:   IPR003522
- PRINTS:   PR01337
- TIGRFAMs:   TIGR02516

Pfam domain/function: PF00263 Secretin; PF03958 Secretin_N

EC number: NA

Molecular weight: Translated: 61767; Mature: 61767

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS00875 T2SP_D

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTHILLARVLACAALVLVTPGYSSEKIPVTGSGFVAKDDSLRTFFDAMALQLKEPVIVS
CCHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCEECCCHHHHHHHHHHHHHCCCHHHH
KMAARKKITGNFEFHDPNALLEKLSLQLGLIWYFDGQAIYIYDASEMRNAVVSLRNVSLN
HHHHHHHCCCCEEECCHHHHHHHHHHEEEEEEEECCEEEEEEEHHHHHHHHHHHHCCCHH
EFNNFLKRSGLYNKNYPLRGDNRKGTFYVSGPPVYVDMVVNAATMMDKQNDGIELGRQKI
HHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCEEEEEHHHHHHHHCCCCCCHHHHHHHE
GVMRLNNTFVGDRTYNLRDQKMVIPGIATAIERLLQGEEQPLGNIVSSEPPAMPAFSANG
EEEEECCEEECCEEECCCCCEEECCHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCC
EKGKAANYAGGMSLQEALKQNAAAGNIKIVAYPDTNSLLVKGTAEQVHFIEMLVKALDVA
CCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHH
KRHVELSLWIVDLNKSDLERLGTSWSGSITIGDKLGVSLNQSSISTLDGSRFIAAVNALE
HHEEEEEEEEEECCHHHHHHCCCCCCCCEEECCCCCCEECCCHHHHCCCCHHHHHHHHHH
EKKQATVVSRPVLLTQENVPAIFDNNRTFYTKLIGERNVALEHVTYGTMIRVLPRFSADG
HHHHHHHHCCCEEEECCCCCEEEECCCEEEEEECCCCCCEEEHHHHHHHHHHHHCCCCCC
QIEMSLDIEDGNDKTPQSDTTTSVDALPEVGRTLISTIARVPHGKSLLVGGYTRDANTDT
EEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCH
VQSIPFLGKLPLIGSLFRYSSKNKSNVVRVFMIEPKEIVDPLTPDASESVNNILKQSGAW
HHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCHHHHCCCCCCHHHHHHHHHHHCCCC
SGDDKLQKWVRVYLDRGQEAIK
CCHHHHHHHHHHHHHCCHHHCC
>Mature Secondary Structure
MKTHILLARVLACAALVLVTPGYSSEKIPVTGSGFVAKDDSLRTFFDAMALQLKEPVIVS
CCHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCEECCCHHHHHHHHHHHHHCCCHHHH
KMAARKKITGNFEFHDPNALLEKLSLQLGLIWYFDGQAIYIYDASEMRNAVVSLRNVSLN
HHHHHHHCCCCEEECCHHHHHHHHHHEEEEEEEECCEEEEEEEHHHHHHHHHHHHCCCHH
EFNNFLKRSGLYNKNYPLRGDNRKGTFYVSGPPVYVDMVVNAATMMDKQNDGIELGRQKI
HHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCEEEEEHHHHHHHHCCCCCCHHHHHHHE
GVMRLNNTFVGDRTYNLRDQKMVIPGIATAIERLLQGEEQPLGNIVSSEPPAMPAFSANG
EEEEECCEEECCEEECCCCCEEECCHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCC
EKGKAANYAGGMSLQEALKQNAAAGNIKIVAYPDTNSLLVKGTAEQVHFIEMLVKALDVA
CCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHH
KRHVELSLWIVDLNKSDLERLGTSWSGSITIGDKLGVSLNQSSISTLDGSRFIAAVNALE
HHEEEEEEEEEECCHHHHHHCCCCCCCCEEECCCCCCEECCCHHHHCCCCHHHHHHHHHH
EKKQATVVSRPVLLTQENVPAIFDNNRTFYTKLIGERNVALEHVTYGTMIRVLPRFSADG
HHHHHHHHCCCEEEECCCCCEEEECCCEEEEEECCCCCCEEEHHHHHHHHHHHHCCCCCC
QIEMSLDIEDGNDKTPQSDTTTSVDALPEVGRTLISTIARVPHGKSLLVGGYTRDANTDT
EEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCH
VQSIPFLGKLPLIGSLFRYSSKNKSNVVRVFMIEPKEIVDPLTPDASESVNNILKQSGAW
HHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCHHHHCCCCCCHHHHHHHHHHHCCCC
SGDDKLQKWVRVYLDRGQEAIK
CCHHHHHHHHHHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7868245; 7997169; 11677609