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The map label for this gene is tctD

Identifier: 16766096

GI number: 16766096

Start: 2933761

End: 2934435

Strand: Reverse

Name: tctD

Synonym: STM2785

Alternate gene names: 16766096

Gene position: 2934435-2933761 (Counterclockwise)

Preceding gene: 16766106

Following gene: 16766095

Centisome position: 60.41

GC content: 54.96

Gene sequence:

>675_bases
ATGCGTCTCTTATTGGCAGAAGATAACCGTGAGCTGGCTCACTGGCTGGAGAAAGCGCTGGTGCAAAACGGCTTTGCCGT
GGACTGCGTATTTGACGGCCTGGCGGCTGACCATCTTCTGCACAGTGAAATGTACGCGCTGGCGGTGCTGGATATCAATA
TGCCGGGAATGGATGGACTGGAGGTGGTGCAACGGCTGCGTAAACGCGGTCAGACCTTGCCCGTTTTGCTGCTCACGGCG
CGAAGCGCGGTGGCGGATCGCGTAAAAGGTCTCAACGTCGGCGCGGATGACTATCTGCCGAAACCCTTTGAACTGGAAGA
GCTGGATGCCCGTTTACGGGCCTTGCTCCGACGCAGCGCTGGGCAGGTTCATGAAGTTCAGCAACTGGGGGAATTGATCT
TTCATGATGAAGGGTATTTTCTGTTACAGGGGCAGCCGTTAGCGCTGACGCCGCGTGAGCAGGCGCTCTTAACCGTATTG
ATGTACCGACGAACGCGACCAGTTTCGCGTCAGCAGCTTTTTGAACAGGTGTTCAGCCTGAACGATGAGGTAAGCCCTGA
AAGCATTGAACTTTATATTCATCGACTGCGTAAAAAACTTCAGGGAAGCGATGTACGAATTACGACGCTGCGCGGCCTGG
GTTATGTGCTGGAGCGCGGCGATGAAGTGGGTTAA

Upstream 100 bases:

>100_bases
TGATTATGTGAGCCGACATGTAGCAGTTCGGTTGCGTGATTGTTAAAACAATAACCTTTCAATTCCCTTTCAATGCGGCA
GAAACTTTACAGGATGTGAT

Downstream 100 bases:

>100_bases
GCCGCAATCGTTGTACCTGCAACTCTTACTGTTCCTGGGGTTGCCGCTGATTCTGCTATGGGGGCTGTCGGCGTTTAACA
GTTATGTCAATGCGCTACAG

Product: regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MRLLLAEDNRELAHWLEKALVQNGFAVDCVFDGLAADHLLHSEMYALAVLDINMPGMDGLEVVQRLRKRGQTLPVLLLTA
RSAVADRVKGLNVGADDYLPKPFELEELDARLRALLRRSAGQVHEVQQLGELIFHDEGYFLLQGQPLALTPREQALLTVL
MYRRTRPVSRQQLFEQVFSLNDEVSPESIELYIHRLRKKLQGSDVRITTLRGLGYVLERGDEVG

Sequences:

>Translated_224_residues
MRLLLAEDNRELAHWLEKALVQNGFAVDCVFDGLAADHLLHSEMYALAVLDINMPGMDGLEVVQRLRKRGQTLPVLLLTA
RSAVADRVKGLNVGADDYLPKPFELEELDARLRALLRRSAGQVHEVQQLGELIFHDEGYFLLQGQPLALTPREQALLTVL
MYRRTRPVSRQQLFEQVFSLNDEVSPESIELYIHRLRKKLQGSDVRITTLRGLGYVLERGDEVG
>Mature_224_residues
MRLLLAEDNRELAHWLEKALVQNGFAVDCVFDGLAADHLLHSEMYALAVLDINMPGMDGLEVVQRLRKRGQTLPVLLLTA
RSAVADRVKGLNVGADDYLPKPFELEELDARLRALLRRSAGQVHEVQQLGELIFHDEGYFLLQGQPLALTPREQALLTVL
MYRRTRPVSRQQLFEQVFSLNDEVSPESIELYIHRLRKKLQGSDVRITTLRGLGYVLERGDEVG

Specific function: Transcriptional activator of the tctI tricarboxylate transport system operon

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain

Homologues:

Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=42.9223744292237, Blast_Score=167, Evalue=6e-43,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=41.7040358744395, Blast_Score=163, Evalue=7e-42,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=37.6106194690265, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=36.405529953917, Blast_Score=133, Evalue=8e-33,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=34.8017621145374, Blast_Score=126, Evalue=9e-31,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=34.9344978165939, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=36.3636363636364, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=35.2678571428571, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI2367329, Length=234, Percent_Identity=38.034188034188, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=32.7354260089686, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=31.0810810810811, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=29.7777777777778, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=35.1851851851852, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788713, Length=135, Percent_Identity=32.5925925925926, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=26.5486725663717, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790299, Length=126, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=6e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): TCTD_SALTY (P22104)

Other databases:

- EMBL:   M28368
- EMBL:   AF020810
- EMBL:   AE006468
- PIR:   A33861
- RefSeq:   NP_461711.1
- ProteinModelPortal:   P22104
- SMR:   P22104
- PRIDE:   P22104
- GeneID:   1254308
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM2785
- HOGENOM:   HBG753323
- OMA:   RCGPLVY
- ProtClustDB:   PRK15479
- BioCyc:   STYP99287:STM2785-MONOMER
- GO:   GO:0005622
- GO:   GO:0006350
- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- SMART:   SM00448
- SMART:   SM00862

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C; SSF46894 Bipartite_resp_reg_C-effector; SSF52172 CheY_like

EC number: NA

Molecular weight: Translated: 25408; Mature: 25408

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS50110 RESPONSE_REGULATORY; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLLAEDNRELAHWLEKALVQNGFAVDCVFDGLAADHLLHSEMYALAVLDINMPGMDGL
CEEEEECCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHEEEEEEECCCCCCHH
EVVQRLRKRGQTLPVLLLTARSAVADRVKGLNVGADDYLPKPFELEELDARLRALLRRSA
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GQVHEVQQLGELIFHDEGYFLLQGQPLALTPREQALLTVLMYRRTRPVSRQQLFEQVFSL
CHHHHHHHHHHHHCCCCCEEEECCCCEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
NDEVSPESIELYIHRLRKKLQGSDVRITTLRGLGYVLERGDEVG
CCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRLLLAEDNRELAHWLEKALVQNGFAVDCVFDGLAADHLLHSEMYALAVLDINMPGMDGL
CEEEEECCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHEEEEEEECCCCCCHH
EVVQRLRKRGQTLPVLLLTARSAVADRVKGLNVGADDYLPKPFELEELDARLRALLRRSA
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GQVHEVQQLGELIFHDEGYFLLQGQPLALTPREQALLTVLMYRRTRPVSRQQLFEQVFSL
CHHHHHHHHHHHHCCCCCEEEECCCCEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
NDEVSPESIELYIHRLRKKLQGSDVRITTLRGLGYVLERGDEVG
CCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2666399; 11083839; 11677609