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The map label for this gene is avrA [H]

Identifier: 16766171

GI number: 16766171

Start: 3009898

End: 3010806

Strand: Reverse

Name: avrA [H]

Synonym: STM2865

Alternate gene names: 16766171

Gene position: 3010806-3009898 (Counterclockwise)

Preceding gene: 16766172

Following gene: 16766166

Centisome position: 61.98

GC content: 42.24

Gene sequence:

>909_bases
ATGATATTTTCGGTGCAGGAGCTATCATGTGGAGGGAAAAGTATGCTAAGTCCTACGACTCGTAATATGGGGGCGAGTTT
ATCGCCTCAGCCTGACGTCAGCGGGGAGCTAAACACCGAAGCATTGACCTGTATTGTTGAGCGTCTGGAAAGTGAAATTA
TAGATGGCAGCTGGATTCATATCAGTTACGAGGAAACCGATCTCGAAATGATGCCTTTTCTTGTTGCACAGGCCAATAAG
AAGTATCCAGAGTTAAATCTTAAATTTGTTATGTCAGTCCATGAGCTTGTTTCCTCTATAAAGGAGACCAGAATGGAAGG
CGTTGAATCTGCCCGATTTCTCGTAAATATGGGAAGTTCAGGTATCCATATTTCAGTCGTCGATTTTAGAGTTATGGACG
GAAAGACATCGGTGATTTTGTTCGAACCAGCAGCGTGTAGCGCTTTTGGACCTGCTTTACTGGCGTTGAGGACCAAAGCA
GCTCTTGAACGTGAACAACTGCCTGATTGTTATTTTGCTATGGTCGAGCTGGACATTCAACGAAGCTCTTCTGAATGCGG
TATTTTTAGCCTGGCGCTCGCCAAAAAACTTCAGCTTGAATTTATGAACTTAGTAAAAATTCATGAAGATAATATTTGTG
AACGTCTGTGTGGTGAAGAACCTTTTCTCCCGTCCGATAAAGCAGACCGCTATCTGCCGGTGAGTTTTTACAAACATACT
CAAGGCGCACAACGATTAAATGAATATGTGGAGGCCAATCCGGCGGCGGGAAGCAGTATAGTAAACAAAAAGAATGAAAC
GCTTTATGAGCGATTCGATAACAATGCCGTTATGCTAAACGATAAAAAACTCTCTATATCCGCTCATAAAAAAAGGATAG
CTGAATATAAGTCTTTACTTAAACCGTAA

Upstream 100 bases:

>100_bases
TAGTAATTCTTATATATAATCATCCGGAGGTGGTTGGTAGCCTGGCTCAATCATTGAGGCATATTTTTGCAGGCAATATA
TTAAATCTGAAAAGTTAAAG

Downstream 100 bases:

>100_bases
TGAAATTATAAGGTTGCCTGCCAGAGGAAATCCTTCCAGCGCCATAAGACTACTCTATATTATGACCGTATGTTTCCTGA
ATAGCAGGCAAAAAAGTGTT

Product: secreted effector protein

Products: NA

Alternate protein names: Virulence factor yopJ [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MIFSVQELSCGGKSMLSPTTRNMGASLSPQPDVSGELNTEALTCIVERLESEIIDGSWIHISYEETDLEMMPFLVAQANK
KYPELNLKFVMSVHELVSSIKETRMEGVESARFLVNMGSSGIHISVVDFRVMDGKTSVILFEPAACSAFGPALLALRTKA
ALEREQLPDCYFAMVELDIQRSSSECGIFSLALAKKLQLEFMNLVKIHEDNICERLCGEEPFLPSDKADRYLPVSFYKHT
QGAQRLNEYVEANPAAGSSIVNKKNETLYERFDNNAVMLNDKKLSISAHKKRIAEYKSLLKP

Sequences:

>Translated_302_residues
MIFSVQELSCGGKSMLSPTTRNMGASLSPQPDVSGELNTEALTCIVERLESEIIDGSWIHISYEETDLEMMPFLVAQANK
KYPELNLKFVMSVHELVSSIKETRMEGVESARFLVNMGSSGIHISVVDFRVMDGKTSVILFEPAACSAFGPALLALRTKA
ALEREQLPDCYFAMVELDIQRSSSECGIFSLALAKKLQLEFMNLVKIHEDNICERLCGEEPFLPSDKADRYLPVSFYKHT
QGAQRLNEYVEANPAAGSSIVNKKNETLYERFDNNAVMLNDKKLSISAHKKRIAEYKSLLKP
>Mature_302_residues
MIFSVQELSCGGKSMLSPTTRNMGASLSPQPDVSGELNTEALTCIVERLESEIIDGSWIHISYEETDLEMMPFLVAQANK
KYPELNLKFVMSVHELVSSIKETRMEGVESARFLVNMGSSGIHISVVDFRVMDGKTSVILFEPAACSAFGPALLALRTKA
ALEREQLPDCYFAMVELDIQRSSSECGIFSLALAKKLQLEFMNLVKIHEDNICERLCGEEPFLPSDKADRYLPVSFYKHT
QGAQRLNEYVEANPAAGSSIVNKKNETLYERFDNNAVMLNDKKLSISAHKKRIAEYKSLLKP

Specific function: Blocks the innate immune response by blocking cytokine production and inducing apoptosis in the infected cells. Inhibits the MAPK and NF-kappa-B signaling pathways by acetylating MAP2K1, MAP2K6 and probably also MAP2K3, MAP2K4 and I-kappa-B kinase on resi

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Note=Secreted via type III secretion system (TTSS) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C55 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005083 [H]

Pfam domain/function: PF03421 YopJ [H]

EC number: NA

Molecular weight: Translated: 33745; Mature: 33745

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFSVQELSCGGKSMLSPTTRNMGASLSPQPDVSGELNTEALTCIVERLESEIIDGSWIH
CEEECHHCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEE
ISYEETDLEMMPFLVAQANKKYPELNLKFVMSVHELVSSIKETRMEGVESARFLVNMGSS
EEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCC
GIHISVVDFRVMDGKTSVILFEPAACSAFGPALLALRTKAALEREQLPDCYFAMVELDIQ
CEEEEEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEEE
RSSSECGIFSLALAKKLQLEFMNLVKIHEDNICERLCGEEPFLPSDKADRYLPVSFYKHT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECHHHHHHH
QGAQRLNEYVEANPAAGSSIVNKKNETLYERFDNNAVMLNDKKLSISAHKKRIAEYKSLL
HHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHCCCEEEEECCEEEHHHHHHHHHHHHHHH
KP
CC
>Mature Secondary Structure
MIFSVQELSCGGKSMLSPTTRNMGASLSPQPDVSGELNTEALTCIVERLESEIIDGSWIH
CEEECHHCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEE
ISYEETDLEMMPFLVAQANKKYPELNLKFVMSVHELVSSIKETRMEGVESARFLVNMGSS
EEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCC
GIHISVVDFRVMDGKTSVILFEPAACSAFGPALLALRTKAALEREQLPDCYFAMVELDIQ
CEEEEEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEEE
RSSSECGIFSLALAKKLQLEFMNLVKIHEDNICERLCGEEPFLPSDKADRYLPVSFYKHT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECHHHHHHH
QGAQRLNEYVEANPAAGSSIVNKKNETLYERFDNNAVMLNDKKLSISAHKKRIAEYKSLL
HHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHCCCEEEEECCEEEHHHHHHHHHHHHHHH
KP
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8045884; 1840573 [H]